ATE123768T1 - Verfahren zur herstellung von prostaglandin- analogen mit hilfe von organozirkoniumderivaten. - Google Patents
Verfahren zur herstellung von prostaglandin- analogen mit hilfe von organozirkoniumderivaten.Info
- Publication number
- ATE123768T1 ATE123768T1 AT91105951T AT91105951T ATE123768T1 AT E123768 T1 ATE123768 T1 AT E123768T1 AT 91105951 T AT91105951 T AT 91105951T AT 91105951 T AT91105951 T AT 91105951T AT E123768 T1 ATE123768 T1 AT E123768T1
- Authority
- AT
- Austria
- Prior art keywords
- organozirconium
- derivatives
- prostaglandin analogues
- producing prostaglandin
- produce
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 229940006138 antiglaucoma drug and miotics prostaglandin analogues Drugs 0.000 title 1
- 239000010949 copper Substances 0.000 abstract 2
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 abstract 1
- QCWXUUIWCKQGHC-UHFFFAOYSA-N Zirconium Chemical compound [Zr] QCWXUUIWCKQGHC-UHFFFAOYSA-N 0.000 abstract 1
- 150000001345 alkine derivatives Chemical class 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- -1 chloride hydride Chemical compound 0.000 abstract 1
- 229910052802 copper Inorganic materials 0.000 abstract 1
- DOBRDRYODQBAMW-UHFFFAOYSA-N copper(i) cyanide Chemical compound [Cu+].N#[C-] DOBRDRYODQBAMW-UHFFFAOYSA-N 0.000 abstract 1
- ZMMRKRFMSDTOLV-UHFFFAOYSA-N cyclopenta-1,3-diene zirconium Chemical compound [Zr].C1C=CC=C1.C1C=CC=C1 ZMMRKRFMSDTOLV-UHFFFAOYSA-N 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229910052726 zirconium Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F1/00—Compounds containing elements of Groups 1 or 11 of the Periodic Table
- C07F1/08—Copper compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Catalysts (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/510,349 US5055604A (en) | 1990-04-17 | 1990-04-17 | Process for preparing prostaglandin analogs using organozirconium compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE123768T1 true ATE123768T1 (de) | 1995-06-15 |
Family
ID=24030385
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT91105951T ATE123768T1 (de) | 1990-04-17 | 1991-04-15 | Verfahren zur herstellung von prostaglandin- analogen mit hilfe von organozirkoniumderivaten. |
| AT94116373T ATE189222T1 (de) | 1990-04-17 | 1991-04-15 | Verfahren zur herstellung von höheren kuprat- komplexen |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94116373T ATE189222T1 (de) | 1990-04-17 | 1991-04-15 | Verfahren zur herstellung von höheren kuprat- komplexen |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5055604A (de) |
| EP (2) | EP0643063B1 (de) |
| JP (1) | JPH04224555A (de) |
| KR (2) | KR100208496B1 (de) |
| AT (2) | ATE123768T1 (de) |
| CA (1) | CA2040468C (de) |
| DE (2) | DE69131944T2 (de) |
| DK (2) | DK0452843T3 (de) |
| ES (2) | ES2073060T3 (de) |
| GR (1) | GR3033236T3 (de) |
| IE (1) | IE911273A1 (de) |
| PT (1) | PT97368A (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5618959A (en) * | 1995-03-10 | 1997-04-08 | Vivus Incorporated | Process for preparing prostaglandin E1, E2 and analogs thereof using furylcopper reagents |
| US6413945B1 (en) * | 1997-04-04 | 2002-07-02 | Pharmacia Corporation | Gastro-specific prodrugs |
| US6030959A (en) * | 1997-04-04 | 2000-02-29 | Monsanto Company | Gastro-specific prodrugs |
| KR20030002365A (ko) * | 2001-06-29 | 2003-01-09 | 주식회사 하이닉스반도체 | 반도체 소자의 포토 레지스트 중합체용 단량체 및 이의제조 방법 |
| KR101045935B1 (ko) | 2009-03-11 | 2011-07-01 | 연성정밀화학(주) | 프로스타글란딘 유도체의 제조방법 |
| HU231185B1 (hu) | 2017-07-11 | 2021-07-28 | CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. | Eljárás Misoprostol előállítására és tisztítására |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3950406A (en) * | 1972-07-24 | 1976-04-13 | American Cyanamid Company | Hydroxylated 15-deoxy derivatives of 9-hydroxy-13-trans-prostenoic acid |
| US3962351A (en) * | 1972-09-29 | 1976-06-08 | Wisconsin Alumni Research Foundation | 3-Substituted iodo alkenyl compounds and methods for preparing same |
| US3962353A (en) * | 1972-09-29 | 1976-06-08 | Wisconsin Alumni Research Foundation | 3-Substituted iodo alkenyl compounds and methods for preparing same |
| US3962352A (en) * | 1972-09-29 | 1976-06-08 | Wisconsin Alumni Research Foundation | 3-Substituted iodo alkenyl compounds and methods for preparing same |
| US3932479A (en) * | 1973-04-27 | 1976-01-13 | American Cyanamid Company | Lithium 3-triphenylmethoxy-1-trans-alkenyl-dialkyl alanates |
| US4007210A (en) * | 1973-04-27 | 1977-02-08 | American Cyanamid Company | Novel 3-triphenylmethoxy-1-alkynes, 3-triphenylmethoxy-1-trans-alkenyl-dialkyl-alanes, and lithium 3-triphenyl-methoxy-1-trans-alkenyl-dialkyl-alanates |
| US3965143A (en) * | 1974-03-26 | 1976-06-22 | G. D. Searle & Co. | 16-Oxygenated prostanoic acid derivatives |
| US4983753A (en) * | 1981-05-21 | 1991-01-08 | Floyd Jr Middleton B | Precursors and synthesis of di-(methyl)-16,16-(dimethyl)-11-alpha,15-alpha beta-dihydroxy-9-oxo-2,13-trans,trans-prostadienoates |
| US4415501A (en) * | 1981-12-16 | 1983-11-15 | American Cyanamid Company | Alkenylzirconium reagents useful for prostaglandin analog synthesis |
| US4822909A (en) * | 1983-06-10 | 1989-04-18 | Asashi Glass Company Ltd. | 7-fluoroprostaglandins and process for their production |
| DK40485A (da) * | 1984-03-02 | 1985-09-03 | Hoffmann La Roche | Prostaglandin-mellemprodukter |
| EP0178139B1 (de) * | 1984-10-08 | 1989-07-05 | Teijin Limited | Verfahren zur Herstellung von 2,3-disubstituierten-4-substituierten Zyklopentanonen, Enantiomorphen oder ihren Mischungen |
| US4873360A (en) * | 1986-07-10 | 1989-10-10 | Board Of Governors Of Wayne State University | Process for the preparation of cyclopentanoids and novel intermediates produced thereby |
| US4904820A (en) * | 1987-06-09 | 1990-02-27 | G. D. Searle & Co. | Process for substituting a hydrocarbon group |
| US4777275A (en) * | 1987-06-09 | 1988-10-11 | G. D. Searle & Co. | Process of preparing higher order cuprate complexes |
| US4916238A (en) * | 1988-12-13 | 1990-04-10 | Syntex (U.S.A.) Inc. | Process for preparing allenic prostanoic acid derivatives |
| US5072010A (en) * | 1990-04-04 | 1991-12-10 | University Of California | Transmetalations from zirconium to copper intermediates |
-
1990
- 1990-04-17 US US07/510,349 patent/US5055604A/en not_active Expired - Lifetime
-
1991
- 1991-04-15 KR KR1019910005994A patent/KR100208496B1/ko not_active Expired - Fee Related
- 1991-04-15 DE DE69131944T patent/DE69131944T2/de not_active Expired - Fee Related
- 1991-04-15 AT AT91105951T patent/ATE123768T1/de not_active IP Right Cessation
- 1991-04-15 DE DE69110343T patent/DE69110343T2/de not_active Expired - Fee Related
- 1991-04-15 PT PT97368A patent/PT97368A/pt not_active Application Discontinuation
- 1991-04-15 DK DK91105951.7T patent/DK0452843T3/da active
- 1991-04-15 CA CA002040468A patent/CA2040468C/en not_active Expired - Fee Related
- 1991-04-15 ES ES91105951T patent/ES2073060T3/es not_active Expired - Lifetime
- 1991-04-15 AT AT94116373T patent/ATE189222T1/de not_active IP Right Cessation
- 1991-04-15 ES ES94116373T patent/ES2143517T3/es not_active Expired - Lifetime
- 1991-04-15 EP EP94116373A patent/EP0643063B1/de not_active Expired - Lifetime
- 1991-04-15 DK DK94116373T patent/DK0643063T3/da active
- 1991-04-15 EP EP91105951A patent/EP0452843B1/de not_active Expired - Lifetime
- 1991-04-16 IE IE127391A patent/IE911273A1/en unknown
- 1991-04-16 JP JP3084081A patent/JPH04224555A/ja active Pending
-
1998
- 1998-12-17 KR KR1019980055838A patent/KR100226368B1/ko not_active Expired - Fee Related
-
2000
- 2000-04-14 GR GR20000400918T patent/GR3033236T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2040468A1 (en) | 1991-10-18 |
| DE69110343T2 (de) | 1995-12-21 |
| DK0643063T3 (da) | 2000-04-25 |
| ES2073060T3 (es) | 1995-08-01 |
| DE69131944D1 (de) | 2000-03-02 |
| KR100208496B1 (ko) | 1999-07-15 |
| KR910018351A (ko) | 1991-11-30 |
| JPH04224555A (ja) | 1992-08-13 |
| DK0452843T3 (da) | 1995-08-14 |
| KR100226368B1 (en) | 1999-10-15 |
| ES2143517T3 (es) | 2000-05-16 |
| EP0643063B1 (de) | 2000-01-26 |
| EP0452843A3 (en) | 1992-07-29 |
| ATE189222T1 (de) | 2000-02-15 |
| EP0452843A2 (de) | 1991-10-23 |
| CA2040468C (en) | 2004-10-26 |
| US5055604A (en) | 1991-10-08 |
| PT97368A (pt) | 1992-01-31 |
| GR3033236T3 (en) | 2000-09-29 |
| IE911273A1 (en) | 1991-10-23 |
| EP0643063A2 (de) | 1995-03-15 |
| EP0643063A3 (de) | 1995-10-11 |
| EP0452843B1 (de) | 1995-06-14 |
| DE69131944T2 (de) | 2000-06-15 |
| DE69110343D1 (de) | 1995-07-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |