DE69321596D1 - Ester und kombinationen von einem organischen nitrat und einem salicyclat - Google Patents

Ester und kombinationen von einem organischen nitrat und einem salicyclat

Info

Publication number
DE69321596D1
DE69321596D1 DE69321596T DE69321596T DE69321596D1 DE 69321596 D1 DE69321596 D1 DE 69321596D1 DE 69321596 T DE69321596 T DE 69321596T DE 69321596 T DE69321596 T DE 69321596T DE 69321596 D1 DE69321596 D1 DE 69321596D1
Authority
DE
Germany
Prior art keywords
organic nitrate
salicyclate
esters
combinations
image
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69321596T
Other languages
English (en)
Other versions
DE69321596T2 (de
Inventor
William Byrne
Andrew Rynne
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cal International Ltd
Original Assignee
Cal International Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cal International Ltd filed Critical Cal International Ltd
Publication of DE69321596D1 publication Critical patent/DE69321596D1/de
Application granted granted Critical
Publication of DE69321596T2 publication Critical patent/DE69321596T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
    • A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/618—Salicylic acid; Derivatives thereof having the carboxyl group in position 1 esterified, e.g. salsalate
    • A61K31/621—Salicylic acid; Derivatives thereof having the carboxyl group in position 1 esterified, e.g. salsalate having the hydroxy group in position 2 esterified, e.g. benorylate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/625—Salicylic acid; Derivatives thereof having heterocyclic substituents, e.g. 4-salicycloylmorpholine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C203/00—Esters of nitric or nitrous acid
    • C07C203/02—Esters of nitric acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C203/00—Esters of nitric or nitrous acid
    • C07C203/02—Esters of nitric acid
    • C07C203/04—Esters of nitric acid having nitrate groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C203/00—Esters of nitric or nitrous acid
    • C07C203/02—Esters of nitric acid
    • C07C203/04—Esters of nitric acid having nitrate groups bound to acyclic carbon atoms
    • C07C203/06—Glycerol trinitrate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DE69321596T 1992-07-30 1993-07-26 Ester und kombinationen von einem organischen nitrat und einem salicyclat Expired - Fee Related DE69321596T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IE922474 1992-07-30
PCT/IE1993/000040 WO1994003421A2 (en) 1992-07-30 1993-07-26 Esters and combinations of an organic nitrate and a salicylate

Publications (2)

Publication Number Publication Date
DE69321596D1 true DE69321596D1 (de) 1998-11-19
DE69321596T2 DE69321596T2 (de) 1999-04-22

Family

ID=11039709

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69321596T Expired - Fee Related DE69321596T2 (de) 1992-07-30 1993-07-26 Ester und kombinationen von einem organischen nitrat und einem salicyclat

Country Status (11)

Country Link
US (1) US5665766A (de)
EP (2) EP0656881B1 (de)
JP (1) JPH07509484A (de)
AT (1) ATE172183T1 (de)
AU (2) AU673846B2 (de)
CA (1) CA2141435A1 (de)
DE (1) DE69321596T2 (de)
DK (1) DK0656881T3 (de)
ES (1) ES2125342T3 (de)
GB (1) GB2284350B (de)
WO (1) WO1994003421A2 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5703073A (en) * 1995-04-19 1997-12-30 Nitromed, Inc. Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs
DE19515970A1 (de) * 1995-05-02 1996-11-07 Bayer Ag Acetylsalicylsäurenitrate
US5674894A (en) * 1995-05-15 1997-10-07 G.D. Searle & Co. Amidine derivatives useful as platelet aggregation inhibitors and vasodilators
AU6708996A (en) * 1995-07-27 1997-02-26 Cal International Limited Transdermal nitrate formulation
AU6709096A (en) * 1995-07-27 1997-02-26 Cal International Limited Pharmaceutical preparation for percutaneous absorbtion
WO1997005128A1 (en) * 1995-07-27 1997-02-13 Cal International Limited Cardioactive aspirinates
US5792758A (en) * 1995-12-08 1998-08-11 G. D. Searle & Co. Steroid nitrite ester derivatives useful as anti-inflammatory drugs
US5707984A (en) * 1995-12-08 1998-01-13 G. D. Searle & Co. Steroid nitrite/nitrate ester derivatives useful as anti-inflammatory drugs
US5837698A (en) * 1996-05-02 1998-11-17 G. D. Searle & Co. Steroid nitrite and nitrate ester derivatives useful as anti-inflammatory drugs
US5985862A (en) * 1996-05-02 1999-11-16 G.D. Searle & Co. Pharmaceutical compositions having steroid nitrate ester derivatives useful as anti-inflammatory drugs
WO1998005306A1 (en) * 1996-08-02 1998-02-12 Cal International Limited Controlled release tablet formulation of isosorbide-5-mononitrate
GB9713549D0 (en) * 1996-10-18 1997-09-03 Euro Celtique Sa Pharmaceutical combination formulation
WO1998017673A1 (en) * 1996-10-21 1998-04-30 Cal International Limited Isosorbide aspirinate esters
US6117911A (en) * 1997-04-11 2000-09-12 Neorx Corporation Compounds and therapies for the prevention of vascular and non-vascular pathologies
ES2142773B1 (es) * 1998-10-07 2001-01-01 Lacer Sa Derivados de mononitrato de isosorbida y su empleo como agentes vasodilatadores con tolerancia desminuida.
BR9905261A (pt) * 1999-09-30 2001-07-24 Libbs Farmaceutica Ltda Uma nova associação medicamentosa de liberação programada
US7086397B2 (en) * 2002-02-16 2006-08-08 Graham Lindley Spruiell Patient usable emergency medical kit
US7163958B2 (en) 2002-07-03 2007-01-16 Nitromed Inc. Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use
US7244753B2 (en) 2002-07-29 2007-07-17 Nitromed, Inc. Cyclooxygenase-2 selective inhibitors, compositions and methods of use
ES2258365B1 (es) * 2003-10-03 2007-12-01 Lacer, S.A. Derivados de disulfuro, sulfuro, sulfoxido y sulfona de azucares ciclicos y sus usos.
US8067464B2 (en) 2004-10-04 2011-11-29 Nitromed, Inc. Compositions and methods using apocynin compounds and nitric oxide donors
EP2149576A1 (de) 2008-07-22 2010-02-03 Lacer, S.A. Isosorbitnitrate mit vasodilatierender Wirksamkeit
CN102757444B (zh) * 2011-04-29 2016-02-10 南京信诺泰医药有限公司 具有一氧化氮供体性质的苯并呋喃类化合物
CN102241687A (zh) * 2011-05-23 2011-11-16 中国人民解放军第四军医大学 抗缺血/再灌注损伤的药物
JP2015515493A (ja) 2012-04-23 2015-05-28 ユニバーシティ オブ オスロＵｎｉｖｅｒｓｉｔｙ ｏｆ Ｏｓｌｏ 抗高血圧症薬としてのトマト抽出物の使用及び水溶性の糖を含まないトマト抽出物の製造方法
GB201223365D0 (en) * 2012-12-24 2013-02-06 Provexis Natural Products Ltd Compositions
TWI837080B (zh) 2016-11-02 2024-04-01 英商普羅維斯天然產物有限公司 防護空氣汙染之不良影響的水溶性蕃茄萃取物

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2187315B1 (de) * 1972-06-05 1975-06-20 Fabre Sa Pierre
GB1540463A (en) * 1976-10-07 1979-02-14 Ici Ltd Alkanolamine derivatives
FR2368272A1 (fr) * 1976-10-20 1978-05-19 Theramex Compositions therapeutiques solides pour combattre l'agregation plaquettaire
CA1248450A (en) * 1984-04-05 1989-01-10 Kazuo Kigasawa Soft patch
DE3421072A1 (de) * 1984-06-06 1985-12-12 Heinrich Mack Nachf., 7918 Illertissen 1,4:3,6-dianhydro-hexit-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3535950A1 (de) * 1985-10-09 1987-04-09 Basf Ag Kombinationspraeparat
US5175187A (en) * 1989-03-06 1992-12-29 Soorianarain Baligadoo Synergistic compositions for the treatment of coronary insufficiency and methods of use thereof
US4891373A (en) * 1988-11-23 1990-01-02 Pfizer Inc. Aminopropanol derivatives of 1,4:3,6-dianhydrohexitol nitrates, processes for their preparation and their use as medicaments
US5133974A (en) * 1989-05-05 1992-07-28 Kv Pharmaceutical Company Extended release pharmaceutical formulations
IE64128B1 (en) * 1990-02-26 1995-07-12 Byrne Rynne Holdings Ltd A pharmaceutical composition
IT1243367B (it) * 1990-07-26 1994-06-10 Italfarmaco Spa Derivati acidi benzoici sostituiti ad attivita' cardiovascolare
IT1245351B (it) * 1991-03-19 1994-09-20 Italfarmaco Spa Isoindoli ad attivita' cardiovascolare

Also Published As

Publication number Publication date
DK0656881T3 (da) 1999-06-23
ATE172183T1 (de) 1998-10-15
EP0656881B1 (de) 1998-10-14
AU4581293A (en) 1994-03-03
WO1994003421A3 (en) 1994-03-31
GB9501785D0 (en) 1995-03-22
WO1994003421A2 (en) 1994-02-17
US5665766A (en) 1997-09-09
AU1225795A (en) 1995-05-04
GB2284350A (en) 1995-06-07
DE69321596T2 (de) 1999-04-22
EP0676204A1 (de) 1995-10-11
EP0656881A1 (de) 1995-06-14
ES2125342T3 (es) 1999-03-01
AU673846B2 (en) 1996-11-28
JPH07509484A (ja) 1995-10-19
CA2141435A1 (en) 1994-02-17
GB2284350B (en) 1996-08-28

Similar Documents

Publication Publication Date Title
DE69321596D1 (de) Ester und kombinationen von einem organischen nitrat und einem salicyclat
FR2683146B1 (fr) Compositions pharmaceutiques a liberation reglee de la substance medicamenteuse.
PT90120A (pt) Processo para a preparacao de uma composicao farmaceutica contendo deprenil para administracao sistemica transdermica
ATE151285T1 (de) Orale arzneimittel mit kolonspezifischer freisetzung
ATE128863T1 (de) Arzneimittelformulierungen mit verzögerter wirkstoffabgabe.
ATE79619T1 (de) Arzneimittel.
PH25905A (en) A controlled release pharmaceutical dosage form
IT1215726B (it) Formulazioni galeniche a cessione programmata.
JPS5793911A (en) Drug composition
PH12363A (en) Oral pharmaceutical compositions of nandrolone-17 esters with a non-steroidal lipoid
ZA905861B (en) Pharmaceutical composition for oral administration containing nac
DE58905681D1 (de) Pharmazeutische Präparate zur verbesserten Resorption antibakterieller Verbindungen.
GB8812653D0 (en) Pharmaceutical composition based on high concentration esters of docosahexaenoic acid
IL88403A0 (en) Esters of pharmacologically active carboxylic acids,their manufacture and pharmaceutical compositions containing them
PT88634A (pt) A process for the preparation of catechol carboxylic acid derivatives and of pharmaceutical compositions containing the same
NZ182046A (en) 9-0-ethers of clavulanic acid,saltd and esters and pharmaceutical compositions
GB2194733B (en) Pharmaceutical compositions containing non-steroidal anti-inflammatory drugs
GB8812621D0 (en) Pharmaceutical composition containing combination of analgesic agents
MX9203575A (es) Esteres de oximas de propenonas y composiciones farmaceuticas que los contienen.
DK152987D0 (da) Dosageform for nonimmediate release of one or more drugs
IT1224897B (it) Composizione farmaceutica per il trattamento delle affezioni parodontali
IT1223097B (it) Formulazione farmaceutica contenente gemfibrozil microincapsulato

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee