DE69322770D1 - Zyklische anti-tumorpromotor-verbindungen, zusammensetzungen und verfahren zur herstellung sowie ihre verwendung - Google Patents

Zyklische anti-tumorpromotor-verbindungen, zusammensetzungen und verfahren zur herstellung sowie ihre verwendung

Info

Publication number
DE69322770D1
DE69322770D1 DE69322770T DE69322770T DE69322770D1 DE 69322770 D1 DE69322770 D1 DE 69322770D1 DE 69322770 T DE69322770 T DE 69322770T DE 69322770 T DE69322770 T DE 69322770T DE 69322770 D1 DE69322770 D1 DE 69322770D1
Authority
DE
Germany
Prior art keywords
production
compositions
connections
methods
cyclic anti
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69322770T
Other languages
English (en)
Other versions
DE69322770T2 (de
Inventor
Marcus TIUS
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Hawaii
Original Assignee
University of Hawaii
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Hawaii filed Critical University of Hawaii
Publication of DE69322770D1 publication Critical patent/DE69322770D1/de
Application granted granted Critical
Publication of DE69322770T2 publication Critical patent/DE69322770T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/45—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C255/46—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of non-condensed rings
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/02—Saturated carboxylic acids or thio analogues thereof; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/16—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound oxygen atoms bound to the same carbon atom of an acyclic carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C35/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C35/02—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring monocyclic
    • C07C35/08—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring monocyclic containing a six-membered rings
    • C07C35/18—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring monocyclic containing a six-membered rings with unsaturation at least in the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C35/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C35/02—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring monocyclic
    • C07C35/205—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring monocyclic containing a nine to twelve-membered rings, e.g. cyclododecanols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C35/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C35/21—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a non-condensed ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C07C45/511—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C07C45/511—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups
    • C07C45/515—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups the singly bound functional group being an acetalised, ketalised hemi-acetalised, or hemi-ketalised hydroxyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/18—Systems containing only non-condensed rings with a ring being at least seven-membered

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69322770T 1992-03-19 1993-03-19 Zyklische anti-tumorpromotor-verbindungen, zusammensetzungen und verfahren zur herstellung sowie ihre verwendung Expired - Fee Related DE69322770T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/854,414 US5276217A (en) 1992-03-19 1992-03-19 Cyclic anti-tumor promoter compounds, compositions and methods for production and use
PCT/US1993/002248 WO1993018651A1 (en) 1992-03-19 1993-03-19 Cyclic anti-tumor promoter compounds, compositions and methods for production and use

Publications (2)

Publication Number Publication Date
DE69322770D1 true DE69322770D1 (de) 1999-02-04
DE69322770T2 DE69322770T2 (de) 1999-07-29

Family

ID=25318627

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69322770T Expired - Fee Related DE69322770T2 (de) 1992-03-19 1993-03-19 Zyklische anti-tumorpromotor-verbindungen, zusammensetzungen und verfahren zur herstellung sowie ihre verwendung

Country Status (9)

Country Link
US (2) US5276217A (de)
EP (1) EP0631474B1 (de)
JP (1) JPH07504675A (de)
KR (1) KR950700684A (de)
AT (1) ATE174756T1 (de)
CA (1) CA2132319A1 (de)
DE (1) DE69322770T2 (de)
DK (1) DK0631474T3 (de)
WO (1) WO1993018651A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8003342B1 (en) * 1990-04-18 2011-08-23 Board Of Regents, The University Of Texas System Method for identifying farnesyl transferase inhibitors
US5276217A (en) * 1992-03-19 1994-01-04 University Of Hawaii Cyclic anti-tumor promoter compounds, compositions and methods for production and use
US5352820A (en) * 1993-06-28 1994-10-04 Levin Jeremy I Expedient route to aryl propenoic esters
US5436263A (en) * 1994-03-22 1995-07-25 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US5420334A (en) * 1994-04-04 1995-05-30 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US5510371A (en) * 1994-06-06 1996-04-23 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US6300371B1 (en) 1998-11-05 2001-10-09 Indian Institute Of Chemical Technology Rameswaralide and rameswaralide derivatives
US20040156799A1 (en) * 2002-06-04 2004-08-12 Zigang Dong Cancer treatment method and compositions
EP2071034A1 (de) 2007-12-12 2009-06-17 bioMérieux Verfahren zur Behandlung einer Lösung zum Vernichten von Ribonukleinsäure nach der Amplifikation

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4181631A (en) * 1975-02-12 1980-01-01 Givaudan Corporation Alpha-hydroxyalkyl-4-tertiary-alkylcyclohexane perfume compositions
GB1542975A (en) * 1976-11-01 1979-03-28 Shell Int Research Unsaturated alcohols and esters
JPS5661317A (en) * 1979-10-25 1981-05-26 Mitsubishi Chem Ind Ltd Cembranolide diterpene
JPS5661318A (en) * 1979-10-26 1981-05-26 Mitsubishi Chem Ind Ltd Cembranolide diterpen
JPS61109713A (ja) * 1984-11-05 1986-05-28 Japan Tobacco Inc 抗腫瘍剤
DE3669497D1 (de) * 1985-02-18 1990-04-19 Kao Corp Cycloalkan-1-ol derivate und duftstoff-zusammensetzungen, die diese enthalten.
JPS6317823A (ja) * 1986-07-10 1988-01-25 Mitsubishi Chem Ind Ltd 抗固形腫瘍剤
JPH0798746B2 (ja) * 1986-12-09 1995-10-25 三菱化学株式会社 リソゾ−ム放出抑制剤
DE3711157A1 (de) * 1987-04-02 1988-10-20 Haarmann & Reimer Gmbh Methylcyclododecatri-2,5,9-en-1-ole, verfahren zu ihrer herstellung und ihre verwendung
US5276217A (en) * 1992-03-19 1994-01-04 University Of Hawaii Cyclic anti-tumor promoter compounds, compositions and methods for production and use

Also Published As

Publication number Publication date
CA2132319A1 (en) 1993-09-30
EP0631474A4 (en) 1995-01-25
ATE174756T1 (de) 1999-01-15
EP0631474A1 (de) 1995-01-04
US5276217A (en) 1994-01-04
WO1993018651A1 (en) 1993-09-30
DK0631474T3 (da) 1999-08-23
EP0631474B1 (de) 1998-12-23
JPH07504675A (ja) 1995-05-25
DE69322770T2 (de) 1999-07-29
US5349112A (en) 1994-09-20
KR950700684A (ko) 1995-02-20

Similar Documents

Publication Publication Date Title
DE69711395D1 (de) Verfahren zur herstellung von cyclohexen-carboxylatderivate
DE58902737D1 (de) Verfahren zur herstellung pharmazeutischer mischungen.
DK590085A (da) Bicycliske heteroarylpiperazinderivater og fremgangsmaade til deres fremstilling
DE3177213D1 (de) Dns-sequenzen, rekombinante dns-molekuele und verfahren zur herstellung von dem menschlichen fibroblast-interferon.
ES2158452T3 (es) Uso de agonistas y antagonistas de estrogenos en la fabricacion de un medicamento para el tratamiento de la ateroesclerosis, independientemente de la disminucion de lipidos.
ATE20889T1 (de) Substituierte 4-aminomethylenchromane bzw. chromene, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln.
ATE77637T1 (de) Antioxidationszusammensetzungen und verfahren zu ihrer verwendung.
DE69407272D1 (de) Verfahren zum reinigen von 20 cs)-camptothecin
UA6044A1 (uk) Спосіб одержання метіленових похідних андроста-1,4 -діен-3,17-діона
DE69322770T2 (de) Zyklische anti-tumorpromotor-verbindungen, zusammensetzungen und verfahren zur herstellung sowie ihre verwendung
ATE140920T1 (de) Indolocarbazol-derivate, verfahren zu deren herstellung und deren verwendung
AT383123B (de) Verfahren zur herstellung von neuen (+)-catechin- alpha- monohydrat
DE3576952D1 (de) Verfahren zur herstellung von 4-phenyl-pyrrol-derivaten.
DE3778089D1 (de) Verfahren zur herstellung und verwendung fester, pflanzenwirksamer zusammensetzungen.
EP0249249A3 (en) Glycerol derivatives
ATE404674T1 (de) Verfahren zur herstellung von ergosterol und dessen zwischenprodukten mittels rekombinanter hefen
DE69313297T2 (de) Benzofuranone, benzodifurantrione und verfahren zur herstellung von benzodifurandionen
DE3482971D1 (de) Landwirtschaftliche zusammensetzungen, verfahren zur herstellung von landwirtschaftlichen zusammensetzungen und verfahren zur verwendung von landwirtschaftlichen zusammensetzungen.
DE59308617D1 (de) 9-chlor-prostaglandin-ester und -amide und ihre verwendung für die herstellung von arzneimitteln
AT380462B (de) Verfahren zur herstellung von calciumcarbid sowie schachtofen zur durchfuehrung des verfahrens
ATE248914T1 (de) Allogenes vakzin und synthesemethode für selbiges
GR80173B (en) Spiro (benzofuran-azalkanes), method for their preparation and their use as medicaments
PT83837A (de) Verfahren zur herstellung von peptiden unter der verwendung von perchloraten
DE3152571A1 (de) Verfahren zur herstellung und verwendung von intravenoesen naehrstoffzusammensetzungen
DE58905083D1 (de) Verfahren zur herstellung von thiophenderivaten sowie dihydrothiophen-1-oxide.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee