DE69230993T3 - Rekombinante viren vektoren zur expression in muskelzellen - Google Patents

Rekombinante viren vektoren zur expression in muskelzellen Download PDF

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Publication number
DE69230993T3
DE69230993T3 DE69230993T DE69230993T DE69230993T3 DE 69230993 T3 DE69230993 T3 DE 69230993T3 DE 69230993 T DE69230993 T DE 69230993T DE 69230993 T DE69230993 T DE 69230993T DE 69230993 T3 DE69230993 T3 DE 69230993T3
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DE
Germany
Prior art keywords
vectors
muscle cells
cells
nucleic acid
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69230993T
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German (de)
English (en)
Other versions
DE69230993T2 (de
DE69230993D1 (de
Inventor
Michel Perricaudet
Pascale Briand
Leslie Stratford-Perricaudet
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Centre National de la Recherche Scientifique
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Centre National de la Recherche Scientifique
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Application filed by Centre National de la Recherche Scientifique filed Critical Centre National de la Recherche Scientifique
Publication of DE69230993D1 publication Critical patent/DE69230993D1/de
Publication of DE69230993T2 publication Critical patent/DE69230993T2/de
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Publication of DE69230993T3 publication Critical patent/DE69230993T3/de
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector
    • C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DE69230993T 1991-09-27 1992-09-25 Rekombinante viren vektoren zur expression in muskelzellen Expired - Lifetime DE69230993T3 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9111947 1991-09-27
FR9111947A FR2681786A1 (fr) 1991-09-27 1991-09-27 Vecteurs recombinants d'origine virale, leur procede d'obtention et leur utilisation pour l'expression de polypeptides dans des cellules musculaires.
PCT/FR1992/000898 WO1993006223A1 (fr) 1991-09-27 1992-09-25 Vecteurs recombinants viraux pour l'expression dans des cellules musculaires

Publications (3)

Publication Number Publication Date
DE69230993D1 DE69230993D1 (de) 2000-06-08
DE69230993T2 DE69230993T2 (de) 2000-11-30
DE69230993T3 true DE69230993T3 (de) 2004-12-16

Family

ID=9417378

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69230993T Expired - Lifetime DE69230993T3 (de) 1991-09-27 1992-09-25 Rekombinante viren vektoren zur expression in muskelzellen

Country Status (12)

Country Link
EP (1) EP0559884B2 (enExample)
JP (1) JP3487597B2 (enExample)
AT (1) ATE192500T1 (enExample)
AU (1) AU666142B2 (enExample)
CA (1) CA2097185C (enExample)
DE (1) DE69230993T3 (enExample)
DK (1) DK0559884T4 (enExample)
ES (1) ES2147553T5 (enExample)
FR (1) FR2681786A1 (enExample)
GR (1) GR3034094T3 (enExample)
SG (1) SG49081A1 (enExample)
WO (1) WO1993006223A1 (enExample)

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US20020136708A1 (en) 1993-06-24 2002-09-26 Graham Frank L. System for production of helper dependent adenovirus vectors based on use of endonucleases
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US7045347B2 (en) 1993-06-24 2006-05-16 Advec, Inc. Helper dependent adenovirus vectors based on integrase family site-specific recombinases
US6730507B1 (en) 1993-06-24 2004-05-04 Merck & Co., Inc. Use of helper-dependent adenoviral vectors of alternative serotypes permits repeat vector administration
US5919676A (en) * 1993-06-24 1999-07-06 Advec, Inc. Adenoviral vector system comprising Cre-loxP recombination
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FR2712812B1 (fr) 1993-11-23 1996-02-09 Centre Nat Rech Scient Composition pour la production de produits thérapeutiques in vivo.
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US6465253B1 (en) 1994-09-08 2002-10-15 Genvec, Inc. Vectors and methods for gene transfer to cells
US5846782A (en) 1995-11-28 1998-12-08 Genvec, Inc. Targeting adenovirus with use of constrained peptide motifs
FR2730637B1 (fr) 1995-02-17 1997-03-28 Rhone Poulenc Rorer Sa Composition pharmaceutique contenant des acides nucleiques, et ses utilisations
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US5792453A (en) * 1995-02-28 1998-08-11 The Regents Of The University Of California Gene transfer-mediated angiogenesis therapy
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US6281010B1 (en) 1995-06-05 2001-08-28 The Trustees Of The University Of Pennsylvania Adenovirus gene therapy vehicle and cell line
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US5866552A (en) * 1996-09-06 1999-02-02 The Trustees Of The University Of Pennsylvania Method for expressing a gene in the absence of an immune response
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CA2294793A1 (fr) 1997-06-30 1999-01-14 Rhone-Poulenc Rorer S.A. Amelioration du transfert d'acide nucleique dans le muscle strie et combinaison permettant la mise en oeuvre du procede
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Also Published As

Publication number Publication date
JP3487597B2 (ja) 2004-01-19
DK0559884T3 (da) 2000-10-02
ES2147553T3 (es) 2000-09-16
CA2097185A1 (fr) 1993-03-28
WO1993006223A1 (fr) 1993-04-01
AU666142B2 (en) 1996-02-01
SG49081A1 (en) 1998-05-18
AU2790292A (en) 1993-04-27
JPH06502771A (ja) 1994-03-31
DE69230993T2 (de) 2000-11-30
CA2097185C (fr) 2007-07-24
DE69230993D1 (de) 2000-06-08
EP0559884B2 (fr) 2004-04-07
GR3034094T3 (en) 2000-11-30
DK0559884T4 (da) 2004-08-02
FR2681786B1 (enExample) 1995-05-12
EP0559884B1 (fr) 2000-05-03
FR2681786A1 (fr) 1993-04-02
EP0559884A1 (fr) 1993-09-15
ES2147553T5 (es) 2004-11-16
ATE192500T1 (de) 2000-05-15

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