DE69120603D1 - Isochromanderivate - Google Patents

Isochromanderivate

Info

Publication number
DE69120603D1
DE69120603D1 DE69120603T DE69120603T DE69120603D1 DE 69120603 D1 DE69120603 D1 DE 69120603D1 DE 69120603 T DE69120603 T DE 69120603T DE 69120603 T DE69120603 T DE 69120603T DE 69120603 D1 DE69120603 D1 DE 69120603D1
Authority
DE
Germany
Prior art keywords
alkyl
hydrogen
group
alkoxy
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69120603T
Other languages
English (en)
Other versions
DE69120603T2 (de
Inventor
Jean-Claude Laigle
Michel Combourieu
Nadine Simbille
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Akzo Nobel NV
Original Assignee
Akzo Nobel NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel NV filed Critical Akzo Nobel NV
Application granted granted Critical
Publication of DE69120603D1 publication Critical patent/DE69120603D1/de
Publication of DE69120603T2 publication Critical patent/DE69120603T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/76—Benzo[c]pyrans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Detergent Compositions (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69120603T 1990-05-25 1991-05-10 Isochromanderivate Expired - Fee Related DE69120603T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP90401407 1990-05-25

Publications (2)

Publication Number Publication Date
DE69120603D1 true DE69120603D1 (de) 1996-08-08
DE69120603T2 DE69120603T2 (de) 1997-01-02

Family

ID=8205714

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69120603T Expired - Fee Related DE69120603T2 (de) 1990-05-25 1991-05-10 Isochromanderivate

Country Status (15)

Country Link
EP (1) EP0458387B1 (de)
JP (1) JPH04253970A (de)
KR (1) KR910020004A (de)
AT (1) ATE140001T1 (de)
AU (1) AU643277B2 (de)
CA (1) CA2042861A1 (de)
DE (1) DE69120603T2 (de)
DK (1) DK0458387T3 (de)
ES (1) ES2091283T3 (de)
FI (1) FI912400A (de)
GR (1) GR3021084T3 (de)
IE (1) IE73232B1 (de)
NZ (1) NZ238243A (de)
PT (1) PT97766B (de)
ZA (1) ZA913691B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1046507C (zh) * 1993-12-28 1999-11-17 法玛西雅厄普约翰美国公司 用于治疗中枢神经系统和心血管疾病的杂环化合物
US7186726B2 (en) 1998-06-30 2007-03-06 Neuromed Pharmaceuticals Ltd. Preferentially substituted calcium channel blockers
US6387897B1 (en) 1998-06-30 2002-05-14 Neuromed Technologies, Inc. Preferentially substituted calcium channel blockers
US6310059B1 (en) 1998-06-30 2001-10-30 Neuromed Technologies, Inc. Fused ring calcium channel blockers
US6492375B2 (en) 1998-06-30 2002-12-10 Neuromed Technologies, Inc. Partially saturated calcium channel blockers
US6011035A (en) * 1998-06-30 2000-01-04 Neuromed Technologies Inc. Calcium channel blockers
US6943168B2 (en) 1998-06-30 2005-09-13 Neuromed Technologies Inc. Calcium channel inhibitors comprising benzhydril spaced from piperazine
US6951862B2 (en) 1998-06-30 2005-10-04 Neuromed Technologies, Inc. Calcium channel blockers comprising two benzhydril moieties
EP2964611B1 (de) 2013-03-08 2022-10-19 The United States of America, as represented by The Secretary, Department of Health and Human Services Wirksame und selektive inhibitoren von monoamintransportern, verfahren zur herstellung und verwendung davon
EP4046995B1 (de) * 2015-02-11 2023-09-13 Sunovion Pharmaceuticals Inc. 1-heterocyclyl-isochromanyl-verbindungen und analoga zum behandeln von zns-störungen
US11365195B2 (en) 2017-11-13 2022-06-21 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Atypical inhibitors of monoamine transporters; method of making; and use thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1552004A (en) * 1976-05-26 1979-09-05 Takeda Chemical Industries Ltd Isochroman derivatives
EP0450689A1 (de) * 1990-04-02 1991-10-09 Akzo Nobel N.V. Isochromanderivate

Also Published As

Publication number Publication date
DK0458387T3 (da) 1996-10-21
PT97766B (pt) 1998-10-30
IE73232B1 (en) 1997-05-21
DE69120603T2 (de) 1997-01-02
FI912400A0 (fi) 1991-05-17
EP0458387B1 (de) 1996-07-03
IE911589A1 (en) 1991-12-04
EP0458387A1 (de) 1991-11-27
ATE140001T1 (de) 1996-07-15
GR3021084T3 (en) 1996-12-31
KR910020004A (ko) 1991-12-19
ZA913691B (en) 1992-02-26
AU7733491A (en) 1991-11-28
AU643277B2 (en) 1993-11-11
PT97766A (pt) 1992-03-31
CA2042861A1 (en) 1991-11-26
ES2091283T3 (es) 1996-11-01
JPH04253970A (ja) 1992-09-09
NZ238243A (en) 1992-12-23
FI912400A (fi) 1991-11-26

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee