JPS5661318A - Cembranolide diterpen - Google Patents
Cembranolide diterpenInfo
- Publication number
- JPS5661318A JPS5661318A JP13843079A JP13843079A JPS5661318A JP S5661318 A JPS5661318 A JP S5661318A JP 13843079 A JP13843079 A JP 13843079A JP 13843079 A JP13843079 A JP 13843079A JP S5661318 A JPS5661318 A JP S5661318A
- Authority
- JP
- Japan
- Prior art keywords
- give
- cembranolide
- sarcophytol
- acetyl
- solvent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
NEW MATERIAL:Cembranolide diterperns of the formula (R is H, acetyl), where it is named sarcophytol A, when R is H and sarcophytol A acetate, when acetyl.
USE: Antileukemia and synthetic intermediate of medicines and agricultural chemicals. Caution should be taken on handling and storing, because they are susceptible to oxidation by air.
PREPARATION: Sarcophyton glaucon living in coral reefs in Indian or Pacific Ocean is dehydrated until it loses the viscous property on the surface and extracted with a solvent such as methanol or chloroform. The solvent is distilled off to give the crude extract. The crude extract is partitioned to give a lipid fraction, which is subjected to silica-gel column chromatography to give the compound of the formula.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP13843079A JPS5661318A (en) | 1979-10-26 | 1979-10-26 | Cembranolide diterpen |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP13843079A JPS5661318A (en) | 1979-10-26 | 1979-10-26 | Cembranolide diterpen |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5661318A true JPS5661318A (en) | 1981-05-26 |
JPS6320213B2 JPS6320213B2 (en) | 1988-04-26 |
Family
ID=15221779
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP13843079A Granted JPS5661318A (en) | 1979-10-26 | 1979-10-26 | Cembranolide diterpen |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5661318A (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6317823A (en) * | 1986-07-10 | 1988-01-25 | Mitsubishi Chem Ind Ltd | Antisolid tumor agent |
EP0462616A2 (en) * | 1990-06-20 | 1991-12-27 | Mitsubishi Chemical Corporation | Conjugated diene compounds, process for producing these compounds and use thereof |
WO1993018651A1 (en) * | 1992-03-19 | 1993-09-30 | University Of Hawaii | Cyclic anti-tumor promoter compounds, compositions and methods for production and use |
CN112876361A (en) * | 2021-01-15 | 2021-06-01 | 宁波大学 | Cedarane diterpenoid compound and preparation method and application thereof |
CN113402528A (en) * | 2020-03-17 | 2021-09-17 | 中国医学科学院药物研究所 | Cedarane type macrocyclic diterpenoid compound, preparation method, pharmaceutical composition and application |
-
1979
- 1979-10-26 JP JP13843079A patent/JPS5661318A/en active Granted
Non-Patent Citations (1)
Title |
---|
CHEMICAL & PHARMACEUTICAL BULLETIN=1979 * |
Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6317823A (en) * | 1986-07-10 | 1988-01-25 | Mitsubishi Chem Ind Ltd | Antisolid tumor agent |
US5300525A (en) * | 1986-07-10 | 1994-04-05 | Mitsubishi Kasei Corporation | Anti-solid tumor agents |
US5387609A (en) * | 1986-07-10 | 1995-02-07 | Mitsubishi Kasei Corporation | Anti-solid tumor agents |
EP0462616A2 (en) * | 1990-06-20 | 1991-12-27 | Mitsubishi Chemical Corporation | Conjugated diene compounds, process for producing these compounds and use thereof |
EP0462616A3 (en) * | 1990-06-20 | 1994-04-20 | Mitsubishi Chem Ind | |
WO1993018651A1 (en) * | 1992-03-19 | 1993-09-30 | University Of Hawaii | Cyclic anti-tumor promoter compounds, compositions and methods for production and use |
US5276217A (en) * | 1992-03-19 | 1994-01-04 | University Of Hawaii | Cyclic anti-tumor promoter compounds, compositions and methods for production and use |
US5349112A (en) * | 1992-03-19 | 1994-09-20 | University Of Hawaii | Cyclic anti-tumor promoter compounds, compositions and methods for production and use |
CN113402528A (en) * | 2020-03-17 | 2021-09-17 | 中国医学科学院药物研究所 | Cedarane type macrocyclic diterpenoid compound, preparation method, pharmaceutical composition and application |
CN113402528B (en) * | 2020-03-17 | 2023-09-26 | 中国医学科学院药物研究所 | Celastracene type macrocyclic diterpenoid compound, preparation method, pharmaceutical composition and application |
CN112876361A (en) * | 2021-01-15 | 2021-06-01 | 宁波大学 | Cedarane diterpenoid compound and preparation method and application thereof |
CN112876361B (en) * | 2021-01-15 | 2022-06-14 | 宁波大学 | Cedarane diterpenoid compound and preparation method and application thereof |
Also Published As
Publication number | Publication date |
---|---|
JPS6320213B2 (en) | 1988-04-26 |
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