DE69316818T2 - Verfahren zur detektion von stickstoffmonoxid, nitrosoniumäquivalenten, s-nitrosothiolen und s-nitrosoproteinen in biologischen systemen - Google Patents

Verfahren zur detektion von stickstoffmonoxid, nitrosoniumäquivalenten, s-nitrosothiolen und s-nitrosoproteinen in biologischen systemen

Info

Publication number
DE69316818T2
DE69316818T2 DE69316818T DE69316818T DE69316818T2 DE 69316818 T2 DE69316818 T2 DE 69316818T2 DE 69316818 T DE69316818 T DE 69316818T DE 69316818 T DE69316818 T DE 69316818T DE 69316818 T2 DE69316818 T2 DE 69316818T2
Authority
DE
Germany
Prior art keywords
nitric oxide
samples
nitrosonium
nitrosothioles
nitrosoproteins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69316818T
Other languages
English (en)
Other versions
DE69316818D1 (de
Inventor
Jonathan Stamler
Joseph Loscalzo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Brigham and Womens Hospital Inc
Original Assignee
Brigham and Womens Hospital Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Brigham and Womens Hospital Inc filed Critical Brigham and Womens Hospital Inc
Application granted granted Critical
Publication of DE69316818D1 publication Critical patent/DE69316818D1/de
Publication of DE69316818T2 publication Critical patent/DE69316818T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/84—Preparation of the fraction to be distributed
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/631—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited using photolysis and investigating photolysed fragments
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/84—Preparation of the fraction to be distributed
    • G01N2030/8429—Preparation of the fraction to be distributed adding modificating material
    • G01N2030/8441—Preparation of the fraction to be distributed adding modificating material to modify physical properties
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
    • G01N2030/8831—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials involving peptides or proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/74—Optical detectors
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/17—Nitrogen containing
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/17—Nitrogen containing
    • Y10T436/170769—N-Nitroso containing [e.g., nitrosamine, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/17—Nitrogen containing
    • Y10T436/176152—Total nitrogen determined
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/17—Nitrogen containing
    • Y10T436/177692—Oxides of nitrogen

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69316818T 1992-04-22 1993-04-21 Verfahren zur detektion von stickstoffmonoxid, nitrosoniumäquivalenten, s-nitrosothiolen und s-nitrosoproteinen in biologischen systemen Expired - Fee Related DE69316818T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/872,237 US5459076A (en) 1992-04-22 1992-04-22 Method for detecting nitric oxide, nitrosonium equivalents, S-nitrosothiols and S-nitroso-proteins in biological systems
PCT/US1993/003785 WO1993021525A1 (en) 1992-04-22 1993-04-21 A method for detecting nitric oxide, nitrosonium equivalents, s-nitrosothiols and s-nitroso-proteins in biological systems

Publications (2)

Publication Number Publication Date
DE69316818D1 DE69316818D1 (de) 1998-03-12
DE69316818T2 true DE69316818T2 (de) 1998-07-16

Family

ID=25359132

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69316818T Expired - Fee Related DE69316818T2 (de) 1992-04-22 1993-04-21 Verfahren zur detektion von stickstoffmonoxid, nitrosoniumäquivalenten, s-nitrosothiolen und s-nitrosoproteinen in biologischen systemen

Country Status (9)

Country Link
US (1) US5459076A (de)
EP (1) EP0591511B1 (de)
JP (1) JPH06510605A (de)
AT (1) ATE163090T1 (de)
AU (1) AU664276B2 (de)
CA (1) CA2112107C (de)
DE (1) DE69316818T2 (de)
ES (1) ES2114049T3 (de)
WO (1) WO1993021525A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1023900B1 (de) * 1991-11-14 2005-03-16 The Brigham And Women's Hospital, Inc. Pharmazeutische Zusammensetzung enthaltend S-Nitrosolipoproteine und deren Verwendung
SE503876C2 (sv) * 1994-11-30 1996-09-23 Kjell Alving Detektion av inflammatoriska tillstånd i tarmkanalen genom att mäta kväveoxidhalten i ett prov taget ur tarmlumen
US5891735A (en) * 1995-09-15 1999-04-06 Duke University Medical Center Method for measuring nitric oxide in nitrosyl (FeII)-hemoglobin and S-nitrosohemoglobin
US6911427B1 (en) 1995-09-15 2005-06-28 Duke University No-modified hemoglobins and uses therefore
US6627738B2 (en) * 1995-09-15 2003-09-30 Duke University No-modified hemoglobins and uses therefor
GB2314156A (en) * 1996-06-12 1997-12-17 Secr Defence Explosives detection
JP3013239B2 (ja) * 1997-04-17 2000-02-28 株式会社エイコム Ｓ−ニトロソ化合物検出方法
DE19854808C2 (de) * 1998-11-27 2001-03-01 Sanol Arznei Schwarz Gmbh Detektionsverfahren
US20040067595A1 (en) * 2000-08-25 2004-04-08 Davies Claire A Assay for s-nitrosothiol compounds
US7419834B2 (en) * 2001-12-12 2008-09-02 University Of Massachusetts System for detection of nitrosylated proteins
JP2005527834A (ja) * 2002-05-29 2005-09-15 デューク・ユニバーシティー 血液ガス中の一酸化窒素の測定およびそれに基づく処置
EP2386864A1 (de) * 2002-10-09 2011-11-16 DMI Biosciences, Inc. Diagnose und Uberwachung von Ischämie
US20050037518A1 (en) * 2003-08-12 2005-02-17 Stefano George B. Anti-inflammatory signal molecules and exercise
US7000560B2 (en) * 2003-12-11 2006-02-21 Honeywell International, Inc. Unmanned underwater vehicle docking station coupling system and method
WO2005081622A1 (en) * 2004-02-17 2005-09-09 Pharmacia & Upjohn Company Llc Methods and compositions for the detection of nitric oxide
CA2599731A1 (en) * 2005-03-03 2006-09-08 Dmi Biosciences, Inc. Quantification of proteins
JP2010534832A (ja) * 2007-07-26 2010-11-11 デューク・ユニバーシティ 血液中において結合し化合している酸化窒素の量の測定
US9651530B2 (en) 2013-01-14 2017-05-16 Lifehealth, Llc Methods and apparatus for measuring nitric oxide in fluid
US9753019B2 (en) * 2013-01-14 2017-09-05 Lifehealth, Llc Measuring nitric oxide in fluid

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3973910A (en) * 1973-02-05 1976-08-10 Thermo Electron Corporation Method of measuring the N-nitrosoamine content of a sample
US3967933A (en) * 1974-05-23 1976-07-06 Monitor Labs, Inc. Dual channel nitrogen oxides analyzer
US4193963A (en) * 1974-09-20 1980-03-18 Petroleo Brasileiro S.A.-Petrobras Apparatus for the determination of chemical compounds by chemiluminescence with ozone
US4843016A (en) * 1974-10-07 1989-06-27 Thermedics Inc. Detection system and method
US4066411A (en) * 1977-01-19 1978-01-03 Thermo Electron Corporation N-nitroso compound analyzer with sample atomization
US4236895A (en) * 1979-06-11 1980-12-02 Meloy Laboratories, Inc. Analytical apparatus and method employing purified ozone
US4272248A (en) * 1979-12-26 1981-06-09 Beckman Instruments, Inc. Nitric oxide interference free sulfur dioxide fluorescence analyzer
US4303419A (en) * 1979-12-28 1981-12-01 University Of Iowa Research Foundation Method and composition for determination of N-nitrosamines
US4368262A (en) * 1981-03-23 1983-01-11 Research Corporation Diagnostic test for the detection of cancer
US4335073A (en) * 1981-05-04 1982-06-15 Beckman Instruments, Inc. NOx Conversion efficiency detector
US4775633A (en) * 1984-04-26 1988-10-04 Thermedics Inc. Detection of hydrazine compounds in gaseous samples by their conversion to nitric oxide-yielding derivatives
US4822564A (en) * 1985-07-02 1989-04-18 Sensors, Inc. Chemiluminescent gas analyzer for measuring the oxides of nitrogen
CA1307480C (en) * 1985-07-10 1992-09-15 Nanibhushan Dattagupta Prolonged chemiluminescence
SU1464084A1 (ru) * 1987-04-16 1989-03-07 Московский научно-исследовательский институт гигиены им.Ф.Ф.Эрисмана Способ определени содержани кронетона в сыворотке крови
US5094815A (en) * 1988-05-18 1992-03-10 Cornell Research Foundation, Inc. Photolytic interface for HPLC-chemiluminescence detection of non volatile N-nitroso compounds
US5025001A (en) * 1988-06-15 1991-06-18 Brigham And Women's Hospital S-nitroso derivatives of ACE inhibitors and the use thereof
US5002964A (en) * 1988-06-15 1991-03-26 Brigham & Women's Hospital S-nitrosocaptopril compounds and the use thereof

Also Published As

Publication number Publication date
ES2114049T3 (es) 1998-05-16
US5459076A (en) 1995-10-17
WO1993021525A1 (en) 1993-10-28
EP0591511A4 (en) 1994-08-17
EP0591511A1 (de) 1994-04-13
EP0591511B1 (de) 1998-02-04
JPH06510605A (ja) 1994-11-24
ATE163090T1 (de) 1998-02-15
CA2112107C (en) 2002-06-25
AU664276B2 (en) 1995-11-09
DE69316818D1 (de) 1998-03-12
AU4111493A (en) 1993-11-18
CA2112107A1 (en) 1993-10-28

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Legal Events

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8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee