DE69130990D1 - Gereinigtes, virusfreies menschliches Thrombin - Google Patents
Gereinigtes, virusfreies menschliches ThrombinInfo
- Publication number
- DE69130990D1 DE69130990D1 DE69130990T DE69130990T DE69130990D1 DE 69130990 D1 DE69130990 D1 DE 69130990D1 DE 69130990 T DE69130990 T DE 69130990T DE 69130990 T DE69130990 T DE 69130990T DE 69130990 D1 DE69130990 D1 DE 69130990D1
- Authority
- DE
- Germany
- Prior art keywords
- virus
- purified
- human thrombin
- free human
- thrombin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 229960003766 thrombin (human) Drugs 0.000 title abstract 2
- 229920002684 Sepharose Polymers 0.000 abstract 1
- 108090000190 Thrombin Proteins 0.000 abstract 1
- 239000003443 antiviral agent Substances 0.000 abstract 1
- 238000005342 ion exchange Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 229960004072 thrombin Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6429—Thrombin (3.4.21.5)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0082—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using chemical substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21005—Thrombin (3.4.21.5)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US48152890A | 1990-02-20 | 1990-02-20 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69130990D1 true DE69130990D1 (de) | 1999-04-22 |
DE69130990T2 DE69130990T2 (de) | 1999-12-02 |
Family
ID=23912280
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69130990T Expired - Lifetime DE69130990T2 (de) | 1990-02-20 | 1991-01-24 | Gereinigtes, virusfreies menschliches Thrombin |
Country Status (6)
Country | Link |
---|---|
US (1) | US5354682A (de) |
EP (1) | EP0443724B1 (de) |
JP (1) | JPH05227962A (de) |
AT (1) | ATE177781T1 (de) |
DE (1) | DE69130990T2 (de) |
ES (1) | ES2131504T3 (de) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5595735A (en) * | 1990-05-23 | 1997-01-21 | Johnson & Johnson Medical, Inc. | Hemostatic thrombin paste composition |
US6197325B1 (en) * | 1990-11-27 | 2001-03-06 | The American National Red Cross | Supplemented and unsupplemented tissue sealants, methods of their production and use |
US6559119B1 (en) | 1990-11-27 | 2003-05-06 | Loyola University Of Chicago | Method of preparing a tissue sealant-treated biomedical material |
US7196054B1 (en) | 1990-11-27 | 2007-03-27 | The American National Red Cross | Methods for treating wound tissue and forming a supplemented fibrin matrix |
US6054122A (en) * | 1990-11-27 | 2000-04-25 | The American National Red Cross | Supplemented and unsupplemented tissue sealants, methods of their production and use |
US6117425A (en) * | 1990-11-27 | 2000-09-12 | The American National Red Cross | Supplemented and unsupplemented tissue sealants, method of their production and use |
FR2679251B1 (fr) * | 1991-07-18 | 1993-11-12 | Nord Assoc Essor Transfusion San | Procede de preparation d'un concentre de thrombine humaine destine a un usage therapeutique. |
AT398079B (de) * | 1991-11-04 | 1994-09-26 | Immuno Ag | Präparation mit thrombinaktivität sowie verfahren zu ihrer herstellung |
DE4137996A1 (de) * | 1991-11-19 | 1993-05-27 | Behringwerke Ag | Verfahren zur herstellung eines virussicheren thrombinkonzentrates |
JP3404038B2 (ja) * | 1991-12-31 | 2003-05-06 | ザイモジェネティクス,インコーポレイティド | トロンビンの製造方法 |
US5527692A (en) * | 1991-12-31 | 1996-06-18 | Zymogenetics, Inc. | Methods for producing thrombin |
US5792623A (en) * | 1992-04-06 | 1998-08-11 | Immuno Aktiengesellschaft | Method for producing activated blood factors with a protease and a detergent |
DK83092D0 (da) * | 1992-06-24 | 1992-06-24 | Unes As | Fremgangsmaade til udvinding af thrombin |
US5795780A (en) * | 1993-06-23 | 1998-08-18 | Bristol-Myers Squibb Company | Method of use of autologous thrombin blood fraction in a cell culture with keratinocytes |
DE4416166C2 (de) * | 1994-05-06 | 1997-11-20 | Immuno Ag | Stabiles Präparat zur Behandlung von Blutgerinnungsstörungen |
US6017891A (en) * | 1994-05-06 | 2000-01-25 | Baxter Aktiengesellschaft | Stable preparation for the treatment of blood coagulation disorders |
JPH07308190A (ja) * | 1994-05-18 | 1995-11-28 | Green Cross Corp:The | トロンビンの製造方法 |
US5506127A (en) * | 1994-09-21 | 1996-04-09 | Proba; Zbigniew | Therapeutic grade thrombin produced by chromatography |
US5677162A (en) * | 1995-05-01 | 1997-10-14 | New York Blood Center, Inc. | Method for activating prothrombin to thrombin |
AUPN436995A0 (en) * | 1995-07-24 | 1995-08-17 | Csl Limited | Method for the production of thrombin |
AT403477B (de) * | 1996-04-30 | 1998-02-25 | Immuno Ag | Biologisches material frei von viralen und molekularen pathogenen und verfahren zur herstellung |
WO2000062828A1 (en) * | 1996-04-30 | 2000-10-26 | Medtronic, Inc. | Autologous fibrin sealant and method for making the same |
DE19781869T1 (de) * | 1996-04-30 | 2000-03-16 | Medtronic Inc | Verfahren zur Herstellung eines autologen Fibrin-Blutstillungsmittels |
DE19710190A1 (de) * | 1997-03-12 | 1998-09-17 | Immuno Ag | Aktivierter Vitamin K-abhängiger Blutfaktor und Verfahren zu dessen Herstellung |
US6168788B1 (en) * | 1997-09-26 | 2001-01-02 | Leon Wortham | Fibrin glue without fibrinogen and biosealant compositions and methods |
US6762336B1 (en) | 1998-01-19 | 2004-07-13 | The American National Red Cross | Hemostatic sandwich bandage |
US6274090B1 (en) | 1998-08-05 | 2001-08-14 | Thermogenesis Corp. | Apparatus and method of preparation of stable, long term thrombin from plasma and thrombin formed thereby |
US6110484A (en) * | 1998-11-24 | 2000-08-29 | Cohesion Technologies, Inc. | Collagen-polymer matrices with differential biodegradability |
US6472162B1 (en) | 1999-06-04 | 2002-10-29 | Thermogenesis Corp. | Method for preparing thrombin for use in a biological glue |
ATE346145T1 (de) * | 1999-09-27 | 2006-12-15 | Sysmex Corp | Verfahren zur stabilisierung von thrombin |
US6942880B1 (en) * | 2001-04-09 | 2005-09-13 | Medtronic, Inc. | Autologous platelet gel having beneficial geometric shapes and methods of making the same |
ES2525945T3 (es) | 2001-11-28 | 2015-01-02 | Sandoz Ag | Purificación cromatográfica de eritropoyetina humana recombinante |
GB0216002D0 (en) * | 2002-07-10 | 2002-08-21 | Nat Blood Authority | Process and composition |
EP1545636B1 (de) | 2002-09-10 | 2015-01-07 | The American National Red Cross | Hämostatischer verband |
ES2395466T3 (es) * | 2004-06-22 | 2013-02-12 | Zymogenetics, Inc. | Composiciones de trombina |
WO2007127841A2 (en) | 2006-04-26 | 2007-11-08 | Arteriocyte Medical Systems, Inc. | Compositions and methods of preparation thereof |
CN101516302B (zh) | 2006-08-04 | 2013-08-21 | Stb有限公司 | 固体创伤敷料的生产方法 |
US20090075891A1 (en) | 2007-08-06 | 2009-03-19 | Macphee Martin | Methods and dressings for sealing internal injuries |
CA2697078A1 (en) * | 2007-09-05 | 2010-02-16 | Zymogenetics, Inc. | Mass spectrometry-based quantitative assay for determining abundance of molecular species in a composition |
US9932388B2 (en) | 2014-11-13 | 2018-04-03 | Hemarus Therapeutics Limited | Chromatographic process for producing high purity fibrinogen and thrombin |
EP3262409B1 (de) | 2015-02-25 | 2020-03-25 | Omrix Biopharmaceuticals Ltd. | Verfahren zur reinigung und quantifizierung von thrombin und seinen abbaupolypeptiden |
CA3040935A1 (en) * | 2016-10-20 | 2018-04-26 | Universal Biosensors Pty Ltd | Non-biohazardous solutions and methods for testing analysers |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2495298A (en) * | 1945-12-28 | 1950-01-24 | Szent-Gyorgyi Albert | Process for the preparation of thrombin |
US4170590A (en) * | 1974-12-14 | 1979-10-09 | Biotest-Serum-Institut Gmbh | Ion exchanger treatment of citrate-stabilized plasma |
CH626917A5 (de) * | 1976-08-17 | 1981-12-15 | Pentapharm Ag | |
US4315919A (en) * | 1980-10-06 | 1982-02-16 | Edward Shanbrom | Depyrogenation process |
US4380511A (en) * | 1981-08-12 | 1983-04-19 | Miles Laboratories, Inc. | Purification of bovine thrombin |
JPS595109A (ja) * | 1982-06-30 | 1984-01-12 | Lion Corp | 口腔用組成物 |
US4960702A (en) * | 1985-09-06 | 1990-10-02 | Codon | Methods for recovery of tissue plasminogen activator |
JPS63243032A (ja) * | 1987-03-27 | 1988-10-07 | Green Cross Corp:The | トロンビンの加熱処理方法 |
DE3877529T2 (de) * | 1987-10-23 | 1996-11-07 | Centre Regional De Transfusion | Herstellung von hoch-gereingtem menschlichen Faktor IX sowie anderem Plasmaproteinkonzentrat und dessen therapeutische Verwendung. |
SU1527261A1 (ru) * | 1988-03-21 | 1989-12-07 | Институт Химической И Биологической Физики Ан Эсср | Способ получени тромбина |
DE3843126C3 (de) * | 1988-12-22 | 1994-10-06 | Octapharma Ag | Verfahren zur Herstellung eines hochreinen Thrombinkonzentrates |
-
1991
- 1991-01-24 DE DE69130990T patent/DE69130990T2/de not_active Expired - Lifetime
- 1991-01-24 AT AT91300558T patent/ATE177781T1/de not_active IP Right Cessation
- 1991-01-24 EP EP91300558A patent/EP0443724B1/de not_active Expired - Lifetime
- 1991-01-24 ES ES91300558T patent/ES2131504T3/es not_active Expired - Lifetime
- 1991-02-20 JP JP3049078A patent/JPH05227962A/ja active Pending
-
1993
- 1993-02-24 US US08/023,143 patent/US5354682A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
ES2131504T3 (es) | 1999-08-01 |
EP0443724A1 (de) | 1991-08-28 |
ATE177781T1 (de) | 1999-04-15 |
EP0443724B1 (de) | 1999-03-17 |
DE69130990T2 (de) | 1999-12-02 |
US5354682A (en) | 1994-10-11 |
JPH05227962A (ja) | 1993-09-07 |
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