DE69109376D1 - Hemmung von Muskelschwund und Proteinabbau von Muskeln bei Säugetieren durch Tetrazyklines. - Google Patents

Hemmung von Muskelschwund und Proteinabbau von Muskeln bei Säugetieren durch Tetrazyklines.

Info

Publication number
DE69109376D1
DE69109376D1 DE69109376T DE69109376T DE69109376D1 DE 69109376 D1 DE69109376 D1 DE 69109376D1 DE 69109376 T DE69109376 T DE 69109376T DE 69109376 T DE69109376 T DE 69109376T DE 69109376 D1 DE69109376 D1 DE 69109376D1
Authority
DE
Germany
Prior art keywords
tetracyclines
mammals
muscles
inhibition
antimicrobial
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69109376T
Other languages
English (en)
Other versions
DE69109376T2 (de
Inventor
Bruce Schneider
Robert A Greenwald
Jonathan Maimon
Kenneth Gorray
Lorne M Golub
Thomas F Mcnamara
Nangavarum S Ramamurthy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Research Foundation of State University of New York
Original Assignee
Research Foundation of State University of New York
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Research Foundation of State University of New York filed Critical Research Foundation of State University of New York
Application granted granted Critical
Publication of DE69109376D1 publication Critical patent/DE69109376D1/de
Publication of DE69109376T2 publication Critical patent/DE69109376T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
DE69109376T 1990-06-28 1991-06-27 Hemmung von Muskelschwund und Proteinabbau von Muskeln bei Säugetieren durch Tetrazyklines. Expired - Fee Related DE69109376T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/545,395 US5045538A (en) 1990-06-28 1990-06-28 Inhibition of wasting and protein degradation of mammalian muscle by tetracyclines

Publications (2)

Publication Number Publication Date
DE69109376D1 true DE69109376D1 (de) 1995-06-08
DE69109376T2 DE69109376T2 (de) 1995-09-07

Family

ID=24176048

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69109376T Expired - Fee Related DE69109376T2 (de) 1990-06-28 1991-06-27 Hemmung von Muskelschwund und Proteinabbau von Muskeln bei Säugetieren durch Tetrazyklines.

Country Status (9)

Country Link
US (1) US5045538A (de)
EP (1) EP0464932B1 (de)
JP (1) JP3148284B2 (de)
AT (1) ATE121938T1 (de)
CA (1) CA2045885C (de)
DE (1) DE69109376T2 (de)
DK (1) DK0464932T3 (de)
ES (1) ES2075331T3 (de)
IE (1) IE67541B1 (de)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3016587B2 (ja) * 1989-12-04 2000-03-06 ザ・リサーチ・ファンデーション・オブ・ステート・ユニバーシティ・オブ・ニューヨーク 非ステロイド抗炎症剤及びテトラサイクリンの配合
US5308839A (en) * 1989-12-04 1994-05-03 The Research Foundation Of State University Of New York Composition comprising non-steroidal anti-inflammatory agent tenidap and effectively non-antibacterial tetracycline
US5770588A (en) * 1991-02-11 1998-06-23 The Research Foundation Of State University Of New York Non-antibacterial tetracycline compositions of the prevention and treatment of root caries
US5494903A (en) 1991-10-04 1996-02-27 American Cyanamid Company 7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines
USRE40183E1 (en) 1991-10-04 2008-03-25 Wyeth Holdings Corporation 7-Substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines
EP0599397B1 (de) * 1992-11-17 1996-08-28 The Research Foundation Of State University Of New York Tetracycline inclusive nicht antimicrobiel wirksame, chemisch modifizierte Tetracycline hemmende exzessive Kollagenquervernetzung bei Diabetes
US6043231A (en) * 1993-03-02 2000-03-28 The Research Foundation Of State Univ. Of New York Inhibition of excessive phospholipase A2 activity and/or production by non-antimicrobial tetracyclines
US5523297A (en) * 1993-03-02 1996-06-04 The Research Foundation Of State University Of New York Inhibition of excessive phospholipase A2 activity and/or production by non-antimicrobial tetracyclines
US5668122A (en) * 1993-07-28 1997-09-16 Fife; Rose S. Method to treat cancer with tetracyclines
US6777217B1 (en) 1996-03-26 2004-08-17 President And Fellows Of Harvard College Histone deacetylases, and uses related thereto
US5773430A (en) * 1997-03-13 1998-06-30 Research Foundation Of State University Of New York Serine proteinase inhibitory activity by hydrophobic tetracycline
US5929055A (en) * 1997-06-23 1999-07-27 The Research Foundation Of State University Of New York Therapeutic method for management of diabetes mellitus
PT1041991E (pt) * 1997-12-19 2008-10-03 Univ New York Tetraciclinas não antibacterianas para o tratamento de esclerose múltipla
US6015804A (en) * 1998-09-11 2000-01-18 The Research Foundation Of State University Of New York Method of using tetracycline compounds to enhance interleukin-10 production
US5977091A (en) * 1998-09-21 1999-11-02 The Research Foundation Of State University Of New York Method of preventing acute lung injury
US6946453B2 (en) 1998-11-18 2005-09-20 Collagenex Pharmaceuticals, Inc. 4-dedimethylaminotracycline derivatives
ES2272097T3 (es) * 1998-11-18 2007-04-16 Collagenex Pharmaceuticals, Inc. Nuevos derivados de 4-desdimetilaminotetraciclina.
US6506740B1 (en) 1998-11-18 2003-01-14 Robert A. Ashley 4-dedimethylaminotetracycline derivatives
US20030129724A1 (en) 2000-03-03 2003-07-10 Grozinger Christina M. Class II human histone deacetylases, and uses related thereto
US7211267B2 (en) 2001-04-05 2007-05-01 Collagenex Pharmaceuticals, Inc. Methods of treating acne
NZ529308A (en) 2001-04-05 2005-03-24 Collagenex Pharm Inc Tetracycline compounds comprising a tetracycline and a controlled release agent to provide delivery at a dose below that required for antibiotic activity
US7244853B2 (en) 2001-05-09 2007-07-17 President And Fellows Of Harvard College Dioxanes and uses thereof
WO2003030819A2 (en) * 2001-10-05 2003-04-17 Tetragenex Pharmaceuticals, Inc. Tetracycline derivatives and methods of use thereof
AU2002357370A1 (en) * 2001-12-20 2003-07-09 Hartmut M. Hanauske-Abel Treatment for averting or delaying premature delivery
CA2475202A1 (en) 2002-03-29 2003-10-09 The Research Foundation Of State University Of New York Use of non-antibacterial tetracycline analogs and formulations thereof for the treatment of bacterial exotoxins
US6958161B2 (en) 2002-04-12 2005-10-25 F H Faulding & Co Limited Modified release coated drug preparation
CA2521885C (en) 2003-04-07 2013-06-25 Shire Laboratories, Inc. Once daily formulations of tetracyclines
EP2491926B1 (de) 2005-03-22 2018-05-09 President and Fellows of Harvard College Behandlung von Proteinabbaustörungen
MX2008010462A (es) 2006-02-14 2009-04-17 Harvard College Inhibidores de histona desacetilasa.
CN101400362B (zh) * 2006-02-14 2016-10-12 哈佛大学校长及研究员协会 双官能组蛋白去乙酰化酶抑制剂
CA2654540C (en) * 2006-05-03 2017-01-17 President And Fellows Of Harvard College Histone deacetylase and tubulin deacetylase inhibitors
RU2515611C2 (ru) 2008-07-23 2014-05-20 Президент Энд Феллоуз Оф Гарвард Колледж Ингибиторы деацетилазы и их применение
WO2011019393A2 (en) 2009-08-11 2011-02-17 President And Fellows Of Harvard College Class- and isoform-specific hdac inhibitors and uses thereof
WO2017042198A2 (en) * 2015-09-08 2017-03-16 Ecole Polytechnique Federale De Lausanne (Epfl) Agents and methods using thereof for the prevention and treatment of stem cell muscle disorders
EP3347023A2 (de) * 2015-09-08 2018-07-18 Ecole Polytechnique Federale de Lausanne (EPFL) Mittel sowie verfahren zu deren verwendung zur vorbeugung und behandlung der seneszenz von stammzellen

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4666897A (en) * 1983-12-29 1987-05-19 Research Foundation Of State University Inhibition of mammalian collagenolytic enzymes by tetracyclines
US4935412A (en) * 1983-12-29 1990-06-19 The Research Foundation Of State University Of New York Non-antibacterial tetracycline compositions possessing anti-collagenolytic properties and methods of preparing and using same
US4925833A (en) * 1983-12-29 1990-05-15 The Research Foundation Of State University Of New York Use of tetracycline to enhance bone protein synthesis and/or treatment of osteoporosis
US4704383A (en) * 1983-12-29 1987-11-03 The Research Foundation Of State University Of New York Non-antibacterial tetracycline compositions possessing anti-collagenolytic properties and methods of preparing and using same

Also Published As

Publication number Publication date
IE912242A1 (en) 1992-01-01
EP0464932B1 (de) 1995-05-03
IE67541B1 (en) 1996-04-17
JP3148284B2 (ja) 2001-03-19
EP0464932A3 (en) 1992-04-01
US5045538A (en) 1991-09-03
ES2075331T3 (es) 1995-10-01
ATE121938T1 (de) 1995-05-15
JPH04230323A (ja) 1992-08-19
DE69109376T2 (de) 1995-09-07
CA2045885C (en) 2003-05-13
DK0464932T3 (da) 1995-07-17
CA2045885A1 (en) 1991-12-29
EP0464932A2 (de) 1992-01-08

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee