DE68923093T2 - Verfahren zur herstellung von 2,4,6-trijod-5-aminoisophthalsäureamid verbindungen. - Google Patents

Verfahren zur herstellung von 2,4,6-trijod-5-aminoisophthalsäureamid verbindungen.

Info

Publication number
DE68923093T2
DE68923093T2 DE68923093T DE68923093T DE68923093T2 DE 68923093 T2 DE68923093 T2 DE 68923093T2 DE 68923093 T DE68923093 T DE 68923093T DE 68923093 T DE68923093 T DE 68923093T DE 68923093 T2 DE68923093 T2 DE 68923093T2
Authority
DE
Germany
Prior art keywords
amino
isophthalamide
substrate
iodine halide
triiodo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE68923093T
Other languages
English (en)
Other versions
DE68923093D1 (de
Inventor
Gregory Cross
Robert Chapman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mallinckrodt Inc
Original Assignee
Mallinckrodt Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc
Application granted granted Critical
Publication of DE68923093D1 publication Critical patent/DE68923093D1/de
Publication of DE68923093T2 publication Critical patent/DE68923093T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DE68923093T 1989-07-24 1989-11-08 Verfahren zur herstellung von 2,4,6-trijod-5-aminoisophthalsäureamid verbindungen. Expired - Lifetime DE68923093T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/383,634 US5013865A (en) 1988-04-06 1989-07-24 Process for the preparation of 2,4,6-triiodo-5-amino-N-alkylisophthalamic acid and 2,4,6-triiodo-5-amino-isophthalamide compounds
PCT/US1989/005036 WO1991001296A1 (en) 1989-07-24 1989-11-08 Process for the preparation of 2,4,6-triiodo-5-amino-n-alkylisophthalamic acid and 2,4,6-triiodo-5-amino-isophthalamide compounds

Publications (2)

Publication Number Publication Date
DE68923093D1 DE68923093D1 (de) 1995-07-20
DE68923093T2 true DE68923093T2 (de) 1995-10-26

Family

ID=23514016

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68923093T Expired - Lifetime DE68923093T2 (de) 1989-07-24 1989-11-08 Verfahren zur herstellung von 2,4,6-trijod-5-aminoisophthalsäureamid verbindungen.

Country Status (8)

Country Link
US (1) US5013865A (de)
EP (1) EP0484328B1 (de)
JP (1) JP2665826B2 (de)
AT (1) ATE123761T1 (de)
AU (1) AU638688B2 (de)
CA (1) CA2005891A1 (de)
DE (1) DE68923093T2 (de)
WO (1) WO1991001296A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0408654B1 (de) * 1988-04-06 1995-05-24 Mallinckrodt, Inc. Verfahren zur herstellung von 2,4,6-triiodo-5-amino-n-alkyl-isophthalsäure
EP0762900B1 (de) * 1994-06-21 2001-11-21 Mallinckrodt Inc. Verbesserte synthese von ioversol unter verwendung einer mit phosphorsäure modifizierten koaddition
AU5773396A (en) * 1995-05-24 1996-12-11 Nycomed Imaging As Iodination process
US5575905A (en) * 1995-05-24 1996-11-19 Nycomed Imaging As Iodination process
DE19641178C2 (de) * 1996-09-24 2000-01-05 Schering Ag Verfahren zur Herstellung von 5-Amino-2,4,6-triiod-isophthalsäure-N-(2,3 dihydroxypropyl)-monoamid
GB9710728D0 (en) * 1997-05-23 1997-07-16 Nycomed Imaging As Method
GB9710725D0 (en) 1997-05-23 1997-07-16 Nycomed Imaging As Process
US6137006A (en) * 1997-05-23 2000-10-24 Nycomed Imaging As Preparation of tri-iodo benzene compounds
GB9710726D0 (en) * 1997-05-23 1997-07-16 Nycomed Imaging As Compound
US8445725B2 (en) 2008-01-14 2013-05-21 Mallinckrodt Llc Process for the preparation of iosimenol
EP2093206A1 (de) 2008-02-20 2009-08-26 BRACCO IMAGING S.p.A. Verfahren zur Iodierung aromatischer Verbindungen
EP2243767A1 (de) 2009-04-21 2010-10-27 Bracco Imaging S.p.A Verfahren zur Iodierung aromatischer Verbindungen
DK2451994T3 (da) 2009-07-07 2014-01-20 Bracco Imaging Spa Fremgangsmåde til fremstilling af et ioderende middel
EP2394984A1 (de) 2010-06-10 2011-12-14 Bracco Imaging S.p.A Verfahren zur Iodinierung von Phenol-Derivaten
KR101887516B1 (ko) * 2011-10-31 2018-08-10 아이맥스 다이어그노스틱 이미징 홀딩 리미티드 3,5-디치환된-2,4,6-트리요오도 아로마틱 아민 화합물의 제조를 위한 요오드화 방법
FR3084668A1 (fr) 2018-08-02 2020-02-07 Guerbet Procede de preparation monotope de composes organo-iodes intermediaires a la synthese du ioversol
CN113563399B (zh) * 2021-07-22 2023-06-27 中国科学院南海海洋研究所 一种制备碘化台勾霉素b和其它几种芳香类碘化产物的方法和应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA616717A (en) * 1961-03-21 Distelmaier Alfred Halogenated aminoisophthalic acids
SU118225A1 (ru) * 1958-07-23 1958-11-30 Ю.А. Фиалков Способ йодировани мета-аминобензойной кислоты
US3145197A (en) * 1961-06-26 1964-08-18 Mallinckrodt Chemical Works 5-acetamido-nu-alkyl-2, 4, 6-trhodoiso-phthalamic acid compounds
US4396598A (en) * 1982-01-11 1983-08-02 Mallinckrodt, Inc. Triiodoisophthalamide X-ray contrast agent
FR2614299B1 (fr) * 1987-04-23 1989-08-18 Guerbet Sa Composes diamino benzeniques iodes, leur procede de preparation et produits de contraste les contenant.
AU612510B2 (en) * 1988-03-01 1991-07-11 Mallinckrodt, Inc. Nonionic x-ray contrast agents, compositions and methods
EP0408654B1 (de) * 1988-04-06 1995-05-24 Mallinckrodt, Inc. Verfahren zur herstellung von 2,4,6-triiodo-5-amino-n-alkyl-isophthalsäure
DE3937118A1 (de) * 1989-11-03 1991-05-08 Schering Ag Nichtionische roentgenkontrastmittel mit hohem jodgehalt

Also Published As

Publication number Publication date
US5013865A (en) 1991-05-07
JP2665826B2 (ja) 1997-10-22
JPH05500500A (ja) 1993-02-04
EP0484328B1 (de) 1995-06-14
EP0484328A1 (de) 1992-05-13
WO1991001296A1 (en) 1991-02-07
AU4661589A (en) 1991-02-22
CA2005891A1 (en) 1991-01-24
AU638688B2 (en) 1993-07-08
DE68923093D1 (de) 1995-07-20
ATE123761T1 (de) 1995-06-15

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