DE69118340T2 - Neue 15-nitro-2-beta, 3 Beta-dihydro und 15-Nitro-2-beta, 3-Beta,6,7-Tetrahydrotabersoninederivate, diese enthaltende Arzneimittel und Verfahren zu deren Herstellung - Google Patents
Neue 15-nitro-2-beta, 3 Beta-dihydro und 15-Nitro-2-beta, 3-Beta,6,7-Tetrahydrotabersoninederivate, diese enthaltende Arzneimittel und Verfahren zu deren HerstellungInfo
- Publication number
- DE69118340T2 DE69118340T2 DE69118340T DE69118340T DE69118340T2 DE 69118340 T2 DE69118340 T2 DE 69118340T2 DE 69118340 T DE69118340 T DE 69118340T DE 69118340 T DE69118340 T DE 69118340T DE 69118340 T2 DE69118340 T2 DE 69118340T2
- Authority
- DE
- Germany
- Prior art keywords
- beta
- nitro
- tetrahydrotabersonine
- dihydro
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/20—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU908313A HU206883B (en) | 1990-12-18 | 1990-12-18 | Process for producing new 15-nitro-2-beta-, 3-beta-dihydro- and 15-nitro-2-beta, 3-beta-, 6,7-tetrahydro-tabersonin derivatives and pharmaceutical compositions containing them |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69118340D1 DE69118340D1 (de) | 1996-05-02 |
DE69118340T2 true DE69118340T2 (de) | 1996-08-29 |
Family
ID=10972531
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69118340T Expired - Fee Related DE69118340T2 (de) | 1990-12-18 | 1991-12-17 | Neue 15-nitro-2-beta, 3 Beta-dihydro und 15-Nitro-2-beta, 3-Beta,6,7-Tetrahydrotabersoninederivate, diese enthaltende Arzneimittel und Verfahren zu deren Herstellung |
Country Status (16)
Country | Link |
---|---|
US (1) | US5204355A (de) |
EP (1) | EP0491549B1 (de) |
JP (1) | JPH04334380A (de) |
KR (1) | KR920012079A (de) |
CN (1) | CN1063690A (de) |
AU (1) | AU8972591A (de) |
CA (1) | CA2057829A1 (de) |
DE (1) | DE69118340T2 (de) |
FI (1) | FI915930A (de) |
HU (1) | HU206883B (de) |
IE (1) | IE914198A1 (de) |
IL (1) | IL100393A0 (de) |
NO (1) | NO914985L (de) |
PL (1) | PL292813A1 (de) |
YU (1) | YU195291A (de) |
ZA (1) | ZA919912B (de) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7205404B1 (en) | 1999-03-05 | 2007-04-17 | Metabasis Therapeutics, Inc. | Phosphorus-containing prodrugs |
CN102558178B (zh) * | 2012-01-09 | 2015-06-03 | 中国科学院昆明植物研究所 | 水甘草碱(tabersonine)衍生物及其药物组合物和制备方法与用途 |
JP2017512183A (ja) | 2014-02-13 | 2017-05-18 | リガンド・ファーマシューティカルズ・インコーポレイテッド | プロドラッグ化合物およびそれらの使用 |
CN106687118A (zh) | 2014-07-02 | 2017-05-17 | 配体药物公司 | 前药化合物及其用途 |
US11970482B2 (en) | 2018-01-09 | 2024-04-30 | Ligand Pharmaceuticals Inc. | Acetal compounds and therapeutic uses thereof |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2358147A1 (fr) * | 1976-07-13 | 1978-02-10 | Parcor | Aspidospermidines |
JPS62234054A (ja) * | 1985-12-16 | 1987-10-14 | Ono Pharmaceut Co Ltd | 3−フエノキシ(またはフエニルチオ)シクロペンタンカルボニルアミノ酸誘導体およびそれらを有効成分として含有する脳浮腫治療剤 |
-
1990
- 1990-12-18 HU HU908313A patent/HU206883B/hu not_active IP Right Cessation
-
1991
- 1991-12-03 IE IE419891A patent/IE914198A1/en not_active Application Discontinuation
- 1991-12-12 US US07/806,975 patent/US5204355A/en not_active Expired - Fee Related
- 1991-12-17 CA CA002057829A patent/CA2057829A1/en not_active Abandoned
- 1991-12-17 KR KR1019910023172A patent/KR920012079A/ko not_active Application Discontinuation
- 1991-12-17 DE DE69118340T patent/DE69118340T2/de not_active Expired - Fee Related
- 1991-12-17 FI FI915930A patent/FI915930A/fi not_active Application Discontinuation
- 1991-12-17 ZA ZA919912A patent/ZA919912B/xx unknown
- 1991-12-17 AU AU89725/91A patent/AU8972591A/en not_active Abandoned
- 1991-12-17 PL PL29281391A patent/PL292813A1/xx unknown
- 1991-12-17 IL IL100393A patent/IL100393A0/xx unknown
- 1991-12-17 NO NO91914985A patent/NO914985L/no unknown
- 1991-12-17 EP EP91311694A patent/EP0491549B1/de not_active Expired - Lifetime
- 1991-12-18 JP JP3334992A patent/JPH04334380A/ja active Pending
- 1991-12-18 CN CN91107991A patent/CN1063690A/zh active Pending
- 1991-12-18 YU YU195291A patent/YU195291A/sh unknown
Also Published As
Publication number | Publication date |
---|---|
EP0491549A1 (de) | 1992-06-24 |
PL292813A1 (en) | 1992-12-14 |
YU195291A (sh) | 1994-04-05 |
ZA919912B (en) | 1992-10-28 |
FI915930A (fi) | 1992-06-19 |
AU8972591A (en) | 1992-06-25 |
HU206883B (en) | 1993-01-28 |
IL100393A0 (en) | 1992-09-06 |
KR920012079A (ko) | 1992-07-25 |
JPH04334380A (ja) | 1992-11-20 |
CN1063690A (zh) | 1992-08-19 |
HU908313D0 (en) | 1991-07-29 |
NO914985D0 (no) | 1991-12-17 |
CA2057829A1 (en) | 1992-06-19 |
NO914985L (no) | 1992-06-19 |
HUT59681A (en) | 1992-06-29 |
EP0491549B1 (de) | 1996-03-27 |
IE914198A1 (en) | 1992-07-01 |
FI915930A0 (fi) | 1991-12-17 |
DE69118340D1 (de) | 1996-05-02 |
US5204355A (en) | 1993-04-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |