DE68918391T2 - Okulare hypotensive Mittel. - Google Patents
Okulare hypotensive Mittel.Info
- Publication number
- DE68918391T2 DE68918391T2 DE68918391T DE68918391T DE68918391T2 DE 68918391 T2 DE68918391 T2 DE 68918391T2 DE 68918391 T DE68918391 T DE 68918391T DE 68918391 T DE68918391 T DE 68918391T DE 68918391 T2 DE68918391 T2 DE 68918391T2
- Authority
- DE
- Germany
- Prior art keywords
- group
- pgs
- use according
- hydrocarbon
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 208000001953 Hypotension Diseases 0.000 title abstract 2
- 208000021822 hypotensive Diseases 0.000 title abstract 2
- 230000001077 hypotensive effect Effects 0.000 title abstract 2
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- 238000011282 treatment Methods 0.000 claims abstract description 8
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- 238000002360 preparation method Methods 0.000 claims description 30
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- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 235000010265 sodium sulphite Nutrition 0.000 description 1
- 239000011343 solid material Substances 0.000 description 1
- 239000008247 solid mixture Substances 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 229940075582 sorbic acid Drugs 0.000 description 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 229940124530 sulfonamide Drugs 0.000 description 1
- 150000003456 sulfonamides Chemical class 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- BCNZYOJHNLTNEZ-UHFFFAOYSA-N tert-butyldimethylsilyl chloride Chemical compound CC(C)(C)[Si](C)(C)Cl BCNZYOJHNLTNEZ-UHFFFAOYSA-N 0.000 description 1
- 150000005621 tetraalkylammonium salts Chemical class 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- ODLHGICHYURWBS-LKONHMLTSA-N trappsol cyclo Chemical compound CC(O)COC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)COCC(O)C)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1COCC(C)O ODLHGICHYURWBS-LKONHMLTSA-N 0.000 description 1
- DSDAICPXUXPBCC-MWDJDSKUSA-N trimethyl-β-cyclodextrin Chemical compound COC[C@H]([C@H]([C@@H]([C@H]1OC)OC)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](COC)[C@H]([C@@H]([C@H]3OC)OC)O[C@H]3O[C@H](COC)[C@H]([C@@H]([C@H]3OC)OC)O[C@H]3O[C@H](COC)[C@H]([C@@H]([C@H]3OC)OC)O[C@H]3O[C@H](COC)[C@H]([C@@H]([C@H]3OC)OC)O3)[C@H](OC)[C@H]2OC)COC)O[C@@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@@H]3O[C@@H]1COC DSDAICPXUXPBCC-MWDJDSKUSA-N 0.000 description 1
- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 229960000281 trometamol Drugs 0.000 description 1
- 229930195735 unsaturated hydrocarbon Natural products 0.000 description 1
- 229940099259 vaseline Drugs 0.000 description 1
- 230000024883 vasodilation Effects 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Compounds Of Unknown Constitution (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Endoscopes (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP24872188A JPH0739344B2 (ja) | 1988-10-01 | 1988-10-01 | 眼圧降下剤 |
| JP24872088A JPH0739343B2 (ja) | 1988-10-01 | 1988-10-01 | 眼圧降下剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE68918391D1 DE68918391D1 (de) | 1994-10-27 |
| DE68918391T2 true DE68918391T2 (de) | 1995-01-19 |
Family
ID=26538919
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE68918391T Expired - Fee Related DE68918391T2 (de) | 1988-10-01 | 1989-09-29 | Okulare hypotensive Mittel. |
| DE68928551T Expired - Fee Related DE68928551T2 (de) | 1988-10-01 | 1989-09-29 | Oculare hypotensive Mittel |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE68928551T Expired - Fee Related DE68928551T2 (de) | 1988-10-01 | 1989-09-29 | Oculare hypotensive Mittel |
Country Status (3)
| Country | Link |
|---|---|
| EP (2) | EP0580268B1 (enExample) |
| AT (2) | ATE111736T1 (enExample) |
| DE (2) | DE68918391T2 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5321128A (en) * | 1988-09-06 | 1994-06-14 | Kabi Pharmacia Ab | Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension |
| EP1300149A3 (en) * | 1988-09-06 | 2003-05-14 | Pharmacia Aktiebolag | Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension |
| US5296504A (en) * | 1988-09-06 | 1994-03-22 | Kabi Pharmacia | Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension |
| US6187813B1 (en) | 1990-04-10 | 2001-02-13 | Pharmacia & Upjohn Aktiebolag | Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension |
| ATE420857T1 (de) * | 1988-09-06 | 2009-01-15 | Pfizer Health Ab | Prostaglandin-derivate zur behandlung von glaukom und ocularer hypertension |
| CA2039420C (en) * | 1990-04-04 | 1996-12-10 | Ryuji Ueno | Treatment of cataract with 15-keto-prostaglandin compounds |
| ES2067864T3 (es) * | 1990-05-22 | 1995-04-01 | R Tech Ueno Ltd | Tratamiento de la hipertension ocular con una combinacion sinergica para administracion ocular. |
| US5166175A (en) * | 1990-05-22 | 1992-11-24 | K.K. Ueno Seiyaku Oyo Kenkyujo | Treatment of ocular hypertension with a synergistic combination |
| DE69106777T2 (de) * | 1990-05-22 | 1995-05-18 | Ueno Seiyaku Oyo Kenkyujo Kk | Behandlung von intraokularem Druck mit einer ophthalmischen synergistischen Kombination. |
| TW210287B (enExample) * | 1991-03-01 | 1993-08-01 | Kabushikaisha Ueno Seiyaku Oyo Kenkyujo | |
| ES2105333T3 (es) * | 1992-10-13 | 1997-10-16 | Alcon Lab Inc | Combinaciones de prostaglandinas y derivados de clonidina para el tratamiento del glaucoma. |
| US6184250B1 (en) | 1993-08-03 | 2001-02-06 | Alcon Laboratories, Inc. | Use of cloprostenol and fluprostenol analogues to treat glaucoma and ocular hypertension |
| US5510383A (en) * | 1993-08-03 | 1996-04-23 | Alcon Laboratories, Inc. | Use of cloprostenol, fluprostenol and their salts and esters to treat glaucoma and ocular hypertension |
| US6294563B1 (en) | 1994-10-27 | 2001-09-25 | Allergan Sales, Inc. | Combinations of prostaglandins and brimonidine or derivatives thereof |
| WO1998020881A1 (en) * | 1996-11-12 | 1998-05-22 | Alcon Laboratories, Inc | 15-ketal prostaglandins for the treatment of glaucoma or ocular hypertension |
| SE9900672D0 (sv) | 1999-02-25 | 1999-02-25 | Synphora Ab | Method and composition for prevention of scar formation in glaucoma filtration bleb and drainage fistula |
| US20020035148A1 (en) * | 2000-07-20 | 2002-03-21 | Ryuji Ueno | Treatment of ocular hypertension |
| JP2004538306A (ja) * | 2001-07-31 | 2004-12-24 | スキャンポ・アーゲー | 高眼圧症および緑内障の処置 |
| EP1420793A1 (en) * | 2001-08-23 | 2004-05-26 | Sucampo AG | Method and composition for treatment of ocular hypertension and glaucoma |
| AU2003215820A1 (en) * | 2002-03-28 | 2003-10-13 | Sucampo Ag | Method for treating ocular hypertension and glaucoma |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1356581A (en) * | 1970-10-09 | 1974-06-12 | Ici Ltd | Cyclopentane derivatives |
| US4599353A (en) * | 1982-05-03 | 1986-07-08 | The Trustees Of Columbia University In The City Of New York | Use of eicosanoids and their derivatives for treatment of ocular hypertension and glaucoma |
| US4824857A (en) * | 1986-05-16 | 1989-04-25 | Yasumasa Goh | Use of prostaglandin D2 -active substances |
| JPH0762626B2 (ja) * | 1987-06-23 | 1995-07-05 | 株式会社大洋バルブ製作所 | 流量検出器 |
| ATE108330T1 (de) * | 1987-09-18 | 1994-07-15 | R Tech Ueno Ltd | Hypotensive okulare mittel. |
| JP2597629B2 (ja) * | 1988-02-26 | 1997-04-09 | 株式会社 上野製薬応用研究所 | １３，１４−ジヒドロ−１５−ケトプロスタグランジン類の安定化 |
-
1989
- 1989-09-29 AT AT89310016T patent/ATE111736T1/de not_active IP Right Cessation
- 1989-09-29 AT AT93202691T patent/ATE162074T1/de not_active IP Right Cessation
- 1989-09-29 DE DE68918391T patent/DE68918391T2/de not_active Expired - Fee Related
- 1989-09-29 EP EP93202691A patent/EP0580268B1/en not_active Expired - Lifetime
- 1989-09-29 DE DE68928551T patent/DE68928551T2/de not_active Expired - Fee Related
- 1989-09-29 EP EP89310016A patent/EP0366279B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0580268A3 (enExample) | 1994-02-23 |
| EP0366279A3 (en) | 1991-12-27 |
| ATE162074T1 (de) | 1998-01-15 |
| ATE111736T1 (de) | 1994-10-15 |
| EP0366279B1 (en) | 1994-09-21 |
| EP0366279A2 (en) | 1990-05-02 |
| DE68928551T2 (de) | 1998-04-23 |
| DE68918391D1 (de) | 1994-10-27 |
| DE68928551D1 (de) | 1998-02-19 |
| EP0580268A2 (en) | 1994-01-26 |
| EP0580268B1 (en) | 1998-01-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |