DE69120899D1 - Neue N-Benzoylprolin-Derivate, Verfahren zur Herstellung und diese enthaltende Arzneimittel - Google Patents

Neue N-Benzoylprolin-Derivate, Verfahren zur Herstellung und diese enthaltende Arzneimittel

Info

Publication number
DE69120899D1
DE69120899D1 DE69120899T DE69120899T DE69120899D1 DE 69120899 D1 DE69120899 D1 DE 69120899D1 DE 69120899 T DE69120899 T DE 69120899T DE 69120899 T DE69120899 T DE 69120899T DE 69120899 D1 DE69120899 D1 DE 69120899D1
Authority
DE
Germany
Prior art keywords
benzoylproline
derivatives
new
production processes
products containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69120899T
Other languages
English (en)
Other versions
DE69120899T2 (de
Inventor
Sylvain Rault
Marie-Paule Foloppe
Max Robba
Michel Boulouard
Pierre Renard
Michelle Devissaguet
Gerard Adam
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ADIR SARL
Original Assignee
ADIR SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ADIR SARL filed Critical ADIR SARL
Publication of DE69120899D1 publication Critical patent/DE69120899D1/de
Application granted granted Critical
Publication of DE69120899T2 publication Critical patent/DE69120899T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems
DE69120899T 1990-11-14 1991-11-14 Neue N-Benzoylprolin-Derivate, Verfahren zur Herstellung und diese enthaltende Arzneimittel Expired - Fee Related DE69120899T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR909014087A FR2669029B1 (fr) 1990-11-14 1990-11-14 Nouveaux derives de la n-benzoyl proline, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.

Publications (2)

Publication Number Publication Date
DE69120899D1 true DE69120899D1 (de) 1996-08-22
DE69120899T2 DE69120899T2 (de) 1997-02-27

Family

ID=9402135

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69120899T Expired - Fee Related DE69120899T2 (de) 1990-11-14 1991-11-14 Neue N-Benzoylprolin-Derivate, Verfahren zur Herstellung und diese enthaltende Arzneimittel

Country Status (15)

Country Link
US (1) US5332735A (de)
EP (1) EP0486386B1 (de)
JP (1) JPH078856B2 (de)
AT (1) ATE140450T1 (de)
AU (1) AU642053B2 (de)
CA (1) CA2055326A1 (de)
DE (1) DE69120899T2 (de)
DK (1) DK0486386T3 (de)
ES (1) ES2091310T3 (de)
FR (1) FR2669029B1 (de)
GR (1) GR3021196T3 (de)
IE (1) IE913963A1 (de)
NZ (1) NZ240575A (de)
PT (1) PT99503B (de)
ZA (1) ZA919030B (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1245712B (it) * 1991-04-09 1994-10-14 Boehringer Mannheim Italia Ammine eterocicliche utili terapia dell'asma e dell'infiammazione delle vie aeree
FR2680508B1 (fr) * 1991-08-20 1995-03-03 Adir Nouveaux composes amidiques des 1-(alcoxybenzyl)piperazines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
DE69333299T2 (de) * 1992-07-24 2004-09-09 The Regents Of The University Of California, Oakland Arzneimittel die den durch AMPA Rezeptoren vermittelten synaptischen Response erhöhen
NZ305940A (en) * 1995-07-26 1999-05-28 Pfizer N-(aroyl)glycine hydroxamic acid derivatives and related compounds that inhibit the production of tnf and are useful in treating asthma
EP1524265A1 (de) * 2003-10-15 2005-04-20 Newron Pharmaceuticals S.p.A. Prolinamide-Derivate als Natrium- und/oder Kalziumkanalblocker oder selektive MAO-B Inhibitoren
MX2007001337A (es) * 2004-08-02 2008-03-13 Genmedica Therapeutics Sl Compuestos para inhibir amina-oxidasas que contienen cobre y usos de los mismos.
ES2328938T3 (es) * 2005-02-28 2009-11-19 Tseti, Ioulia Medicamento para el alzheimer.
EP1883402A2 (de) 2005-04-13 2008-02-06 Astex Therapeutics Limited Hydroxybenzamidderivate und ihre verwendung als hsp90-inhibitoren
US7754725B2 (en) 2006-03-01 2010-07-13 Astex Therapeutics Ltd. Dihydroxyphenyl isoindolymethanones
GB0620259D0 (en) 2006-10-12 2006-11-22 Astex Therapeutics Ltd Pharmaceutical compounds
JP5410285B2 (ja) * 2006-10-12 2014-02-05 アステックス、セラピューティックス、リミテッド 医薬化合物
US9730912B2 (en) 2006-10-12 2017-08-15 Astex Therapeutics Limited Pharmaceutical compounds
US8277807B2 (en) 2006-10-12 2012-10-02 Astex Therapeutics Limited Pharmaceutical combinations
JP5528807B2 (ja) 2006-10-12 2014-06-25 アステックス、セラピューティックス、リミテッド 複合薬剤
WO2008044041A1 (en) 2006-10-12 2008-04-17 Astex Therapeutics Limited Pharmaceutical combinations
GB0806527D0 (en) * 2008-04-11 2008-05-14 Astex Therapeutics Ltd Pharmaceutical compounds

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3524849A (en) * 1967-10-27 1970-08-18 Hoffmann La Roche Process for the preparation of pyrrolo-benzodiazepine acrylamides and intermediates useful therein
JPS5015793B2 (de) * 1972-06-07 1975-06-07
US3763183A (en) * 1972-07-10 1973-10-02 Sterling Drug Inc 1,2,3,10,11,11a-hexahydro-5h-pyrrolo (2,1-c)(1,4)benzodiazepines
US4123544A (en) * 1977-03-02 1978-10-31 Merrell Toraude S. A. Acetylsalicylic acid derivatives
JPS5419969A (en) * 1977-07-15 1979-02-15 Yoshitomi Pharmaceut Ind Ltd Proline derivative and its preparation
US4427587A (en) * 1982-11-10 1984-01-24 Bristol-Myers Company Total synthesis of antitumor antibiotics BBM-2040A and BBM-2040B
JPS6137764A (ja) * 1984-07-31 1986-02-22 Suntory Ltd 抗プロリルエンドペプチダ−ゼ活性を有する新規生理活性化合物
JPH0623190B2 (ja) * 1985-04-16 1994-03-30 サントリー株式会社 インヒビタ−活性を有するｎ−アシルピロリジン誘導体及びその製法並びに用途
US4880827A (en) * 1986-03-18 1989-11-14 Sumitomo Pharmaceuticals Company, Ltd. Pyrrolidine derivatives having inhibitory action for proline specific endopepidase
US4833155A (en) * 1986-11-25 1989-05-23 Syntex (U.S.A.) Inc. 3-(ω-(3,5,-di-t-butyl-4-hydroxyphenyl)-alkanoyl)pyrroles, and anti-inflammatory uses thereof
US4912231A (en) * 1987-06-15 1990-03-27 E. R. Squibb & Sons, Inc. Process for preparing (trans)-4-phenyl-L-proline derivatives
NZ228329A (en) * 1988-03-18 1991-12-23 Mitsui Toatsu Chemicals Catechol derivatives and pharmaceutical compositions thereof
US5053414A (en) * 1988-04-08 1991-10-01 Ono Pharmaceutical Co., Ltd. Heterocyclic compounds
US5142065A (en) * 1988-08-20 1992-08-25 Bayer Aktiengesellschaft 3-aryl-pyrrolidine-2,4-diones

Also Published As

Publication number Publication date
PT99503A (pt) 1992-09-30
GR3021196T3 (en) 1996-12-31
ATE140450T1 (de) 1996-08-15
CA2055326A1 (fr) 1992-05-15
NZ240575A (en) 1993-07-27
JPH078856B2 (ja) 1995-02-01
EP0486386A2 (de) 1992-05-20
AU642053B2 (en) 1993-10-07
AU8777691A (en) 1992-05-21
EP0486386B1 (de) 1996-07-17
ZA919030B (en) 1992-08-26
EP0486386A3 (en) 1992-10-14
JPH04283561A (ja) 1992-10-08
IE913963A1 (en) 1992-05-20
US5332735A (en) 1994-07-26
FR2669029B1 (fr) 1994-09-02
FR2669029A1 (fr) 1992-05-15
PT99503B (pt) 1999-04-30
ES2091310T3 (es) 1996-11-01
DE69120899T2 (de) 1997-02-27
DK0486386T3 (da) 1996-11-25

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee