DE69023844D1 - Acyloxymethylester der Bisphonsäuren als Knochenresorptions-Inhibitoren. - Google Patents

Acyloxymethylester der Bisphonsäuren als Knochenresorptions-Inhibitoren.

Info

Publication number
DE69023844D1
DE69023844D1 DE69023844T DE69023844T DE69023844D1 DE 69023844 D1 DE69023844 D1 DE 69023844D1 DE 69023844 T DE69023844 T DE 69023844T DE 69023844 T DE69023844 T DE 69023844T DE 69023844 D1 DE69023844 D1 DE 69023844D1
Authority
DE
Germany
Prior art keywords
bisphonic
acids
bone resorption
resorption inhibitors
acyloxymethyl ester
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69023844T
Other languages
English (en)
Other versions
DE69023844T2 (de
Inventor
Walfred S Saari
Paul S Anderson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of DE69023844D1 publication Critical patent/DE69023844D1/de
Publication of DE69023844T2 publication Critical patent/DE69023844T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/40—Esters thereof
    • C07F9/4071—Esters thereof the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4075—Esters with hydroxyalkyl compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4025—Esters of poly(thio)phosphonic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/58—Pyridine rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/59—Hydrogenated pyridine rings
DE69023844T 1989-09-06 1990-08-29 Acyloxymethylester der Bisphonsäuren als Knochenresorptions-Inhibitoren. Expired - Fee Related DE69023844T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US40341189A 1989-09-06 1989-09-06

Publications (2)

Publication Number Publication Date
DE69023844D1 true DE69023844D1 (de) 1996-01-11
DE69023844T2 DE69023844T2 (de) 1996-06-20

Family

ID=23595658

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69023844T Expired - Fee Related DE69023844T2 (de) 1989-09-06 1990-08-29 Acyloxymethylester der Bisphonsäuren als Knochenresorptions-Inhibitoren.

Country Status (5)

Country Link
EP (1) EP0416689B1 (de)
JP (1) JPH07119230B2 (de)
CA (1) CA2024694C (de)
DE (1) DE69023844T2 (de)
LV (1) LV11473B (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2114946T3 (es) * 1991-09-05 1998-06-16 Toray Industries Derivado de acido metanodifosfonico, su produccion y uso medicinal.
US5283057A (en) * 1992-04-24 1994-02-01 The Procter & Gamble Company Risedronate in oral compositions
HUT69699A (en) * 1992-05-29 1995-09-28 Procter & Gamble Pharma Sulfur-containing phosphonate compounds for treating abnormal calcium and phosphate metabolism
NZ272608A (en) 1994-07-22 2000-05-26 Lilly Co Eli Inhibiting bone loss by administering a bisphosphonate and a second compound selected from various compounds, including 2-phenyl-3-aroylbenzothienes; bisphosphonate combination salts
SE9703691D0 (sv) * 1997-10-10 1997-10-10 Astra Ab Pharmaceutical compositions
FI104901B (fi) * 1997-10-20 2000-04-28 Leiras Oy Uudet metyleenibisfosfonihappojohdannaiset
US6818787B2 (en) 2001-06-11 2004-11-16 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
FR2837490B1 (fr) * 2002-03-21 2009-04-17 Univ Paris 13 Nouveaux derives de bisphosphonates, leurs preparations et utilisations
CA2451881A1 (fr) * 2001-07-16 2003-01-30 Universite Paris 13 Nouveaux derives de bisphosphonates, leurs preparations et utilisations
US6927036B2 (en) 2002-02-19 2005-08-09 Xero Port, Inc. Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof
US7662987B2 (en) 2003-07-15 2010-02-16 Xenoport, Inc. Methods for synthesis of acyloxyalkyl compounds
KR101140559B1 (ko) 2003-08-20 2012-07-05 제노포트 인코포레이티드 아실옥시알킬 카르바메이트 프로드러그, 합성 및 사용 방법
EP1716115B1 (de) 2003-12-30 2013-02-27 XenoPort, Inc. Synthese von acyloxyalkylcarbamat-prodrugs und zwischenprodukten davon
JP4938771B2 (ja) 2005-06-20 2012-05-23 ゼノポート，インコーポレーテッド トラネキサム酸のカルバミン酸アシルオキシアルキルプロドラッグ、合成法、および使用
US7531572B2 (en) 2006-07-28 2009-05-12 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs of α-amino acids, methods of synthesis and use

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2534391C2 (de) * 1975-08-01 1983-01-13 Henkel KGaA, 4000 Düsseldorf 1-Hydroxy-3-aminoalkan-1,1-diphosphonsäuren
DE2745083C2 (de) * 1977-10-07 1985-05-02 Henkel KGaA, 4000 Düsseldorf Hydroxydiphosphonsäuren und Verfahren zu deren Herstellung
FR2531088B1 (fr) * 1982-07-29 1987-08-28 Sanofi Sa Produits anti-inflammatoires derives de l'acide methylenediphosphonique et leur procede de preparation
GB8419489D0 (en) * 1984-07-31 1984-09-05 Leo Pharm Prod Ltd Chemical compounds
GB8530603D0 (en) * 1985-12-12 1986-01-22 Leo Pharm Prod Ltd Chemical compounds
DE3623397A1 (de) * 1986-07-11 1988-01-14 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel

Also Published As

Publication number Publication date
EP0416689A3 (en) 1991-06-26
LV11473A (lv) 1996-08-20
LV11473B (en) 1996-12-20
JPH03106893A (ja) 1991-05-07
CA2024694A1 (en) 1991-03-07
JPH07119230B2 (ja) 1995-12-20
DE69023844T2 (de) 1996-06-20
EP0416689B1 (de) 1995-11-29
CA2024694C (en) 2000-10-17
EP0416689A2 (de) 1991-03-13

Similar Documents

Publication Publication Date Title
DE69412540T2 (de) Gleichzeitige Amplifikation von Vielfachzielen
DE69023844D1 (de) Acyloxymethylester der Bisphonsäuren als Knochenresorptions-Inhibitoren.
BR9405802A (pt) Composição de éster epoxídico
DE58904306D1 (de) Verfahren zur kontinuierlichen veresterung von fettsaeuren.
DE69213276D1 (de) Substituierte Piperidimylmethyl-Ester von 3-Indolcarbonsäure
NO903419D0 (no) Fremgangsmaate for rensning av aminometylenfosfonsyrer.
PT88075A (pt) Metodo de isolamento de inibidor do factor de tecido
MX9100998A (es) Novedosos inhibidores de escualen sintetasa
PT923530E (pt) Inibicao de metaloproteases de matriz por acidos biaril oxibutiricos substituidos
DE69014807D1 (de) Alkylester der Rosinsäure.
DK0422975T3 (da) Alfa-Glucosidase-inhibitorer
DK0384211T3 (da) Substituerede acrylsyreestere
FI942581A (fi) Menetelmä 5-bromi-6-metoksi-1-naftoehappometyyliesterin valmistamiseksi
ITTO930519A1 (it) Procedimento di sintesi di acidi cloroacetici.
DE69305714T2 (de) Abspaltbare Carbonsäuren
ID20291A (id) Asam-asam oksobutirat tersubstitusi sebagai penghamba-penghambat matriks metaloproteasa
MX9300026A (es) Procedimiento para la preparacion de benzoesteres y benzoacidos.
DE69707882D1 (de) Carbonylierungsverfahren der pentensäuren
ITRM930260A0 (it) Procedimento per la produzione di acidi perfluoroetercarbossilici.
DE68910029T2 (de) Ester-Derivat von Phenylbicyclohexanol.
DE69002859T2 (de) Verfahren zur Haltbarmachung von Natriumperboratmonohydrat.
FI962306A (fi) Fosforihappojen amidit metallien uuttamiseksi
ES2010642B3 (es) Esteres alquilicos de l-aspartil-3-(bicicloalquil)-l-alanina.
DE69215932T2 (de) Ester von Pregna-21-säure
ATE221519T1 (de) Ester von 3-hydroxy-piperidinmethanol-derivaten

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee