ATE123761T1 - Verfahren zur herstellung von 2,4,6-trijod-5- aminoisophthalsäureamid verbindungen. - Google Patents

Verfahren zur herstellung von 2,4,6-trijod-5- aminoisophthalsäureamid verbindungen.

Info

Publication number
ATE123761T1
ATE123761T1 AT90901154T AT90901154T ATE123761T1 AT E123761 T1 ATE123761 T1 AT E123761T1 AT 90901154 T AT90901154 T AT 90901154T AT 90901154 T AT90901154 T AT 90901154T AT E123761 T1 ATE123761 T1 AT E123761T1
Authority
AT
Austria
Prior art keywords
amino
isophthalamide
substrate
iodine halide
triiodo
Prior art date
Application number
AT90901154T
Other languages
English (en)
Inventor
Gregory D Cross
Robert C Chapman
Original Assignee
Mallinckrodt Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc
Application granted granted Critical
Publication of ATE123761T1 publication Critical patent/ATE123761T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AT90901154T 1989-07-24 1989-11-08 Verfahren zur herstellung von 2,4,6-trijod-5- aminoisophthalsäureamid verbindungen. ATE123761T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/383,634 US5013865A (en) 1988-04-06 1989-07-24 Process for the preparation of 2,4,6-triiodo-5-amino-N-alkylisophthalamic acid and 2,4,6-triiodo-5-amino-isophthalamide compounds

Publications (1)

Publication Number Publication Date
ATE123761T1 true ATE123761T1 (de) 1995-06-15

Family

ID=23514016

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90901154T ATE123761T1 (de) 1989-07-24 1989-11-08 Verfahren zur herstellung von 2,4,6-trijod-5- aminoisophthalsäureamid verbindungen.

Country Status (8)

Country Link
US (1) US5013865A (de)
EP (1) EP0484328B1 (de)
JP (1) JP2665826B2 (de)
AT (1) ATE123761T1 (de)
AU (1) AU638688B2 (de)
CA (1) CA2005891A1 (de)
DE (1) DE68923093T2 (de)
WO (1) WO1991001296A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE123018T1 (de) * 1988-04-06 1995-06-15 Mallinckrodt Inc Verfahren zur herstellung von 2,4,6-triiodo-5- amino-n-alkyl-isophthalsäure.
WO1995035122A1 (en) * 1994-06-21 1995-12-28 Mallinckrodt Medical, Inc. Improved synthesis of ioversol using phosphoric acid modified co-addition
PT828705E (pt) * 1995-05-24 2000-12-29 Nycomed Imaging As Processo para iodacao
US5575905A (en) * 1995-05-24 1996-11-19 Nycomed Imaging As Iodination process
DE19641178C2 (de) * 1996-09-24 2000-01-05 Schering Ag Verfahren zur Herstellung von 5-Amino-2,4,6-triiod-isophthalsäure-N-(2,3 dihydroxypropyl)-monoamid
GB9710728D0 (en) * 1997-05-23 1997-07-16 Nycomed Imaging As Method
US6137006A (en) * 1997-05-23 2000-10-24 Nycomed Imaging As Preparation of tri-iodo benzene compounds
GB9710726D0 (en) * 1997-05-23 1997-07-16 Nycomed Imaging As Compound
GB9710725D0 (en) * 1997-05-23 1997-07-16 Nycomed Imaging As Process
ES2391002T3 (es) 2008-01-14 2012-11-20 Mallinckrodt Llc Proceso para la preparación de iosimenol
EP2093206A1 (de) 2008-02-20 2009-08-26 BRACCO IMAGING S.p.A. Verfahren zur Iodierung aromatischer Verbindungen
EP2243767A1 (de) 2009-04-21 2010-10-27 Bracco Imaging S.p.A Verfahren zur Iodierung aromatischer Verbindungen
KR101699065B1 (ko) 2009-07-07 2017-01-23 브라코 이미징 에스.피.에이. 요오드화제의 제조방법
EP2394984A1 (de) 2010-06-10 2011-12-14 Bracco Imaging S.p.A Verfahren zur Iodinierung von Phenol-Derivaten
BR112014010327B8 (pt) * 2011-10-31 2019-05-14 Imax Diagnostc Imagining Holding Ltd processo para a preparação de compostos
FR3084668A1 (fr) 2018-08-02 2020-02-07 Guerbet Procede de preparation monotope de composes organo-iodes intermediaires a la synthese du ioversol
CN113563399B (zh) * 2021-07-22 2023-06-27 中国科学院南海海洋研究所 一种制备碘化台勾霉素b和其它几种芳香类碘化产物的方法和应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA616717A (en) * 1961-03-21 Distelmaier Alfred Halogenated aminoisophthalic acids
SU118225A1 (ru) * 1958-07-23 1958-11-30 Ю.А. Фиалков Способ йодировани мета-аминобензойной кислоты
US3145197A (en) * 1961-06-26 1964-08-18 Mallinckrodt Chemical Works 5-acetamido-nu-alkyl-2, 4, 6-trhodoiso-phthalamic acid compounds
US4396598A (en) * 1982-01-11 1983-08-02 Mallinckrodt, Inc. Triiodoisophthalamide X-ray contrast agent
FR2614299B1 (fr) * 1987-04-23 1989-08-18 Guerbet Sa Composes diamino benzeniques iodes, leur procede de preparation et produits de contraste les contenant.
JPH0625094B2 (ja) * 1988-03-01 1994-04-06 マリンクロット，インコーポレイテッド 非イオン性ｘ線コントラスト剤、組成物及び方法
ATE123018T1 (de) * 1988-04-06 1995-06-15 Mallinckrodt Inc Verfahren zur herstellung von 2,4,6-triiodo-5- amino-n-alkyl-isophthalsäure.
DE3937118A1 (de) * 1989-11-03 1991-05-08 Schering Ag Nichtionische roentgenkontrastmittel mit hohem jodgehalt

Also Published As

Publication number Publication date
DE68923093D1 (de) 1995-07-20
US5013865A (en) 1991-05-07
WO1991001296A1 (en) 1991-02-07
JP2665826B2 (ja) 1997-10-22
AU638688B2 (en) 1993-07-08
CA2005891A1 (en) 1991-01-24
EP0484328B1 (de) 1995-06-14
JPH05500500A (ja) 1993-02-04
EP0484328A1 (de) 1992-05-13
DE68923093T2 (de) 1995-10-26
AU4661589A (en) 1991-02-22

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