DE69214980T2 - Verfahren zur Reinigung von rekombinantem Hepatitis B-Virus-Oberflächenproteinen aus rekombinanten Zellen - Google Patents
Verfahren zur Reinigung von rekombinantem Hepatitis B-Virus-Oberflächenproteinen aus rekombinanten ZellenInfo
- Publication number
- DE69214980T2 DE69214980T2 DE69214980T DE69214980T DE69214980T2 DE 69214980 T2 DE69214980 T2 DE 69214980T2 DE 69214980 T DE69214980 T DE 69214980T DE 69214980 T DE69214980 T DE 69214980T DE 69214980 T2 DE69214980 T2 DE 69214980T2
- Authority
- DE
- Germany
- Prior art keywords
- recombinant
- purification
- surface proteins
- virus surface
- hepatitis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2730/00—Reverse transcribing DNA viruses
- C12N2730/00011—Details
- C12N2730/10011—Hepadnaviridae
- C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
- C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/82—Proteins from microorganisms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/82—Proteins from microorganisms
- Y10S530/823—Lower fungi, e.g. mold
- Y10S530/824—Yeasts
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/82—Proteins from microorganisms
- Y10S530/825—Bacteria
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/82—Proteins from microorganisms
- Y10S530/826—Viruses
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Virology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/669,705 US5102989A (en) | 1991-03-15 | 1991-03-15 | Method of stabilizing recombinant hepatitis B virus surface proteins from recombinant host cells |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69214980D1 DE69214980D1 (de) | 1996-12-12 |
DE69214980T2 true DE69214980T2 (de) | 1997-05-15 |
Family
ID=24687385
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69214980T Expired - Fee Related DE69214980T2 (de) | 1991-03-15 | 1992-03-12 | Verfahren zur Reinigung von rekombinantem Hepatitis B-Virus-Oberflächenproteinen aus rekombinanten Zellen |
Country Status (5)
Country | Link |
---|---|
US (1) | US5102989A (de) |
EP (1) | EP0503950B1 (de) |
JP (1) | JPH0734753B2 (de) |
CA (1) | CA2062460A1 (de) |
DE (1) | DE69214980T2 (de) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL86833A0 (en) * | 1987-06-22 | 1988-11-30 | Medico Labs | Peptide containing immunogenic particles |
EP0491077A1 (de) * | 1990-12-19 | 1992-06-24 | Medeva Holdings B.V. | Zusammensetzung verwendbar als therapeutisches Mittel gegen chronische virale Leberkrankheiten |
WO1992013951A1 (en) * | 1991-02-04 | 1992-08-20 | The Salk Institute Biotechnology/Industrial Associates, Inc. | Production of human serum albumin in methylotrophic yeast cells |
KR19990045763A (ko) * | 1995-09-18 | 1999-06-25 | 유나이티드 스테이트 아미 메디칼 리서치 머티어리얼커맨드 (유에스에이엠알엠씨) | 비공유결합성으로 착염화된 다가의 프로테오좀 서브-유니트 백신의 개선된 제조 방법 |
US20040057969A1 (en) * | 2002-09-20 | 2004-03-25 | Smith Mark L | Compositions containing stabilized hepatitis antigen and methods of their use |
JP4936272B2 (ja) * | 2006-02-13 | 2012-05-23 | 独立行政法人科学技術振興機構 | バイオナノカプセルの効率的な精製法 |
CN110305807B (zh) * | 2013-05-17 | 2024-02-20 | 北京安百胜生物科技有限公司 | 用汉逊酵母表达系统产生hpv33 l1蛋白的方法 |
CN110295190A (zh) * | 2013-05-17 | 2019-10-01 | 北京安百胜生物科技有限公司 | 用汉逊酵母表达系统产生hpv45 l1蛋白的方法 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS59101426A (ja) * | 1982-11-29 | 1984-06-12 | Green Cross Corp:The | B型肝炎感染予防用ワクチンの製造方法 |
US4707542A (en) * | 1983-08-22 | 1987-11-17 | Merck & Co., Inc. | Immunogenic HbsAg derived from transformed yeast |
JPS60197629A (ja) * | 1984-03-16 | 1985-10-07 | Chemo Sero Therapeut Res Inst | HBs抗原の精製方法 |
JPH066066B2 (ja) * | 1984-06-07 | 1994-01-26 | 旭化成工業株式会社 | 遺伝子組換体の産生する生理活性物質の熱処理法 |
US4683294A (en) * | 1985-04-03 | 1987-07-28 | Smith Kline Rit, S.A. | Process for the extraction and purification of proteins from culture media producing them |
US4649192A (en) * | 1985-05-30 | 1987-03-10 | Smith Kline-Rit | Method for the isolation and purification of hepatitis B surface antigen using polysorbate |
US4816564A (en) * | 1986-01-31 | 1989-03-28 | Merck & Co., Inc. | Method for producing hepatitis B virus proteins in yeast |
EP0280470B1 (de) * | 1987-02-27 | 1993-07-07 | Merck & Co. Inc. | Verfahren zur Herstellung des pres 1/S2/S-Hepatitis-B-Antigens aus Hefe |
AU609824B2 (en) * | 1987-06-15 | 1991-05-09 | Southern Cross Biotech Pty Ltd. | Production of proteins in active forms |
US5011915A (en) * | 1987-10-26 | 1991-04-30 | Merck & Co., Inc. | Process for purifying recombinant hepatitis antigens |
JPH01196293A (ja) * | 1988-01-29 | 1989-08-08 | Green Cross Corp:The | B型肝炎ウイルス表面抗原の抽出方法 |
US5004688A (en) * | 1988-04-15 | 1991-04-02 | Phillips Petroleum Company | Purification of hepatitis proteins |
-
1991
- 1991-03-15 US US07/669,705 patent/US5102989A/en not_active Expired - Fee Related
-
1992
- 1992-03-06 CA CA002062460A patent/CA2062460A1/en not_active Abandoned
- 1992-03-11 JP JP4051980A patent/JPH0734753B2/ja not_active Expired - Lifetime
- 1992-03-12 DE DE69214980T patent/DE69214980T2/de not_active Expired - Fee Related
- 1992-03-12 EP EP92302152A patent/EP0503950B1/de not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JPH05252976A (ja) | 1993-10-05 |
EP0503950B1 (de) | 1996-11-06 |
DE69214980D1 (de) | 1996-12-12 |
EP0503950A2 (de) | 1992-09-16 |
JPH0734753B2 (ja) | 1995-04-19 |
CA2062460A1 (en) | 1992-09-16 |
US5102989A (en) | 1992-04-07 |
EP0503950A3 (en) | 1993-03-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |