DE69230418D1 - GRF-Analoge (Growth Hormone Releasing Factors) - Google Patents
GRF-Analoge (Growth Hormone Releasing Factors)Info
- Publication number
- DE69230418D1 DE69230418D1 DE69230418T DE69230418T DE69230418D1 DE 69230418 D1 DE69230418 D1 DE 69230418D1 DE 69230418 T DE69230418 T DE 69230418T DE 69230418 T DE69230418 T DE 69230418T DE 69230418 D1 DE69230418 D1 DE 69230418D1
- Authority
- DE
- Germany
- Prior art keywords
- ala
- aib
- leu
- tyr
- phe
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102000018997 Growth Hormone Human genes 0.000 title 1
- 108010051696 Growth Hormone Proteins 0.000 title 1
- 239000000122 growth hormone Substances 0.000 title 1
- 239000003488 releasing hormone Substances 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- HNDVDQJCIGZPNO-RXMQYKEDSA-N D-histidine Chemical compound OC(=O)[C@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-RXMQYKEDSA-N 0.000 abstract 1
- COLNVLDHVKWLRT-MRVPVSSYSA-N D-phenylalanine Chemical compound OC(=O)[C@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-MRVPVSSYSA-N 0.000 abstract 1
- OUYCCCASQSFEME-MRVPVSSYSA-N D-tyrosine Chemical compound OC(=O)[C@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-MRVPVSSYSA-N 0.000 abstract 1
- SGCGMORCWLEJNZ-UWVGGRQHSA-N His-His Chemical compound C([C@H]([NH3+])C(=O)N[C@@H](CC=1NC=NC=1)C([O-])=O)C1=CN=CN1 SGCGMORCWLEJNZ-UWVGGRQHSA-N 0.000 abstract 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- -1 Phe Chemical compound 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000015556 catabolic process Effects 0.000 abstract 1
- 238000006731 degradation reaction Methods 0.000 abstract 1
- 230000001817 pituitary effect Effects 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 230000004936 stimulating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Endocrinology (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Surface Acoustic Wave Elements And Circuit Networks Thereof (AREA)
- Junction Field-Effect Transistors (AREA)
- Revetment (AREA)
- Control Of High-Frequency Heating Circuits (AREA)
- Diaphragms For Electromechanical Transducers (AREA)
- Lighting Device Outwards From Vehicle And Optical Signal (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/701,414 US5262519A (en) | 1991-05-15 | 1991-05-15 | GRF analogs XI |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE69230418D1 true DE69230418D1 (de) | 2000-01-20 |
Family
ID=24817283
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69230418T Expired - Lifetime DE69230418D1 (de) | 1991-05-15 | 1992-05-15 | GRF-Analoge (Growth Hormone Releasing Factors) |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US5262519A (de) |
| EP (1) | EP0514210B1 (de) |
| JP (1) | JPH06500575A (de) |
| KR (1) | KR100236413B1 (de) |
| AT (1) | ATE187741T1 (de) |
| AU (1) | AU654195B2 (de) |
| CA (1) | CA2086676A1 (de) |
| DE (1) | DE69230418D1 (de) |
| FI (1) | FI930152A0 (de) |
| IL (1) | IL101764A (de) |
| NZ (1) | NZ242610A (de) |
| WO (1) | WO1992020710A1 (de) |
| ZA (1) | ZA923281B (de) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06502618A (ja) * | 1990-05-04 | 1994-03-24 | ジ・アドミニストレイターズ・オブ・ザ・テュレイン・エデュケイショナル・ファンド | 新規な合成ｇｒｆ類似物 |
| CA2158782C (en) * | 1994-09-23 | 2010-01-12 | Pierrette Gaudreau | Marker for growth hormone-releasing factor receptors |
| AU5441096A (en) * | 1995-04-14 | 1996-10-30 | The Administrators Of The Tulane Eductional Fund | Analogs of growth hormone-releasing factor |
| CN1688696A (zh) * | 2002-09-18 | 2005-10-26 | 蒙特利尔大学医疗中心 | Ghrh类似物 |
| CA2939778C (en) | 2007-01-31 | 2019-01-29 | Dana-Farber Cancer Institute, Inc. | Stabilized p53 peptides and uses thereof |
| KR101525754B1 (ko) | 2007-03-28 | 2015-06-09 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 스티칭된 폴리펩티드 |
| US20090088380A1 (en) * | 2007-07-12 | 2009-04-02 | Pierrette Gaudreau | Ghrh analogs and therapeutic uses thereof |
| US8980249B2 (en) | 2010-06-03 | 2015-03-17 | University Of Miami | Agonists of growth hormone releasing hormone as effectors for survival and proliferation of pancreatic islets |
| SI2603600T1 (sl) | 2010-08-13 | 2019-04-30 | Aileron Therapeutics, Inc. | Peptidomimetični makrocikli |
| BR112013027150A2 (pt) * | 2011-04-21 | 2017-06-06 | Theratechnologies Inc | thera |
| KR20140100937A (ko) | 2011-10-18 | 2014-08-18 | 에일러론 테라퓨틱스 인코포레이티드 | 펩티도미메틱 거대고리 |
| US9079974B2 (en) | 2011-12-21 | 2015-07-14 | The University Of Miami | GH-RH analogs with potent agonistic effects |
| WO2013123267A1 (en) | 2012-02-15 | 2013-08-22 | Aileron Therapeutics, Inc. | Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles |
| CN104159595A (zh) | 2012-02-15 | 2014-11-19 | 爱勒让治疗公司 | 拟肽大环化合物 |
| BR112015009470A2 (pt) | 2012-11-01 | 2019-12-17 | Aileron Therapeutics Inc | aminoácidos dissubstituídos e seus métodos de preparação e uso |
| WO2014100816A2 (en) | 2012-12-21 | 2014-06-26 | University Of Miami | Ghrh agonists for islet cell transplantation and function and the treatment of diabetes |
| WO2014100809A2 (en) | 2012-12-21 | 2014-06-26 | University Of Miami | Ghrh agonists for the treatment of ischemic disorders |
| KR20170058424A (ko) | 2014-09-24 | 2017-05-26 | 에일러론 테라퓨틱스 인코포레이티드 | 펩티드모방 거대고리 및 이의 용도 |
| AU2016235424A1 (en) | 2015-03-20 | 2017-10-05 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4649131A (en) * | 1984-09-24 | 1987-03-10 | Hoffmann-La Roche Inc. | Growth hormone releasing factor analogs |
| US4689318A (en) * | 1985-08-29 | 1987-08-25 | The Salk Institute For Biological Studies | GRF analogs |
| US4746772A (en) * | 1986-09-23 | 1988-05-24 | Fisher Controls International, Inc. | Adjustable position indicating apparatus |
| US4843064A (en) * | 1987-01-13 | 1989-06-27 | The Salk Institute For Biological Studies | GRF analogs V |
| US5002931A (en) * | 1987-05-22 | 1991-03-26 | The Salk Institute For Biological Studies | GRF analogs VII |
| US5098995A (en) * | 1987-05-22 | 1992-03-24 | The Salk Institute For Biological Studies | GRF Analogs VIIA |
| US5043322A (en) * | 1988-07-22 | 1991-08-27 | The Salk Institute For Biological Studies | Cyclic GRF analogs |
| JPH06502618A (ja) * | 1990-05-04 | 1994-03-24 | ジ・アドミニストレイターズ・オブ・ザ・テュレイン・エデュケイショナル・ファンド | 新規な合成ｇｒｆ類似物 |
-
1991
- 1991-05-15 US US07/701,414 patent/US5262519A/en not_active Expired - Lifetime
-
1992
- 1992-05-01 IL IL10176492A patent/IL101764A/en not_active IP Right Cessation
- 1992-05-05 NZ NZ242610A patent/NZ242610A/en unknown
- 1992-05-06 ZA ZA923281A patent/ZA923281B/xx unknown
- 1992-05-12 JP JP5500150A patent/JPH06500575A/ja not_active Withdrawn
- 1992-05-12 KR KR1019930700097A patent/KR100236413B1/ko not_active IP Right Cessation
- 1992-05-12 WO PCT/US1992/003965 patent/WO1992020710A1/en active Application Filing
- 1992-05-12 CA CA002086676A patent/CA2086676A1/en not_active Abandoned
- 1992-05-12 AU AU19963/92A patent/AU654195B2/en not_active Ceased
- 1992-05-15 EP EP92304437A patent/EP0514210B1/de not_active Expired - Lifetime
- 1992-05-15 AT AT92304437T patent/ATE187741T1/de not_active IP Right Cessation
- 1992-05-15 DE DE69230418T patent/DE69230418D1/de not_active Expired - Lifetime
-
1993
- 1993-01-14 FI FI930152A patent/FI930152A0/fi unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FI930152A (fi) | 1993-01-14 |
| US5262519A (en) | 1993-11-16 |
| EP0514210A3 (en) | 1993-04-28 |
| JPH06500575A (ja) | 1994-01-20 |
| WO1992020710A1 (en) | 1992-11-26 |
| ATE187741T1 (de) | 2000-01-15 |
| FI930152A0 (fi) | 1993-01-14 |
| IL101764A0 (en) | 1992-12-30 |
| AU1996392A (en) | 1992-12-30 |
| CA2086676A1 (en) | 1992-11-16 |
| NZ242610A (en) | 1993-11-25 |
| ZA923281B (en) | 1993-01-27 |
| AU654195B2 (en) | 1994-10-27 |
| KR100236413B1 (ko) | 1999-12-15 |
| KR930701483A (ko) | 1993-06-11 |
| EP0514210A2 (de) | 1992-11-19 |
| EP0514210B1 (de) | 1999-12-15 |
| IL101764A (en) | 1996-07-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8332 | No legal effect for de |