DE69022393D1 - Verbesserte Zusammensetzung, Vorrichtung und Verfahren zur Untersuchung einer peroxidativ aktiven Substanz. - Google Patents

Verbesserte Zusammensetzung, Vorrichtung und Verfahren zur Untersuchung einer peroxidativ aktiven Substanz.

Info

Publication number
DE69022393D1
DE69022393D1 DE69022393T DE69022393T DE69022393D1 DE 69022393 D1 DE69022393 D1 DE 69022393D1 DE 69022393 T DE69022393 T DE 69022393T DE 69022393 T DE69022393 T DE 69022393T DE 69022393 D1 DE69022393 D1 DE 69022393D1
Authority
DE
Germany
Prior art keywords
active substance
indicator
peroxidatively active
assay
improved
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69022393T
Other languages
English (en)
Other versions
DE69022393T2 (de
Inventor
Michael J Pugia
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens Healthcare Diagnostics Inc
Original Assignee
Bayer AG
Bayer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG, Bayer Corp filed Critical Bayer AG
Publication of DE69022393D1 publication Critical patent/DE69022393D1/de
Application granted granted Critical
Publication of DE69022393T2 publication Critical patent/DE69022393T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
    • G01N33/521—Single-layer analytical elements
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • C12Q1/28—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving peroxidase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
    • G01N33/721—Haemoglobin
    • G01N33/725—Haemoglobin using peroxidative activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2326/00—Chromogens for determinations of oxidoreductase enzymes
    • C12Q2326/10—Benzidines
    • C12Q2326/12—3,3',5,5'-Tetramethylbenzidine, i.e. TMB
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/904—Oxidation - reduction indicators

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
DE69022393T 1990-01-30 1990-12-12 Verbesserte Zusammensetzung, Vorrichtung und Verfahren zur Untersuchung einer peroxidativ aktiven Substanz. Expired - Lifetime DE69022393T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/472,295 US5318894A (en) 1990-01-30 1990-01-30 Composition, device and method of assaying for peroxidatively active substances

Publications (2)

Publication Number Publication Date
DE69022393D1 true DE69022393D1 (de) 1995-10-19
DE69022393T2 DE69022393T2 (de) 1996-03-28

Family

ID=23874919

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69022393T Expired - Lifetime DE69022393T2 (de) 1990-01-30 1990-12-12 Verbesserte Zusammensetzung, Vorrichtung und Verfahren zur Untersuchung einer peroxidativ aktiven Substanz.

Country Status (11)

Country Link
US (2) US5318894A (de)
EP (1) EP0444263B1 (de)
JP (1) JP2922003B2 (de)
KR (1) KR0163793B1 (de)
AT (1) ATE127851T1 (de)
AU (1) AU623038B2 (de)
CA (1) CA2025803A1 (de)
DE (1) DE69022393T2 (de)
DK (1) DK0444263T3 (de)
ES (1) ES2078934T3 (de)
GR (1) GR3017415T3 (de)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5830765A (en) * 1993-09-22 1998-11-03 Ranpak Corp. Feline urinary tract disease-detecting paper cat litter and method
US5567621A (en) * 1993-07-14 1996-10-22 Shimadzu Corporation Method of and apparatus for analyzing nitrogen compound and phosphorus compound contained in water
US5702955A (en) * 1995-05-22 1997-12-30 Bayer Corporation Ascorbate resistant detection of hydrogen peroxide
CA2168625A1 (en) * 1996-02-01 1997-08-02 Francois Rousseau Method and device for specifically detecting myoglobin using a non-discriminating peroxidase-sensitive assay
US5885789A (en) * 1997-03-20 1999-03-23 Stc Technologies Incorporated Solution-based assay for peroxidatively-active substances in bodily fluids
SE9602818D0 (sv) * 1996-07-19 1996-07-19 Pharmacia & Upjohn Ab Colored composition
AU8334698A (en) * 1997-07-15 1999-02-10 Kem-En-Tec A/S Pre-stained 3,3',5,5'-tetramethylbenzidine substrates for the detection of enzyme activity
US6121050A (en) * 1997-08-29 2000-09-19 Han; Chi-Neng Arthur Analyte detection systems
CA2249778A1 (en) * 1997-12-15 1999-06-15 Bayer Corporation Competitive apo-peroxidase assay
ES2143434B1 (es) * 1998-09-16 2000-12-16 Cerrato Paula Jimenez Pañal con indicadores sensibles al estado de la orina que lo impregna visualiazables desde el exterior.
US6001656A (en) * 1998-09-28 1999-12-14 Bayer Corporation Method for the detection of creatinine
US6689618B1 (en) 2000-04-03 2004-02-10 Shuenn Tzong Chen Method and test strip of detecting oxidizing adulterant in urine
US6743597B1 (en) * 2000-06-13 2004-06-01 Lifescan, Inc. Compositions containing a urea derivative dye for detecting an analyte and methods for using the same
AU2002314772A1 (en) * 2001-05-09 2002-11-18 Biofx Laboratories, Inc. Stabilizing peroxides with stannous halides
JP4618932B2 (ja) * 2001-05-28 2011-01-26 株式会社同仁化学研究所 塩素濃度の測定用組成物
US7459127B2 (en) * 2002-02-26 2008-12-02 Siemens Healthcare Diagnostics Inc. Method and apparatus for precise transfer and manipulation of fluids by centrifugal and/or capillary forces
US20030170905A1 (en) * 2002-03-05 2003-09-11 Alexander Kamyshny Diagnostic beads for the detection of blood in animal excreta and a method for production thereof
US7125711B2 (en) * 2002-12-19 2006-10-24 Bayer Healthcare Llc Method and apparatus for splitting of specimens into multiple channels of a microfluidic device
US7094354B2 (en) * 2002-12-19 2006-08-22 Bayer Healthcare Llc Method and apparatus for separation of particles in a microfluidic device
US7435381B2 (en) * 2003-05-29 2008-10-14 Siemens Healthcare Diagnostics Inc. Packaging of microfluidic devices
US20080257754A1 (en) * 2003-06-27 2008-10-23 Pugia Michael J Method and apparatus for entry of specimens into a microfluidic device
US20040265172A1 (en) * 2003-06-27 2004-12-30 Pugia Michael J. Method and apparatus for entry and storage of specimens into a microfluidic device
US20040265171A1 (en) * 2003-06-27 2004-12-30 Pugia Michael J. Method for uniform application of fluid into a reactive reagent area
US7347617B2 (en) * 2003-08-19 2008-03-25 Siemens Healthcare Diagnostics Inc. Mixing in microfluidic devices
MX2007010449A (es) * 2005-02-28 2007-11-08 Premd Inc Metodo y aparato para la medicion no invasiva de colesterol en tejido cutaneo.
US8304254B2 (en) * 2007-05-02 2012-11-06 Siemens Healthcare Diagnostics Inc. Piezo dispensing of a diagnostic liquid onto a reagent surface
JP5422108B2 (ja) 2007-10-16 2014-02-19 栄研化学株式会社 ヘムタンパク質の安定化方法及び保存溶液
CA2623328A1 (en) * 2008-02-28 2009-08-28 Francois Mestrallet Mammalian disease detection system
US20130202499A1 (en) * 2012-01-31 2013-08-08 Kimberly-Clark Worldwide, Inc. Composition and Sensor for Detecting Occult Blood
KR101847748B1 (ko) 2013-08-22 2018-04-10 소니 주식회사 수용성 형광 또는 유색 염료 및 그의 사용 방법
KR101829159B1 (ko) 2014-01-16 2018-02-13 소니 주식회사 수용성 형광 또는 유색 염료
US9091682B1 (en) 2014-05-01 2015-07-28 Steven M Hacker Tissue specimen bottle with color indicator in lid verifying and confirming presence of human tissue or blood contained in specimen bottle
US11084932B2 (en) 2015-02-26 2021-08-10 Sony Group Corporation Phenylethynylnaphthalene dyes and methods for their use
CN107454903B (zh) * 2015-02-26 2021-01-01 索尼公司 包含共轭基团的水溶性荧光或着色染料
JP6849599B2 (ja) 2015-05-11 2021-03-24 ソニー株式会社 超明色ダイマーまたはポリマー染料
DE102016203335A1 (de) * 2016-03-01 2017-09-07 Axagarius Gmbh & Co. Kg Test zur Bestimmung einer Basen-Konzentration
CA3018564C (en) 2016-04-01 2024-04-23 Sony Corporation Ultra bright dimeric or polymeric fluorescent and colored dyes
WO2017173348A1 (en) 2016-04-01 2017-10-05 Sony Corporation Ultra bright dimeric or polymeric dyes with rigid spacing groups
US9851359B2 (en) 2016-04-06 2017-12-26 Sony Corporation Of America Ultra bright dimeric or polymeric dyes with spacing linker groups
WO2017196954A1 (en) 2016-05-10 2017-11-16 Sony Corporation Ultra bright polymeric dyes with peptide backbones
EP3455299B1 (de) 2016-05-10 2024-01-17 Sony Group Corporation Zusammensetzungen mit einem polymeren farbstoff und einem cyclodextrin und verwendungen davon
CN109071961B (zh) 2016-05-11 2021-04-27 索尼公司 超亮二聚或聚合染料
JP7068191B2 (ja) 2016-06-06 2022-05-16 ソニーグループ株式会社 蛍光または有色レポーター基を含むイオン性ポリマー
JP7312929B2 (ja) 2016-07-29 2023-07-24 ソニーグループ株式会社 超明色二量体またはポリマー色素およびその調製のための方法
EP3691690B1 (de) 2017-10-05 2024-08-14 Sony Group Corporation Programmierbare polymere arzneimittel
CN111093711A (zh) 2017-10-05 2020-05-01 索尼公司 可编程的树枝状药物
CN111836645A (zh) 2017-11-16 2020-10-27 索尼公司 可编程的聚合药物
JP2021510698A (ja) 2018-01-12 2021-04-30 ソニー株式会社 生物学的に活性な化合物を含むホスホアルキルリボースポリマー
JP2021510696A (ja) 2018-01-12 2021-04-30 ソニー株式会社 生物学的に活性な化合物を含む剛性間隔基を有するポリマー
JP2021520423A (ja) 2018-03-19 2021-08-19 ソニーグループ株式会社 蛍光シグナルを増強するための二価金属の使用
JP7515786B2 (ja) 2018-03-21 2024-07-16 ソニーグループ株式会社 リンカー基を有するポリマータンデム色素
WO2020006285A1 (en) 2018-06-27 2020-01-02 Sony Corporation Polymeric dyes with linker groups comprising deoxyribose
WO2020139767A1 (en) * 2018-12-28 2020-07-02 Beckman Coulter, Inc. Methods for enhanced detection of hemoglobin
KR102718543B1 (ko) 2019-09-26 2024-10-18 소니그룹주식회사 링커 그룹을 갖는 중합체성 탠덤 염료
CN111239124A (zh) * 2020-03-06 2020-06-05 中国药科大学 一种利用二硫化铂的过氧化氢比色检测法
WO2022125564A1 (en) 2020-12-07 2022-06-16 Sony Group Corporation Spacing linker group design for brightness enhancement in dimeric or polymeric dyes
CN113533704A (zh) * 2021-06-21 2021-10-22 南京市第一医院 一种呕吐物隐血检测装置及方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE220142C (de) * 1908-11-27 1910-03-16
DE2235127C2 (de) * 1972-07-18 1974-08-08 Boehringer Mannheim Gmbh, 6800 Mannheim Diagnostisches Mittel zum Nachweis von Blut und anderen peroxidatisch wirksamen Substanzen in Körperflüssigkeiten
JPS6010261B2 (ja) * 1975-07-31 1985-03-15 和光純薬工業株式会社 潜血検出用組成物
NL7610608A (nl) * 1976-09-24 1978-03-29 Akzo Nv Werkwijze voor het stabiliseren van peroxidase- -bevattende composities.
US4288541A (en) * 1979-10-15 1981-09-08 Miles Laboratories, Inc. Ascorbate resistant composition, test device and method for detecting a component in a liquid test sample
US4251223A (en) * 1979-12-17 1981-02-17 Miles Laboratories, Inc. Sensitizers for peroxidative activity tests
US4310626A (en) * 1980-06-02 1982-01-12 Miles Laboratories, Inc. Interference-resistant composition, device and method for determining a peroxidatively active substance in a test sample
US4587220A (en) * 1983-03-28 1986-05-06 Miles Laboratories, Inc. Ascorbate interference-resistant composition, device and method for the determination of peroxidatively active substances
JPS6066994A (ja) * 1983-09-19 1985-04-17 Wako Pure Chem Ind Ltd 発色試液の安定化方法
US4615982A (en) * 1984-12-11 1986-10-07 Lawrence Paul J Fecal occult blood test

Also Published As

Publication number Publication date
EP0444263B1 (de) 1995-09-13
JP2922003B2 (ja) 1999-07-19
DK0444263T3 (da) 1995-12-04
ES2078934T3 (es) 1996-01-01
AU6366190A (en) 1991-08-01
US5362633A (en) 1994-11-08
ATE127851T1 (de) 1995-09-15
US5318894A (en) 1994-06-07
JPH04213063A (ja) 1992-08-04
DE69022393T2 (de) 1996-03-28
EP0444263A1 (de) 1991-09-04
GR3017415T3 (en) 1995-12-31
KR910014703A (ko) 1991-08-31
AU623038B2 (en) 1992-04-30
KR0163793B1 (ko) 1999-03-30
CA2025803A1 (en) 1991-07-31

Similar Documents

Publication Publication Date Title
DE69022393D1 (de) Verbesserte Zusammensetzung, Vorrichtung und Verfahren zur Untersuchung einer peroxidativ aktiven Substanz.
ATE113664T1 (de) Zusammensetzung, vorrichtung und verfahren zur untersuchung einer peroxidativ aktiven substanz.
FI832756A0 (fi) Askorbatresistant, pao brett omraode verkande glukostestkomposition, testapparat och -metod
ES8606650A1 (es) Una composicion para detectar la presencia de una sustancia peroxidativamente activa en una muestra a ensayar
DE69117588D1 (de) Zusammensetzung und Verfahren zur Bestimmung von Ketonkörpern
CA1141636A (en) Sensitizers for peroxidative activity tests
DK0476454T3 (da) Analysemetode under anvendelse af tetrazoliumsalt-indikatorer med et reflektansplateau
FI831688L (fi) Test foer esterasaktivitet i ett flytande specimen
CA1227113A (en) Enzymatic atp/fmn assay
Kather et al. Chemiluminescent determination of adenosine, inosine, and hypoxanthine/xanthine
CA1272125A (en) Chemiluminescent methods and kit
FI850717A0 (fi) Iontesthjaelpmedel med poroes baermatris.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: SIEMENS HEALTHCARE DIAGNOSTICS INC. (N.D.GES.D, US

8328 Change in the person/name/address of the agent

Representative=s name: MAIER, D., DIPL.-ING. UNIV., PAT.-ASS., 81739 MUEN