RU95104325A - Коньюгаты антител с улучшенными свойствами - Google Patents

Коньюгаты антител с улучшенными свойствами

Info

Publication number
RU95104325A
RU95104325A RU95104325/14A RU95104325A RU95104325A RU 95104325 A RU95104325 A RU 95104325A RU 95104325/14 A RU95104325/14 A RU 95104325/14A RU 95104325 A RU95104325 A RU 95104325A RU 95104325 A RU95104325 A RU 95104325A
Authority
RU
Russia
Prior art keywords
conjugate
improved properties
antibody conjugates
conjugates showing
showing
Prior art date
Application number
RU95104325/14A
Other languages
English (en)
Inventor
Муррау Др.Брендан
Ch]
О'Рейлли Др.Теренс
Плюшке Др.Герд
De]
Original Assignee
Циба-Гейге А.Г. (CH)
Циба-Гейге А.Г.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Циба-Гейге А.Г. (CH), Циба-Гейге А.Г. filed Critical Циба-Гейге А.Г. (CH)
Publication of RU95104325A publication Critical patent/RU95104325A/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/6415—Toxins or lectins, e.g. clostridial toxins or Pseudomonas exotoxins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Изобретение относится к растворимому конъюгату, в котором белок-носитель ковалентно связан с моноклональным антителом, фармацевтическому препарату, содержащему такой конъюгат, и способу его получения. Конъюгат пригоден, например, для активной иммунотерапии млекопитающего, в особенности человека

Claims (1)

  1. Изобретение относится к растворимому конъюгату, в котором белок-носитель ковалентно связан с моноклональным антителом, фармацевтическому препарату, содержащему такой конъюгат, и способу его получения. Конъюгат пригоден, например, для активной иммунотерапии млекопитающего, в особенности человека.
RU95104325/14A 1994-03-21 1995-03-17 Коньюгаты антител с улучшенными свойствами RU95104325A (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE94810173.8 1994-03-21
EP94810173 1994-03-21

Publications (1)

Publication Number Publication Date
RU95104325A true RU95104325A (ru) 1996-12-27

Family

ID=8218230

Family Applications (1)

Application Number Title Priority Date Filing Date
RU95104325/14A RU95104325A (ru) 1994-03-21 1995-03-17 Коньюгаты антител с улучшенными свойствами

Country Status (11)

Country Link
JP (1) JPH0820545A (ru)
KR (1) KR950031111A (ru)
AU (1) AU1481795A (ru)
CA (1) CA2144936A1 (ru)
FI (1) FI951276A (ru)
HU (1) HUT71776A (ru)
IL (1) IL113022A (ru)
NO (1) NO951061L (ru)
NZ (1) NZ270734A (ru)
RU (1) RU95104325A (ru)
ZA (1) ZA952269B (ru)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2865737B1 (fr) * 2004-02-03 2006-03-31 Anteis Sa Gel reticule biocompatible

Also Published As

Publication number Publication date
AU1481795A (en) 1995-09-28
NO951061D0 (no) 1995-03-20
CA2144936A1 (en) 1995-09-22
HU9500586D0 (en) 1995-04-28
ZA952269B (en) 1995-09-21
NZ270734A (en) 1997-05-26
KR950031111A (ko) 1995-12-18
IL113022A (en) 2000-02-29
FI951276A0 (fi) 1995-03-17
IL113022A0 (en) 1995-06-29
FI951276A (fi) 1995-09-22
JPH0820545A (ja) 1996-01-23
NO951061L (no) 1995-09-22
HUT71776A (en) 1996-01-29

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