DE69121408T2 - Pgf 1-alkohole und deren verwendung als augendrucksenkende mittel - Google Patents
Pgf 1-alkohole und deren verwendung als augendrucksenkende mittelInfo
- Publication number
- DE69121408T2 DE69121408T2 DE69121408T DE69121408T DE69121408T2 DE 69121408 T2 DE69121408 T2 DE 69121408T2 DE 69121408 T DE69121408 T DE 69121408T DE 69121408 T DE69121408 T DE 69121408T DE 69121408 T2 DE69121408 T2 DE 69121408T2
- Authority
- DE
- Germany
- Prior art keywords
- configuration
- alpha
- independently
- indicate
- pgf
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Ophthalmology & Optometry (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/538,204 US5238961A (en) | 1990-06-14 | 1990-06-14 | Pgf 1-alcohols and their use as ocular hypotensives |
PCT/US1991/004103 WO1991019490A1 (en) | 1990-06-14 | 1991-06-11 | Pgf 1-alcohols and their use as ocular hypotensives |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69121408D1 DE69121408D1 (de) | 1996-09-19 |
DE69121408T2 true DE69121408T2 (de) | 1997-02-20 |
Family
ID=24145936
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69121408T Expired - Fee Related DE69121408T2 (de) | 1990-06-14 | 1991-06-11 | Pgf 1-alkohole und deren verwendung als augendrucksenkende mittel |
Country Status (13)
Country | Link |
---|---|
US (1) | US5238961A (de) |
EP (1) | EP0533828B1 (de) |
JP (1) | JP3139766B2 (de) |
KR (1) | KR100196769B1 (de) |
AT (1) | ATE141163T1 (de) |
AU (1) | AU638587B2 (de) |
BR (1) | BR9106549A (de) |
CA (1) | CA2084769A1 (de) |
DE (1) | DE69121408T2 (de) |
ES (1) | ES2090341T3 (de) |
HU (1) | HUT63371A (de) |
IE (1) | IE912011A1 (de) |
WO (1) | WO1991019490A1 (de) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5270049A (en) * | 1990-11-09 | 1993-12-14 | Allergan, Inc. | 2-decarboxyl-2-aminoalkyl-prostaglandins as ocular hypotensives |
US5139491A (en) * | 1990-12-06 | 1992-08-18 | Allergan, Inc. | 2-decarboxyl-2-alkoxyalkyl prostaglandins as ocular hypotensives |
IE920397A1 (en) * | 1991-02-07 | 1992-08-12 | Allergan Inc | 2-decarboxyl-2-hydroxyalkyl-5-trans prostaglandin f¹derivatives |
US5312832A (en) * | 1991-05-17 | 1994-05-17 | Allergan, Inc. | Ocular hypotensive 2-decarboxyl-2-acylthioalkyl prostaglandin derivatives |
US5288754A (en) * | 1992-02-04 | 1994-02-22 | Allergan, Inc. | Polar C-1 esters of prostaglandins |
US5834498A (en) * | 1992-09-21 | 1998-11-10 | Allergan | Cyclopentane heptan(ene)oic acid, 2-heteroarylalkenyl derivatives as therapeutic agents |
US6124353A (en) * | 1992-11-12 | 2000-09-26 | Allergan Sales, Inc. | Method of treating ocular hypertension with 8-epi prostaglandins |
US5476872A (en) * | 1993-10-18 | 1995-12-19 | Allergan, Inc. | 1,11-diesters of prostaglandin-F2α having a polar ester group at C-1 |
US5545665A (en) * | 1993-12-28 | 1996-08-13 | Allergan | Cyclopentane(ene) heptenoic or heptanoic acids and derivatives thereof useful as therapeutic agents |
US6441047B2 (en) | 1995-11-17 | 2002-08-27 | Alcon Manufacturing Ltd.. | Combination therapy for treating glaucoma |
AU729318B2 (en) * | 1996-05-28 | 2001-02-01 | Allergan, Inc. | Cyclopentan(en)e heptenoic acid, 2-alkenyl derivatives as therapeutic agents in the treatment of ocular hypertension |
US6770675B2 (en) | 1997-03-17 | 2004-08-03 | Novartis Ag | Compositions and methods for reducing ocular hypertension |
WO2001055102A1 (fr) * | 2000-01-28 | 2001-08-02 | Asahi Glass Company, Limited | Nouveau derive difluoroprostaglandine |
US6414021B1 (en) * | 2000-08-25 | 2002-07-02 | Sucampo Ag | Control of intraocular pressure during surgery |
US20040216749A1 (en) * | 2003-01-23 | 2004-11-04 | Hosheng Tu | Vasomodulation during glaucoma surgery |
US20040151691A1 (en) | 2003-01-30 | 2004-08-05 | Oxman Joel D. | Hardenable thermally responsive compositions |
US6949518B1 (en) | 2003-06-25 | 2005-09-27 | Pao-Hsien Chu | Methods for treating macular degeneration with topiramate |
US20090148527A1 (en) * | 2007-12-07 | 2009-06-11 | Robinson Michael R | Intraocular formulation |
US10206813B2 (en) | 2009-05-18 | 2019-02-19 | Dose Medical Corporation | Implants with controlled drug delivery features and methods of using same |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4055593A (en) * | 1971-02-19 | 1977-10-25 | Alza Corporation | Alkyl diethers of prostaglandins |
US3940438A (en) * | 1971-05-24 | 1976-02-24 | Alza Corporation | Crystalline racemic 9α,11α,15(S)-trihydroxy-5-cis,13-trans-prostadienoic acid |
US3853854A (en) * | 1971-06-24 | 1974-12-10 | Alza Corp | Novel 5{40 ,6{40 -dihydro-2h-pyran-4{40 -yl prostaglandin ethers |
US4001306A (en) * | 1971-12-30 | 1977-01-04 | The Upjohn Company | Prostaglandin F.sub.α 15-monoacrylates |
US3941886A (en) * | 1973-09-21 | 1976-03-02 | Alza Corporation | Pharmaceutical compositions containing crystalline racemic 9α, 11α, 15(S)-trihydroxy-5-cis, 13-trans-prostadienoic acid |
NL7605381A (nl) * | 1975-05-26 | 1976-11-30 | Schering Ag | Werkwijze voor het bereiden van prostaanderi- vaten en werkwijze voor het bereiden van een geneesmiddel met prostaglandinewerking. |
US4025577A (en) * | 1975-06-12 | 1977-05-24 | Exxon Research And Engineering Company | Hydroalkylation of paraffins with olefins utilizing hydrogen fluoride and metal pentafluoride catalyst |
US4049678A (en) * | 1976-03-29 | 1977-09-20 | The Upjohn Company | 9-Deoxy-PGD-type, 1,15-lactones |
US4016184A (en) * | 1975-09-17 | 1977-04-05 | The Upjohn Company | 9-Deoxy-9,10-didehydro-PGD1 compounds |
US4201873A (en) * | 1975-09-17 | 1980-05-06 | The Upjohn Company | 9-Deoxy-9,10-didehydro-PGD2 analogs |
US4033989A (en) * | 1975-09-17 | 1977-07-05 | The Upjohn Company | 9-Deoxy-PGF2 Analogs |
US4060540A (en) * | 1975-09-18 | 1977-11-29 | American Cyanamid Company | Novel 3-triphenylmethoxy-1-alkynes, 3-triphenyl-methoxy-1-trans-alkenyl-dialkyl-alanes, and lithium 3-triphenylmethoxy-1-trans-alkenyl-dialkyl alanates |
GB2048254B (en) * | 1979-04-02 | 1983-05-25 | Upjohn Co | 19,20 -didehydro-19-hydroxy and 19-oxo-prostaglandin derivatives |
US4599353A (en) * | 1982-05-03 | 1986-07-08 | The Trustees Of Columbia University In The City Of New York | Use of eicosanoids and their derivatives for treatment of ocular hypertension and glaucoma |
US4883819A (en) * | 1986-07-31 | 1989-11-28 | The Trustees Of Columbia University In The City Of New York | Use of A, B and C prostaglandins and derivatives thereof to treat ocular hypertension and glaucoma |
US4824857A (en) * | 1986-05-16 | 1989-04-25 | Yasumasa Goh | Use of prostaglandin D2 -active substances |
US4822819A (en) * | 1986-11-07 | 1989-04-18 | Alcon Laboratories, Inc. | Use of trimoprostil and derivatives in glaucoma therapy |
ZA88963B (en) * | 1987-02-27 | 1989-11-29 | Allergan Inc | Prostaglandins useful for lowering intraocular pressure |
ES2042625T5 (es) * | 1987-04-03 | 2000-07-16 | Univ Columbia | Uso de una prostaglandina en combinacion con un agente bloqueante adrenergico para la reduccion de presion intraocular. |
SE8703854D0 (sv) * | 1987-10-07 | 1987-10-07 | Pharmacia Ab | Prostaglandinderivat for behandling av glaukom eller okuler hypertension |
US5139491A (en) * | 1990-12-06 | 1992-08-18 | Allergan, Inc. | 2-decarboxyl-2-alkoxyalkyl prostaglandins as ocular hypotensives |
IE920397A1 (en) * | 1991-02-07 | 1992-08-12 | Allergan Inc | 2-decarboxyl-2-hydroxyalkyl-5-trans prostaglandin f¹derivatives |
-
1990
- 1990-06-14 US US07/538,204 patent/US5238961A/en not_active Expired - Lifetime
-
1991
- 1991-06-11 JP JP03511495A patent/JP3139766B2/ja not_active Expired - Fee Related
- 1991-06-11 ES ES91912254T patent/ES2090341T3/es not_active Expired - Lifetime
- 1991-06-11 HU HU923920A patent/HUT63371A/hu unknown
- 1991-06-11 WO PCT/US1991/004103 patent/WO1991019490A1/en active IP Right Grant
- 1991-06-11 AU AU80539/91A patent/AU638587B2/en not_active Ceased
- 1991-06-11 EP EP91912254A patent/EP0533828B1/de not_active Expired - Lifetime
- 1991-06-11 AT AT91912254T patent/ATE141163T1/de not_active IP Right Cessation
- 1991-06-11 BR BR919106549A patent/BR9106549A/pt not_active Application Discontinuation
- 1991-06-11 KR KR1019920703189A patent/KR100196769B1/ko not_active IP Right Cessation
- 1991-06-11 DE DE69121408T patent/DE69121408T2/de not_active Expired - Fee Related
- 1991-06-11 CA CA002084769A patent/CA2084769A1/en not_active Abandoned
- 1991-06-13 IE IE201191A patent/IE912011A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
EP0533828B1 (de) | 1996-08-14 |
HUT63371A (en) | 1993-08-30 |
BR9106549A (pt) | 1993-06-01 |
WO1991019490A1 (en) | 1991-12-26 |
US5238961A (en) | 1993-08-24 |
EP0533828A4 (en) | 1993-08-11 |
AU638587B2 (en) | 1993-07-01 |
JPH05507928A (ja) | 1993-11-11 |
KR100196769B1 (ko) | 1999-06-15 |
ES2090341T3 (es) | 1996-10-16 |
ATE141163T1 (de) | 1996-08-15 |
IE912011A1 (en) | 1991-12-18 |
EP0533828A1 (de) | 1993-03-31 |
JP3139766B2 (ja) | 2001-03-05 |
DE69121408D1 (de) | 1996-09-19 |
CA2084769A1 (en) | 1991-12-15 |
AU8053991A (en) | 1992-01-07 |
HU9203920D0 (en) | 1993-03-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69121408T2 (de) | Pgf 1-alkohole und deren verwendung als augendrucksenkende mittel | |
YU47204B (sh) | Derivati didehidro-vitamina d3 | |
DK0410785T3 (da) | 11-Acylprostaglandiner, som reducerer intraokulartryk | |
KR900700101A (ko) | 항녹내장성 안과용 조성물 | |
NZ311083A (en) | Aromatic compounds and pharmaceutical compositions containing them useful as antagonists of E-type prostaglandins | |
ES2155566T3 (es) | Uso de derivados de rifamicina para el tratamiento de enfermedades infecciosas por clamidia. | |
ES2046500T3 (es) | Derivado de la histamina, su preparacion y su aplicacion en terapeutica. | |
ES2062443T3 (es) | Nuevos derivados peptidicos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen. | |
FI812804L (fi) | 2-(1,4-bensodioxan-2-ylalkyl)-imidazoler anvaendbara som antidepressiva laekemedel | |
ES2124256T3 (es) | Arilmorfolina, preparacion y uso. | |
KR960003719A (ko) | 녹내장 치료제 및 안압 강하제 | |
MX9204457A (es) | Compuestos de 6-oxo-azepinoidol, asi como procedimientos y productos intermedios para su preparacion, y medicamentos que contienen estos compuestos. | |
SE7701778L (sv) | 2,9-dioxatricyklo /4,3,1,0?723?717/ dekaner och forfarande for framstellning derav | |
DK0508955T3 (da) | Anvendelse af 2-iminothiazolidin-4-onderivater som nye lægemidler | |
DE69112080D1 (de) | 2-decarboxyl-2-alkoxyalkyl-prostaglandine als augenbinnendrucksenkende mittel. | |
AR034088A1 (es) | Composicion que comprende derivados anticonvulsivantes utiles en el tratamiento de esquizofrenia y el uso de dicho derivado para la manufactura de un medicamento | |
MX9201392A (es) | Derivados de imidazol y procedimiento para su preparacion. | |
ES465221A1 (es) | Procedimiento para la preparacion de nuevos derivados de 4- ter-buti-3'-clorodifenilamina con actividad antihistaminica. | |
ES472208A1 (es) | Procedimiento para la obtencion de nuevos derivados de 2- bencimidazol. | |
ATE138574T1 (de) | Verwendung von prostaglandin f3alpha als okulares hypotensivum | |
ATE40359T1 (de) | Racemische und optisch aktive 7-oxo-prostacyclin- derivate, verfahren zu deren herstellung und diese verbindungen enthaltende pharmazeutische praeparate. | |
ES467519A1 (es) | Un procedimiento de preparacion de acidos furoil- o tenoil- naftiloxialcohilcarboxilicos. | |
ATE63305T1 (de) | Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel. | |
DE69704759D1 (de) | Ellipticinederivate, ihre Herstellung und diese enthaltende pharmazeutische Zubereitungen | |
YU47017B (sh) | Derivati indola, postupak za njihovo dobijanje i postupak za dobijanje farmaceutskih preparata koji ih sadrže |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |