DE69316911D1 - Reine tsh zubereitung, verfahren zur herstellung und ihre anwendung für die herstellung von tsh spürelementen für tsh rezeptor nachweis und in tsh rezeptor testproben - Google Patents
Reine tsh zubereitung, verfahren zur herstellung und ihre anwendung für die herstellung von tsh spürelementen für tsh rezeptor nachweis und in tsh rezeptor testprobenInfo
- Publication number
- DE69316911D1 DE69316911D1 DE69316911T DE69316911T DE69316911D1 DE 69316911 D1 DE69316911 D1 DE 69316911D1 DE 69316911 T DE69316911 T DE 69316911T DE 69316911 T DE69316911 T DE 69316911T DE 69316911 D1 DE69316911 D1 DE 69316911D1
- Authority
- DE
- Germany
- Prior art keywords
- tsh
- production
- preparation
- receptor
- pure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 238000001514 detection method Methods 0.000 title 1
- 241000283690 Bos taurus Species 0.000 abstract 2
- 102000003911 Thyrotropin Receptors Human genes 0.000 abstract 2
- 108090000253 Thyrotropin Receptors Proteins 0.000 abstract 2
- 238000003556 assay Methods 0.000 abstract 2
- 238000000746 purification Methods 0.000 abstract 2
- 239000000700 radioactive tracer Substances 0.000 abstract 2
- 239000004952 Polyamide Substances 0.000 abstract 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract 1
- 102000011923 Thyrotropin Human genes 0.000 abstract 1
- 108010061174 Thyrotropin Proteins 0.000 abstract 1
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 238000001042 affinity chromatography Methods 0.000 abstract 1
- 230000004071 biological effect Effects 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001768 cations Chemical class 0.000 abstract 1
- 238000004255 ion exchange chromatography Methods 0.000 abstract 1
- 229920002647 polyamide Polymers 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 239000000741 silica gel Substances 0.000 abstract 1
- 229910002027 silica gel Inorganic materials 0.000 abstract 1
- 229960000874 thyrotropin Drugs 0.000 abstract 1
- 230000001748 thyrotropin Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
- G01N33/76—Human chorionic gonadotropin including luteinising hormone, follicle stimulating hormone, thyroid stimulating hormone or their receptors
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Organic Chemistry (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Reproductive Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Food Science & Technology (AREA)
- Toxicology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE69316911T DE69316911T2 (de) | 1992-11-05 | 1993-10-27 | Reine tsh zubereitung, verfahren zur herstellung und ihre anwendung für die herstellung von tsh spürelementen für tsh rezeptor nachweis und in tsh rezeptor testproben |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4237430A DE4237430C1 (de) | 1992-11-05 | 1992-11-05 | Aufgereinigtes TSH-Präparat, Verfahren zu seiner Herstellung und seine Verwendung zur Herstellung von TSH-Tracern für TSH-Rezeptorassays und in TSH-Rezeptorassays |
| PCT/EP1993/002980 WO1994009814A1 (en) | 1992-11-05 | 1993-10-27 | Purified tsh preparation, process for its production and its use for the production of tsh tracers for tsh receptor assays and in tsh receptor assays |
| DE69316911T DE69316911T2 (de) | 1992-11-05 | 1993-10-27 | Reine tsh zubereitung, verfahren zur herstellung und ihre anwendung für die herstellung von tsh spürelementen für tsh rezeptor nachweis und in tsh rezeptor testproben |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69316911D1 true DE69316911D1 (de) | 1998-03-12 |
| DE69316911T2 DE69316911T2 (de) | 1998-05-28 |
Family
ID=6472210
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE4237430A Expired - Fee Related DE4237430C1 (de) | 1992-11-05 | 1992-11-05 | Aufgereinigtes TSH-Präparat, Verfahren zu seiner Herstellung und seine Verwendung zur Herstellung von TSH-Tracern für TSH-Rezeptorassays und in TSH-Rezeptorassays |
| DE69316911T Expired - Lifetime DE69316911T2 (de) | 1992-11-05 | 1993-10-27 | Reine tsh zubereitung, verfahren zur herstellung und ihre anwendung für die herstellung von tsh spürelementen für tsh rezeptor nachweis und in tsh rezeptor testproben |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE4237430A Expired - Fee Related DE4237430C1 (de) | 1992-11-05 | 1992-11-05 | Aufgereinigtes TSH-Präparat, Verfahren zu seiner Herstellung und seine Verwendung zur Herstellung von TSH-Tracern für TSH-Rezeptorassays und in TSH-Rezeptorassays |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP0668775B1 (de) |
| JP (1) | JP2835781B2 (de) |
| AT (1) | ATE162948T1 (de) |
| AU (1) | AU669953B2 (de) |
| CA (1) | CA2148690A1 (de) |
| DE (2) | DE4237430C1 (de) |
| FI (1) | FI952140A0 (de) |
| WO (1) | WO1994009814A1 (de) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7238338B1 (en) * | 2001-06-22 | 2007-07-03 | Triumf | System and method for the large scale labeling of compounds with radiohalogens |
| ITRM20030214A1 (it) * | 2003-05-05 | 2004-11-06 | Univ Roma | Ormone stimolante la tiroide (tsh) radiomarcato e suo uso |
| TW200918058A (en) * | 2007-08-31 | 2009-05-01 | Organon Nv | TSH receptor antagonizing tetrahydroquinoline compounds |
| CN102050875B (zh) * | 2010-12-10 | 2013-05-29 | 天津市协和医药科技有限公司 | 一种促甲状腺素受体的提取及纯化方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4357310A (en) * | 1980-08-08 | 1982-11-02 | Baxter Travenol Laboratories, Inc. | Method and composition for reducing the nonspecific binding of radioiodinated protein hormones |
| US4474891A (en) * | 1982-06-10 | 1984-10-02 | Warren Michelle P | Mini-iodinated polypeptide hormone tracer and method for its use |
| GB8510177D0 (en) * | 1985-04-22 | 1985-05-30 | Public Health Laborotory Servi | Isolating pituitary glycoprotein hormones |
| JPH04108397A (ja) * | 1990-08-27 | 1992-04-09 | Internatl Reagents Corp | モノクローナル抗体及びそれを用いたｔｓｈ測定法 |
-
1992
- 1992-11-05 DE DE4237430A patent/DE4237430C1/de not_active Expired - Fee Related
-
1993
- 1993-10-27 EP EP93923561A patent/EP0668775B1/de not_active Expired - Lifetime
- 1993-10-27 AU AU53387/94A patent/AU669953B2/en not_active Ceased
- 1993-10-27 DE DE69316911T patent/DE69316911T2/de not_active Expired - Lifetime
- 1993-10-27 CA CA002148690A patent/CA2148690A1/en not_active Abandoned
- 1993-10-27 JP JP6510683A patent/JP2835781B2/ja not_active Expired - Fee Related
- 1993-10-27 AT AT93923561T patent/ATE162948T1/de active
- 1993-10-27 WO PCT/EP1993/002980 patent/WO1994009814A1/en active IP Right Grant
-
1995
- 1995-05-04 FI FI952140A patent/FI952140A0/fi not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU669953B2 (en) | 1996-06-27 |
| FI952140A (fi) | 1995-05-04 |
| DE4237430C1 (de) | 1994-03-17 |
| WO1994009814A1 (en) | 1994-05-11 |
| CA2148690A1 (en) | 1994-05-11 |
| JP2835781B2 (ja) | 1998-12-14 |
| EP0668775B1 (de) | 1998-02-04 |
| ATE162948T1 (de) | 1998-02-15 |
| DE69316911T2 (de) | 1998-05-28 |
| AU5338794A (en) | 1994-05-24 |
| FI952140A0 (fi) | 1995-05-04 |
| JPH08505369A (ja) | 1996-06-11 |
| EP0668775A1 (de) | 1995-08-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8327 | Change in the person/name/address of the patent owner |
Owner name: B.R.A.H.M.S AG, 16761 HENNIGSDORF, DE |
|
| 8327 | Change in the person/name/address of the patent owner |
Owner name: B.R.A.H.M.S GMBH, 16761 HENNIGSDORF, DE |