DE69125207D1 - Verfahren zur Herstellung von 10-(2-Propynyl)estr-4-en-3,17-dion - Google Patents

Verfahren zur Herstellung von 10-(2-Propynyl)estr-4-en-3,17-dion

Info

Publication number
DE69125207D1
DE69125207D1 DE69125207T DE69125207T DE69125207D1 DE 69125207 D1 DE69125207 D1 DE 69125207D1 DE 69125207 T DE69125207 T DE 69125207T DE 69125207 T DE69125207 T DE 69125207T DE 69125207 D1 DE69125207 D1 DE 69125207D1
Authority
DE
Germany
Prior art keywords
dione
propynyl
estr
preparation
ene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69125207T
Other languages
English (en)
Other versions
DE69125207T2 (de
Inventor
Jeffrey P Whitten
Harvey D Benson
Cynthia L Rand
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Publication of DE69125207D1 publication Critical patent/DE69125207D1/de
Application granted granted Critical
Publication of DE69125207T2 publication Critical patent/DE69125207T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0059—Estrane derivatives substituted in position 17 by a keto group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C07J21/008—Ketals at position 17
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69125207T 1990-05-30 1991-05-28 Verfahren zur Herstellung von 10-(2-Propynyl)estr-4-en-3,17-dion Expired - Fee Related DE69125207T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US53067490A 1990-05-30 1990-05-30

Publications (2)

Publication Number Publication Date
DE69125207D1 true DE69125207D1 (de) 1997-04-24
DE69125207T2 DE69125207T2 (de) 1997-06-26

Family

ID=24114524

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69125207T Expired - Fee Related DE69125207T2 (de) 1990-05-30 1991-05-28 Verfahren zur Herstellung von 10-(2-Propynyl)estr-4-en-3,17-dion

Country Status (13)

Country Link
EP (1) EP0459381B1 (de)
JP (1) JP2989935B2 (de)
KR (1) KR0171410B1 (de)
AT (1) ATE150465T1 (de)
AU (1) AU649251B2 (de)
DE (1) DE69125207T2 (de)
DK (1) DK0459381T3 (de)
ES (1) ES2101702T3 (de)
GR (1) GR3023380T3 (de)
HU (1) HU212575B (de)
IE (1) IE911834A1 (de)
IL (1) IL98384A (de)
ZA (1) ZA913963B (de)

Also Published As

Publication number Publication date
JP2989935B2 (ja) 1999-12-13
ZA913963B (en) 1992-04-29
IE911834A1 (en) 1991-12-04
HU212575B (en) 1996-08-29
KR0171410B1 (ko) 1999-02-01
EP0459381A3 (en) 1992-06-10
ATE150465T1 (de) 1997-04-15
JPH04235997A (ja) 1992-08-25
HUT57791A (en) 1991-12-30
GR3023380T3 (en) 1997-08-29
AU649251B2 (en) 1994-05-19
IL98384A (en) 1995-03-30
DK0459381T3 (da) 1997-04-07
KR910020028A (ko) 1991-12-19
ES2101702T3 (es) 1997-07-16
AU7729091A (en) 1991-12-05
EP0459381B1 (de) 1997-03-19
EP0459381A2 (de) 1991-12-04
DE69125207T2 (de) 1997-06-26

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee