DE69124857D1 - DNS, die ein menschliches, gefässverengendes Peptid kodiert, und dessen Verwendung - Google Patents

DNS, die ein menschliches, gefässverengendes Peptid kodiert, und dessen Verwendung

Info

Publication number
DE69124857D1
DE69124857D1 DE69124857T DE69124857T DE69124857D1 DE 69124857 D1 DE69124857 D1 DE 69124857D1 DE 69124857 T DE69124857 T DE 69124857T DE 69124857 T DE69124857 T DE 69124857T DE 69124857 D1 DE69124857 D1 DE 69124857D1
Authority
DE
Germany
Prior art keywords
human
human endothelin
dna encoding
vasoconstrictor peptide
seq
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69124857T
Other languages
English (en)
Other versions
DE69124857T2 (de
Inventor
Haruo Onda
Shoichi Ohkubo
Takuo Kosaka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of DE69124857D1 publication Critical patent/DE69124857D1/de
Application granted granted Critical
Publication of DE69124857T2 publication Critical patent/DE69124857T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57536—Endothelin, vasoactive intestinal contractor [VIC]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Vascular Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DE69124857T 1990-07-18 1991-07-16 DNS, die ein menschliches, gefässverengendes Peptid kodiert, und dessen Verwendung Expired - Fee Related DE69124857T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP18796090 1990-07-18
JP145191 1991-01-10
JP3143127A JP2999579B2 (ja) 1990-07-18 1991-06-14 Ｄｎａおよびその用途

Publications (2)

Publication Number Publication Date
DE69124857D1 true DE69124857D1 (de) 1997-04-10
DE69124857T2 DE69124857T2 (de) 1997-07-24

Family

ID=27274926

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69124857T Expired - Fee Related DE69124857T2 (de) 1990-07-18 1991-07-16 DNS, die ein menschliches, gefässverengendes Peptid kodiert, und dessen Verwendung

Country Status (6)

Country Link
US (2) US6365725B1 (de)
EP (1) EP0468337B1 (de)
JP (1) JP2999579B2 (de)
AT (1) ATE149524T1 (de)
CA (1) CA2046754A1 (de)
DE (1) DE69124857T2 (de)

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JPH05271286A (ja) * 1990-10-19 1993-10-19 General Hospital Corp エンドテリン前駆体、その遺伝子および受容体
US5756295A (en) * 1994-12-05 1998-05-26 Takeda Chemical Industries, Ltd. DNA primer and a method for screening DNAS
WO2000059855A1 (en) * 1999-04-01 2000-10-12 Esperion Therapeutics, Inc. Ether compounds, compositions, and uses thereof
CA2425311C (en) 2000-10-11 2011-06-14 Esperion Therapeutics, Inc. Ketone compounds and compositions for cholesterol management and related uses
US20040122091A1 (en) * 2000-10-11 2004-06-24 Esperion Therapeutics, Inc. Sulfoxide and bis-sulfoxide compounds and compositions for cholesterol management and related uses
CN101426763A (zh) 2000-10-11 2009-05-06 埃斯佩里安医疗公司 用于胆固醇治疗和相关应用的硫化物和二硫化物化合物和组合物
US7304093B2 (en) * 2000-10-11 2007-12-04 Esperion Therapeutics, Inc. Ketone compounds and compositions for cholesterol management and related uses
CN1479721A (zh) 2000-10-11 2004-03-03 ͨ��ҽ�ƹ�˾ 用于胆固醇治疗和相关应用的亚砜和双亚砜化合物和组合物
WO2002030863A2 (en) 2000-10-11 2002-04-18 Esperion Therapeutics, Inc. Ether compounds and compositions for cholesterol management and related uses
US20040192771A1 (en) * 2001-10-11 2004-09-30 Dasseux Jean-Louis Henri Ether compounds and compositions for cholesterol management and related uses
US20040204502A1 (en) * 2001-10-11 2004-10-14 Dasseux Jean-Louis Henri Sulfoxide and bis-sulfoxide compounds and compositions for cholesterol management and related uses
US20050020694A1 (en) * 2001-10-11 2005-01-27 Dasseux Jean-Louis Henri Sulfide and disulfide compounds and compositions for cholesterol management and related uses
US20030236212A1 (en) * 2002-04-10 2003-12-25 Jean-Louis Dasseux Functionalized long chain derivatives as acyl coenzyme-A mimics, compositions thereof, and methods of cholesterol management and related uses
WO2004004774A2 (en) * 2002-07-03 2004-01-15 Esperion Therapeutics, Inc. Compositions comprising panthetine for the treatment of dyslipidemia
MXPA05007674A (es) * 2003-01-23 2005-09-22 Esperion Therapeutics Inc Compuestos de hidroxilo y composiciones para el manejo del colesterol y usos relacionados.
CA2543596A1 (en) * 2003-11-07 2005-05-26 Jj Pharma, Inc. Hdl-boosting combination therapy complexes
BR0318685A (pt) 2003-12-24 2006-12-19 Esperion Therapeutics Inc compostos de cetona e composições para controle de colesterol e usos relacionados
US20060075861A1 (en) * 2004-10-07 2006-04-13 Flooding Daniel L Film cutter
WO2006045010A2 (en) * 2004-10-20 2006-04-27 Resverlogix Corp. Stilbenes and chalcones for the prevention and treatment of cardiovascular diseases
AU2006275514B2 (en) * 2005-07-29 2012-04-05 Resverlogix Corp. Pharmaceutical compositions for the prevention and treatment of complex diseases and their delivery by insertable medical devices
US20100027114A1 (en) * 2006-12-19 2010-02-04 Koninklijke Philips Electronics N.V. Lens structure and manufacturing method, and the manufacture of shaped polymer articles
CA2676984C (en) 2007-02-01 2015-03-17 Resverlogix Corp. Compounds for the prevention and treatment of cardiovascular diseases
ES2372652T3 (es) 2007-05-23 2012-01-25 Amcol International Corporation Filosilicatos estratificados, que interactúan con el colesterol y métodos para reducir la hipercolesterolemia en un mamífero.
JP2010538993A (ja) * 2007-09-11 2010-12-16 モンドバイオテック ラボラトリーズ アクチエンゲゼルシャフト ペプチドＰｒｏ−Ｇｌｙ−Ｔｈｒ−Ｃｙｓ−Ｇｌｕ−Ｉｌｅ−Ｃｙｓ−Ａｌａ−Ｔｙｒ−Ａｌａ−Ａｌａ−Ｃｙｓ−Ｔｈｒ−Ｇｌｙ−Ｃｙｓの治療剤としての使用
US8114995B2 (en) 2008-06-26 2012-02-14 Resverlogix Corp. Methods of preparing quinazolinone derivatives
ES2542835T3 (es) 2009-01-08 2015-08-12 Resverlogix Corporation Compuestos para la prevención y el tratamiento de enfermedades cardiovasculares
JP5795304B2 (ja) 2009-03-18 2015-10-14 レスバーロジックス コーポレイション 新規抗炎症剤
KR101892987B1 (ko) 2009-04-22 2018-08-30 리스버로직스 코퍼레이션 신규한 소염제
EP2473605B1 (de) 2009-09-03 2018-04-11 Pfizer Vaccines LLC Pcsk9-impfstoff
US20140004142A1 (en) 2011-03-02 2014-01-02 Pfizer Inc. Pcsk9 vaccine
CA2851996C (en) 2011-11-01 2020-01-07 Resverlogix Corp. Pharmaceutical compositions for substituted quinazolinones
WO2014080291A2 (en) 2012-11-21 2014-05-30 Rvx Therapeutics Inc. Biaryl derivatives as bromodomain inhibitors
WO2014080290A2 (en) 2012-11-21 2014-05-30 Rvx Therapeutics Inc. Cyclic amines as bromodomain inhibitors
EP2935253B1 (de) 2012-12-21 2018-08-01 Zenith Epigenetics Ltd. Neuartige heterocyclische verbindungen als bromdomänenhemmer
US10279019B2 (en) 2014-02-11 2019-05-07 Stc.Unm PCSK9 peptide vaccine conjugated to a Qbeta carrier and methods of using the same
CN107530307A (zh) 2015-03-13 2018-01-02 艾斯柏伦治疗公司 包含etc1002和依泽替米贝的固定剂量组合和制剂以及治疗心血管疾病或降低心血管疾病风险的方法
CA2977308A1 (en) 2015-03-13 2016-09-22 Resverlogix Corp. Compositions and therapeutic methods for the treatment of complement-associated diseases
MA41793A (fr) 2015-03-16 2018-01-23 Esperion Therapeutics Inc Associations de doses fixes comprenant du etc1002 et une ou plusieurs statines permettant de traiter ou de réduire un risque cardiovasculaire
EP3986860A1 (de) 2019-06-21 2022-04-27 Esperion Therapeutics, Inc. Salzformen von bempedoinsäure und verfahren zu deren verwendung

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2807474B2 (ja) 1987-11-02 1998-10-08 武田薬品工業株式会社 Ｄｎａおよびその用途
US5231166A (en) 1988-10-25 1993-07-27 Takeda Chemical Industries, Ltd. Endothelin

Also Published As

Publication number Publication date
JPH04281790A (ja) 1992-10-07
US6365725B1 (en) 2002-04-02
EP0468337A1 (de) 1992-01-29
CA2046754A1 (en) 1992-01-19
ATE149524T1 (de) 1997-03-15
JP2999579B2 (ja) 2000-01-17
US5756344A (en) 1998-05-26
EP0468337B1 (de) 1997-03-05
DE69124857T2 (de) 1997-07-24

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: TAKEDA PHARMACEUTICAL CO. LTD., OSAKA, JP

8339 Ceased/non-payment of the annual fee