DE69110685D1 - Substituierte imidazobenzazepine und imidazopyridoazepine. - Google Patents

Substituierte imidazobenzazepine und imidazopyridoazepine.

Info

Publication number
DE69110685D1
DE69110685D1 DE69110685T DE69110685T DE69110685D1 DE 69110685 D1 DE69110685 D1 DE 69110685D1 DE 69110685 T DE69110685 T DE 69110685T DE 69110685 T DE69110685 T DE 69110685T DE 69110685 D1 DE69110685 D1 DE 69110685D1
Authority
DE
Germany
Prior art keywords
alkyl
substituted
aryl
arylmethyl
cycloalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69110685T
Other languages
English (en)
Other versions
DE69110685T2 (de
Inventor
Richard Friary
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme Corp
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of DE69110685D1 publication Critical patent/DE69110685D1/de
Application granted granted Critical
Publication of DE69110685T2 publication Critical patent/DE69110685T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE69110685T 1990-10-10 1991-10-04 Substituierte imidazobenzazepine und imidazopyridoazepine. Expired - Fee Related DE69110685T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US59533190A 1990-10-10 1990-10-10
PCT/US1991/007156 WO1992006981A1 (en) 1990-10-10 1991-10-04 Substituted imidazobenzazepines and imidazopyridoazepines

Publications (2)

Publication Number Publication Date
DE69110685D1 true DE69110685D1 (de) 1995-07-27
DE69110685T2 DE69110685T2 (de) 1995-11-09

Family

ID=24382815

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69110685T Expired - Fee Related DE69110685T2 (de) 1990-10-10 1991-10-04 Substituierte imidazobenzazepine und imidazopyridoazepine.

Country Status (9)

Country Link
US (1) US5393753A (de)
EP (1) EP0552292B1 (de)
JP (1) JPH089616B2 (de)
AT (1) ATE124045T1 (de)
AU (1) AU8902591A (de)
CA (1) CA2093797C (de)
DE (1) DE69110685T2 (de)
HK (1) HK186696A (de)
WO (1) WO1992006981A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL101850A (en) * 1991-06-13 1996-01-31 Janssen Pharmaceutica Nv History 11-) 4-Pipridinyl (-Imidazo] B-1, 2 [] 3 [Benzazepine, their preparation and pharmaceutical preparations containing them
GR1001385B (el) * 1992-10-12 1993-10-29 Janssen Pharmaceutica Nv Παράγωγα ιμιδαζο 1,2-α (πυρρολο,?ειενο η φουρανο) 3,2-d αζεπίνης συν?έσεις και μέ?οδοι χρήσεως.
GR1001393B (el) * 1992-10-12 1993-10-29 Janssen Pharmaceutica Nv Παράγωγα ιμιδαζο[2,1-Β] 3] βενζαζεπίνης, συν?έσεις και μέ?οδος χρήσεως.
CA2150806C (en) * 1992-12-04 2006-01-31 Frans Eduard Janssens Antiallergic triazolobenzazepine derivatives
ATE194350T1 (de) * 1992-12-04 2000-07-15 Janssen Pharmaceutica Nv Antiallergisch triazolo (pyrrolo, thieno oder furano) azepinderivate
HU223466B1 (hu) * 1992-12-04 2004-07-28 Janssen Pharmaceutica N.V. Allergia elleni imidazo[1,2a]tieno[2,3-d]azepin-származékok, eljárás előállításukra és az ezeket tartalmazó gyógyszerkészítmények
DE69426528T2 (de) * 1993-07-13 2001-08-23 Janssen Pharmaceutica Nv Antiallergische imidazoazepine
US5700806A (en) * 1995-03-24 1997-12-23 Schering Corporation Tricyclic amide and urea compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
TW382017B (en) * 1995-12-27 2000-02-11 Janssen Pharmaceutica Nv 1-(1,2-disubstituted piperidinyl)-4-(fused imidazole)-piperidine derivatives
TW527186B (en) * 1996-03-19 2003-04-11 Janssen Pharmaceutica Nv Fused imidazole derivatives as multidrug resistance modulators
AU764820C (en) * 1998-12-19 2004-11-18 Janssen Pharmaceutica N.V. Antihistaminic spiro compounds
CN100491378C (zh) 2001-06-12 2009-05-27 詹森药业有限公司 新的取代四环咪唑衍生物,其制备方法,包含它们的药物组合物及它们作为药物的用途
US20050272936A1 (en) * 2002-06-03 2005-12-08 Axten Jeffrey M Imidazolium cxcr3 inhibitors
ES2752823T3 (es) 2006-03-31 2020-04-06 Vistakon Pharmaceuticals Llc Tratamiento de alergias oculares
WO2014083571A1 (en) 2012-11-29 2014-06-05 Neuland Laboratories Limited A process for the preparation of alcaftadine

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL297097A (de) * 1962-08-31
US3491103A (en) * 1963-12-19 1970-01-20 Sandoz Ag Certain 4h-benzo(4,5)cyclohepta-(1,2-b) thiophenes
FR1447527A (fr) * 1964-08-11 1966-07-29 Sandoz Sa Nouveaux benzo-cyclohepta-thiophènes et leur préparation
US3458522A (en) * 1967-05-17 1969-07-29 Sandoz Ag 4-piperidine substituted benzocycloheptaoxazoles and benzocycloheptathiazoles
US3485846A (en) * 1967-06-30 1969-12-23 Eugene E Galantay Benzocycloheptaimidazoles
US3442903A (en) * 1967-08-30 1969-05-06 Sandoz Ag Certain aminopropylidenebenzo(5,6)cyclohepta(1,2-d)thiazoles
CH531000A (de) * 1970-03-11 1972-11-30 Sandoz Ag Verfahren zur Herstellung neuer Benzocycloheptathiophene
US3960894A (en) * 1972-01-24 1976-06-01 Sandoz Ltd. 9-Bromo-or chloro-9,10-dihydro-10-dihydro-10-alkoxy-4H-benzo[4,5]cyclo-hepta[1,2-b]thiophen-4-ones
US3994915A (en) * 1972-06-30 1976-11-30 Sandoz, Inc. Preparation of substituted oxazoles
CH579077A5 (en) * 1972-08-17 1976-08-31 Sandoz Ag Antiallergic benzo(4,5) cyclohepta(1,2-b)-thiophene derivs - prepd by reacting 4-(4-piperidinylidene)-4 H-benzo(4,5)6 cyclohepta(1,2-b)thiophen-9(10H)-one with a benz(hydr)yl halide
US4148903A (en) * 1977-07-28 1979-04-10 Merck & Co., Inc. Antipsychotic, antiserotonin and antihistaminic pyrrolo[2,1-b][3]benzazepines
US4282233B1 (en) * 1980-06-19 2000-09-05 Schering Corp Antihistaminic 11-(4-piperidylidene)-5h-benzoÄ5,6Ü-cyclohepta-Ä1,2Ü-pyridines
US4355036A (en) * 1980-06-19 1982-10-19 Schering Corporation Tricyclic-substituted piperidine antihistamines
EP0047226B1 (de) * 1980-09-02 1985-05-15 Sandoz Ag Piperidyliden-Derivate, deren Herstellung und diese enthaltende pharmazeutische Zusammensetzungen
US4596809A (en) * 1985-03-25 1986-06-24 Schering Corporation Substituted 1,8-naphthyridinones, useful as anti-allergic agents
US4826853A (en) * 1986-10-31 1989-05-02 Schering Corporation 6,11-Dihydro-11-(N-substituted-4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines and compositions and methods of use
US5089496A (en) * 1986-10-31 1992-02-18 Schering Corporation Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies
DE68916699T2 (de) * 1988-04-28 1994-12-01 Schering Corp Benzopyridopiperidin, -piperidyliden und -piperazin-Verbindungen, Zusammensetzungen, Methoden zur Herstellung und Verwendung.
MY106964A (en) * 1988-04-28 1995-08-30 Schering Corp Fused polycyclic compounds, compositions, methods of manufacture, and their use as paf antagonists, antihistamines and/or antiinflammatory agents.
CA2004211A1 (en) * 1988-11-30 1990-05-31 Masataka Syoji Piperidine derivatives and hyportensives containing the same

Also Published As

Publication number Publication date
ATE124045T1 (de) 1995-07-15
JPH089616B2 (ja) 1996-01-31
EP0552292A1 (de) 1993-07-28
DE69110685T2 (de) 1995-11-09
EP0552292B1 (de) 1995-06-21
CA2093797C (en) 1998-09-22
JPH05508661A (ja) 1993-12-02
HK186696A (en) 1996-10-11
US5393753A (en) 1995-02-28
WO1992006981A1 (en) 1992-04-30
CA2093797A1 (en) 1992-04-11
AU8902591A (en) 1992-05-20

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee