DE69232565T2 - Verfahren zur behandlung von lungenerkrankungen mit uridin-triphosphaten - Google Patents

Verfahren zur behandlung von lungenerkrankungen mit uridin-triphosphaten

Info

Publication number
DE69232565T2
DE69232565T2 DE69232565T DE69232565T DE69232565T2 DE 69232565 T2 DE69232565 T2 DE 69232565T2 DE 69232565 T DE69232565 T DE 69232565T DE 69232565 T DE69232565 T DE 69232565T DE 69232565 T2 DE69232565 T2 DE 69232565T2
Authority
DE
Germany
Prior art keywords
lung diseases
treating lung
uridine triphosphates
triphosphates
uridine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69232565T
Other languages
English (en)
Other versions
DE69232565D1 (de
Inventor
Boucher, Jr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of North Carolina at Chapel Hill
University of North Carolina System
Original Assignee
University of North Carolina at Chapel Hill
University of North Carolina System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of North Carolina at Chapel Hill, University of North Carolina System filed Critical University of North Carolina at Chapel Hill
Publication of DE69232565D1 publication Critical patent/DE69232565D1/de
Application granted granted Critical
Publication of DE69232565T2 publication Critical patent/DE69232565T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/10Expectorants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/12Mucolytics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69232565T 1991-06-19 1992-10-09 Verfahren zur behandlung von lungenerkrankungen mit uridin-triphosphaten Expired - Fee Related DE69232565T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/717,747 US5292498A (en) 1991-06-19 1991-06-19 Method of treating lung disease with uridine triphosphates
PCT/US1992/008620 WO1994008593A1 (en) 1991-06-19 1992-10-09 Method of treating lung disease with uridine triphosphates

Publications (2)

Publication Number Publication Date
DE69232565D1 DE69232565D1 (de) 2002-05-23
DE69232565T2 true DE69232565T2 (de) 2002-11-14

Family

ID=26785072

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69232565T Expired - Fee Related DE69232565T2 (de) 1991-06-19 1992-10-09 Verfahren zur behandlung von lungenerkrankungen mit uridin-triphosphaten

Country Status (8)

Country Link
US (1) US5292498A (de)
EP (1) EP0663830B1 (de)
JP (1) JPH08502078A (de)
AU (1) AU688258B2 (de)
DE (1) DE69232565T2 (de)
ES (1) ES2173869T3 (de)
NO (1) NO309176B1 (de)
WO (1) WO1994008593A1 (de)

Families Citing this family (86)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3481236B2 (ja) * 1990-10-05 2003-12-22 ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル 固体粒状薬剤及び固体粒状薬剤エーロゾル投薬装置
EP0517573A1 (de) * 1991-06-05 1992-12-09 Synthelabo Pharmazeutische Zusammensetzungen zur Behandlung von Atemwegserkrankungen
US5512269A (en) * 1993-06-09 1996-04-30 Burroughs Wellcome, Co. Method of treating retained pulmonary secretions
US5514665A (en) * 1993-12-30 1996-05-07 University Of British Columbia Method of preventing or reducing the risk of infection by bacterial pathogens utilizing simple and conjugated dextrans
US6204382B1 (en) 1994-08-05 2001-03-20 Cytec Technology Corp. Carboxylated amino-1,3,5-triazines, derivatives thereof and processes for preparing the same
US5656256A (en) * 1994-12-14 1997-08-12 The University Of North Carolina At Chapel Hill Methods of treating lung disease by an aerosol containing benzamil or phenamil
US6096721A (en) * 1995-04-13 2000-08-01 Milkhaus Laboratory, Inc. Method for treating mucositis by sublingual administration of DNA
JP2961709B2 (ja) * 1995-04-13 1999-10-12 ミルカウス ラボラトリー, インコーポレイテッド 呼吸器系疾患の治療方法および治療用薬剤組成物
US20020115632A1 (en) * 1995-04-13 2002-08-22 Milkhaus Laboratory, Inc. Treatment of symptoms of asthma and allergies
US20030032614A1 (en) * 1995-04-13 2003-02-13 Mcmichael John Method of treating respiratory distress using synthetic polynucleic acids
US5948768A (en) * 1995-04-13 1999-09-07 Milkhaus Laboratory Treatment of otitis media by sublingual administration of DNA
US5908611A (en) * 1995-05-05 1999-06-01 The Scripps Research Institute Treatment of viscous mucous-associated diseases
US5635160A (en) 1995-06-07 1997-06-03 The University Of North Carolina At Chapel Hill Dinucleotides useful for the treatment of cystic fibrosis and for hydrating mucus secretions
US5628984A (en) 1995-07-31 1997-05-13 University Of North Carolina At Chapel Hill Method of detecting lung disease
US6423694B1 (en) * 1996-02-21 2002-07-23 Inspire Pharmaceuticals, Inc. Method of treating otitis media with uridine triphosphates and related compounds
WO1997035591A2 (en) * 1996-03-27 1997-10-02 Inspire Pharmaceuticals, Inc. Method of treating ciliary dyskinesia with uridine triphosphates and related compounds
US6420347B1 (en) * 1997-03-27 2002-07-16 Inspire Pharmaceuticals, Inc. Method of treating ciliary dyskinesia with uridine triphosphates and related compounds
US6673779B2 (en) * 1996-03-27 2004-01-06 Inspire Pharmaceuticals, Inc. Method of treating ciliary dyskinesia with dinucleoside polyphosphate compounds or UTP analogues
US5900407A (en) * 1997-02-06 1999-05-04 Inspire Pharmaceuticals, Inc. Method of treating dry eye disease with uridine triphosphates and related compounds
US5968913A (en) * 1996-07-03 1999-10-19 Inspire Pharmaceuticals, Inc. Pharmaceutical compositions of uridine triphosphate
US5789391A (en) * 1996-07-03 1998-08-04 Inspire Pharmaceuticals, Inc. Method of treating sinusitis with uridine triphosphates and related compounds
US5962432A (en) * 1996-07-03 1999-10-05 Inspire Pharmaceuticals, Inc. Sterilized, isotonic and pH-adjusted pharmaceutical formulation of uridine triphosphate
US6319908B1 (en) 1996-07-03 2001-11-20 Inspire Pharmaceuticals, Inc. Method for large-scale production of di(uridine 5′-tetraphosphate) and salts thereof
US5763447C1 (en) * 1996-07-23 2002-05-07 Inspire Pharmaceuticals Method of preventing or treating pneumonia in immobilized patients with uridine triphosphates and related compounds
US6159952A (en) * 1996-11-07 2000-12-12 Inspire Pharmaceuticals, Inc. Method of treating bronchitis with uridine triphosphate and related compounds
AU738907C (en) 1997-02-06 2002-05-16 Merck Sharp & Dohme Corp. Dinucleotides and their use
US6696425B2 (en) * 1997-02-06 2004-02-24 Inspire Pharmaceuticals, Inc. Method of treating dry eye disease with purinergic receptor agonists
US6921755B2 (en) * 1998-02-06 2005-07-26 Inspire Pharmaceuticals, Inc. Method of treating dry eye disease with purinergic receptor agonists
US6998121B2 (en) * 2003-01-23 2006-02-14 Milkhaus Laboratory, Inc. Method of treatment of connective tissue disorders by administration of streptolysin O
ES2217569T3 (es) 1997-07-25 2004-11-01 Inspire Pharmaceuticals, Inc. Sales de di(uridina 5'-tetrafosfato), metodo para su preparacion y usos de las mismas.
US6872710B2 (en) * 1997-07-25 2005-03-29 Inspire Pharmaceuticals, Inc. Di(uridine 5′)-tetraphosphate and salts thereof
TW593331B (en) 1997-07-25 2004-06-21 Inspire Pharmaceuticals Inc Method for large-scale production of di(uridine 5')-tetraphosphate and salts thereof
CN1268056A (zh) * 1997-08-29 2000-09-27 查珀尔希尔北卡罗来纳大学 尿苷5’-二磷酸酯及其类似物在治疗肺疾病中的应用
CN1301168A (zh) 1998-05-22 2001-06-27 印斯拜尔药品股份有限公司 治疗性二核苷酸和衍生物
US6294188B1 (en) 1998-07-09 2001-09-25 Aviana Biopharm Inc. Methods involving changing the constitutive and stimulated secretions of the local reproductive system of women
CA2356637C (en) 1998-12-22 2011-09-13 The University Of North Carolina At Chapel Hill Compounds and methods for the treatment of airway diseases and for the delivery of airway drugs
US7544772B2 (en) 2001-06-26 2009-06-09 Biomarck Pharmaceuticals, Ltd. Methods for regulating inflammatory mediators and peptides useful therein
US8501911B2 (en) * 1999-02-24 2013-08-06 Biomarck Pharmaceuticals, Ltd Methods of reducing inflammation and mucus hypersecretion
AU782966B2 (en) * 1999-06-08 2005-09-15 University Of Iowa Research Foundation, The Compounds and methods to enhance RAAV transduction
US6475509B1 (en) 1999-07-19 2002-11-05 The University Of North Carolina At Chapel Hill Covalent conjugates of sodium channel blockers and active compounds
US7241447B1 (en) * 1999-10-07 2007-07-10 University Of Iowa Research Foundation Adeno-associated virus vectors and uses thereof
AU2001260643B9 (en) * 2000-05-30 2006-10-19 Merck Sharp & Dohme Corp. Ectocornea extension promoters
US7132408B2 (en) 2000-08-21 2006-11-07 Inspire Pharmaceuticals, Inc. Composition and method for inhibiting platelet aggregation
US7018985B1 (en) 2000-08-21 2006-03-28 Inspire Pharmaceuticals, Inc. Composition and method for inhibiting platelet aggregation
US6867199B2 (en) 2000-08-21 2005-03-15 Inspire Pharmaceuticals, Inc. Dinucleoside polyphosphate compositions and their therapeutic use
US7115585B2 (en) * 2000-08-21 2006-10-03 Inspire Pharmaceuticals, Inc. Compositions for treating epithelial and retinal tissue diseases
US7452870B2 (en) * 2000-08-21 2008-11-18 Inspire Pharmaceuticals, Inc. Drug-eluting stents coated with P2Y12 receptor antagonist compound
US6555675B2 (en) * 2000-08-21 2003-04-29 Inspire Pharmaceuticals, Inc. Dinucleoside polyphosphate compositions and their therapuetic use as purinergic receptor agonists
WO2002062816A1 (en) * 2001-02-07 2002-08-15 Celltech R & D Limited Non-natural nucleotides and dinucleotides
WO2003000056A1 (en) 2001-06-25 2003-01-03 Inspire Pharmaceuticals, Inc. Joint lubrication with p2y purinergic receptor agonists
PT1411967E (pt) * 2001-06-26 2011-09-30 Univ North Carolina State Péptido bloqueador que atua sobre a secreção de células inflamatórias
US20050009777A1 (en) * 2001-07-25 2005-01-13 Mack Stephen Robert Non-natural carbon-linked nucleotides and dinucleotides
WO2003039473A2 (en) * 2001-11-06 2003-05-15 Inspire Pharmaceuticals, Inc. Method for treating or preventing inflammatory diseases
US6858615B2 (en) 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenyl guanidine sodium channel blockers
US7435724B2 (en) 2002-02-27 2008-10-14 Inspire Pharmaceutical, Inc. Degradation-resistant mononucleoside phosphate compounds
US7629312B2 (en) 2003-01-23 2009-12-08 Milkhaus Laboratory, Inc. Method of treatment of tendonitis by administration of streptolysin O
US20100144602A1 (en) * 2003-01-23 2010-06-10 Milkhaus Laboratory, Inc. Methods of Inhibiting Metastatic Cancer by Administration of Streptolysin O
AU2004227358B8 (en) * 2003-03-31 2009-12-10 Targeted Genetics Corporation Compounds and methods to enhance rAAV transduction
SI1663235T1 (sl) 2003-08-18 2013-12-31 Parion Sciences, Inc. Zaščiteni pirazinoilgvanidinski blokatorji natrijevega kanala
US7745442B2 (en) 2003-08-20 2010-06-29 Parion Sciences, Inc. Methods of reducing risk of infection from pathogens
US20090253714A1 (en) * 2003-08-20 2009-10-08 Johnson Michael R Methods of reducing risk of infection from pathogens
CA2595406C (en) * 2005-01-20 2017-07-11 Biomarck Pharmaceuticals, Ltd. Mucin hypersecretion inhibitors based on the structure of mans-related peptides and methods of use
US7851456B2 (en) * 2005-06-29 2010-12-14 Inspire Pharmaceuticals, Inc. P2Y6 receptor agonists for treating lung diseases
US20070021439A1 (en) * 2005-07-25 2007-01-25 Parion Sciences, Inc. Methods of reducing risk of infection from pathogens with soluble amide and ester pyrazinoylguanidine sodium channel blockers
EP2036567A3 (de) 2005-12-06 2009-12-09 P2-Science APS Modulation des p2y2-Rezeptorpfads
AU2007243184A1 (en) * 2006-04-28 2007-11-08 University Of Iowa Research Foundation Methods and compounds to modulate parvovirus transduction of mammalian cells or to alter virus infection, method to identify a viral receptor or co-receptor
JP5378998B2 (ja) 2006-07-26 2013-12-25 バイオマーク・フアーマシユーテイカルズ・リミテツド 炎症性メディエーターの放出を減弱させるための方法及びそれにおいて有用なペプチド
WO2008094379A2 (en) * 2007-01-30 2008-08-07 Milkhaus Laboratory, Inc. Methods for treatment of pulmonary fibrosis
WO2009049159A1 (en) * 2007-10-10 2009-04-16 Parion Sciences, Inc. Delivering osmolytes by nasal cannula
TWI432198B (zh) 2008-02-26 2014-04-01 Parion Sciences Inc 多芳香族鈉通道阻斷劑
CN102596010A (zh) 2009-08-10 2012-07-18 P2科学有限公司 用于诊断狭窄和其他血流受限之病症的utp
CN103328038A (zh) 2010-12-01 2013-09-25 史拜诺莫度雷森公司 向神经解剖结构直接递送药剂
CA2838529C (en) 2011-06-07 2020-03-24 Parion Sciences, Inc. Methods of treatment
US8945605B2 (en) 2011-06-07 2015-02-03 Parion Sciences, Inc. Aerosol delivery systems, compositions and methods
AR086745A1 (es) 2011-06-27 2014-01-22 Parion Sciences Inc 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida
PT2723176T (pt) 2011-06-27 2017-07-18 Parion Sciences Inc Dipéptido química e metabolicamente estável que possui potente atividade bloqueadora do canal de sódio
EP2809780B1 (de) 2012-02-01 2018-05-02 Protalix Ltd. Inhalierbare flüssige formulierungen der dnase i
EA032734B1 (ru) 2012-05-29 2019-07-31 Парион Сайэнс, Инк. Дендримероподобные аминоамиды, обладающие активностью блокаторов натриевых каналов, для лечения сухости глаз и других заболеваний слизистых оболочек
KR102258469B1 (ko) 2012-12-17 2021-05-31 패리온 사이언스 인코퍼레이티드 불충분한 점막 수화에 의해 유발되는 질환의 치료에 유용한 클로로-피라진 카르복스아미드 유도체
EP3428153A1 (de) 2012-12-17 2019-01-16 Parion Sciences, Inc. 3,5-diamino-6-chlor-n-(n-(4-phenylbutyl) carbamimidoyl)-pyrazin-2-carboxamid-verbindungen
ES2674665T3 (es) 2012-12-17 2018-07-03 Parion Sciences, Inc. Compuestos de 3,5-diamino-6-cloro-N-(N-(4-fenilbutilo)carbamimidoilo)-pirazina-2-carboxamida
US9102633B2 (en) 2013-12-13 2015-08-11 Parion Sciences, Inc. Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds
US11702672B2 (en) 2016-02-08 2023-07-18 University Of Iowa Research Foundation Methods to produce chimeric adeno-associated virus/bocavirus parvovirus
CA3016985C (en) 2016-03-07 2023-07-04 University Of Iowa Research Foundation Aav-mediated expression using a synthetic promoter and enhancer
WO2018132747A1 (en) 2017-01-13 2018-07-19 University Of Iowa Research Foundation Bocaparvovirus small noncoding rna and uses thereof
US20230158125A1 (en) 2020-04-20 2023-05-25 Sorrento Therapeutics, Inc. Pulmonary Administration of ACE2 Polypeptides

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4501729A (en) * 1982-12-13 1985-02-26 Research Corporation Aerosolized amiloride treatment of retained pulmonary secretions
JPS60126220A (ja) * 1983-12-09 1985-07-05 Otsuka Pharmaceut Factory Inc 核酸成分組成物
US5100647A (en) * 1990-10-02 1992-03-31 The Trustees Of The University Of Pennsylvania Method and formulations for the therapy of cystic fibrosis, Bartter's syndrome and secretory diarrheas, and for diuretic treatment
GB9027968D0 (en) * 1990-12-22 1991-02-13 Fisons Plc Method of treatment

Also Published As

Publication number Publication date
DE69232565D1 (de) 2002-05-23
EP0663830B1 (de) 2002-04-17
NO951340L (no) 1995-06-02
NO951340D0 (no) 1995-04-06
ES2173869T3 (es) 2002-11-01
JPH08502078A (ja) 1996-03-05
US5292498A (en) 1994-03-08
NO309176B1 (no) 2000-12-27
EP0663830A1 (de) 1995-07-26
AU2872592A (en) 1994-05-09
EP0663830A4 (de) 1996-01-24
AU688258B2 (en) 1998-03-12
WO1994008593A1 (en) 1994-04-28

Similar Documents

Publication Publication Date Title
DE69232565T2 (de) Verfahren zur behandlung von lungenerkrankungen mit uridin-triphosphaten
DE3888205D1 (de) Verfahren zur behandlung von lungenaffektionen und zubereitungen dafür.
DE69116623D1 (de) Verfahren zur Reinigung von 1,1,1,2-Tetrafluorethan
DE69314962D1 (de) Verfahren zur entkeimung von lebensmitteln
DE561667T1 (de) Verfahren zur Wärmebehandlung von Metallbändern.
DE59200262D1 (de) Verfahren zur Reinigung von Bisphenolen.
DE59106539D1 (de) Verfahren zur Oberflächenbehandlung von Bauteilen.
DE69109964D1 (de) Verfahren und Vorrichtung zur Herstellung von Sole.
DE69209256D1 (de) Verfahren zur Reinigung von 1,1,1,2-Tetrafluorethan
DE69029587T2 (de) Verfahren zur herstellung von 3-trifluormethylbenzylchlorid
DE68907326T2 (de) Verfahren zur kontinuierlichen Reinigung von Bisphenolen.
DE59208224D1 (de) Verfahren zur Antriebsschlupfregelung
DE69636034D1 (de) Verfahren zur bekämpfung sozialer insekten mit 1-arylpyrazolen oder 1-heteroarylpyrazolen
DE69307803D1 (de) Verfahren zur elektrolytischen Behandlung
DE69112391T2 (de) Verfahren zur reinigung von fluorwasserstoff.
DE59103291D1 (de) Verfahren zur bekämpfung von samen- und/oder bodenbürtigen schaderregern durch saatgutbehandlung.
DE69229202D1 (de) Verfahren zur reinigung von menschlichem bcdf
DE3683628D1 (de) Verfahren zur flaechenbehandlung.
DE3688395D1 (de) Verfahren zur flaechenbehandlung.
DE69006509D1 (de) Verfahren zur behandlung von häuten.
DE69007027D1 (de) Verfahren zur abwasserbehandlung.
DE69210925D1 (de) Verfahren zur Herstellung von Hydroxocobalamin
DE59208599D1 (de) Verfahren zur Antriebsschlupfregelung
DE69214139D1 (de) Verfahren zur behandlung von mit feuchtigkeit enthaltenden feinkohlen
DE68907914T2 (de) Verfahren zur behandlung von brandwunden.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee