ES2069893T3 - Derivados de disulfuros de mercaptoacilaminoacidos. - Google Patents

Derivados de disulfuros de mercaptoacilaminoacidos.

Info

Publication number
ES2069893T3
ES2069893T3 ES91911546T ES91911546T ES2069893T3 ES 2069893 T3 ES2069893 T3 ES 2069893T3 ES 91911546 T ES91911546 T ES 91911546T ES 91911546 T ES91911546 T ES 91911546T ES 2069893 T3 ES2069893 T3 ES 2069893T3
Authority
ES
Spain
Prior art keywords
lower alkyl
aryl
heteroaryl
alkyl
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91911546T
Other languages
English (en)
Inventor
Martin F Haslanger
Bernard R Neustadt
Elizabeth M Smith
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme Corp
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of ES2069893T3 publication Critical patent/ES2069893T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE PRESENTAN NUEVOS DERIVADOS DISULFUROS DE ACIDO MERCATPACILAMINO DE LA FORMULA (I) Y (II), EN LAS QUE R1 ES ALQUIL INFERIOR, CICLOALQUIL INFERIOR, ARIL O HETEROARIL; R2 ES HIDROGENO; ALQUIL INFERIOR; CICLOALQUIL INFERIOR; ALQUIL INFERIOR SUBSTITUIDO CON HIDROXIDO, ALCOXIDO INFERIOR, MERCAPTO, ALQUILTIO INFERIOR, HETEROARIL DE ARIL, ARALQUILOXIDO O ALQUILTIO; ARIL; O HETEROARIL; R3 ES -OR5 O -NR5R6; R4 Y R9 SON INDEPENDIETEMENTE -(CH2)QR8; R5 Y R6 ESTAN IDEPENDIENTEMENTE SELECCIONADAS ENTRE EL GRUPO QUE CONSTA DE HIDROGENO, ALQUIL INFERIOR, ALQUIL INFERIOR DE HIDROXIDO, ALQUIL INFERIOR DE ALCOXIDO INFERIOR Y ALQUIL INFERIOR DE ARIL, O R5 Y R67 JUNTO CON EL ATOMO DE NITROGENO AL CUAL ESTAN SUJETAS FORMAN UN ANILLO DE ENTRE 5 Y 7 MIEMBROS; R7 ES FENIL SUBSTITUIDO POR ENTRE 1 Y 3 SUBSTITUYENTES SELECCIONADOS ENTRE EL GRUPO QUE CONSTA DE ALQUIL INFERIOR, ACOXIDO INFERIOR, CICLOALQUIL, CIANO Y AMINOETIL; R6 ES HIDROGENO, HIDROXIDO, ALCOXIDO INFERIOR, MERCAPTO, ALQUILTIO INFERIOR, ARIL O HETEROARIL; N ES 1 O 2; P ES 0 O 1; Q ES 0, 1 O 2; T ES 0 O 1; ASIMISMO SE PRESENTAN LAS SALES FARMACEUTICAMENTE ACEPTABLES DE LOS MISMOS UTILES EN EL TRATAMIENTO DE ENFERMEDADES CARDIOVASCULARES Y ESTADOS DE DOLOR Y COMBINACIONES DE DERIVADOS DE DISULFURO DE ACIDO MERCAPTOLAMINO Y FACTORES NATRIURETICOS O INHIBIDORES DE LA ENZIMA DE CONVERSION DE LA ANGIOTENSINA UTILES EN EL TRATAMIENTO DE ENFERMEDADES CARDIOVASCULARES.
ES91911546T 1990-05-17 1991-05-15 Derivados de disulfuros de mercaptoacilaminoacidos. Expired - Lifetime ES2069893T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US52537090A 1990-05-17 1990-05-17

Publications (1)

Publication Number Publication Date
ES2069893T3 true ES2069893T3 (es) 1995-05-16

Family

ID=24092967

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91911546T Expired - Lifetime ES2069893T3 (es) 1990-05-17 1991-05-15 Derivados de disulfuros de mercaptoacilaminoacidos.

Country Status (14)

Country Link
EP (1) EP0528997B1 (es)
JP (1) JPH06102648B2 (es)
AT (1) ATE117988T1 (es)
AU (1) AU7957291A (es)
DE (1) DE69107207T2 (es)
DK (1) DK0528997T3 (es)
ES (1) ES2069893T3 (es)
GR (1) GR3015801T3 (es)
IE (1) IE911666A1 (es)
IL (1) IL98149A0 (es)
NZ (1) NZ238154A (es)
PT (1) PT97669A (es)
WO (1) WO1991017980A1 (es)
ZA (1) ZA913685B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69737719D1 (de) * 1996-10-23 2007-06-21 Warner Lambert Co Substituierte gamma-aminobuttersäurederivate als arzneimittel

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4173704A (en) * 1976-05-10 1979-11-06 E. R. Squibb & Sons, Inc. Dithio aminoacid derivatives
US4053651A (en) * 1976-05-10 1977-10-11 E. R. Squibb & Sons, Inc. Compounds and method for alleviating angiotensin related hypertension
CH637374A5 (en) * 1977-12-02 1983-07-29 Squibb & Sons Inc Substituted amino acids
US4329495A (en) * 1981-05-18 1982-05-11 Pfizer Inc. Enkephalinase enzyme inhibiting compounds
EP0136883B1 (en) * 1983-10-03 1987-11-25 E.R. Squibb & Sons, Inc. Enkephalinase inhibitors
JPS60136554A (ja) * 1983-10-03 1985-07-20 イ−・ア−ル・スクイブ・アンド・サンズ・インコ−ポレイテッド エンケフアリナ−ゼ抑制剤
FR2556721B1 (fr) * 1983-12-14 1986-05-16 Roussel Uclaf Nouveaux derives de o-mercaptopropanamide d'o amino-acides, leur procede de preparation, leur application comme medicaments et les compositions les renfermant
DE3814374A1 (de) * 1988-04-28 1989-11-09 Joerg Schwarzbich Kugelraste

Also Published As

Publication number Publication date
JPH05502038A (ja) 1993-04-15
DK0528997T3 (da) 1995-04-24
ZA913685B (en) 1992-02-26
DE69107207T2 (de) 1995-06-29
WO1991017980A1 (en) 1991-11-28
NZ238154A (en) 1993-07-27
IL98149A0 (en) 1992-06-21
EP0528997A1 (en) 1993-03-03
DE69107207D1 (de) 1995-03-16
JPH06102648B2 (ja) 1994-12-14
EP0528997B1 (en) 1995-02-01
AU7957291A (en) 1991-12-10
ATE117988T1 (de) 1995-02-15
IE911666A1 (en) 1991-11-20
GR3015801T3 (en) 1995-07-31
PT97669A (pt) 1992-02-28

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