DE637236T1 - Pharmazeutische zubereitung und verfahren für ihre herstellung. - Google Patents
Pharmazeutische zubereitung und verfahren für ihre herstellung.Info
- Publication number
- DE637236T1 DE637236T1 DE0637236T DE93908973T DE637236T1 DE 637236 T1 DE637236 T1 DE 637236T1 DE 0637236 T DE0637236 T DE 0637236T DE 93908973 T DE93908973 T DE 93908973T DE 637236 T1 DE637236 T1 DE 637236T1
- Authority
- DE
- Germany
- Prior art keywords
- dissolves
- film
- agent according
- dichloromethylene
- diphosphonic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 title claims 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- ACSIXWWBWUQEHA-UHFFFAOYSA-N clodronic acid Chemical compound OP(O)(=O)C(Cl)(Cl)P(O)(O)=O ACSIXWWBWUQEHA-UHFFFAOYSA-N 0.000 claims abstract 5
- 150000003839 salts Chemical class 0.000 claims abstract 4
- 239000003795 chemical substances by application Substances 0.000 claims 5
- 229920003132 hydroxypropyl methylcellulose phthalate Polymers 0.000 claims 3
- 229940031704 hydroxypropyl methylcellulose phthalate Drugs 0.000 claims 3
- 229920000623 Cellulose acetate phthalate Polymers 0.000 claims 2
- 229940081734 cellulose acetate phthalate Drugs 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 238000012377 drug delivery Methods 0.000 claims 2
- 229920000639 hydroxypropylmethylcellulose acetate succinate Polymers 0.000 claims 2
- 229940100467 polyvinyl acetate phthalate Drugs 0.000 claims 2
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical class [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 claims 1
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical class CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims 1
- ZUAAPNNKRHMPKG-UHFFFAOYSA-N acetic acid;butanedioic acid;methanol;propane-1,2-diol Chemical compound OC.CC(O)=O.CC(O)CO.OC(=O)CCC(O)=O ZUAAPNNKRHMPKG-UHFFFAOYSA-N 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 229920002301 cellulose acetate Polymers 0.000 claims 1
- WZNRVWBKYDHTKI-UHFFFAOYSA-N cellulose, acetate 1,2,4-benzenetricarboxylate Chemical compound OC1C(O)C(O)C(CO)OC1OC1C(CO)OC(O)C(O)C1O.OC1C(O)C(O)C(CO)OC1OC1C(CO)OC(O)C(O)C1O.CC(=O)OCC1OC(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(COC(C)=O)O1.CC(=O)OCC1OC(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(COC(C)=O)O1.OC(=O)C1=CC(C(=O)O)=CC=C1C(=O)OCC1C(OC2C(C(OC(=O)C=3C(=CC(=CC=3)C(O)=O)C(O)=O)C(OC(=O)C=3C(=CC(=CC=3)C(O)=O)C(O)=O)C(COC(=O)C=3C(=CC(=CC=3)C(O)=O)C(O)=O)O2)OC(=O)C=2C(=CC(=CC=2)C(O)=O)C(O)=O)C(OC(=O)C=2C(=CC(=CC=2)C(O)=O)C(O)=O)C(OC(=O)C=2C(=CC(=CC=2)C(O)=O)C(O)=O)C(OC(=O)C=2C(=CC(=CC=2)C(O)=O)C(O)=O)O1 WZNRVWBKYDHTKI-UHFFFAOYSA-N 0.000 claims 1
- 239000008187 granular material Substances 0.000 claims 1
- 210000000936 intestine Anatomy 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000008188 pellet Substances 0.000 claims 1
- 229920002744 polyvinyl acetate phthalate Polymers 0.000 claims 1
- 125000005591 trimellitate group Chemical group 0.000 claims 1
- 239000013543 active substance Substances 0.000 abstract 1
- 229960002286 clodronic acid Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9201299A SE501389C2 (sv) | 1992-04-24 | 1992-04-24 | Farmaceutiskt preparat och förfarande för dess framställning |
| PCT/FI1993/000166 WO1993021907A1 (en) | 1992-04-24 | 1993-04-21 | Pharmaceutical preparation and process for its manufacture |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE637236T1 true DE637236T1 (de) | 1995-07-06 |
Family
ID=20386054
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE0637236T Pending DE637236T1 (de) | 1992-04-24 | 1993-04-21 | Pharmazeutische zubereitung und verfahren für ihre herstellung. |
| DE69305335T Expired - Fee Related DE69305335T2 (de) | 1992-04-24 | 1993-04-21 | Pharmazeutische zubereitung und verfahren für ihre herstellung |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69305335T Expired - Fee Related DE69305335T2 (de) | 1992-04-24 | 1993-04-21 | Pharmazeutische zubereitung und verfahren für ihre herstellung |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US5525354A (enExample) |
| EP (1) | EP0637236B1 (enExample) |
| JP (1) | JP3536106B2 (enExample) |
| AT (1) | ATE143802T1 (enExample) |
| AU (1) | AU671830B2 (enExample) |
| CA (1) | CA2134196C (enExample) |
| CZ (1) | CZ282871B6 (enExample) |
| DE (2) | DE637236T1 (enExample) |
| DK (1) | DK0637236T3 (enExample) |
| EE (1) | EE03107B1 (enExample) |
| ES (1) | ES2094539T3 (enExample) |
| FI (1) | FI110667B (enExample) |
| GR (1) | GR3022249T3 (enExample) |
| HK (1) | HK13097A (enExample) |
| HU (1) | HU219342B (enExample) |
| IL (1) | IL105403A (enExample) |
| NO (1) | NO306654B1 (enExample) |
| RU (1) | RU2116074C1 (enExample) |
| SE (1) | SE501389C2 (enExample) |
| TW (1) | TW273515B (enExample) |
| WO (1) | WO1993021907A1 (enExample) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6406714B1 (en) | 1992-12-02 | 2002-06-18 | Merck & Co., Inc. | Dry mix formulation for bisphosphonic acids |
| ATE128363T1 (de) * | 1993-05-15 | 1995-10-15 | Boehringer Mannheim Gmbh | Tablette mit verbesserter bioverfügbarkeit enthaltend dichlormethylendiphosphonsäure als wirkstoff. |
| US5431920A (en) * | 1993-09-21 | 1995-07-11 | Merck Frosst, Canada, Inc. | Enteric coated oral compositions containing bisphosphonic acid antihypercalcemic agents |
| FI94926C (fi) * | 1993-11-12 | 1995-11-27 | Leiras Oy | Menetelmä klodronaattivalmisteen valmistamiseksi |
| TW390813B (en) * | 1994-04-29 | 2000-05-21 | Merck & Co Inc | Wet granulation formulation for bisphosphonic acids |
| US20010007863A1 (en) | 1998-06-18 | 2001-07-12 | Merck & Co., Inc. | Wet granulation formulation for bisphosphonic acids |
| FI98343C (fi) * | 1995-03-21 | 1997-06-10 | Orion Yhtymae Oy | Peroraalinen formulaatio |
| DE19719680A1 (de) | 1997-05-09 | 1998-11-19 | Boehringer Mannheim Gmbh | Verwendung von Diphosphonsäuren zur präventiven Behandlung von Spätfolgen bei Harnblasenerweiterung oder Harnblasenersatz |
| JPH11137208A (ja) * | 1997-11-14 | 1999-05-25 | Nikken Chem Co Ltd | 口腔内速溶性固形物及びその製造方法 |
| EP0998932A1 (de) * | 1998-10-09 | 2000-05-10 | Boehringer Mannheim Gmbh | Feste pharmazeutische Darreichungsform enthaltend Diphosphonsäure oder deren Salze und Verfahren zu ihrer Herstellung |
| EP0998933A1 (de) * | 1998-10-09 | 2000-05-10 | Boehringer Mannheim Gmbh | Verfahren zur Herstellung von bisphosphonathaltigen pharmazeutischen Zusammensetzungen zur oralen Applikation |
| DE60038097T2 (de) * | 1999-02-22 | 2009-02-12 | Merrion Research I Ltd. | Feste orale dosierungsform enthaltend einen resorptionsverstärker |
| US7658938B2 (en) | 1999-02-22 | 2010-02-09 | Merrion Reasearch III Limited | Solid oral dosage form containing an enhancer |
| SE9901272D0 (sv) * | 1999-04-09 | 1999-04-09 | Astra Ab | New improved formulation |
| PE20011065A1 (es) | 2000-02-01 | 2001-11-21 | Procter & Gamble | Proceso para fabricar bisfosfonatos geminales |
| US6410520B2 (en) | 2000-02-01 | 2002-06-25 | The Procter & Gamble Company | Selective crystallization of 3-pyridyl-1-hydroxyethylidene-1, 1-bisphosphonic acid sodium as the hemipentahydrate or monohydrate |
| WO2002070438A2 (en) * | 2001-03-01 | 2002-09-12 | Emisphere Technologies, Inc. | Compositions for delivering bisphosphonates |
| WO2002092616A1 (en) | 2001-05-11 | 2002-11-21 | Orasense, Ltd. | Antisense permeation enhancers |
| US20030070584A1 (en) * | 2001-05-15 | 2003-04-17 | Cynthia Gulian | Dip coating compositions containing cellulose ethers |
| AU4061702A (en) * | 2001-05-15 | 2003-04-03 | Mcneil-Ppc, Inc. | Dip coating compositions containing starch or dextrin |
| US8309118B2 (en) * | 2001-09-28 | 2012-11-13 | Mcneil-Ppc, Inc. | Film forming compositions containing sucralose |
| US7429619B2 (en) * | 2002-08-02 | 2008-09-30 | Mcneil Consumer Healthcare | Polyacrylic film forming compositions |
| US20080287400A1 (en) | 2004-05-24 | 2008-11-20 | Richard John Dansereau | Low Dosage Forms Of Risedronate Or Its Salts |
| US7645459B2 (en) | 2004-05-24 | 2010-01-12 | The Procter & Gamble Company | Dosage forms of bisphosphonates |
| US20080286359A1 (en) | 2004-05-24 | 2008-11-20 | Richard John Dansereau | Low Dosage Forms Of Risedronate Or Its Salts |
| US7645460B2 (en) | 2004-05-24 | 2010-01-12 | The Procter & Gamble Company | Dosage forms of risedronate |
| US7862552B2 (en) * | 2005-05-09 | 2011-01-04 | Boston Scientific Scimed, Inc. | Medical devices for treating urological and uterine conditions |
| BRPI0710503A2 (pt) | 2006-04-07 | 2011-08-16 | Merrion Res Iii Ltd | uso de uma composição farmacêutica, composição farmacêutica, e, forma de dosagem oral |
| DE102008022520A1 (de) * | 2008-05-07 | 2009-11-12 | Bayer Animal Health Gmbh | Feste Arzneimittelformulierung mit verzögerter Freisetzung |
| US20090280169A1 (en) | 2008-05-07 | 2009-11-12 | Merrion Research Iii Limited | Compositions of peptides and processes of preparation thereof |
| WO2011120033A1 (en) | 2010-03-26 | 2011-09-29 | Merrion Research Iii Limited | Pharmaceutical compositions of selective factor xa inhibitors for oral administration |
| AU2012204213A1 (en) | 2011-01-07 | 2013-06-13 | Merrion Research Iii Limited | Pharmaceutical compositions of iron for oral administration |
| JP7211704B2 (ja) | 2015-01-29 | 2023-01-24 | ノヴォ ノルディスク アー／エス | Ｇｌｐ－１アゴニスト及び腸溶コーティングを含む錠剤 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57171428A (en) * | 1981-04-13 | 1982-10-22 | Sankyo Co Ltd | Preparation of coated solid preparation |
| ES2040733T3 (es) * | 1986-12-20 | 1993-11-01 | Boehringer Mannheim Gmbh | Medicamentos que contienen clodronato y procedimiento para su preparacion. |
| EP0313845A1 (en) * | 1987-09-29 | 1989-05-03 | Warner-Lambert Company | Stabilization of enteric coated dosage form |
| FR2629716B1 (fr) * | 1988-04-07 | 1991-07-19 | Sanofi Sa | Composition pharmaceutique pour administration orale a base d'un derive d'acide diphosphonique |
-
1992
- 1992-04-24 SE SE9201299A patent/SE501389C2/sv not_active IP Right Cessation
-
1993
- 1993-04-13 TW TW082102782A patent/TW273515B/zh active
- 1993-04-15 IL IL105403A patent/IL105403A/en not_active IP Right Cessation
- 1993-04-21 CA CA002134196A patent/CA2134196C/en not_active Expired - Fee Related
- 1993-04-21 DK DK93908973.6T patent/DK0637236T3/da active
- 1993-04-21 US US08/318,650 patent/US5525354A/en not_active Expired - Lifetime
- 1993-04-21 RU RU94045950A patent/RU2116074C1/ru not_active IP Right Cessation
- 1993-04-21 HU HU9403067A patent/HU219342B/hu not_active IP Right Cessation
- 1993-04-21 WO PCT/FI1993/000166 patent/WO1993021907A1/en not_active Ceased
- 1993-04-21 AU AU39550/93A patent/AU671830B2/en not_active Ceased
- 1993-04-21 AT AT93908973T patent/ATE143802T1/de not_active IP Right Cessation
- 1993-04-21 EP EP93908973A patent/EP0637236B1/en not_active Expired - Lifetime
- 1993-04-21 DE DE0637236T patent/DE637236T1/de active Pending
- 1993-04-21 ES ES93908973T patent/ES2094539T3/es not_active Expired - Lifetime
- 1993-04-21 JP JP51895893A patent/JP3536106B2/ja not_active Expired - Fee Related
- 1993-04-21 DE DE69305335T patent/DE69305335T2/de not_active Expired - Fee Related
- 1993-04-21 CZ CZ942614A patent/CZ282871B6/cs not_active IP Right Cessation
-
1994
- 1994-10-21 NO NO944001A patent/NO306654B1/no unknown
- 1994-10-21 FI FI944961A patent/FI110667B/fi active
- 1994-11-15 EE EE9400134A patent/EE03107B1/xx not_active IP Right Cessation
-
1997
- 1997-01-09 GR GR970400013T patent/GR3022249T3/el unknown
- 1997-02-05 HK HK13097A patent/HK13097A/en not_active IP Right Cessation
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