DE68922844D1 - Agglutinationsverfahren zur Bestimmung von mehreren Liganden. - Google Patents

Agglutinationsverfahren zur Bestimmung von mehreren Liganden.

Info

Publication number
DE68922844D1
DE68922844D1 DE68922844T DE68922844T DE68922844D1 DE 68922844 D1 DE68922844 D1 DE 68922844D1 DE 68922844 T DE68922844 T DE 68922844T DE 68922844 T DE68922844 T DE 68922844T DE 68922844 D1 DE68922844 D1 DE 68922844D1
Authority
DE
Germany
Prior art keywords
specimen
beads
ligands
determination
bead
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE68922844T
Other languages
English (en)
Other versions
DE68922844T2 (de
Inventor
Hoegaerden Michel Van
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chemunex SA
Original Assignee
Chemunex SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chemunex SA filed Critical Chemunex SA
Publication of DE68922844D1 publication Critical patent/DE68922844D1/de
Application granted granted Critical
Publication of DE68922844T2 publication Critical patent/DE68922844T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/973—Simultaneous determination of more than one analyte
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/80—Fluorescent dyes, e.g. rhodamine
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/805—Optical property
DE68922844T 1988-11-04 1989-11-03 Agglutinationsverfahren zur Bestimmung von mehreren Liganden. Expired - Fee Related DE68922844T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8814420A FR2638848B1 (fr) 1988-11-04 1988-11-04 Procede de detection et/ou de dosage dans un milieu liquide ou semi-liquide d'au moins une substance organique, biologique ou medicamenteuse soluble, par une methode d'agglutination
PCT/FR1989/000573 WO1990005307A1 (fr) 1988-11-04 1989-11-03 Methode d'agglutination pour l'analyse d'une substance

Publications (2)

Publication Number Publication Date
DE68922844D1 true DE68922844D1 (de) 1995-06-29
DE68922844T2 DE68922844T2 (de) 1995-12-21

Family

ID=9371582

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68922844T Expired - Fee Related DE68922844T2 (de) 1988-11-04 1989-11-03 Agglutinationsverfahren zur Bestimmung von mehreren Liganden.

Country Status (8)

Country Link
US (2) US5219763A (de)
EP (1) EP0397828B1 (de)
JP (1) JPH03502246A (de)
AT (1) ATE123150T1 (de)
AU (1) AU4518689A (de)
DE (1) DE68922844T2 (de)
FR (1) FR2638848B1 (de)
WO (1) WO1990005307A1 (de)

Families Citing this family (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5547839A (en) * 1989-06-07 1996-08-20 Affymax Technologies N.V. Sequencing of surface immobilized polymers utilizing microflourescence detection
JPH03225277A (ja) * 1990-01-31 1991-10-04 Fujirebio Inc 多項目の免疫化学的測定法
EP0562047A4 (en) * 1990-12-06 1995-11-02 Affymax Tech Nv Sequencing by hybridization of a target nucleic acid to a matrix of defined oligonucleotides
WO1994007138A1 (en) 1992-09-14 1994-03-31 Fodstad Oystein Detection of specific target cells in specialized or mixed cell population and solutions containing mixed cell populations
US5561045A (en) * 1994-01-04 1996-10-01 Intracel Corporation Detection reagent, article, and immunoassay method
NO180658C (no) 1994-03-10 1997-05-21 Oeystein Fodstad Fremgangsmåte og anordning for deteksjon av spesifikke målceller i spesialiserte eller blandede cellepopulasjoner og opplösninger som inneholder blandede cellepopulasjoner
US6159748A (en) * 1995-03-13 2000-12-12 Affinitech, Ltd Evaluation of autoimmune diseases using a multiple parameter latex bead suspension and flow cytometry
US5736330A (en) * 1995-10-11 1998-04-07 Luminex Corporation Method and compositions for flow cytometric determination of DNA sequences
CA2227895C (en) 1995-10-11 2012-07-17 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and methods
US5981180A (en) * 1995-10-11 1999-11-09 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and methods
NO961031D0 (no) 1996-03-13 1996-03-13 Det Norske Radiumshospital Tum Fremgangsmåte til å drepe uönskede målceller
US5747349A (en) * 1996-03-20 1998-05-05 University Of Washington Fluorescent reporter beads for fluid analysis
US7144119B2 (en) * 1996-04-25 2006-12-05 Bioarray Solutions Ltd. System and method for programmable illumination pattern generation
US6958245B2 (en) 1996-04-25 2005-10-25 Bioarray Solutions Ltd. Array cytometry
US6251691B1 (en) 1996-04-25 2001-06-26 Bioarray Solutions, Llc Light-controlled electrokinetic assembly of particles near surfaces
US6387707B1 (en) * 1996-04-25 2002-05-14 Bioarray Solutions Array Cytometry
US7041510B2 (en) 1996-04-25 2006-05-09 Bioarray Solutions Ltd. System and method for programmable illumination pattern generation
US6449562B1 (en) 1996-10-10 2002-09-10 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and method
DE59606885D1 (de) * 1996-12-18 2001-06-13 Diagnostische Forsch Stiftung Synthetische Partikel als Agglutinationsreagenzien
NO308755B1 (no) * 1996-12-20 2000-10-23 Iystein Fodstad FremgangsmÕte til karakterisering av unormale celler, anvendelse og sett for utførelse av fremgangsmÕten
US20030027126A1 (en) 1997-03-14 2003-02-06 Walt David R. Methods for detecting target analytes and enzymatic reactions
US7622294B2 (en) 1997-03-14 2009-11-24 Trustees Of Tufts College Methods for detecting target analytes and enzymatic reactions
AU756945B2 (en) * 1997-05-23 2003-01-30 Bioarray Solutions Ltd Color-encoding and in-situ interrogation of matrix-coupled chemical compounds
US6908770B1 (en) 1998-07-16 2005-06-21 Board Of Regents, The University Of Texas System Fluid based analysis of multiple analytes by a sensor array
US7189519B2 (en) * 1998-08-10 2007-03-13 Stc.Unm Bead-based detection of ligand-GPCR-G protein complexes
US7018846B1 (en) 1998-08-10 2006-03-28 Science & Technology Corporation @ Unm Display of receptors and analysis of binding interactions and drug libraries
CA2254223A1 (en) * 1998-11-16 2000-05-16 Biophys, Inc. Device and method for analyzing a biologic sample
US7297554B2 (en) * 1998-11-18 2007-11-20 Microdiagnostics, Inc. Immunoassay system
US6815172B1 (en) 1999-06-11 2004-11-09 The United States Of America As Represented By The Department Of Health And Human Services Methods and compositions for opsonophagocytic assays
WO2001006253A2 (en) 1999-07-16 2001-01-25 Board Of Regents, The University Of Texas System Detection system based on an analyte reactive particle
US7022517B1 (en) 1999-07-16 2006-04-04 Board Of Regents, The University Of Texas System Method and apparatus for the delivery of samples to a chemical sensor array
AU2001236597A1 (en) * 2000-01-31 2001-08-07 Board Of Regents, The University Of Texas System System and method for the analysis of bodily fluids
DE60117556T2 (de) 2000-06-21 2006-11-02 Bioarray Solutions Ltd. Multianalytische molekularanalyse durch verwendung anwendungsspezifischer zufallspartikelarrays
US9709559B2 (en) 2000-06-21 2017-07-18 Bioarray Solutions, Ltd. Multianalyte molecular analysis using application-specific random particle arrays
US7057704B2 (en) * 2000-09-17 2006-06-06 Bioarray Solutions Ltd. System and method for programmable illumination pattern generation
US20030045005A1 (en) * 2000-10-17 2003-03-06 Michael Seul Light-controlled electrokinetic assembly of particles near surfaces
US7691645B2 (en) * 2001-01-09 2010-04-06 Agilent Technologies, Inc. Immunosubtraction method
EP1373874A4 (de) * 2001-01-31 2004-03-31 Univ Texas Verfahren und vorrichtung zum eingrenzen von materialien in einem mikrobearbeiteten chemischen sensorarray
US20030003436A1 (en) * 2001-02-05 2003-01-02 Willson C. Grant Use of mesoscale self-assembly and recognition to effect delivery of sensing reagent for arrayed sensors
US7262063B2 (en) 2001-06-21 2007-08-28 Bio Array Solutions, Ltd. Directed assembly of functional heterostructures
NZ532947A (en) 2001-10-15 2006-01-27 Bioarray Solutions Ltd Multiplexed analysis of polymorphic loci by concurrent interrogation and enzyme-mediated detection
US6838289B2 (en) * 2001-11-14 2005-01-04 Beckman Coulter, Inc. Analyte detection system
US7241629B2 (en) 2001-12-20 2007-07-10 Corning Incorporated Detectable labels, methods of manufacture and use
US20040171076A1 (en) * 2001-12-20 2004-09-02 Dejneka Matthew J. Detectable micro to nano sized structures, methods of manufacture and use
CA2523626A1 (en) 2002-04-26 2003-11-06 Board Of Regents, The University Of Texas System Method and system for the detection of cardiac risk factors
ATE339687T1 (de) * 2002-05-22 2006-10-15 Sysmex Corp Immunologische verfahren, vorrichtungen und reagenzien
AU2003298655A1 (en) 2002-11-15 2004-06-15 Bioarray Solutions, Ltd. Analysis, secure access to, and transmission of array images
US7232659B1 (en) 2003-02-04 2007-06-19 Stc.Unm Multiplex analysis for high throughput discrimination of GPCR agonists and antagonists
WO2004097371A2 (en) * 2003-04-25 2004-11-11 Board Of Regents, The University Of Texas System System and method for the detection of analytes
US9317922B2 (en) 2003-05-16 2016-04-19 Board Of Regents The University Of Texas System Image and part recognition technology
WO2004104922A2 (en) * 2003-05-16 2004-12-02 Board Of Regents, The University Of Texas System Image and part recognition technology
EP1641809B2 (de) * 2003-07-05 2018-10-03 The Johns Hopkins University Verfahren und zusammensetzungen zum nachweis und zur auflistung genetischer variationen
WO2005029705A2 (en) 2003-09-18 2005-03-31 Bioarray Solutions, Ltd. Number coding for identification of subtypes of coded types of solid phase carriers
ATE532066T1 (de) 2003-09-22 2011-11-15 Bioarray Solutions Ltd Oberflächenimmobilisierter polyelektrolyt mit mehreren, zur kovalenten bindung an biomoleküle fähigen funktionellen gruppen
US20050079484A1 (en) * 2003-10-10 2005-04-14 Heineman William Richard Method of detecting biological materials in liquid
WO2005042763A2 (en) 2003-10-28 2005-05-12 Bioarray Solutions Ltd. Optimization of gene expression analysis using immobilized capture probes
EP1694859B1 (de) 2003-10-29 2015-01-07 Bioarray Solutions Ltd Multiplex-nukleinsäureanalyse mittels fragmentierung doppelsträngiger dna
US7651868B2 (en) * 2003-12-11 2010-01-26 The Board Of Regents Of The University Of Texas System Method and system for the analysis of saliva using a sensor array
US8101431B2 (en) 2004-02-27 2012-01-24 Board Of Regents, The University Of Texas System Integration of fluids and reagents into self-contained cartridges containing sensor elements and reagent delivery systems
US8105849B2 (en) 2004-02-27 2012-01-31 Board Of Regents, The University Of Texas System Integration of fluids and reagents into self-contained cartridges containing sensor elements
US7848889B2 (en) 2004-08-02 2010-12-07 Bioarray Solutions, Ltd. Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification
CA2610793A1 (en) 2005-05-31 2007-05-10 Labnow, Inc. Methods and compositions related to determination and use of white blood cell counts
US8486629B2 (en) 2005-06-01 2013-07-16 Bioarray Solutions, Ltd. Creation of functionalized microparticle libraries by oligonucleotide ligation or elongation
CA2613078A1 (en) * 2005-06-24 2007-01-04 Board Of Regents, The University Of Texas System Systems and methods including self-contained cartridges with detection systems and fluid delivery systems
US20070043510A1 (en) * 2005-08-19 2007-02-22 Beckman Coulter, Inc. Assay system
US7572990B2 (en) * 2007-03-30 2009-08-11 Intermec Ip Corp. Keypad overlay membrane
JP6277099B2 (ja) * 2014-09-09 2018-02-07 富士フイルム株式会社 試薬キット、測定キット及び被検物質の測定方法。
US20220236272A1 (en) 2019-06-13 2022-07-28 Fundació Hospital Universitari Vall D'hebron - Institut De Recerca Synthrocyte: erythrocyte-mimicking reagent and fast methods for pathogen characterization and serology testing

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2123146B (en) * 1982-06-28 1985-09-25 Abbott Lab Dual parameter flow immunoassays
US4564598A (en) * 1982-07-12 1986-01-14 Syntex (U.S.A.) Inc. Limited volume method for particle counting
US4499052A (en) * 1982-08-30 1985-02-12 Becton, Dickinson And Company Apparatus for distinguishing multiple subpopulations of cells
US4717655A (en) * 1982-08-30 1988-01-05 Becton, Dickinson And Company Method and apparatus for distinguishing multiple subpopulations of cells
US4550017A (en) * 1982-10-15 1985-10-29 Syntex (U.S.A.) Inc. Fluorescence screening for blood typing
DE3322373C2 (de) * 1983-05-19 1986-12-04 Ioannis Dr. 3000 Hannover Tripatzis Testmittel und Verfahren zum Nachweis von Antigenen und/oder Antikörpern
US4745075A (en) * 1984-09-06 1988-05-17 Burroughs Wellcome Co. Diagnostic test methods
JPS61128169A (ja) * 1984-11-27 1986-06-16 Mitsubishi Chem Ind Ltd 免疫分析法
US4918004A (en) * 1984-12-24 1990-04-17 Caribbean Microparticles Corporation Method of calibrating a flow cytometer or fluorescence microscope for quantitating binding antibodies on a selected sample, and microbead calibration kit therefor
CA1291031C (en) * 1985-12-23 1991-10-22 Nikolaas C.J. De Jaeger Method for the detection of specific binding agents and their correspondingbindable substances
JPH07104349B2 (ja) * 1987-04-11 1995-11-13 株式会社日立製作所 細胞測定法
US4829011A (en) * 1987-08-27 1989-05-09 Biotrack, Inc. Agglutination assay
FR2627286B1 (fr) * 1988-02-15 1993-08-20 Canon Kk Procede et appareil pour l'examen d'un echantillon en immunologie
US4934811A (en) * 1988-04-01 1990-06-19 Syntex (U.S.A.) Inc. Apparatus and method for detection of fluorescence or light scatter
US5047321A (en) * 1988-06-15 1991-09-10 Becton Dickinson & Co. Method for analysis of cellular components of a fluid

Also Published As

Publication number Publication date
WO1990005307A1 (fr) 1990-05-17
AU4518689A (en) 1990-05-28
US5219763A (en) 1993-06-15
DE68922844T2 (de) 1995-12-21
FR2638848B1 (fr) 1993-01-22
US5405784A (en) 1995-04-11
EP0397828A1 (de) 1990-11-22
JPH03502246A (ja) 1991-05-23
ATE123150T1 (de) 1995-06-15
EP0397828B1 (de) 1995-05-24
FR2638848A1 (fr) 1990-05-11

Similar Documents

Publication Publication Date Title
DE68922844D1 (de) Agglutinationsverfahren zur Bestimmung von mehreren Liganden.
DE68920176D1 (de) Festphasenanalytische Vorrichtung und Verfahren zum Gebrauch derselben.
ATE452206T1 (de) Verfahren für verbesserte lumineszenztests unter verwendung von mikropartikeln
ATE187820T1 (de) Verfahren zur analyse partikelverstärkter agglutinationsreaktionen auf zentrifugalanalysatoren durch bestimmung der trübungsaufhellung
ATE87743T1 (de) Verfahren zum nachweis von spezifischen bindemitteln und ihren korrespondierenden bindbaren stoffen.
NO900534L (no) Bestemmelse av omgivelseskonsentrasjonen i flere analytter
ATE241139T1 (de) Vorrichtung zur durchführung eines oder mehrerer kompetitiver immunoassays
ATE57577T1 (de) Immunoassay-methoden unter anwendung von mustern fuer die auffindung von loeslichen antigenen und zelloberflaechenantigenen.
DE69227379T2 (de) Verfahren und Reagenzien zur Bestimmung von Bakterien in der zerebrospinalen Flüssigkeit
DE69333289D1 (de) Verfahren zur bestimmung von säugetier nukleinsäuren aus stuhlproben und dafür benötigte reagenzien
ATE133257T1 (de) Ermittlung und quantifizierung mehrerer analyten unter verwendung von markierungstechniken
ATE65092T1 (de) Verstaerkung von hybridisierungssignalen durch verwendung von komplementarischen dns-straengen.
ATE12010T1 (de) Verfahren zur bestimmung von antigen-antikoerper- reaktionen und reagens hierfuer.
ATE524737T1 (de) Verfahren und vorrichtung zur bestimmung mehrerer analyten mit simultaner internen kontrolle in einer grafischen kombination
DE3650437T2 (de) Verfahren zum Messen von Freiliganden in biologischen Flüssigkeiten.
CA2021658A1 (en) Multiplex immunoassay system
MY106963A (en) Agglutination assay.
ATE114050T1 (de) Verfahren zur quantitativen und qualitativen bestimmung von antikörpern gegen bakterielle antigene mittels photometrischer messung der agglutination.
CA2051618A1 (en) Immunoassay for pyridostigmine
DE69016265T2 (de) Verfahren zur Bestimmung von Isoenzymen.
ATE119670T1 (de) Nichtspezifische adsorptionsfreie methode zur bestimmung eines antikörpers und bestimmungsreagentien.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee