DE69129743D1 - Humanisierte chimäre anti-"icam-1" antikörper, herstellungsverfahren und verwendung - Google Patents

Humanisierte chimäre anti-"icam-1" antikörper, herstellungsverfahren und verwendung

Info

Publication number
DE69129743D1
DE69129743D1 DE69129743T DE69129743T DE69129743D1 DE 69129743 D1 DE69129743 D1 DE 69129743D1 DE 69129743 T DE69129743 T DE 69129743T DE 69129743 T DE69129743 T DE 69129743T DE 69129743 D1 DE69129743 D1 DE 69129743D1
Authority
DE
Germany
Prior art keywords
antibodies
icam
humanized
infection
chimeral
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69129743T
Other languages
English (en)
Other versions
DE69129743T2 (de
Inventor
John Adair
Martyn Robinson
Susan Bright
Robert Rothlein
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BOEHRINGER INGELHEIM PHARMACEUTICALS Inc RIDGEFIELD CONN US
UCB Celltech Ltd
Boehringer Ingelheim Pharmaceuticals Inc
Original Assignee
BOEHRINGER INGELHEIM PHARMACEUTICALS Inc RIDGEFIELD CONN US
Celltech R&D Ltd
Boehringer Ingelheim Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BOEHRINGER INGELHEIM PHARMACEUTICALS Inc RIDGEFIELD CONN US, Celltech R&D Ltd, Boehringer Ingelheim Pharmaceuticals Inc filed Critical BOEHRINGER INGELHEIM PHARMACEUTICALS Inc RIDGEFIELD CONN US
Application granted granted Critical
Publication of DE69129743D1 publication Critical patent/DE69129743D1/de
Publication of DE69129743T2 publication Critical patent/DE69129743T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2821—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against ICAM molecules, e.g. CD50, CD54, CD102
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69129743T 1990-04-27 1991-04-29 Humanisierte chimäre anti-"icam-1" antikörper, herstellungsverfahren und verwendung Expired - Fee Related DE69129743T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB909009548A GB9009548D0 (en) 1990-04-27 1990-04-27 Chimeric antibody and method
PCT/US1991/002946 WO1991016928A1 (en) 1990-04-27 1991-04-29 Humanized chimeric anti-icam-1 antibodies, methods of preparation and use

Publications (2)

Publication Number Publication Date
DE69129743D1 true DE69129743D1 (de) 1998-08-13
DE69129743T2 DE69129743T2 (de) 1999-02-11

Family

ID=10675133

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69129743T Expired - Fee Related DE69129743T2 (de) 1990-04-27 1991-04-29 Humanisierte chimäre anti-"icam-1" antikörper, herstellungsverfahren und verwendung

Country Status (14)

Country Link
EP (1) EP0528931B1 (de)
JP (1) JPH05507406A (de)
AT (1) ATE168013T1 (de)
AU (1) AU649682B2 (de)
BR (1) BR9106394A (de)
CA (1) CA2081479A1 (de)
DE (1) DE69129743T2 (de)
DK (1) DK0528931T3 (de)
ES (1) ES2118084T3 (de)
FI (1) FI924819A (de)
GB (1) GB9009548D0 (de)
HU (1) HUT66103A (de)
NO (2) NO924088L (de)
WO (1) WO1991016928A1 (de)

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WO1993014776A1 (en) * 1992-01-27 1993-08-05 Icos Corporation Icam-related protein
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US5532127A (en) * 1992-01-27 1996-07-02 Icos Corporation Assay for 1-CAM related protein expression
US5837822A (en) * 1992-01-27 1998-11-17 Icos Corporation Humanized antibodies specific for ICAM related protein
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US5880268A (en) * 1992-01-27 1999-03-09 Icos Corporation Modulators of the interaction between ICAM-R and αd /CD18
US6100383A (en) * 1992-01-27 2000-08-08 Icos Corporation Fusion proteins comprising ICAM-R polypeptides and immunoglobulin constant regions
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US5472693A (en) * 1993-02-16 1995-12-05 The Dow Chemical Company Family of anti-carcinoembryonic antigen chimeric antibodies
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US20020081294A1 (en) 1996-01-23 2002-06-27 Genentech, Inc. Co-administration of a thrombolytic and an anti-CD18 antibody in stroke
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US6903194B1 (en) 1996-09-26 2005-06-07 Chungai Seiyaku Kabushiki Kaisha Antibody against human parathormone related peptides
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US7531643B2 (en) 1997-09-11 2009-05-12 Chugai Seiyaku Kabushiki Kaisha Monoclonal antibody inducing apoptosis
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US20080050367A1 (en) 1998-04-07 2008-02-28 Guriq Basi Humanized antibodies that recognize beta amyloid peptide
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US6670321B1 (en) 1998-12-30 2003-12-30 The Children's Medical Center Corporation Prevention and treatment for retinal ischemia and edema
US7696325B2 (en) 1999-03-10 2010-04-13 Chugai Seiyaku Kabushiki Kaisha Polypeptide inducing apoptosis
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US6582698B1 (en) 1999-03-19 2003-06-24 Genentech, Inc. Treatment method
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US7674466B2 (en) 1999-08-05 2010-03-09 The Trustees Of The University Of Pennsylvania Targeting and prolonging association of drugs to the luminal surface of the pulmonary vascular endothelial cells using antibodies that bind to ICAM-1
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WO2001082968A1 (fr) 2000-04-28 2001-11-08 Chugai Seiyaku Kabushiki Kaisha Inhibiteurs de proliferation cellulaire
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Also Published As

Publication number Publication date
FI924819A0 (fi) 1992-10-23
DE69129743T2 (de) 1999-02-11
NO924088D0 (no) 1992-10-22
BR9106394A (pt) 1993-04-27
NO984136L (no) 1992-12-23
FI924819A (fi) 1992-10-23
EP0528931A4 (en) 1993-04-28
HU9203370D0 (en) 1993-01-28
DK0528931T3 (da) 1999-04-19
NO984136D0 (no) 1998-09-08
HUT66103A (en) 1994-09-28
ATE168013T1 (de) 1998-07-15
AU7860391A (en) 1991-11-27
JPH05507406A (ja) 1993-10-28
NO924088L (no) 1992-12-23
AU649682B2 (en) 1994-06-02
WO1991016928A1 (en) 1991-11-14
GB9009548D0 (en) 1990-06-20
CA2081479A1 (en) 1991-10-28
EP0528931B1 (de) 1998-07-08
EP0528931A1 (de) 1993-03-03
ES2118084T3 (es) 1998-09-16

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