DE68918197T2 - Methode zur Herstellung von rekombinantem menschlichem beta-Interleukin-1 in homogener Form. - Google Patents

Methode zur Herstellung von rekombinantem menschlichem beta-Interleukin-1 in homogener Form.

Info

Publication number
DE68918197T2
DE68918197T2 DE68918197T DE68918197T DE68918197T2 DE 68918197 T2 DE68918197 T2 DE 68918197T2 DE 68918197 T DE68918197 T DE 68918197T DE 68918197 T DE68918197 T DE 68918197T DE 68918197 T2 DE68918197 T2 DE 68918197T2
Authority
DE
Germany
Prior art keywords
beta
interleukin
recombinant human
homogeneous form
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE68918197T
Other languages
English (en)
Other versions
DE68918197D1 (de
Inventor
Bellini Ada Velati
Giuliano Galli
Guido Grandi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eni Tecnologie SpA
Original Assignee
Eniricerche SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eniricerche SpA filed Critical Eniricerche SpA
Publication of DE68918197D1 publication Critical patent/DE68918197D1/de
Application granted granted Critical
Publication of DE68918197T2 publication Critical patent/DE68918197T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/545—IL-1
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/75—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Bacillus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DE68918197T 1988-08-05 1989-07-13 Methode zur Herstellung von rekombinantem menschlichem beta-Interleukin-1 in homogener Form. Expired - Fee Related DE68918197T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8821667A IT1226713B (it) 1988-08-05 1988-08-05 Procedimento per la preparazione di interleuchina 1 beta umana ricombinante in forma omogenea.

Publications (2)

Publication Number Publication Date
DE68918197D1 DE68918197D1 (de) 1994-10-20
DE68918197T2 true DE68918197T2 (de) 1995-01-26

Family

ID=11185088

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68918197T Expired - Fee Related DE68918197T2 (de) 1988-08-05 1989-07-13 Methode zur Herstellung von rekombinantem menschlichem beta-Interleukin-1 in homogener Form.

Country Status (6)

Country Link
EP (1) EP0353516B1 (de)
JP (1) JPH02113892A (de)
AT (1) ATE111522T1 (de)
DE (1) DE68918197T2 (de)
ES (1) ES2060703T3 (de)
IT (1) IT1226713B (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1231156B (it) * 1989-07-19 1991-11-19 Eniricerche Spa Espressione e secrezione di interleuchina 1 beta umana matura in bacillus subtilis e mezzi e metodi per il suo ottenimento.
US6270758B1 (en) 1998-10-08 2001-08-07 Duke University Substantially non-toxic biologically active mucosal adjuvants in vertebrate subjects

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60137291A (ja) * 1983-12-26 1985-07-20 Takeda Chem Ind Ltd 発現ベクター
US5831022A (en) * 1986-02-18 1998-11-03 Hoffmann-La Roche Inc. Purification of recombinant human IL-1α
US4801686A (en) * 1986-09-04 1989-01-31 Immunex Corporation Purification of recombinant interleukin-1
IT1202612B (it) * 1987-03-03 1989-02-09 Eniricerche Spa Plasmidi ricombinanti utili per l'espressione in bacillus di proteine eterologhe

Also Published As

Publication number Publication date
IT8821667A0 (it) 1988-08-05
ATE111522T1 (de) 1994-09-15
DE68918197D1 (de) 1994-10-20
EP0353516A2 (de) 1990-02-07
EP0353516B1 (de) 1994-09-14
ES2060703T3 (es) 1994-12-01
JPH02113892A (ja) 1990-04-26
EP0353516A3 (en) 1990-09-26
IT1226713B (it) 1991-02-05

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee