ES2091768T3 - Factor neurotrofico ciliar purificado. - Google Patents
Factor neurotrofico ciliar purificado.Info
- Publication number
- ES2091768T3 ES2091768T3 ES90100226T ES90100226T ES2091768T3 ES 2091768 T3 ES2091768 T3 ES 2091768T3 ES 90100226 T ES90100226 T ES 90100226T ES 90100226 T ES90100226 T ES 90100226T ES 2091768 T3 ES2091768 T3 ES 2091768T3
- Authority
- ES
- Spain
- Prior art keywords
- cntf
- neurotrophic factor
- supplied
- data
- purified
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 108010025020 Nerve Growth Factor Proteins 0.000 title 1
- 102000007072 Nerve Growth Factors Human genes 0.000 title 1
- 239000003900 neurotrophic factor Substances 0.000 title 1
- 108010005939 Ciliary Neurotrophic Factor Proteins 0.000 abstract 5
- 102100031614 Ciliary neurotrophic factor Human genes 0.000 abstract 5
- 238000000034 method Methods 0.000 abstract 2
- 241000283973 Oryctolagus cuniculus Species 0.000 abstract 1
- 108020004511 Recombinant DNA Proteins 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 210000005036 nerve Anatomy 0.000 abstract 1
- 150000007523 nucleic acids Chemical group 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 238000003259 recombinant expression Methods 0.000 abstract 1
- 241000894007 species Species 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH], i.e. somatotropin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Toxicology (AREA)
- Wood Science & Technology (AREA)
- Endocrinology (AREA)
- General Engineering & Computer Science (AREA)
- Psychiatry (AREA)
- Physics & Mathematics (AREA)
- Epidemiology (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Hospice & Palliative Care (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Abstract
SE PRESENTA UN FACTOR NEUROTROFICO CILIAR (CNTF), PARTICULARMENTE UN NERVIO CIATICO CNTF (SN-CNTF). EL SN-CNTF DESCRITO AQUI ES UNA ESPECIA DE PROTEINA SIMPLE Y TIENE UNA ACTIVIDAD ESPECIFICA INCREMENTADA MAS ALLA DE 25.000 PLIEGUES A PARTIR DEL EXTRACTO CRUDO. TAMBIEN SE SUMINISTRAN DATOS DE UN ACIDO AMINO PARA ESTE SN-CNTF. ADEMAS TAMBIEN SE SUMINISTRAN METODOS PARA USAR ESTOS DATOS SUMINISTRANDO ENSAYOS DE SN-CNTF Y ASI MISMO SE SUMINISTRAN BIBLIOTECAS GENOMICAS. SE DESCRIBEN METODOS DE DNA RECOMBINANTE PARA LA PRODUCCION DEL SN-CNTF. SE SUMINISTRAN SECUENCIAS DE ACIDO NUCLEICO QUE CODIFICAN CNTF HUMANO Y DE CONEJO. TAMBIEN SE SUMINISTRA UN SISTEMA DE EXPRESION RECOMBINANTE PARA PRODUCIR CNTF BIOLOGICAMENTE ACTIVO.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/293,851 US5011914A (en) | 1989-01-05 | 1989-01-05 | Purified ciliary neurotrophic factor |
US07/404,533 US4997929A (en) | 1989-01-05 | 1989-09-08 | Purified ciliary neurotrophic factor |
US07/458,564 US5141856A (en) | 1989-01-05 | 1989-12-28 | Expression of purified ciliary neurotrophic factor |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2091768T3 true ES2091768T3 (es) | 1996-11-16 |
Family
ID=27404236
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES90100226T Expired - Lifetime ES2091768T3 (es) | 1989-01-05 | 1990-01-05 | Factor neurotrofico ciliar purificado. |
Country Status (21)
Country | Link |
---|---|
US (2) | US5141856A (es) |
EP (1) | EP0385060B1 (es) |
JP (2) | JPH0768270B2 (es) |
KR (1) | KR930012105B1 (es) |
AU (1) | AU7032496A (es) |
BR (1) | BR9006996A (es) |
CH (1) | CH681426A5 (es) |
DD (1) | DD299318A5 (es) |
DE (1) | DE4090006C2 (es) |
DK (1) | DK131391A (es) |
ES (1) | ES2091768T3 (es) |
FI (1) | FI104375B (es) |
GB (1) | GB2246132B (es) |
GR (1) | GR3021705T3 (es) |
HU (2) | HUT58792A (es) |
IE (1) | IE81151B1 (es) |
IL (1) | IL92958A (es) |
NL (1) | NL9020024A (es) |
NZ (1) | NZ231985A (es) |
SE (1) | SE513358C2 (es) |
WO (1) | WO1990007341A1 (es) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5714585A (en) * | 1987-10-26 | 1998-02-03 | Sterling Winthrop, Inc. | Antibodies that are immunoreactive with interleukin-7 |
US5328988A (en) * | 1987-10-26 | 1994-07-12 | Immunex Corporation | Interleukin-7 |
US5141856A (en) * | 1989-01-05 | 1992-08-25 | Synergen, Inc. | Expression of purified ciliary neurotrophic factor |
IE903130A1 (en) * | 1989-09-15 | 1991-03-27 | Regeneron Pharma | Ciliary neurotrophic factor |
EP0446931A1 (en) * | 1990-03-14 | 1991-09-18 | FIDIA S.p.A. | Human ciliary neuronotrophic factor, DNA sequence encoding the factor, and production of the factor by recombinant technology |
US6511823B1 (en) * | 1990-08-20 | 2003-01-28 | American Cyanamid Corporation | Heparin binding neurotrophic factor gene sequence |
IT1247150B (it) * | 1991-01-21 | 1994-12-12 | Fidia Spa | Processo per la sintesi e la purificazione del fattore neuronotroficociliare umano (cntf) da escherichia coli. |
US5593857A (en) * | 1991-08-23 | 1997-01-14 | Scios Inc. | Production of homogeneous truncated CNTF |
CA2123234A1 (en) * | 1991-11-11 | 1993-05-27 | Lanfranco Callegaro | Synthesis and purification of truncated and mutein forms of human ciliary neuronotrophic factor |
US5360740A (en) * | 1992-07-02 | 1994-11-01 | Regeneron Pharmaceuticals, Inc. | Assay system for degenerative muscle disease |
IL108464A0 (en) * | 1993-01-29 | 1994-04-12 | Regeneron Pharma | Methods of treatment using ciliary neurotrophic factor |
ATE163006T1 (de) * | 1993-06-01 | 1998-02-15 | Ono Pharmaceutical Co | Pentansäurederivate |
WO1995022560A1 (en) * | 1994-02-22 | 1995-08-24 | The Syntex-Synergen Neuroscience Joint Venture | Pharmaceutical formulations of cntf |
US7258983B2 (en) * | 1994-04-25 | 2007-08-21 | Genentech, Inc. | Cardiotrophin-1 compositions and methods for the treatment of tumor |
ATE339503T1 (de) * | 1994-04-25 | 2006-10-15 | Genentech Inc | Cardiotrophin und verwendung davon |
US6472585B1 (en) | 1994-04-25 | 2002-10-29 | Genentech, Inc. | Cardiotrophin-1 defective mouse |
US5534615A (en) * | 1994-04-25 | 1996-07-09 | Genentech, Inc. | Cardiac hypertrophy factor and uses therefor |
US6743628B1 (en) | 1995-08-28 | 2004-06-01 | Washington University | Method of cell culture using neurturin |
US5739307A (en) * | 1995-08-28 | 1998-04-14 | Washington University | Polynucleotide encoding neurturin neurotrophic factor |
US6222022B1 (en) | 1996-03-14 | 2001-04-24 | Washington University | Persephin and related growth factors |
US7015316B1 (en) | 1996-03-14 | 2006-03-21 | Washington University | Polynucleotides encoding human persephin and related growth factors |
EP0886651B1 (en) | 1996-03-14 | 2005-01-26 | Washington University | Persephin and related growth factors |
US6299895B1 (en) | 1997-03-24 | 2001-10-09 | Neurotech S.A. | Device and method for treating ophthalmic diseases |
IT1288388B1 (it) | 1996-11-19 | 1998-09-22 | Angeletti P Ist Richerche Bio | Uso di sostanze che attivano il recettore del cntf ( fattore neurotrofico ciliare) per la preparazione di farmaci per la terapia |
US6042579A (en) * | 1997-04-30 | 2000-03-28 | Medtronic, Inc. | Techniques for treating neurodegenerative disorders by infusion of nerve growth factors into the brain |
US6689573B1 (en) * | 1999-05-24 | 2004-02-10 | New England Biolabs, Inc. | Method for screening restriction endonucleases |
CA2409190A1 (en) | 2000-04-14 | 2001-10-25 | The Uab Research Foundation | Poliovirus replicons encoding therapeutic agents and uses thereof |
WO2005014641A2 (en) * | 2003-07-09 | 2005-02-17 | Xencor, Inc. | Ciliary neurotrophic factor variants |
WO2008054786A2 (en) * | 2006-10-31 | 2008-05-08 | The Ohio State University Research Foundation | Methods and compositions for inhibiting gsk-3 in glial cell related disorders |
RU2013129990A (ru) | 2010-12-02 | 2015-01-10 | НЬЮРОТЕК ЮЭсЭй, ИНК. | Клеточные линии, которые секретируют конструкции "антиангиогенное антитело-каркасы" и растворимые рецепторы, и их применение |
EP3302524B1 (en) | 2015-05-27 | 2020-09-23 | Neurotech USA, Inc. | Use of encapsulated cell therapy for treatment of glaucoma |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US429517A (en) * | 1890-06-03 | Packing-box | ||
US293851A (en) * | 1884-02-19 | de castro | ||
US408172A (en) * | 1889-07-30 | Steam-boiler house | ||
US458564A (en) * | 1891-09-01 | Ring-gage | ||
US404533A (en) * | 1889-06-04 | Signments | ||
US570651A (en) * | 1896-11-03 | Motor-driven fan | ||
US4399216A (en) * | 1980-02-25 | 1983-08-16 | The Trustees Of Columbia University | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
US4923696A (en) * | 1987-05-04 | 1990-05-08 | Baylor College Of Medicine | Method to prepare a neurotrophic composition |
US5028622A (en) * | 1988-05-06 | 1991-07-02 | Ajinomoto Company, Inc. | Administration of amino acids as treatment for neurodegenerative disorders |
US4997929A (en) * | 1989-01-05 | 1991-03-05 | Synergen, Inc. | Purified ciliary neurotrophic factor |
US5011914A (en) * | 1989-01-05 | 1991-04-30 | Collins Franklin D | Purified ciliary neurotrophic factor |
US5141856A (en) * | 1989-01-05 | 1992-08-25 | Synergen, Inc. | Expression of purified ciliary neurotrophic factor |
CA2047718A1 (en) * | 1989-03-15 | 1990-09-16 | Marston Manthorpe | Purified ciliary neurotrophic factor |
NO911867L (no) * | 1989-09-15 | 1991-07-09 | Max Planck Gesellsch Zur Foerd | Ciliaer neurotrofisk faktor. |
IE903130A1 (en) * | 1989-09-15 | 1991-03-27 | Regeneron Pharma | Ciliary neurotrophic factor |
US5349056A (en) * | 1992-10-09 | 1994-09-20 | Regeneron Pharmaceuticals | Modified ciliary neurotrophic factors |
-
1989
- 1989-12-28 US US07/458,564 patent/US5141856A/en not_active Expired - Lifetime
-
1990
- 1990-01-03 IE IE2090A patent/IE81151B1/en not_active IP Right Cessation
- 1990-01-03 IL IL92958A patent/IL92958A/xx not_active IP Right Cessation
- 1990-01-04 DD DD90336941A patent/DD299318A5/de unknown
- 1990-01-04 NZ NZ231985A patent/NZ231985A/en unknown
- 1990-01-05 CH CH2920/90A patent/CH681426A5/de not_active IP Right Cessation
- 1990-01-05 GB GB9113704A patent/GB2246132B/en not_active Expired - Lifetime
- 1990-01-05 NL NL9020024A patent/NL9020024A/nl not_active Application Discontinuation
- 1990-01-05 BR BR909006996A patent/BR9006996A/pt not_active Application Discontinuation
- 1990-01-05 JP JP2502273A patent/JPH0768270B2/ja not_active Expired - Fee Related
- 1990-01-05 KR KR1019900701975A patent/KR930012105B1/ko not_active IP Right Cessation
- 1990-01-05 DE DE4090006A patent/DE4090006C2/de not_active Expired - Lifetime
- 1990-01-05 HU HU90997A patent/HUT58792A/hu unknown
- 1990-01-05 ES ES90100226T patent/ES2091768T3/es not_active Expired - Lifetime
- 1990-01-05 WO PCT/US1990/000022 patent/WO1990007341A1/en active IP Right Grant
- 1990-01-05 EP EP90100226A patent/EP0385060B1/en not_active Expired - Lifetime
-
1991
- 1991-07-03 SE SE9102079A patent/SE513358C2/sv not_active IP Right Cessation
- 1991-07-04 FI FI913251A patent/FI104375B/fi active
- 1991-07-05 DK DK131391A patent/DK131391A/da not_active Application Discontinuation
-
1995
- 1995-05-24 US US08/448,909 patent/US5780600A/en not_active Expired - Fee Related
- 1995-06-27 HU HU95P/P00452P patent/HU211933A9/hu unknown
-
1996
- 1996-10-21 AU AU70324/96A patent/AU7032496A/en not_active Abandoned
- 1996-11-20 GR GR960403098T patent/GR3021705T3/el unknown
-
1998
- 1998-01-14 JP JP10005805A patent/JPH1129598A/ja active Pending
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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