DE69233223D1 - Herstellung von polyalkanoat - Google Patents

Herstellung von polyalkanoat

Info

Publication number
DE69233223D1
DE69233223D1 DE69233223T DE69233223T DE69233223D1 DE 69233223 D1 DE69233223 D1 DE 69233223D1 DE 69233223 T DE69233223 T DE 69233223T DE 69233223 T DE69233223 T DE 69233223T DE 69233223 D1 DE69233223 D1 DE 69233223D1
Authority
DE
Germany
Prior art keywords
polyalkanoate
production
genes
genees
ketothiolase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69233223T
Other languages
English (en)
Other versions
DE69233223T2 (de
Inventor
Matthias Liebergesell
Alexander Steinbuechel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yield10 Bioscience Inc
Original Assignee
Metabolix Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Metabolix Inc filed Critical Metabolix Inc
Publication of DE69233223D1 publication Critical patent/DE69233223D1/de
Application granted granted Critical
Publication of DE69233223T2 publication Critical patent/DE69233223T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C12P7/625—Polyesters of hydroxy carboxylic acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Nutrition Science (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Biological Depolymerization Polymers (AREA)
  • Polyesters Or Polycarbonates (AREA)
DE69233223T 1991-07-16 1992-07-15 Herstellung von polyalkanoat Expired - Lifetime DE69233223T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9115245 1991-07-16
GB919115245A GB9115245D0 (en) 1991-07-16 1991-07-16 Production of polyalkanoate
PCT/GB1992/001291 WO1993002194A1 (en) 1991-07-16 1992-07-15 Production of polyalkanoate

Publications (2)

Publication Number Publication Date
DE69233223D1 true DE69233223D1 (de) 2003-11-06
DE69233223T2 DE69233223T2 (de) 2004-08-26

Family

ID=10698374

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69233223T Expired - Lifetime DE69233223T2 (de) 1991-07-16 1992-07-15 Herstellung von polyalkanoat

Country Status (9)

Country Link
US (2) US6515205B1 (de)
EP (1) EP0594678B1 (de)
JP (1) JPH07501926A (de)
AT (1) ATE251218T1 (de)
AU (1) AU671595B2 (de)
CA (1) CA2113432C (de)
DE (1) DE69233223T2 (de)
GB (1) GB9115245D0 (de)
WO (1) WO1993002194A1 (de)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5245023A (en) 1987-06-29 1993-09-14 Massachusetts Institute Of Technology Method for producing novel polyester biopolymers
GB9108756D0 (en) * 1991-04-24 1991-06-12 Ici Plc Production of polyalkanoate in plants
CA2113412C (en) * 1991-07-19 2000-01-25 Christopher R. Somerville Transgenic plants producing polyhydroxyalkanoates
US5610041A (en) * 1991-07-19 1997-03-11 Board Of Trustees Operating Michigan State University Processes for producing polyhydroxybutyrate and related polyhydroxyalkanoates in the plastids of higher plants
US5646167A (en) * 1993-01-06 1997-07-08 Ciba-Geigy Corporation Arylsulfonamido-substituted hydroxamix acids
ES2251716T3 (es) * 1994-01-28 2006-05-01 THE PROCTER & GAMBLE COMPANY Copolimeros biodegradables y articulos de plastico que comprenden copolimeros biodegradables de 3-hidroxihexanoato.
SG49096A1 (en) * 1994-01-28 1998-05-18 Procter & Gamble Biodegradable 3-polyhydtoxybuyrate/3- polyhydroxyhexanoate copolymer films
ZA95627B (en) * 1994-01-28 1995-10-05 Procter & Gamble Biodegradable copolymers and plastic articles comprising biodegradable copolymers
ID23491A (id) * 1994-01-28 1995-09-07 Procter & Gamble Kopolimer-kopolimer yang dapat dibiodegradasi dan baha-bahan plastik yang terdiri dari kopolimer-kopolimer yang dapat dibiodegradasi
US6083729A (en) * 1995-10-26 2000-07-04 Metabolix, Inc. Methods for isolating polyhydroxyalkanoates from plants
US6143947A (en) * 1996-01-29 2000-11-07 The Procter & Gamble Company Fibers, nonwoven fabrics and absorbent articles comprising a biodegradable polyhydroxyalkanoate comprising 3-hydroxybutyrate and 3-hydroxyhexanoate
WO1997038110A2 (en) * 1996-04-05 1997-10-16 Kieta Holding S.A. Compositions and methods relating to drug discovery and detection and treatment of gastrointestinal diseases
US5750848A (en) * 1996-08-13 1998-05-12 Monsanto Company DNA sequence useful for the production of polyhydroxyalkanoates
ATE323152T1 (de) 1997-09-19 2006-04-15 Metabolix Inc Biologische systeme zur herstellung von polyhydroxyalkanoate polymeren die 4-hydroxysäure enthalten
CA2317314C (en) 1998-01-07 2003-12-30 Metabolix, Inc. Animal nutrition compositions
DE69924830T2 (de) * 1998-01-19 2006-03-02 Lg Chemical Ltd. Gene von alcaligenes latus, die mit der biosynthese von polyhydroxyalkanoaten assoziiert sind.
US6586658B1 (en) 1998-03-06 2003-07-01 Metabolix, Inc. Modification of fatty acid metabolism in plants
DE69942060D1 (de) 1998-04-08 2010-04-08 Metabolix Inc Verfahren für die trennung und reinigung von biopolymeren
DE69938105T2 (de) 1998-08-04 2009-01-29 Metabolix, Inc., Cambridge Herstellung von polyhydroxyalkanoaten aus polyolen
US6077931A (en) * 1998-12-21 2000-06-20 The Procter & Gamble Company Biodegradable PHA copolymers
US6174990B1 (en) 1998-12-21 2001-01-16 The Procter & Gamble Company Films comprising biodegradable PHA copolymers
US6160199A (en) * 1998-12-21 2000-12-12 The Procter & Gamble Company Absorbent articles comprising biodegradable PHA copolymers
AU2008229076B2 (en) 2007-03-16 2014-05-15 Genomatica, Inc. Compositions and methods for the biosynthesis of 1,4-butanediol and its precursors
US7947483B2 (en) 2007-08-10 2011-05-24 Genomatica, Inc. Methods and organisms for the growth-coupled production of 1,4-butanediol
EP3514242A3 (de) * 2008-09-10 2019-08-28 Genomatica, Inc. Mikroorganismen zur herstellung von 1,4-butandiol
CN106119113A (zh) 2009-04-30 2016-11-16 基因组股份公司 用于生产 1,3‑丁二醇的生物
VN29801A1 (de) 2009-06-04 2012-05-25
CN102459138A (zh) * 2009-06-04 2012-05-16 基因组股份公司 分离发酵液成分的方法
CN102762735B (zh) * 2009-10-13 2016-08-03 基因组股份公司 生产1,4-丁二醇、4-羟基丁醛、4-羟基丁酰-coa、腐胺和相关化合物的微生物及其相关方法
WO2011066076A1 (en) 2009-11-25 2011-06-03 Genomatica, Inc. Microorganisms and methods for the coproduction of 1,4-butanediol and gamma-butyrolactone
RU2012128843A (ru) * 2009-12-10 2014-01-20 Дженоматика, Инк. Способы и организмы для превращения синтез-газа или других газообразных источников углерода и метанола в 1,3-бутандиол
WO2011100601A1 (en) 2010-02-11 2011-08-18 Metabolix, Inc. Process for gamma-butyrolactone production
US8637286B2 (en) * 2010-02-23 2014-01-28 Genomatica, Inc. Methods for increasing product yields
US8048661B2 (en) * 2010-02-23 2011-11-01 Genomatica, Inc. Microbial organisms comprising exogenous nucleic acids encoding reductive TCA pathway enzymes
CN104685058B (zh) 2012-06-04 2020-07-07 基因组股份公司 制造4-羟基丁酸酯、1，4-丁二醇和相关化合物的微生物和方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1229123A3 (de) * 1987-06-29 2004-11-03 Massachusetts Institute Of Technology Verfahren zur Herstellung von Polyester-Biopolymeren
ES2125222T3 (es) * 1989-07-10 1999-03-01 Massachusetts Inst Technology Procedimiento de produccion de biopolimeros a base de poliesteres.

Also Published As

Publication number Publication date
CA2113432A1 (en) 1993-02-04
US20040088751A1 (en) 2004-05-06
DE69233223T2 (de) 2004-08-26
EP0594678B1 (de) 2003-10-01
AU2312792A (en) 1993-02-23
EP0594678A1 (de) 1994-05-04
WO1993002194A1 (en) 1993-02-04
US6515205B1 (en) 2003-02-04
AU671595B2 (en) 1996-09-05
ATE251218T1 (de) 2003-10-15
JPH07501926A (ja) 1995-03-02
GB9115245D0 (en) 1991-08-28
CA2113432C (en) 2007-10-02

Similar Documents

Publication Publication Date Title
ATE251218T1 (de) Herstellung von polyalkanoat
PL298239A1 (en) Genetic sequences encoding the enzymes of flavonoid path and their applications
ES2182819T3 (es) Produccion de polihidroxialcanoato en plantas.
ATE323152T1 (de) Biologische systeme zur herstellung von polyhydroxyalkanoate polymeren die 4-hydroxysäure enthalten
ES2154624T1 (es) Regulacion de la expresion de la quinolato fosforribosil transferasa.
ATE172497T1 (de) Verfahren zur herstellung von polyester- biopolymeren
FI960977A (fi) Bakteeriperäiset eksportoidut proteiinit ja niihin perustuvat asellulaariset rokotteet
ATE382685T1 (de) Bakteriophagen-lysin
BR0014663A (pt) Moléculas de ácido nucléico para a detecção de bactérias e unidades filogenéticas de bactérias
ATE430803T1 (de) Gene, welche für flavon-synthasen kodieren
DE3856512T2 (de) Nucleotidsequenz für Acetoacetyl-CoA Reduktase kodierend und Verfahren zur Herstellung von Polyester-Biopolymeren
ATE113982T1 (de) Verzweigungsenzym und dessen verwendung.
ES2058108T3 (es) Sistema de expresion de genes.
AU655797B2 (en) Process for the genetic manipulation of myxobacteria
ATE346940T1 (de) Drosophilia melanogaster p70 s6 kinase
TH7509A (th) กระบวนการที่ใช้ในการรวมยีนที่เลือกสรรแล้วเข้าเป็นหน่วยเดียวกันกับโครโมโซมของแบคทีเรีย และแบคทีเรียที่ได้จากกระบวนการดังกล่าว

Legal Events

Date Code Title Description
8364 No opposition during term of opposition