DE69124335D1 - Pyrrolo[2,3-d]Pyrimidine mit kardiovasculärer Aktivität, Verfahren zur Herstellung und diese enthaltende Zusammensetzungen - Google Patents

Pyrrolo[2,3-d]Pyrimidine mit kardiovasculärer Aktivität, Verfahren zur Herstellung und diese enthaltende Zusammensetzungen

Info

Publication number
DE69124335D1
DE69124335D1 DE69124335T DE69124335T DE69124335D1 DE 69124335 D1 DE69124335 D1 DE 69124335D1 DE 69124335 T DE69124335 T DE 69124335T DE 69124335 T DE69124335 T DE 69124335T DE 69124335 D1 DE69124335 D1 DE 69124335D1
Authority
DE
Germany
Prior art keywords
alkyl
phenyl
cycloalkyl
pharmaceutically
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69124335T
Other languages
English (en)
Inventor
Rodney Brian Hargreaves
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syngenta Ltd
Original Assignee
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zeneca Ltd filed Critical Zeneca Ltd
Application granted granted Critical
Publication of DE69124335D1 publication Critical patent/DE69124335D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Detergent Compositions (AREA)
  • Air Bags (AREA)
DE69124335T 1990-10-18 1991-10-14 Pyrrolo[2,3-d]Pyrimidine mit kardiovasculärer Aktivität, Verfahren zur Herstellung und diese enthaltende Zusammensetzungen Expired - Lifetime DE69124335D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909022644A GB9022644D0 (en) 1990-10-18 1990-10-18 Heterocyclic compounds

Publications (1)

Publication Number Publication Date
DE69124335D1 true DE69124335D1 (de) 1997-03-06

Family

ID=10683928

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69124335T Expired - Lifetime DE69124335D1 (de) 1990-10-18 1991-10-14 Pyrrolo[2,3-d]Pyrimidine mit kardiovasculärer Aktivität, Verfahren zur Herstellung und diese enthaltende Zusammensetzungen

Country Status (14)

Country Link
US (1) US5328910A (de)
EP (1) EP0482804B1 (de)
JP (1) JPH04273878A (de)
AT (1) ATE148119T1 (de)
AU (1) AU8581391A (de)
CA (1) CA2053626A1 (de)
DE (1) DE69124335D1 (de)
FI (1) FI914910A (de)
GB (1) GB9022644D0 (de)
IE (1) IE913598A1 (de)
IL (1) IL99709A0 (de)
NZ (1) NZ240180A (de)
PT (1) PT99264A (de)
ZA (1) ZA918134B (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6765008B1 (en) 1992-12-17 2004-07-20 Pfizer Inc Pyrrolopyrimidines as CRF antagonists
IL112248A0 (en) 1994-01-25 1995-03-30 Warner Lambert Co Tricyclic heteroaromatic compounds and pharmaceutical compositions containing them
IL112249A (en) 1994-01-25 2001-11-25 Warner Lambert Co Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds
TW530047B (en) * 1994-06-08 2003-05-01 Pfizer Corticotropin releasing factor antagonists
EP0766684A4 (de) * 1994-06-09 1997-07-16 Smithkline Beecham Corp Endothelin-rezeptor antagonisten
US6956047B1 (en) 1995-06-06 2005-10-18 Pfizer Inc. Corticotropin releasing factor antagonists
US7067664B1 (en) 1995-06-06 2006-06-27 Pfizer Inc. Corticotropin releasing factor antagonists
US6403599B1 (en) 1995-11-08 2002-06-11 Pfizer Inc Corticotropin releasing factor antagonists
JP3711238B2 (ja) * 1997-08-05 2005-11-02 ファイザー・プロダクツ・インク 神経ペプチドＹ受容体アンタゴニストとしての４−アミノピロ−ル（３，２−ｄ）ピリミジン
US7279474B2 (en) 2001-04-30 2007-10-09 Glaxo Group Limited Substituted pyrrolo[2,3-d]pyrimidines as antagonists of the corticotropin releasing factor (CRF)
JP2004533465A (ja) 2001-06-12 2004-11-04 グラクソ　グループ　リミテッド コルチコトロピン放出因子アンタゴニスト
DE10163991A1 (de) * 2001-12-24 2003-07-03 Merck Patent Gmbh Pyrrolo-pyrimidine
US7115525B2 (en) * 2004-09-02 2006-10-03 Micron Technology, Inc. Method for integrated circuit fabrication using pitch multiplication
CN112585147B (zh) 2017-10-13 2023-12-05 帝国理工学院创新有限公司 Map4k4抑制剂

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB815833A (en) * 1956-09-26 1959-07-01 Boots Pure Drug Co Ltd Phenanthridine compounds
BE492034A (de) * 1948-11-05
US2748124A (en) * 1954-05-06 1956-05-29 Searle & Co 1-(4-anilino-2-pyrimidino)-3-alkylureas
DE1241832B (de) * 1963-02-23 1967-06-08 Hoechst Ag Verfahren zur Herstellung von Pyrimidiniumverbindungen
DE1445740A1 (de) * 1963-09-04 1968-11-28 Bayer Ag Verfahren zur Herstellung von Bispyrimidinium-Verbindungen
DE2818676A1 (de) * 1978-04-27 1979-11-08 Troponwerke Gmbh & Co Kg Substituierte 5,6-dimethylpyrrolo 2,3-d pyrimidine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US4339453A (en) * 1979-07-23 1982-07-13 Merck & Co., Inc. Antimicrobial aminopyrimidinium salts
DE3145287A1 (de) * 1981-11-14 1983-05-19 Troponwerke GmbH & Co KG, 5000 Köln Pyrrolo (2.3-d)pyrimidine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US4503050A (en) * 1983-06-02 1985-03-05 Riker Laboratories, Inc. Substituted imidazo[1,2-c]pyrimidines
US4725600A (en) * 1984-07-13 1988-02-16 Fujisawa Pharmaceutical Co., Ltd. Pyrimidine compounds having activity as a cardiotonic anti-hypertensive cerebrovascular vasodilator and anti-platelet aggregation agent
IL88507A (en) * 1987-12-03 1993-02-21 Smithkline Beckman Intercredit 2,4-diaminoquinazolines, process for their preparation and pharmaceutical compositions comprising them
ZA902280B (en) * 1989-03-29 1990-12-28 Merrell Dow Pharma Selective adenosine receptor agents
IE63502B1 (en) * 1989-04-21 1995-05-03 Zeneca Ltd Aminopyrimidine derivatives useful for treating cardiovascular disorders
GB8929022D0 (en) * 1989-12-22 1990-02-28 Ici Plc Diazine derivatives

Also Published As

Publication number Publication date
EP0482804A1 (de) 1992-04-29
AU8581391A (en) 1992-07-02
EP0482804B1 (de) 1997-01-22
US5328910A (en) 1994-07-12
ATE148119T1 (de) 1997-02-15
IL99709A0 (en) 1992-08-18
IE913598A1 (en) 1992-04-22
ZA918134B (en) 1992-07-29
PT99264A (pt) 1992-08-31
NZ240180A (en) 1993-12-23
JPH04273878A (ja) 1992-09-30
GB9022644D0 (en) 1990-11-28
FI914910A (fi) 1992-04-19
FI914910A0 (fi) 1991-10-17
CA2053626A1 (en) 1992-04-19

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