DE69325096D1 - Morphinderivate sowie deren konjugate und labels mit proteinen und polypeptiden - Google Patents

Morphinderivate sowie deren konjugate und labels mit proteinen und polypeptiden

Info

Publication number
DE69325096D1
DE69325096D1 DE69325096T DE69325096T DE69325096D1 DE 69325096 D1 DE69325096 D1 DE 69325096D1 DE 69325096 T DE69325096 T DE 69325096T DE 69325096 T DE69325096 T DE 69325096T DE 69325096 D1 DE69325096 D1 DE 69325096D1
Authority
DE
Germany
Prior art keywords
polypeptides
proteins
labels
conjugates
receptors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69325096T
Other languages
English (en)
Other versions
DE69325096T2 (de
Inventor
Kenneth Francis Buechler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alere San Diego Inc
Original Assignee
Biosite Diagnostics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biosite Diagnostics Inc filed Critical Biosite Diagnostics Inc
Publication of DE69325096D1 publication Critical patent/DE69325096D1/de
Application granted granted Critical
Publication of DE69325096T2 publication Critical patent/DE69325096T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G01N33/948—Sedatives, e.g. cannabinoids, barbiturates
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/961—Chemistry: molecular biology and microbiology including a step of forming, releasing, or exposing the antigen or forming the hapten-immunogenic carrier complex or the antigen per se
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/815—Test for named compound or class of compounds
    • Y10S436/816—Alkaloids, amphetamines, and barbiturates
DE69325096T 1992-04-06 1993-03-31 Morphinderivate sowie deren konjugate und labels mit proteinen und polypeptiden Expired - Fee Related DE69325096T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86410792A 1992-04-06 1992-04-06
PCT/US1993/003009 WO1993020079A1 (en) 1992-04-06 1993-03-31 Novel opiate derivatives and protein and polypeptide opiate derivative conjugates and labels

Publications (2)

Publication Number Publication Date
DE69325096D1 true DE69325096D1 (de) 1999-07-01
DE69325096T2 DE69325096T2 (de) 1999-09-30

Family

ID=25342546

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69325096T Expired - Fee Related DE69325096T2 (de) 1992-04-06 1993-03-31 Morphinderivate sowie deren konjugate und labels mit proteinen und polypeptiden

Country Status (8)

Country Link
US (1) US5610283A (de)
EP (1) EP0635019B1 (de)
JP (1) JPH07505634A (de)
AT (1) ATE180484T1 (de)
AU (1) AU3941893A (de)
CA (1) CA2132342A1 (de)
DE (1) DE69325096T2 (de)
WO (1) WO1993020079A1 (de)

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Publication number Priority date Publication date Assignee Title
US6784186B1 (en) 1998-01-29 2004-08-31 Roy W. Jackson Therapeutic compounds
US7060708B2 (en) * 1999-03-10 2006-06-13 New River Pharmaceuticals Inc. Active agent delivery systems and methods for protecting and administering active agents
US6262265B1 (en) * 1999-06-18 2001-07-17 Microgenics Corporation Non-hydrolyzable analogs of heroin metabolites suitable for use in immunoassay
EP2080511A3 (de) * 2000-08-22 2009-09-30 Shire LLC Aktivmittelzufuhrsysteme und Verfahren zum Schutz und zur Lieferung von Aktivmitteln
US8394813B2 (en) * 2000-11-14 2013-03-12 Shire Llc Active agent delivery systems and methods for protecting and administering active agents
BR0210179A (pt) * 2001-06-05 2004-04-27 Control Delivery Sys Inc Compostos analgésicos de liberação sustentada
US7169752B2 (en) * 2003-09-30 2007-01-30 New River Pharmaceuticals Inc. Compounds and compositions for prevention of overdose of oxycodone
US20060014697A1 (en) * 2001-08-22 2006-01-19 Travis Mickle Pharmaceutical compositions for prevention of overdose or abuse
AU2002350207A1 (en) * 2001-11-19 2003-06-10 Control Delivery Systems, Inc. Topical delivery of codrugs
GB0130535D0 (en) * 2001-12-20 2002-02-06 Randox Lab Ltd Haptens immunogens antibodies and conjugates to oxycodone and its metabolites
US7700561B2 (en) 2002-02-22 2010-04-20 Shire Llc Abuse-resistant amphetamine prodrugs
US6991911B2 (en) * 2003-12-15 2006-01-31 Dade Behring Inc. Assay for entactogens
US20050130243A1 (en) * 2003-12-15 2005-06-16 Zheng Yi F. Assay for entactogens
US7022492B2 (en) * 2003-12-15 2006-04-04 Dade Behring Inc. Ecstasy haptens and immunogens
US7037669B2 (en) * 2004-03-22 2006-05-02 Dade Behring Inc. Assays for amphetamine and methamphetamine using stereospecific reagents
US7115383B2 (en) * 2004-03-22 2006-10-03 Dade Behring Inc. Assays for amphetamine and methamphetamine
US7692013B2 (en) * 2004-10-27 2010-04-06 Mallinkrodt Inc. Method for separation and purification of hydrocodone by preparative chromatography
US7238791B1 (en) * 2005-12-16 2007-07-03 Roche Diagnostics Operations, Inc. 6-monoacetylmorphine derivatives useful in immunoassay
AU2007238858A1 (en) * 2006-04-10 2007-10-25 Shire Llc Mono and di-substituted oxycodone compounds and compositions
EP2007389A2 (de) * 2006-04-14 2008-12-31 Shire LLC Zusammensetzungen und verfahren zur verstärkung der analgetischen wirkung kovalent gebundener verbindungen, verminderung ihrer nebenwirkungen und verhinderung ihres missbrauchs
US20080207668A1 (en) * 2006-10-06 2008-08-28 New River Pharmaceuticals Inc. Pharmaceutical compositions of hydromorphone for prevention of overdose or abuse
PT2506857T (pt) 2009-12-01 2018-05-14 Translate Bio Inc Entrega de arnm para o acréscimo de proteínas e enzimas em doenças genéticas humanas
TR201910686T4 (tr) 2011-06-08 2019-08-21 Translate Bio Inc Mrna iletimine yönelik lipit nanopartikül bileşimleri ve yöntemler.
US20150343054A1 (en) * 2011-12-21 2015-12-03 Kim D. Janda Heroin Haptens, Immunoconjugates and Related Uses
US20150267192A1 (en) 2012-06-08 2015-09-24 Shire Human Genetic Therapies, Inc. Nuclease resistant polynucleotides and uses thereof
PL2968586T3 (pl) 2013-03-14 2019-01-31 Translate Bio, Inc. Kompozycje mrna cftr i związne z nimi sposoby i zastosowania
EA201591229A1 (ru) 2013-03-14 2016-01-29 Шир Хьюман Дженетик Терапис, Инк. Способы очистки матричной рнк
CA2905484C (en) * 2013-03-14 2020-07-21 Alere San Diego, Inc. 6-acetylmorphine analogs, and methods for their synthesis and use
EP3060258A1 (de) 2013-10-22 2016-08-31 Shire Human Genetic Therapies, Inc. Mrna-therapie für phenylketonurie
EP4276176A3 (de) 2013-10-22 2024-01-10 Translate Bio, Inc. Mrna-therapie für argininosuccinat-synthase-mangel
EA201691696A1 (ru) 2014-04-25 2017-03-31 Шир Хьюман Дженетик Терапис, Инк. Способы очистки матричной рнк
WO2017127390A1 (en) 2016-01-21 2017-07-27 The Scripps Research Institute Synthetic opioid vaccine
MA47603A (fr) 2017-02-27 2020-01-01 Translate Bio Inc Nouvel arnm cftr à codons optimisés
WO2018213476A1 (en) 2017-05-16 2018-11-22 Translate Bio, Inc. Treatment of cystic fibrosis by delivery of codon-optimized mrna encoding cftr
WO2019094528A1 (en) 2017-11-09 2019-05-16 The Scripps Research Institute An improved heroin vaccine
CA3108544A1 (en) 2018-08-24 2020-02-27 Translate Bio, Inc. Methods for purification of messenger rna

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3852157A (en) * 1971-05-14 1974-12-03 Syva Corp Compounds for enzyme amplification assay
US3884898A (en) * 1972-08-18 1975-05-20 Syva Co Normorphine derivatives bonded to proteins
SE404553B (sv) * 1977-03-04 1978-10-09 Pharmacia Diagnostics Ab Sett vid bestemningsmetoder involverande biospecifika affinitetsreaktioner
SE427505B (sv) * 1977-03-04 1983-04-11 Pharmacia Diagnostics Ab Reagens till anvendning vid immunkemiska bestemningsmetoder
US4695624A (en) * 1984-05-10 1987-09-22 Merck & Co., Inc. Covalently-modified polyanionic bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins with bigeneric spacers, and methods of preparing such polysaccharides and conjugates and of confirming covalency
US4939264A (en) * 1986-07-14 1990-07-03 Abbott Laboratories Immunoassay for opiate alkaloids and their metabolites; tracers, immunogens and antibodies
EP0579767B1 (de) * 1991-04-11 2000-08-23 Biosite Diagnostics Inc. Neue konjugate und testverfahren für die gleichzeitige bestimmung von multiplen liganden

Also Published As

Publication number Publication date
AU3941893A (en) 1993-11-08
US5610283A (en) 1997-03-11
CA2132342A1 (en) 1993-10-14
EP0635019B1 (de) 1999-05-26
ATE180484T1 (de) 1999-06-15
WO1993020079A1 (en) 1993-10-14
EP0635019A1 (de) 1995-01-25
DE69325096T2 (de) 1999-09-30
EP0635019A4 (de) 1995-02-01
JPH07505634A (ja) 1995-06-22

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee