DE69304885D1 - Verwendung der 3-Indolbrenztraubensäure zur Erniedrigung der Glucocorticoidblutspiegel und zur Vorbeugung cerebraler Störungen - Google Patents

Verwendung der 3-Indolbrenztraubensäure zur Erniedrigung der Glucocorticoidblutspiegel und zur Vorbeugung cerebraler Störungen

Info

Publication number
DE69304885D1
DE69304885D1 DE69304885T DE69304885T DE69304885D1 DE 69304885 D1 DE69304885 D1 DE 69304885D1 DE 69304885 T DE69304885 T DE 69304885T DE 69304885 T DE69304885 T DE 69304885T DE 69304885 D1 DE69304885 D1 DE 69304885D1
Authority
DE
Germany
Prior art keywords
pyruvic acid
blood levels
cerebral disorders
prevent cerebral
indole pyruvic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69304885T
Other languages
English (en)
Other versions
DE69304885T2 (de
Inventor
Vincenzo Politi
Mario Materazzi
Stazio Giovanni Di
Luca Giovanna De
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Polifarma SpA
Original Assignee
Polifarma SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Polifarma SpA filed Critical Polifarma SpA
Application granted granted Critical
Publication of DE69304885D1 publication Critical patent/DE69304885D1/de
Publication of DE69304885T2 publication Critical patent/DE69304885T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
DE69304885T 1993-01-25 1993-12-29 Verwendung der 3-Indolbrenztraubensäure zur Erniedrigung der Glucocorticoidblutspiegel und zur Vorbeugung cerebraler Störungen Expired - Fee Related DE69304885T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITRM930034A IT1261165B (it) 1993-01-25 1993-01-25 Agente attivo per ridurre il livello ematico di glucocorticoidi e prevenire disturbi cerebrali da stress e senilita'.

Publications (2)

Publication Number Publication Date
DE69304885D1 true DE69304885D1 (de) 1996-10-24
DE69304885T2 DE69304885T2 (de) 1997-03-27

Family

ID=11401415

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69304885T Expired - Fee Related DE69304885T2 (de) 1993-01-25 1993-12-29 Verwendung der 3-Indolbrenztraubensäure zur Erniedrigung der Glucocorticoidblutspiegel und zur Vorbeugung cerebraler Störungen

Country Status (7)

Country Link
US (1) US5447951A (de)
EP (1) EP0608671B1 (de)
JP (1) JP2562278B2 (de)
AT (1) ATE142878T1 (de)
DE (1) DE69304885T2 (de)
ES (1) ES2093953T3 (de)
IT (1) IT1261165B (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002076390A2 (en) * 2001-03-23 2002-10-03 Corcept Therapeutics, Inc. Methods for treating stress disorders using glucocorticoid receptor-specific antagonists
US7371763B2 (en) * 2001-04-20 2008-05-13 Bayer Pharmaceuticals Corporation Inhibition of raf kinase using quinolyl, isoquinolyl or pyridyl ureas
CN103860694A (zh) * 2014-02-14 2014-06-18 四川蜀源博业医药科技有限公司 一种鼻腔用离子敏感型原位凝胶剂及其制备方法和用途
JP7093961B2 (ja) * 2018-02-13 2022-07-01 国立大学法人金沢大学 ストレス低減薬剤

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1148618B (it) * 1982-10-11 1986-12-03 Polifarma Spa Procedimento enzimatico per la produzione di acido 3-indolpiruvico e utilizzazione farmaceutica di questo
IT1184282B (it) * 1985-06-28 1987-10-22 Polifarma Spa Procedimento per la produzione di alfa-chetoacidi indolici a partire da un rispettivo alfa-ammino-acido,particolarmente per produrre acido indolpiruvico
IT1206078B (it) * 1987-06-03 1989-04-14 Polifarma Spa Procedimento per la produzione di acido 3-indolpiruvico e suoi derivati loro uso farmaceutico
IT1224546B (it) * 1988-09-29 1990-10-04 Polifarma Spa Utilizzatore farmaceutica di acido 3 -indolpiruvico come agente inibitore di patologie degenerative
IT1232167B (it) * 1989-08-08 1992-01-25 Polifarma Spa Uso cosmetico di acido 3-indolpiruvico

Also Published As

Publication number Publication date
ITRM930034A0 (it) 1993-01-25
ES2093953T3 (es) 1997-01-01
IT1261165B (it) 1996-05-09
US5447951A (en) 1995-09-05
EP0608671A1 (de) 1994-08-03
DE69304885T2 (de) 1997-03-27
JPH06234634A (ja) 1994-08-23
ATE142878T1 (de) 1996-10-15
JP2562278B2 (ja) 1996-12-11
EP0608671B1 (de) 1996-09-18
ITRM930034A1 (it) 1994-07-25

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee