DE69131944D1 - Verfahren zur Herstellung von höheren Kuprat-Komplexen - Google Patents

Verfahren zur Herstellung von höheren Kuprat-Komplexen

Info

Publication number
DE69131944D1
DE69131944D1 DE69131944T DE69131944T DE69131944D1 DE 69131944 D1 DE69131944 D1 DE 69131944D1 DE 69131944 T DE69131944 T DE 69131944T DE 69131944 T DE69131944 T DE 69131944T DE 69131944 D1 DE69131944 D1 DE 69131944D1
Authority
DE
Germany
Prior art keywords
production
produce
cuprate complexes
higher order
cuprate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69131944T
Other languages
English (en)
Other versions
DE69131944T2 (de
Inventor
Kevin Anthony Babiak
James Richard Behling
John Henry Dygos
Ng John Sau-Hoi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
Original Assignee
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GD Searle LLC filed Critical GD Searle LLC
Publication of DE69131944D1 publication Critical patent/DE69131944D1/de
Application granted granted Critical
Publication of DE69131944T2 publication Critical patent/DE69131944T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F1/00—Compounds containing elements of Groups 1 or 11 of the Periodic Table
    • C07F1/08—Copper compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
DE69131944T 1990-04-17 1991-04-15 Verfahren zur Herstellung von höheren Kuprat-Komplexen Expired - Fee Related DE69131944T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/510,349 US5055604A (en) 1990-04-17 1990-04-17 Process for preparing prostaglandin analogs using organozirconium compounds

Publications (2)

Publication Number Publication Date
DE69131944D1 true DE69131944D1 (de) 2000-03-02
DE69131944T2 DE69131944T2 (de) 2000-06-15

Family

ID=24030385

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69131944T Expired - Fee Related DE69131944T2 (de) 1990-04-17 1991-04-15 Verfahren zur Herstellung von höheren Kuprat-Komplexen
DE69110343T Expired - Fee Related DE69110343T2 (de) 1990-04-17 1991-04-15 Verfahren zur Herstellung von Prostaglandin-Analogen mit Hilfe von Organozirkoniumderivaten.

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69110343T Expired - Fee Related DE69110343T2 (de) 1990-04-17 1991-04-15 Verfahren zur Herstellung von Prostaglandin-Analogen mit Hilfe von Organozirkoniumderivaten.

Country Status (12)

Country Link
US (1) US5055604A (de)
EP (2) EP0643063B1 (de)
JP (1) JPH04224555A (de)
KR (2) KR100208496B1 (de)
AT (2) ATE123768T1 (de)
CA (1) CA2040468C (de)
DE (2) DE69131944T2 (de)
DK (2) DK0452843T3 (de)
ES (2) ES2073060T3 (de)
GR (1) GR3033236T3 (de)
IE (1) IE911273A1 (de)
PT (1) PT97368A (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5618959A (en) * 1995-03-10 1997-04-08 Vivus Incorporated Process for preparing prostaglandin E1, E2 and analogs thereof using furylcopper reagents
US6030959A (en) * 1997-04-04 2000-02-29 Monsanto Company Gastro-specific prodrugs
US6413945B1 (en) * 1997-04-04 2002-07-02 Pharmacia Corporation Gastro-specific prodrugs
KR20030002365A (ko) * 2001-06-29 2003-01-09 주식회사 하이닉스반도체 반도체 소자의 포토 레지스트 중합체용 단량체 및 이의제조 방법
KR101045935B1 (ko) 2009-03-11 2011-07-01 연성정밀화학(주) 프로스타글란딘 유도체의 제조방법
HU231185B1 (hu) 2017-07-11 2021-07-28 CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. Eljárás Misoprostol előállítására és tisztítására

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3950406A (en) * 1972-07-24 1976-04-13 American Cyanamid Company Hydroxylated 15-deoxy derivatives of 9-hydroxy-13-trans-prostenoic acid
US3962351A (en) * 1972-09-29 1976-06-08 Wisconsin Alumni Research Foundation 3-Substituted iodo alkenyl compounds and methods for preparing same
US3962352A (en) * 1972-09-29 1976-06-08 Wisconsin Alumni Research Foundation 3-Substituted iodo alkenyl compounds and methods for preparing same
US3962353A (en) * 1972-09-29 1976-06-08 Wisconsin Alumni Research Foundation 3-Substituted iodo alkenyl compounds and methods for preparing same
US3932479A (en) * 1973-04-27 1976-01-13 American Cyanamid Company Lithium 3-triphenylmethoxy-1-trans-alkenyl-dialkyl alanates
US4007210A (en) * 1973-04-27 1977-02-08 American Cyanamid Company Novel 3-triphenylmethoxy-1-alkynes, 3-triphenylmethoxy-1-trans-alkenyl-dialkyl-alanes, and lithium 3-triphenyl-methoxy-1-trans-alkenyl-dialkyl-alanates
US3965143A (en) * 1974-03-26 1976-06-22 G. D. Searle & Co. 16-Oxygenated prostanoic acid derivatives
US4983753A (en) * 1981-05-21 1991-01-08 Floyd Jr Middleton B Precursors and synthesis of di-(methyl)-16,16-(dimethyl)-11-alpha,15-alpha beta-dihydroxy-9-oxo-2,13-trans,trans-prostadienoates
US4415501A (en) * 1981-12-16 1983-11-15 American Cyanamid Company Alkenylzirconium reagents useful for prostaglandin analog synthesis
US4822909A (en) * 1983-06-10 1989-04-18 Asashi Glass Company Ltd. 7-fluoroprostaglandins and process for their production
DK40485A (da) * 1984-03-02 1985-09-03 Hoffmann La Roche Prostaglandin-mellemprodukter
DE3571319D1 (en) * 1984-10-08 1989-08-10 Teijin Ltd Process for producing 2,3-disubstituted -4-substituted cyclopentanones, enantiomorphs, or mixtures thereof
US4873360A (en) * 1986-07-10 1989-10-10 Board Of Governors Of Wayne State University Process for the preparation of cyclopentanoids and novel intermediates produced thereby
US4777275A (en) * 1987-06-09 1988-10-11 G. D. Searle & Co. Process of preparing higher order cuprate complexes
US4904820A (en) * 1987-06-09 1990-02-27 G. D. Searle & Co. Process for substituting a hydrocarbon group
US4916238A (en) * 1988-12-13 1990-04-10 Syntex (U.S.A.) Inc. Process for preparing allenic prostanoic acid derivatives
US5072010A (en) * 1990-04-04 1991-12-10 University Of California Transmetalations from zirconium to copper intermediates

Also Published As

Publication number Publication date
KR100226368B1 (en) 1999-10-15
CA2040468A1 (en) 1991-10-18
EP0452843A3 (en) 1992-07-29
PT97368A (pt) 1992-01-31
DK0643063T3 (da) 2000-04-25
ES2143517T3 (es) 2000-05-16
IE911273A1 (en) 1991-10-23
ATE123768T1 (de) 1995-06-15
ATE189222T1 (de) 2000-02-15
JPH04224555A (ja) 1992-08-13
US5055604A (en) 1991-10-08
EP0452843B1 (de) 1995-06-14
DK0452843T3 (da) 1995-08-14
KR100208496B1 (ko) 1999-07-15
DE69110343T2 (de) 1995-12-21
EP0643063B1 (de) 2000-01-26
GR3033236T3 (en) 2000-09-29
CA2040468C (en) 2004-10-26
KR910018351A (ko) 1991-11-30
ES2073060T3 (es) 1995-08-01
EP0643063A2 (de) 1995-03-15
DE69131944T2 (de) 2000-06-15
EP0643063A3 (de) 1995-10-11
EP0452843A2 (de) 1991-10-23
DE69110343D1 (de) 1995-07-20

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee