ATE111522T1 - Methode zur herstellung von rekombinantem menschlichem beta-interleukin-1 in homogener form. - Google Patents

Methode zur herstellung von rekombinantem menschlichem beta-interleukin-1 in homogener form.

Info

Publication number
ATE111522T1
ATE111522T1 AT89112825T AT89112825T ATE111522T1 AT E111522 T1 ATE111522 T1 AT E111522T1 AT 89112825 T AT89112825 T AT 89112825T AT 89112825 T AT89112825 T AT 89112825T AT E111522 T1 ATE111522 T1 AT E111522T1
Authority
AT
Austria
Prior art keywords
beta
interleukin
recombinant human
homogeneous form
production
Prior art date
Application number
AT89112825T
Other languages
English (en)
Inventor
Bellini Ada Velati
Giuliano Galli
Guido Grandi
Original Assignee
Eniricerche Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eniricerche Spa filed Critical Eniricerche Spa
Application granted granted Critical
Publication of ATE111522T1 publication Critical patent/ATE111522T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/545—IL-1
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/75—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Bacillus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT89112825T 1988-08-05 1989-07-13 Methode zur herstellung von rekombinantem menschlichem beta-interleukin-1 in homogener form. ATE111522T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8821667A IT1226713B (it) 1988-08-05 1988-08-05 Procedimento per la preparazione di interleuchina 1 beta umana ricombinante in forma omogenea.

Publications (1)

Publication Number Publication Date
ATE111522T1 true ATE111522T1 (de) 1994-09-15

Family

ID=11185088

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89112825T ATE111522T1 (de) 1988-08-05 1989-07-13 Methode zur herstellung von rekombinantem menschlichem beta-interleukin-1 in homogener form.

Country Status (6)

Country Link
EP (1) EP0353516B1 (de)
JP (1) JPH02113892A (de)
AT (1) ATE111522T1 (de)
DE (1) DE68918197T2 (de)
ES (1) ES2060703T3 (de)
IT (1) IT1226713B (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1231156B (it) * 1989-07-19 1991-11-19 Eniricerche Spa Espressione e secrezione di interleuchina 1 beta umana matura in bacillus subtilis e mezzi e metodi per il suo ottenimento.
US6270758B1 (en) 1998-10-08 2001-08-07 Duke University Substantially non-toxic biologically active mucosal adjuvants in vertebrate subjects

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60137291A (ja) * 1983-12-26 1985-07-20 Takeda Chem Ind Ltd 発現ベクター
US5831022A (en) * 1986-02-18 1998-11-03 Hoffmann-La Roche Inc. Purification of recombinant human IL-1α
US4801686A (en) * 1986-09-04 1989-01-31 Immunex Corporation Purification of recombinant interleukin-1
IT1202612B (it) * 1987-03-03 1989-02-09 Eniricerche Spa Plasmidi ricombinanti utili per l'espressione in bacillus di proteine eterologhe

Also Published As

Publication number Publication date
EP0353516A3 (en) 1990-09-26
IT1226713B (it) 1991-02-05
EP0353516A2 (de) 1990-02-07
ES2060703T3 (es) 1994-12-01
DE68918197D1 (de) 1994-10-20
DE68918197T2 (de) 1995-01-26
JPH02113892A (ja) 1990-04-26
IT8821667A0 (it) 1988-08-05
EP0353516B1 (de) 1994-09-14

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee