DE69225107T2 - Teilchenanalysator - Google Patents

Teilchenanalysator

Info

Publication number
DE69225107T2
DE69225107T2 DE69225107T DE69225107T DE69225107T2 DE 69225107 T2 DE69225107 T2 DE 69225107T2 DE 69225107 T DE69225107 T DE 69225107T DE 69225107 T DE69225107 T DE 69225107T DE 69225107 T2 DE69225107 T2 DE 69225107T2
Authority
DE
Germany
Prior art keywords
particle analyzer
analyzer
particle
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69225107T
Other languages
English (en)
Other versions
DE69225107D1 (de
Inventor
Tokihiro Kosaka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sysmex Corp
Original Assignee
Sysmex Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP03270107A external-priority patent/JP3102926B2/ja
Priority claimed from JP03270106A external-priority patent/JP3102925B2/ja
Application filed by Sysmex Corp filed Critical Sysmex Corp
Publication of DE69225107D1 publication Critical patent/DE69225107D1/de
Application granted granted Critical
Publication of DE69225107T2 publication Critical patent/DE69225107T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1468—Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle
    • G01N15/147—Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle the analysis being performed on a sample stream
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1429—Signal processing
    • G01N15/1433—Signal processing using image recognition
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1434—Optical arrangements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N2015/1497—Particle shape
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/05—Flow-through cuvettes
    • G01N2021/058—Flat flow cell

Landscapes

  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Signal Processing (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
DE69225107T 1991-09-20 1992-09-21 Teilchenanalysator Expired - Fee Related DE69225107T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP03270107A JP3102926B2 (ja) 1991-09-20 1991-09-20 粒子分析装置
JP03270106A JP3102925B2 (ja) 1991-09-20 1991-09-20 粒子分析装置

Publications (2)

Publication Number Publication Date
DE69225107D1 DE69225107D1 (de) 1998-05-20
DE69225107T2 true DE69225107T2 (de) 1998-08-06

Family

ID=26549068

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69225107T Expired - Fee Related DE69225107T2 (de) 1991-09-20 1992-09-21 Teilchenanalysator

Country Status (3)

Country Link
US (1) US5548395A (de)
EP (1) EP0539022B1 (de)
DE (1) DE69225107T2 (de)

Families Citing this family (86)

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JP3165309B2 (ja) * 1993-12-22 2001-05-14 株式会社日立製作所 粒子画像解析装置
DE69533469T2 (de) * 1994-12-26 2005-09-22 Sysmex Corp. Durchflusszytometer
JP3504030B2 (ja) * 1995-07-04 2004-03-08 シスメックス株式会社 粒子判定基準の決定方法およびその装置並びにその判定基準を用いた粒子分析装置
JP3640461B2 (ja) * 1996-04-03 2005-04-20 シスメックス株式会社 粒子分析装置
US5790246A (en) * 1996-04-18 1998-08-04 Montores Pty. Ltd. Apparatus and network for determining a parameter of a particle in a fluid employing detector and processor
JP4323571B2 (ja) 1997-01-31 2009-09-02 エックスワイ， インコーポレイテッド 光学装置
US6149867A (en) 1997-12-31 2000-11-21 Xy, Inc. Sheath fluids and collection systems for sex-specific cytometer sorting of sperm
US6251615B1 (en) 1998-02-20 2001-06-26 Cell Analytics, Inc. Cell analysis methods
JP3871456B2 (ja) * 1998-12-10 2007-01-24 シスメックス株式会社 粒子画像分析装置
US8885913B2 (en) 1999-01-25 2014-11-11 Amnis Corporation Detection of circulating tumor cells using imaging flow cytometry
US6580504B1 (en) 1999-01-25 2003-06-17 Amnis Corporation Multipass cavity for illumination and excitation of moving objects
US6707551B2 (en) * 2000-01-24 2004-03-16 Amnis Corporation Multipass cavity for illumination and excitation of moving objects
US6671044B2 (en) 1999-01-25 2003-12-30 Amnis Corporation Imaging and analyzing parameters of small moving objects such as cells in broad flat flow
US8406498B2 (en) * 1999-01-25 2013-03-26 Amnis Corporation Blood and cell analysis using an imaging flow cytometer
US7450229B2 (en) * 1999-01-25 2008-11-11 Amnis Corporation Methods for analyzing inter-cellular phenomena
US8005314B2 (en) * 2005-12-09 2011-08-23 Amnis Corporation Extended depth of field imaging for high speed object analysis
US8131053B2 (en) * 1999-01-25 2012-03-06 Amnis Corporation Detection of circulating tumor cells using imaging flow cytometry
US20060257884A1 (en) * 2004-05-20 2006-11-16 Amnis Corporation Methods for preparing and analyzing cells having chromosomal abnormalities
US6473176B2 (en) 1999-01-25 2002-10-29 Amnis Corporation Imaging and analyzing parameters of small moving objects such as cells
US7057732B2 (en) * 1999-01-25 2006-06-06 Amnis Corporation Imaging platform for nanoparticle detection applied to SPR biomolecular interaction analysis
US6249341B1 (en) 1999-01-25 2001-06-19 Amnis Corporation Imaging and analyzing parameters of small moving objects such as cells
US6608682B2 (en) 1999-01-25 2003-08-19 Amnis Corporation Imaging and analyzing parameters of small moving objects such as cells
US6975400B2 (en) * 1999-01-25 2005-12-13 Amnis Corporation Imaging and analyzing parameters of small moving objects such as cells
US7208265B1 (en) 1999-11-24 2007-04-24 Xy, Inc. Method of cryopreserving selected sperm cells
US6608680B2 (en) 2000-08-25 2003-08-19 Amnis Corporation TDI imaging system for kinetic studies
US6583865B2 (en) * 2000-08-25 2003-06-24 Amnis Corporation Alternative detector configuration and mode of operation of a time delay integration particle analyzer
JP4994560B2 (ja) 2000-08-25 2012-08-08 アムニス コーポレイション 細胞などの小さな移動物体の速度測定
US6934408B2 (en) * 2000-08-25 2005-08-23 Amnis Corporation Method and apparatus for reading reporter labeled beads
US6875973B2 (en) * 2000-08-25 2005-04-05 Amnis Corporation Auto focus for a flow imaging system
US6778263B2 (en) * 2000-08-25 2004-08-17 Amnis Corporation Methods of calibrating an imaging system using calibration beads
US20020028434A1 (en) 2000-09-06 2002-03-07 Guava Technologies, Inc. Particle or cell analyzer and method
WO2002031467A1 (en) 2000-10-12 2002-04-18 Amnis Corporation Multipass cavity for illumination and excitation of moving objects
US7009651B2 (en) 2000-10-12 2006-03-07 Amnis Corporation System and method for high numeric aperture imaging systems
AU2002220018A1 (en) 2000-11-29 2002-06-11 Colorado State University System for in-vitro fertilization with spermatozoa separated into x-chromosome and y-chromosome bearing populations
US7713687B2 (en) 2000-11-29 2010-05-11 Xy, Inc. System to separate frozen-thawed spermatozoa into x-chromosome bearing and y-chromosome bearing populations
WO2002100157A2 (en) * 2001-02-21 2002-12-19 Amnis Corporation Method and apparatus for labeling and analyzing cellular components
US6519355B2 (en) * 2001-03-28 2003-02-11 Alan C. Nelson Optical projection imaging system and method for automatically detecting cells having nuclear and cytoplasmic densitometric features associated with disease
US7907765B2 (en) 2001-03-28 2011-03-15 University Of Washington Focal plane tracking for optical microtomography
EP1389956B1 (de) * 2001-04-25 2012-10-31 Amnis Corporation Verfahren und vorrichtung zur korrektur von übersprechen und der räumlichen auflösung für die mehrkanal-abbildung
AU2002319621A1 (en) 2001-07-17 2003-03-03 Amnis Corporation Computational methods for the segmentation of images of objects from background in a flow imaging instrument
EP1432972A1 (de) 2001-09-07 2004-06-30 Inficon, Inc. Signalverarbeitungsverfahren zur in-situ-teilchenüberwachung mit einem gescannten strahl
US20030133119A1 (en) * 2002-01-17 2003-07-17 Bachur Nicholas R. Rapid imaging of particles in a large fluid volume through flow cell imaging
US7738945B2 (en) * 2002-04-19 2010-06-15 University Of Washington Method and apparatus for pseudo-projection formation for optical tomography
US7260253B2 (en) 2002-04-19 2007-08-21 Visiongate, Inc. Method for correction of relative object-detector motion between successive views
US6710874B2 (en) * 2002-07-05 2004-03-23 Rashid Mavliev Method and apparatus for detecting individual particles in a flowable sample
MX337304B (es) 2002-08-01 2016-02-24 Xy Llc Sistema de separacion de baja presion para celulas de esperma.
US8486618B2 (en) 2002-08-01 2013-07-16 Xy, Llc Heterogeneous inseminate system
WO2004017041A2 (en) 2002-08-15 2004-02-26 Xy, Inc. High resolution flow cytometer
US7169548B2 (en) 2002-09-13 2007-01-30 Xy, Inc. Sperm cell processing and preservation systems
EP2306174B1 (de) 2003-03-28 2016-05-11 Inguran, LLC Durchflusszytometriedüse zur Orientierung von Partikeln und entsprechendes Verfahren
NZ544103A (en) 2003-05-15 2010-10-29 Xy Llc Efficient haploid cell sorting for flow cytometer systems
US7415136B2 (en) * 2003-12-10 2008-08-19 Woods Hole Oceanographic Institution Optical method and system for rapid identification of multiple refractive index materials using multiscale texture and color invariants
US8103080B2 (en) 2004-03-16 2012-01-24 Amnis Corporation Method for imaging and differential analysis of cells
EP1800124B1 (de) 2004-03-16 2011-12-21 Amnis Corporation Auf bildlicher darstellung beruhende quantifizierung molekularer translokation
US8953866B2 (en) 2004-03-16 2015-02-10 Amnis Corporation Method for imaging and differential analysis of cells
CN104974983A (zh) 2004-03-29 2015-10-14 英格朗公司 用于授精的精子悬浮液
AU2005266930B2 (en) 2004-07-22 2010-09-16 Inguran, Llc Process for enriching a population of sperm cells
US7355696B2 (en) * 2005-02-01 2008-04-08 Arryx, Inc Method and apparatus for sorting cells
US7804594B2 (en) 2006-12-29 2010-09-28 Abbott Laboratories, Inc. Method and apparatus for rapidly counting and identifying biological particles in a flow stream
US7835561B2 (en) 2007-05-18 2010-11-16 Visiongate, Inc. Method for image processing and reconstruction of images for optical tomography
US7787112B2 (en) * 2007-10-22 2010-08-31 Visiongate, Inc. Depth of field extension for optical tomography
US8159670B2 (en) * 2007-11-05 2012-04-17 Abbott Laboratories Method and apparatus for rapidly counting and identifying biological particles in a flow stream
US8143600B2 (en) 2008-02-18 2012-03-27 Visiongate, Inc. 3D imaging of live cells with ultraviolet radiation
US8090183B2 (en) * 2009-03-12 2012-01-03 Visiongate, Inc. Pattern noise correction for pseudo projections
US7738101B2 (en) * 2008-07-08 2010-06-15 Rashid Mavliev Systems and methods for in-line monitoring of particles in opaque flows
JP2010085194A (ja) * 2008-09-30 2010-04-15 Sysmex Corp 試料分析装置
JP5301232B2 (ja) * 2008-09-30 2013-09-25 シスメックス株式会社 血球画像表示装置、検体分析システム、血球画像表示方法、及びコンピュータプログラム
US8842900B2 (en) * 2008-10-28 2014-09-23 Sysmex Corporation Specimen processing system and blood cell image classifying apparatus
US8254023B2 (en) * 2009-02-23 2012-08-28 Visiongate, Inc. Optical tomography system with high-speed scanner
DE102009014080B4 (de) * 2009-03-23 2011-12-15 Baumer Innotec Ag Vorrichtung zum Bestimmen von Partikelgrössen
US8451524B2 (en) * 2009-09-29 2013-05-28 Amnis Corporation Modifying the output of a laser to achieve a flat top in the laser's Gaussian beam intensity profile
JP5537347B2 (ja) * 2009-11-30 2014-07-02 シスメックス株式会社 粒子分析装置
EP2513635A4 (de) 2009-12-18 2017-06-28 FPInnovations Online-analysegerät und -verfahren für makroverunreinigungen
US8817115B1 (en) 2010-05-05 2014-08-26 Amnis Corporation Spatial alignment of image data from a multichannel detector using a reference image
CN104094099B (zh) 2011-04-15 2017-05-03 罗氏血液诊断股份有限公司 测量细胞体积和成份
US9897530B2 (en) 2011-08-25 2018-02-20 Sony Corporation Compensation of motion-related error in a stream of moving micro-entities
US9176055B2 (en) * 2012-01-04 2015-11-03 Sony Corporation System and method for measuring narrow and wide angle light scatter on a high-speed cell sorting device
US9746412B2 (en) 2012-05-30 2017-08-29 Iris International, Inc. Flow cytometer
US8820538B1 (en) * 2014-03-17 2014-09-02 Namocell LLC Method and apparatus for particle sorting
JP2016080563A (ja) 2014-10-20 2016-05-16 日本光電工業株式会社 分析システム、分析装置
ES2607633A1 (es) * 2015-10-01 2017-04-03 Universidad Carlos Iii De Madrid Dispositivo de carga múltiple para microscopio de haz láser plano
US11069054B2 (en) 2015-12-30 2021-07-20 Visiongate, Inc. System and method for automated detection and monitoring of dysplasia and administration of immunotherapy and chemotherapy
JP6602211B2 (ja) * 2016-01-22 2019-11-06 株式会社堀場製作所 粒子分析装置、粒子分析方法及び粒子分析プログラム
US10337975B2 (en) * 2016-05-06 2019-07-02 Deutsches Rheuma-Forschungszentrum Berlin Method and system for characterizing particles using a flow cytometer
JP6999129B2 (ja) * 2017-09-06 2022-01-18 浜松ホトニクス株式会社 細胞観察システムおよび細胞観察方法
EP4012377B1 (de) * 2020-12-09 2024-04-24 Wilde, Axel Vorrichtung und verfahren zur erfassung von partikeln in fluid-gemischen und gas-gemischen

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Also Published As

Publication number Publication date
DE69225107D1 (de) 1998-05-20
US5548395A (en) 1996-08-20
EP0539022A3 (en) 1993-11-03
EP0539022A2 (de) 1993-04-28
EP0539022B1 (de) 1998-04-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee