DE69204733T2 - Antibiotikverbindungen und ihre Herstellung. - Google Patents

Antibiotikverbindungen und ihre Herstellung.

Info

Publication number
DE69204733T2
DE69204733T2 DE69204733T DE69204733T DE69204733T2 DE 69204733 T2 DE69204733 T2 DE 69204733T2 DE 69204733 T DE69204733 T DE 69204733T DE 69204733 T DE69204733 T DE 69204733T DE 69204733 T2 DE69204733 T2 DE 69204733T2
Authority
DE
Germany
Prior art keywords
compound
formula
ethyl acetate
solvent
culture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69204733T
Other languages
German (de)
English (en)
Other versions
DE69204733D1 (de
Inventor
Juergen Dr Blumbach
Louis Ernest Linus Coutinho
Hans-Wolf Dr Fehlhaber
Bimal Naresh Dr Ganguli
Herbert Dr Kogler
Christopher Milton Dr Mathew
Dilip Jatashankar Upadhyay
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Application granted granted Critical
Publication of DE69204733D1 publication Critical patent/DE69204733D1/de
Publication of DE69204733T2 publication Critical patent/DE69204733T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/06—Benzopyran radicals
    • C07H17/065—Benzo[b]pyrans
    • C07H17/07—Benzo[b]pyran-4-ones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/605—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin to a 1-benzopyran-2-on (or the chalcones and hydrogenated chalcones thereof, e.g. coumermycin, novobiocin, novenamin)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/886—Streptomyces

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE69204733T 1991-02-26 1992-05-06 Antibiotikverbindungen und ihre Herstellung. Expired - Fee Related DE69204733T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN57BO1991 IN172911B (enExample) 1991-02-26 1991-02-26
EP91107618 1991-05-10

Publications (2)

Publication Number Publication Date
DE69204733D1 DE69204733D1 (de) 1995-10-19
DE69204733T2 true DE69204733T2 (de) 1996-03-21

Family

ID=33454354

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69204733T Expired - Fee Related DE69204733T2 (de) 1991-02-26 1992-05-06 Antibiotikverbindungen und ihre Herstellung.

Country Status (9)

Country Link
US (1) US5270182A (enExample)
EP (1) EP0512522B1 (enExample)
JP (1) JP3166126B2 (enExample)
AT (1) ATE127806T1 (enExample)
DE (1) DE69204733T2 (enExample)
DK (1) DK0512522T3 (enExample)
ES (1) ES2079724T3 (enExample)
GR (1) GR3017749T3 (enExample)
IN (1) IN172911B (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2002027010A1 (ja) * 2000-09-29 2004-02-05 大正製薬株式会社 キサントン系化合物
KR100474653B1 (ko) * 2004-04-16 2005-03-14 동국제약 주식회사 타이코플라닌의 고순도 생산방법
US20050271755A1 (en) * 2004-05-12 2005-12-08 Ilya Raskin Phytomedicinal compositions for the control of lipid accumulation and metabolism in mammals
KR102679066B1 (ko) * 2021-12-07 2024-06-27 한국해양과학기술원 항암효과가 우수한 신규 잔톤계 화합물

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4230692A (en) * 1978-11-03 1980-10-28 Ayerst Mckenna & Harrison, Inc. Ravidomycin and process of preparation
US4598145A (en) * 1982-08-16 1986-07-01 Bristol-Myers Company Albacarcins V and M
US4518589A (en) * 1983-10-03 1985-05-21 Bristol-Myers Company BBM-2478 Antibiotic complex
DE3683822D1 (de) * 1985-10-23 1992-03-19 Ishihara Sangyo Kaisha Chartreusinderivate und salze, diese enthaltende antitumorzusammensetzungen und verfahren zu ihrer herstellung.
JPS62207284A (ja) * 1986-03-07 1987-09-11 Rikagaku Kenkyusho 抗生物質ｒｋ−９５５ａ及びその製造法
EP0372986B1 (en) * 1988-12-09 1993-03-24 Kyowa Hakko Kogyo Kabushiki Kaisha Compound ks-505 and a process for producing the same

Also Published As

Publication number Publication date
IN172911B (enExample) 1994-01-01
DK0512522T3 (da) 1996-01-29
EP0512522B1 (en) 1995-09-13
US5270182A (en) 1993-12-14
EP0512522A1 (en) 1992-11-11
DE69204733D1 (de) 1995-10-19
JPH05155888A (ja) 1993-06-22
GR3017749T3 (en) 1996-01-31
ATE127806T1 (de) 1995-09-15
JP3166126B2 (ja) 2001-05-14
ES2079724T3 (es) 1996-01-16

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee