DE69029615D1 - Protein- und Polypeptidvarianten mit erhöhter Affinität für metallgebundene Affinitätsmatrizen - Google Patents
Protein- und Polypeptidvarianten mit erhöhter Affinität für metallgebundene AffinitätsmatrizenInfo
- Publication number
- DE69029615D1 DE69029615D1 DE69029615T DE69029615T DE69029615D1 DE 69029615 D1 DE69029615 D1 DE 69029615D1 DE 69029615 T DE69029615 T DE 69029615T DE 69029615 T DE69029615 T DE 69029615T DE 69029615 D1 DE69029615 D1 DE 69029615D1
- Authority
- DE
- Germany
- Prior art keywords
- protein
- metal
- affinity
- polypeptide variants
- bound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 102000004169 proteins and genes Human genes 0.000 title abstract 5
- 108090000623 proteins and genes Proteins 0.000 title abstract 5
- 229920001184 polypeptide Polymers 0.000 title abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
- 239000002184 metal Substances 0.000 title abstract 2
- 235000018102 proteins Nutrition 0.000 abstract 4
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 125000000539 amino acid group Chemical group 0.000 abstract 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N aspartic acid group Chemical group N[C@@H](CC(=O)O)C(=O)O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 abstract 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 abstract 1
- 229920005989 resin Polymers 0.000 abstract 1
- 239000011347 resin Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Feed For Specific Animals (AREA)
- Fodder In General (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/383,778 US5115102A (en) | 1989-07-21 | 1989-07-21 | Variant proteins and polypeptides possessing enhanced affinity for immobilized-metal affinity matrices |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69029615D1 true DE69029615D1 (de) | 1997-02-20 |
| DE69029615T2 DE69029615T2 (de) | 1997-06-12 |
Family
ID=23514691
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69029615T Expired - Fee Related DE69029615T2 (de) | 1989-07-21 | 1990-07-16 | Protein- und Polypeptidvarianten mit erhöhter Affinität für metallgebundene Affinitätsmatrizen |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5115102A (de) |
| EP (1) | EP0409814B1 (de) |
| JP (1) | JP3576161B2 (de) |
| AT (1) | ATE147433T1 (de) |
| CA (1) | CA2021722C (de) |
| DE (1) | DE69029615T2 (de) |
| DK (1) | DK0409814T3 (de) |
| ES (1) | ES2096584T3 (de) |
| GR (1) | GR3023052T3 (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5821088A (en) * | 1990-05-11 | 1998-10-13 | Siga Pharmaceuticals, Inc. | Use of gram-positive bacteria to express recombinant proteins |
| AU9113991A (en) * | 1990-11-19 | 1992-06-11 | Biotechnology Research And Development Corporation | Mutant orientable proteins and coated substrates |
| US5646016A (en) * | 1991-02-06 | 1997-07-08 | Genetics Institute, Inc. | Peptide and protein fusions to thioredoxin, thioredoxin-like molecules, and modified thioredoxin-like molecules |
| DE4105480A1 (de) * | 1991-02-21 | 1992-08-27 | Boehringer Mannheim Gmbh | Verbesserte aktivierung von rekombinanten proteinen |
| WO1996007744A1 (en) * | 1994-09-08 | 1996-03-14 | Chiron Corporation | A method of improved production of insulin-like growth factor |
| US6068993A (en) * | 1997-07-02 | 2000-05-30 | Biobras Sa | Vector for expression of heterologous protein and methods for extracting recombinant protein and for purifying isolated recombinant insulin |
| US5932102A (en) * | 1998-01-12 | 1999-08-03 | Schering Corporation | Immobilized metal, affinity chromatography |
| DE19822823A1 (de) * | 1998-05-20 | 2000-02-10 | Basf Ag | Neue Peptidfragmente zur Reinigung von Proteinen |
| US20100233678A1 (en) * | 2007-11-13 | 2010-09-16 | Beadling Leslie C | Tunable affinity ligands for the separation and detection of target substances |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4569794A (en) * | 1984-12-05 | 1986-02-11 | Eli Lilly And Company | Process for purifying proteins and compounds useful in such process |
| JP3155984B2 (ja) * | 1987-04-06 | 2001-04-16 | ノヴォザイムズ・アクティーゼルスカブ | タンパク質の安定化のための金属イオン結合部位における静電的相互作用の操作 |
-
1989
- 1989-07-21 US US07/383,778 patent/US5115102A/en not_active Expired - Lifetime
-
1990
- 1990-07-16 DK DK90870109.7T patent/DK0409814T3/da active
- 1990-07-16 AT AT90870109T patent/ATE147433T1/de not_active IP Right Cessation
- 1990-07-16 EP EP90870109A patent/EP0409814B1/de not_active Expired - Lifetime
- 1990-07-16 DE DE69029615T patent/DE69029615T2/de not_active Expired - Fee Related
- 1990-07-16 ES ES90870109T patent/ES2096584T3/es not_active Expired - Lifetime
- 1990-07-20 JP JP19379990A patent/JP3576161B2/ja not_active Expired - Fee Related
- 1990-07-20 CA CA002021722A patent/CA2021722C/en not_active Expired - Lifetime
-
1997
- 1997-04-07 GR GR970400719T patent/GR3023052T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK0409814T3 (da) | 1997-06-30 |
| EP0409814B1 (de) | 1997-01-08 |
| JP3576161B2 (ja) | 2004-10-13 |
| CA2021722A1 (en) | 1991-01-22 |
| JPH03101693A (ja) | 1991-04-26 |
| EP0409814A1 (de) | 1991-01-23 |
| CA2021722C (en) | 2002-12-17 |
| ES2096584T3 (es) | 1997-03-16 |
| GR3023052T3 (en) | 1997-07-30 |
| US5115102A (en) | 1992-05-19 |
| ATE147433T1 (de) | 1997-01-15 |
| DE69029615T2 (de) | 1997-06-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |