PE20030613A1 - Compuestos de 1h-quinolin-2-ona sustituidos - Google Patents
Compuestos de 1h-quinolin-2-ona sustituidosInfo
- Publication number
- PE20030613A1 PE20030613A1 PE2002001054A PE2002001054A PE20030613A1 PE 20030613 A1 PE20030613 A1 PE 20030613A1 PE 2002001054 A PE2002001054 A PE 2002001054A PE 2002001054 A PE2002001054 A PE 2002001054A PE 20030613 A1 PE20030613 A1 PE 20030613A1
- Authority
- PE
- Peru
- Prior art keywords
- quinolin
- hydroxy
- alkyl
- compounds
- substitute
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
Abstract
SE REFIERE A COMPUESTOS DE 1H-QUINOLIN-2-ONA SUSTITUIDOS DE FORMULA I DONDE R1, R2, R3 Y R4 SON ALQUILO C1-C10, CICLOALQUILO C3-C7 CON H, HALO, OH; R5 ES H, ALQUJILO C1-C10, ARILO, HETEROARILO, ENTRE OTROS; R6 ES OH, OR7 DONDE R7 ES ALQUILO C1-C10, CICLOALQUILO, C3-C6; A ES UN PUENTE DE FORMULA -(CH2)3-, -CH2-CH=CH-, -CH2COO-, -CH2CONH-, ENTRE OTROS; X ES UN HETEROCICLO. SON COMPUESTOS PREFERIDOS 2'-(7-CLORO-4-HIDROXI-2-OXO-1,2-DIHIDROQUINOLIN-3-IL)-N-[3''-(N,N-DIMETILAMINOMETIL)-4''-HIDROXI-4''-(m-METOXIFENIL)CICLOHEXIL]ACETAMIDA, 2'-(7-CLORO-4-METOXI-2-OXO-1,2-DIHIDROQUINOLIN-3-IL)-N-[3''-(N,N-DIMETILAMINOMETIL)-4''-HIDROXI-4''-(m-METOXIFENIL)CICLOHEXIL]ACETAMIDA, ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO PARA LA PREPARACION. LOS COMPUESTOS MENCIONADOS SON UTILES PARA EL TRATAMIENTO DEL DOLOR
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10153347A DE10153347A1 (de) | 2001-10-29 | 2001-10-29 | Substituierte 1H-Chinolin-2-on-Verbindungen |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20030613A1 true PE20030613A1 (es) | 2003-07-26 |
Family
ID=7704097
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2002001054A PE20030613A1 (es) | 2001-10-29 | 2002-10-28 | Compuestos de 1h-quinolin-2-ona sustituidos |
Country Status (11)
Country | Link |
---|---|
US (1) | US20040224980A1 (es) |
EP (1) | EP1442021A1 (es) |
JP (1) | JP2005511567A (es) |
AR (1) | AR037250A1 (es) |
CA (1) | CA2465306A1 (es) |
DE (1) | DE10153347A1 (es) |
HU (1) | HUP0401831A2 (es) |
MX (1) | MXPA04004090A (es) |
PE (1) | PE20030613A1 (es) |
PL (1) | PL369829A1 (es) |
WO (1) | WO2003037870A1 (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9108948B2 (en) | 2006-06-23 | 2015-08-18 | Abbvie Inc. | Cyclopropyl amine derivatives |
TW200808773A (en) | 2006-06-23 | 2008-02-16 | Abbott Lab | Cyclopropyl amine derivatives |
US9186353B2 (en) | 2009-04-27 | 2015-11-17 | Abbvie Inc. | Treatment of osteoarthritis pain |
US8853390B2 (en) | 2010-09-16 | 2014-10-07 | Abbvie Inc. | Processes for preparing 1,2-substituted cyclopropyl derivatives |
CN112759546B (zh) * | 2019-11-06 | 2022-08-26 | 复旦大学 | 3-(二甲氨基甲基)哌啶-4-醇衍生物及其制备方法和药物用途 |
CN112759587B (zh) * | 2019-11-06 | 2022-12-30 | 复旦大学 | 3-(二甲氨基甲基)哌啶-4-醇类衍生物及其制备方法和药物用途 |
CN112759544B (zh) * | 2019-11-06 | 2022-08-26 | 复旦大学 | 3-(二甲氨基甲基)哌啶-4-醇衍生物制备方法和药物用途 |
WO2021088758A1 (zh) * | 2019-11-06 | 2021-05-14 | 复旦大学 | 一类阿片受体激动剂及其制备方法和药物用途 |
CN112759545B (zh) * | 2019-11-06 | 2022-12-13 | 复旦大学 | 3-(二甲氨基甲基)哌啶-4-醇类衍生物及其制备方法和药物用途 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19525137C2 (de) * | 1995-07-11 | 2003-02-27 | Gruenenthal Gmbh | 6-Dimethylaminomethyl-1-phenyl-cyclohexanverbin -dungen als Zwischenprodukte zur Herstellung pharmazeutischer Wirkstoffe |
PL199781B1 (pl) * | 1999-10-25 | 2008-10-31 | Active Biotech Ab | Nowe związki pochodne chinoliny, zastosowanie związków pochodnych chinoliny, zawierające je kompozycje farmaceutyczne i sposób ich wytwarzania |
DE10049481A1 (de) * | 2000-09-29 | 2002-05-02 | Gruenenthal Gmbh | Substituierte C-Cyclohexylmethylamin-Derivate |
-
2001
- 2001-10-29 DE DE10153347A patent/DE10153347A1/de not_active Withdrawn
-
2002
- 2002-10-23 JP JP2003540152A patent/JP2005511567A/ja active Pending
- 2002-10-23 EP EP02782979A patent/EP1442021A1/de not_active Withdrawn
- 2002-10-23 PL PL02369829A patent/PL369829A1/xx not_active Application Discontinuation
- 2002-10-23 CA CA002465306A patent/CA2465306A1/en not_active Abandoned
- 2002-10-23 HU HU0401831A patent/HUP0401831A2/hu unknown
- 2002-10-23 WO PCT/EP2002/011833 patent/WO2003037870A1/de not_active Application Discontinuation
- 2002-10-23 MX MXPA04004090A patent/MXPA04004090A/es not_active Application Discontinuation
- 2002-10-28 PE PE2002001054A patent/PE20030613A1/es not_active Application Discontinuation
- 2002-10-29 AR ARP020104099A patent/AR037250A1/es unknown
-
2004
- 2004-04-26 US US10/832,191 patent/US20040224980A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JP2005511567A (ja) | 2005-04-28 |
CA2465306A1 (en) | 2003-05-08 |
DE10153347A1 (de) | 2003-05-08 |
EP1442021A1 (de) | 2004-08-04 |
HUP0401831A2 (hu) | 2004-12-28 |
WO2003037870A1 (de) | 2003-05-08 |
PL369829A1 (en) | 2005-05-02 |
MXPA04004090A (es) | 2004-07-08 |
AR037250A1 (es) | 2004-11-03 |
US20040224980A1 (en) | 2004-11-11 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant, registration | ||
FD | Application declared void or lapsed |