DE69118533T2 - Verfahren zur herstellung poröser zellulosenmatrizen - Google Patents

Verfahren zur herstellung poröser zellulosenmatrizen

Info

Publication number
DE69118533T2
DE69118533T2 DE69118533T DE69118533T DE69118533T2 DE 69118533 T2 DE69118533 T2 DE 69118533T2 DE 69118533 T DE69118533 T DE 69118533T DE 69118533 T DE69118533 T DE 69118533T DE 69118533 T2 DE69118533 T2 DE 69118533T2
Authority
DE
Germany
Prior art keywords
matrices
pct
cellulose
porous cellulose
sec
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69118533T
Other languages
English (en)
Other versions
DE69118533D1 (de
Inventor
Bo Ek
Kjell Eriksson
Per Nyqvist
Gert Ragnarsson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Health AB
Original Assignee
Pharmacia AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia AB filed Critical Pharmacia AB
Publication of DE69118533D1 publication Critical patent/DE69118533D1/de
Application granted granted Critical
Publication of DE69118533T2 publication Critical patent/DE69118533T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J9/00—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof
    • C08J9/26—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof by elimination of a solid phase from a macromolecular composition or article, e.g. leaching out
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B15/00—Preparation of other cellulose derivatives or modified cellulose, e.g. complexes
    • C08B15/02—Oxycellulose; Hydrocellulose; Cellulosehydrate, e.g. microcrystalline cellulose
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L1/00—Compositions of cellulose, modified cellulose or cellulose derivatives
    • C08L1/02—Cellulose; Modified cellulose
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2201/00—Foams characterised by the foaming process
    • C08J2201/04—Foams characterised by the foaming process characterised by the elimination of a liquid or solid component, e.g. precipitation, leaching out, evaporation
    • C08J2201/044—Elimination of an inorganic solid phase
    • C08J2201/0444—Salts
    • C08J2201/0446—Elimination of NaCl only
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2301/00—Characterised by the use of cellulose, modified cellulose or cellulose derivatives
    • C08J2301/02—Cellulose; Modified cellulose

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Materials Engineering (AREA)
  • Biochemistry (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicinal Preparation (AREA)
  • Amplifiers (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE69118533T 1990-06-06 1991-06-05 Verfahren zur herstellung poröser zellulosenmatrizen Expired - Fee Related DE69118533T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9002017A SE9002017D0 (sv) 1990-06-06 1990-06-06 Process for manufacture of matrices
PCT/SE1991/000396 WO1991018590A1 (en) 1990-06-06 1991-06-05 Process for the manufacture of porous cellulose matrices

Publications (2)

Publication Number Publication Date
DE69118533D1 DE69118533D1 (de) 1996-05-09
DE69118533T2 true DE69118533T2 (de) 1996-09-12

Family

ID=20379691

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69118533T Expired - Fee Related DE69118533T2 (de) 1990-06-06 1991-06-05 Verfahren zur herstellung poröser zellulosenmatrizen

Country Status (14)

Country Link
US (1) US5607695A (de)
EP (1) EP0532611B1 (de)
JP (1) JPH05507696A (de)
AT (1) ATE136213T1 (de)
AU (1) AU644887B2 (de)
CA (1) CA2084680C (de)
DE (1) DE69118533T2 (de)
DK (1) DK0532611T3 (de)
ES (1) ES2086542T3 (de)
FI (1) FI101195B (de)
GR (1) GR3020047T3 (de)
NO (1) NO304726B1 (de)
SE (1) SE9002017D0 (de)
WO (1) WO1991018590A1 (de)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2702160B1 (fr) * 1993-03-02 1995-06-02 Biovecteurs As Vecteurs particulaires synthétiques et procédé de préparation.
SE9301220D0 (sv) * 1993-04-14 1993-04-14 Kabi Pharmacia Ab Manufacturing matrices
US5858409A (en) * 1996-04-17 1999-01-12 Fmc Corporation Hydrolyzed cellulose granulations for pharmaceuticals
US5874064A (en) 1996-05-24 1999-02-23 Massachusetts Institute Of Technology Aerodynamically light particles for pulmonary drug delivery
US5985309A (en) * 1996-05-24 1999-11-16 Massachusetts Institute Of Technology Preparation of particles for inhalation
US5855913A (en) * 1997-01-16 1999-01-05 Massachusetts Instite Of Technology Particles incorporating surfactants for pulmonary drug delivery
US6652837B1 (en) 1996-05-24 2003-11-25 Massachusetts Institute Of Technology Preparation of novel particles for inhalation
US6254854B1 (en) 1996-05-24 2001-07-03 The Penn Research Foundation Porous particles for deep lung delivery
US20020052310A1 (en) * 1997-09-15 2002-05-02 Massachusetts Institute Of Technology The Penn State Research Foundation Particles for inhalation having sustained release properties
USRE37053E1 (en) 1996-05-24 2001-02-13 Massachusetts Institute Of Technology Particles incorporating surfactants for pulmonary drug delivery
SE9604124D0 (sv) 1996-11-12 1996-11-12 Pharmacia & Upjohn Ab Compact member, method of manufacturing and use thereof
NZ335737A (en) * 1996-11-12 2000-09-29 Pharmacia & Upjohn Ab Compact member comprising a plurality of porous cellulose matrices (PCMs)
DE69835275T2 (de) * 1997-01-07 2007-07-19 Kaneka Corp. Absorbens zum reinigen von körperflüssigkeiten
US7052678B2 (en) 1997-09-15 2006-05-30 Massachusetts Institute Of Technology Particles for inhalation having sustained release properties
DE19745629A1 (de) * 1997-10-16 1999-04-22 Cff Cellulose Fuellstoff Fabri Verfahren zur Herstellung eines aus zerkleinerten Pflanzenfasern bestehenden Ballast- oder Füllstoffes und seine Verwendung
JP2001526733A (ja) * 1997-12-14 2001-12-18 シェリンギッシェス インスティチュート フュア テクスチル−ウント クンストストッフェ−フォルシュング エー．ブイ． 正規粒状セルローズの製造方法と粒状セルローズおよびその使用
US6956021B1 (en) 1998-08-25 2005-10-18 Advanced Inhalation Research, Inc. Stable spray-dried protein formulations
CA2360655C (en) 1999-01-29 2007-03-20 Losan Pharma Gmbh Pharmaceutical compositions
US6610317B2 (en) 1999-05-27 2003-08-26 Acusphere, Inc. Porous paclitaxel matrices and methods of manufacture thereof
US6749835B1 (en) 1999-08-25 2004-06-15 Advanced Inhalation Research, Inc. Formulation for spray-drying large porous particles
US7678364B2 (en) 1999-08-25 2010-03-16 Alkermes, Inc. Particles for inhalation having sustained release properties
AU763041B2 (en) * 1999-08-25 2003-07-10 Alkermes, Inc. Modulation of release from dry powder formulations
US20010036481A1 (en) * 1999-08-25 2001-11-01 Advanced Inhalation Research, Inc. Modulation of release from dry powder formulations
WO2001034684A1 (en) * 1999-11-12 2001-05-17 R.P. Scherer Technologies, Inc. Microcrystalline cellulose cushioning granules
US6309454B1 (en) 2000-05-12 2001-10-30 Johnson & Johnson Medical Limited Freeze-dried composite materials and processes for the production thereof
EP1345629A2 (de) * 2000-12-29 2003-09-24 Advanced Inhalation Research, Inc. Inhalationspartikel mit verzögerter freigabe
US20020141946A1 (en) * 2000-12-29 2002-10-03 Advanced Inhalation Research, Inc. Particles for inhalation having rapid release properties
US20030125236A1 (en) * 2000-12-29 2003-07-03 Advenced Inhalation Research, Inc. Particles for inhalation having rapid release properties
US20060287254A1 (en) * 2001-01-26 2006-12-21 Schering Corporation Use of substituted azetidinone compounds for the treatment of sitosterolemia
US20030129250A1 (en) * 2001-11-20 2003-07-10 Advanced Inhalation Research Inc. Particulate compositions for improving solubility of poorly soluble agents
AU2002352836B2 (en) * 2001-11-20 2005-09-29 Alkermes, Inc. Improved particulate compositions for pulmonary delivery
US9107804B2 (en) 2002-12-10 2015-08-18 Nortec Development Associates, Inc. Method of preparing biologically active formulations
TW200507882A (en) * 2003-07-17 2005-03-01 Kyowa Hakko Kogyo Kk Solid formulations
US7198653B2 (en) 2003-07-31 2007-04-03 Delavau Llc Calcium carbonate granulation
CN100402585C (zh) * 2004-01-30 2008-07-16 旭化成化学株式会社 多孔纤维素聚集体以及包含这种聚集体的组合物成形品
US9138414B1 (en) 2006-09-15 2015-09-22 Delavau Llc Calcium supplement having enhanced absorption
NO20065147L (no) * 2006-11-08 2008-05-09 Ntnu Tech Transfer As Nanokompositter basert på cellulosewhiskers og celluloseplast
FR2945945B1 (fr) 2009-05-29 2011-07-29 Flamel Tech Sa Procede de preparation de particules creuses et leurs applications
US8765308B2 (en) * 2011-10-13 2014-07-01 Tokushu Tokai Paper Co., Ltd. Porous membrane and process for preparing the same
CN103329310B (zh) 2011-10-13 2016-09-21 特种东海制纸株式会社 微多孔膜及其制造方法
TW201332194A (zh) * 2011-10-13 2013-08-01 Tokushu Tokai Paper Co Ltd 微多孔膜及其製造方法（一）
WO2013054888A1 (ja) * 2011-10-13 2013-04-18 特種東海製紙株式会社 電気化学素子用セパレータ及びその製造方法
CN111116761B (zh) * 2019-11-13 2022-02-18 王卫 改性微晶纤维素的制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL286829A (de) * 1961-12-29
CS172640B1 (de) * 1974-05-30 1977-01-28
SE434848B (sv) * 1976-04-22 1984-08-20 Purdue Research Foundation Forfaringssett for framstellning av porosa cellulosaperlor
US4063017A (en) * 1976-04-22 1977-12-13 Purdue Research Foundation Porous cellulose beads and the immobilization of enzymes therewith
GB1561204A (en) * 1977-06-01 1980-02-13 Ici Ltd Sustained release pharmaceutical composition
US4269859A (en) * 1979-04-19 1981-05-26 Brown Company Cellulose floc granules and process
GB8618811D0 (en) * 1986-08-01 1986-09-10 Approved Prescription Services Sustained release ibuprofen formulation
GB8628728D0 (en) * 1986-12-02 1987-01-07 Euro Celtique Sa Spheroids
US4808413A (en) * 1987-04-28 1989-02-28 E. R. Squibb & Sons, Inc. Pharmaceutical compositions in the form of beadlets and method
JPS6443530A (en) * 1987-08-10 1989-02-15 Asahi Chemical Ind Porous cellulose particle and its production
US5049394A (en) * 1987-09-11 1991-09-17 E. R. Squibb & Sons, Inc. Pharmaceutical composition containing high drug load and method for preparing same
US4806360A (en) * 1987-10-23 1989-02-21 Advanced Polymer Systems Synthetic melanin aggregates

Also Published As

Publication number Publication date
ATE136213T1 (de) 1996-04-15
EP0532611B1 (de) 1996-04-03
JPH05507696A (ja) 1993-11-04
NO924671L (no) 1992-12-03
AU644887B2 (en) 1993-12-23
FI925531A (fi) 1992-12-04
ES2086542T3 (es) 1996-07-01
NO924671D0 (no) 1992-12-03
EP0532611A1 (de) 1993-03-24
AU7994091A (en) 1991-12-31
DE69118533D1 (de) 1996-05-09
CA2084680A1 (en) 1991-12-07
WO1991018590A1 (en) 1991-12-12
US5607695A (en) 1997-03-04
DK0532611T3 (da) 1996-08-05
NO304726B1 (no) 1999-02-08
SE9002017D0 (sv) 1990-06-06
FI101195B1 (fi) 1998-05-15
GR3020047T3 (en) 1996-08-31
FI925531A0 (fi) 1992-12-04
FI101195B (fi) 1998-05-15
CA2084680C (en) 2001-10-02

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee