DE69131106T2 - Gentechnologisch hergestellte lipasen für die therapeutische behandlung - Google Patents

Gentechnologisch hergestellte lipasen für die therapeutische behandlung

Info

Publication number
DE69131106T2
DE69131106T2 DE69131106T DE69131106T DE69131106T2 DE 69131106 T2 DE69131106 T2 DE 69131106T2 DE 69131106 T DE69131106 T DE 69131106T DE 69131106 T DE69131106 T DE 69131106T DE 69131106 T2 DE69131106 T2 DE 69131106T2
Authority
DE
Germany
Prior art keywords
therapeutic treatment
genetically produced
lipases
produced lipases
lipase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69131106T
Other languages
English (en)
Other versions
DE69131106D1 (de
Inventor
Birgitte Huge-Jensen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Products GmbH
Original Assignee
Novo Nordisk AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DK137990A external-priority patent/DK137990D0/da
Application filed by Novo Nordisk AS filed Critical Novo Nordisk AS
Application granted granted Critical
Publication of DE69131106D1 publication Critical patent/DE69131106D1/de
Publication of DE69131106T2 publication Critical patent/DE69131106T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C12N9/20—Triglyceride splitting, e.g. by means of lipase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
DE69131106T 1990-06-06 1991-06-04 Gentechnologisch hergestellte lipasen für die therapeutische behandlung Expired - Lifetime DE69131106T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DK137990A DK137990D0 (da) 1990-06-06 1990-06-06 Rekombinante terapeutiske lipaser
DK173590A DK173590D0 (da) 1990-06-06 1990-07-19 Rekombinante terapeutiske lipaser
PCT/DK1991/000149 WO1991018623A1 (en) 1990-06-06 1991-06-04 Recombinantly produced lipases for therapeutical treatment

Publications (2)

Publication Number Publication Date
DE69131106D1 DE69131106D1 (de) 1999-05-12
DE69131106T2 true DE69131106T2 (de) 1999-11-18

Family

ID=26065679

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69131106T Expired - Lifetime DE69131106T2 (de) 1990-06-06 1991-06-04 Gentechnologisch hergestellte lipasen für die therapeutische behandlung

Country Status (10)

Country Link
US (1) US5614189A (de)
EP (1) EP0600868B1 (de)
JP (1) JP3072853B2 (de)
AT (1) ATE178492T1 (de)
AU (1) AU645583B2 (de)
CA (1) CA2084184A1 (de)
DE (1) DE69131106T2 (de)
DK (1) DK173590D0 (de)
FI (1) FI925530A (de)
WO (1) WO1991018623A1 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6140475A (en) * 1997-04-11 2000-10-31 Altus Biologics Inc. Controlled dissolution crosslinked protein crystals
US6541606B2 (en) 1997-12-31 2003-04-01 Altus Biologics Inc. Stabilized protein crystals formulations containing them and methods of making them
US20010046493A1 (en) * 2000-02-24 2001-11-29 Alex Margolin Lipase-containing composition and methods of use thereof
PT1729797E (pt) 2004-03-22 2008-12-17 Solvay Pharm Gmbh Composições farmacêuticas orais de produtos contendo lipase, em particular de pancreatina, contendo tensioactivos
BRPI0510817A (pt) * 2004-05-24 2007-11-20 Novozymes As protease, uso de uma protease, composição farmacêutica, e, método para o tratamento de uma doença
PL2198880T3 (pl) 2004-10-14 2017-04-28 Eli Lilly And Co. Kompozycje zawierające lipazę, proteazę i amylazę do leczenia niewydolności trzustki
BRPI0611936A2 (pt) * 2005-06-24 2011-02-22 Solvay Pharm Gmbh protease, uso de uma protease, composição farmacêutica, e, método para o tratamento de doença
CN101208429A (zh) * 2005-06-24 2008-06-25 诺维信公司 用于药物用途的脂肪酶
MX2007015471A (es) 2005-06-24 2008-04-04 Novozymes As Amilasas para uso farmaceutico.
BRPI0614914A2 (pt) * 2005-07-29 2011-04-19 Solvay Pharm Gmbh processos para a fabricação de pó de pancreatina esterilizada
US11266607B2 (en) 2005-08-15 2022-03-08 AbbVie Pharmaceuticals GmbH Process for the manufacture and use of pancreatin micropellet cores
US9198871B2 (en) 2005-08-15 2015-12-01 Abbott Products Gmbh Delayed release pancreatin compositions
US20100196344A1 (en) * 2005-10-14 2010-08-05 Cystic Fibrosis Foundation Therapeutics, Inc. Compositions and methods for treating pancreatic insufficiency
US8071089B2 (en) 2005-11-01 2011-12-06 Bio-Cat, Inc. Composition with a fungal (yeast) lipase and method for treating lipid malabsorption in cystic fibrosis as well as people suffering from pancreatic lipase insufficiency
US20070104805A1 (en) * 2005-11-01 2007-05-10 Udell Ronald G Compositions of Hoodia Gordonii and Pinolenic Acid Derivatives
US10072256B2 (en) 2006-05-22 2018-09-11 Abbott Products Gmbh Process for separating and determining the viral load in a pancreatin sample
CA2670643C (en) 2006-12-21 2017-04-25 Novozymes A/S Lipase variants for pharmaceutical use
US20090130063A1 (en) * 2007-11-15 2009-05-21 Solvay Pharmaceuticals Gmbh Process for separating and determining the viral load in a pancreatin sample
RU2010127329A (ru) * 2007-12-04 2012-01-10 Новозимс А/С (Dk) Варианты протеаз для фармацевтического применения
BRPI0906439A2 (pt) * 2008-01-03 2018-12-04 Abbott Products Gmbh composições farmacêuticas que compreendem grânulos de lipase microbiana purificada e métodos para a prevenção ou tratamento de distúrbios digestivos
JP5970189B2 (ja) * 2009-01-29 2016-08-17 ノルドマルク・アルツナイミッテル・ゲゼルシヤフト・ミト・ベシュレンクテル・ハフツング・ウント・コンパニー・コマンデイトゲゼルシヤフト 医薬調製物
WO2011000924A1 (en) 2009-07-03 2011-01-06 Abbott Products Gmbh Spray-dried amylase, pharmaceutical preparations comprising the same and use
US8268305B1 (en) 2011-09-23 2012-09-18 Bio-Cat, Inc. Method and compositions to reduce serum levels of triacylglycerides in human beings using a fungal lipase
CN105392496A (zh) * 2013-07-22 2016-03-09 阿普塔利斯制药有限公司 高效的胰酶药物组合物
JP2014193909A (ja) * 2014-06-04 2014-10-09 Nordmark Arzneimittel Gmbh & Co Kg 医薬調製物
GB201501081D0 (en) 2015-01-22 2015-03-11 Cilian Ag Use of enzymes with a wide pH activity range as medicaments for promoting digestion
WO2016126970A1 (en) 2015-02-04 2016-08-11 Abbvie Inc. Pharmaceutical compositions and methods of use thereof to treat pancreatic enzyme insufficiency
DE102015114857A1 (de) * 2015-09-04 2017-03-09 Nordmark Arzneimittel Gmbh & Co. Kg Getränk, enthaltend eine pharmazeutische Zusammensetzung

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8421210D0 (en) * 1984-08-21 1984-09-26 Celltech Ltd Polypeptide and polypeptide composition
US4659667A (en) * 1985-02-26 1987-04-21 Miles Laboratories, Inc. Process to recover crystalline enzymes and crystalline enzymes produced thereby
US5108457A (en) * 1986-11-19 1992-04-28 The Clorox Company Enzymatic peracid bleaching system with modified enzyme
ATE125865T1 (de) * 1987-08-28 1995-08-15 Novo Nordisk As Rekombinante humicola-lipase und verfahren zur herstellung von rekombinanten humicola-lipasen.
JPH05502584A (ja) * 1989-12-21 1993-05-13 ノボ　ノルディスク　アクティーゼルスカブ 酵素含有調製品及び該調製品を含有する洗剤

Also Published As

Publication number Publication date
WO1991018623A1 (en) 1991-12-12
DK173590D0 (da) 1990-07-19
EP0600868B1 (de) 1999-04-07
AU8096491A (en) 1991-12-31
JPH06501147A (ja) 1994-02-10
EP0600868A1 (de) 1994-06-15
ATE178492T1 (de) 1999-04-15
CA2084184A1 (en) 1991-12-07
US5614189A (en) 1997-03-25
FI925530A0 (fi) 1992-12-04
JP3072853B2 (ja) 2000-08-07
FI925530A (fi) 1992-12-04
DE69131106D1 (de) 1999-05-12
AU645583B2 (en) 1994-01-20

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: NOVOZYMES A/S, BAGSVAERD, DK

8327 Change in the person/name/address of the patent owner

Owner name: SOLVAY PHARMACEUTICALS GMBH, 30173 HANNOVER, DE