DE69107207T2 - Disulfidderivate von mercapto-acyl-aminsäuren. - Google Patents

Disulfidderivate von mercapto-acyl-aminsäuren.

Info

Publication number
DE69107207T2
DE69107207T2 DE69107207T DE69107207T DE69107207T2 DE 69107207 T2 DE69107207 T2 DE 69107207T2 DE 69107207 T DE69107207 T DE 69107207T DE 69107207 T DE69107207 T DE 69107207T DE 69107207 T2 DE69107207 T2 DE 69107207T2
Authority
DE
Germany
Prior art keywords
lower alkyl
aryl
heteroaryl
alkyl
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69107207T
Other languages
English (en)
Other versions
DE69107207D1 (de
Inventor
Martin Haslanger
Bernard Neustadt
Elizabeth Smith
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme Corp
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of DE69107207D1 publication Critical patent/DE69107207D1/de
Publication of DE69107207T2 publication Critical patent/DE69107207T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE69107207T 1990-05-17 1991-05-15 Disulfidderivate von mercapto-acyl-aminsäuren. Expired - Fee Related DE69107207T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52537090A 1990-05-17 1990-05-17
PCT/US1991/003251 WO1991017980A1 (en) 1990-05-17 1991-05-15 Disulfide derivatives of mercaptoacylamino acids

Publications (2)

Publication Number Publication Date
DE69107207D1 DE69107207D1 (de) 1995-03-16
DE69107207T2 true DE69107207T2 (de) 1995-06-29

Family

ID=24092967

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69107207T Expired - Fee Related DE69107207T2 (de) 1990-05-17 1991-05-15 Disulfidderivate von mercapto-acyl-aminsäuren.

Country Status (14)

Country Link
EP (1) EP0528997B1 (de)
JP (1) JPH06102648B2 (de)
AT (1) ATE117988T1 (de)
AU (1) AU7957291A (de)
DE (1) DE69107207T2 (de)
DK (1) DK0528997T3 (de)
ES (1) ES2069893T3 (de)
GR (1) GR3015801T3 (de)
IE (1) IE911666A1 (de)
IL (1) IL98149A0 (de)
NZ (1) NZ238154A (de)
PT (1) PT97669A (de)
WO (1) WO1991017980A1 (de)
ZA (1) ZA913685B (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6153650A (en) * 1996-10-23 2000-11-28 Warner-Lambert Company Substituted gamma aminobutyric acids as pharmaceutical agents

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4173704A (en) * 1976-05-10 1979-11-06 E. R. Squibb & Sons, Inc. Dithio aminoacid derivatives
US4053651A (en) * 1976-05-10 1977-10-11 E. R. Squibb & Sons, Inc. Compounds and method for alleviating angiotensin related hypertension
CH637374A5 (en) * 1977-12-02 1983-07-29 Squibb & Sons Inc Substituted amino acids
US4329495A (en) * 1981-05-18 1982-05-11 Pfizer Inc. Enkephalinase enzyme inhibiting compounds
DE3467754D1 (de) * 1983-10-03 1988-01-07 Squibb & Sons Inc Enkephalinase inhibitors
JPS60136554A (ja) * 1983-10-03 1985-07-20 イ−・ア−ル・スクイブ・アンド・サンズ・インコ−ポレイテッド エンケフアリナ−ゼ抑制剤
FR2556721B1 (fr) * 1983-12-14 1986-05-16 Roussel Uclaf Nouveaux derives de o-mercaptopropanamide d'o amino-acides, leur procede de preparation, leur application comme medicaments et les compositions les renfermant
DE3814374A1 (de) * 1988-04-28 1989-11-09 Joerg Schwarzbich Kugelraste

Also Published As

Publication number Publication date
JPH05502038A (ja) 1993-04-15
PT97669A (pt) 1992-02-28
ZA913685B (en) 1992-02-26
EP0528997B1 (de) 1995-02-01
DE69107207D1 (de) 1995-03-16
NZ238154A (en) 1993-07-27
JPH06102648B2 (ja) 1994-12-14
IE911666A1 (en) 1991-11-20
WO1991017980A1 (en) 1991-11-28
DK0528997T3 (da) 1995-04-24
GR3015801T3 (en) 1995-07-31
ATE117988T1 (de) 1995-02-15
ES2069893T3 (es) 1995-05-16
AU7957291A (en) 1991-12-10
IL98149A0 (en) 1992-06-21
EP0528997A1 (de) 1993-03-03

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee