DE60335490D1 - Spezifisch in postmitotischen dopamin-produzierenden neuronalen vorläuferzellen exprimiertes gen - Google Patents
Spezifisch in postmitotischen dopamin-produzierenden neuronalen vorläuferzellen exprimiertes genInfo
- Publication number
- DE60335490D1 DE60335490D1 DE60335490T DE60335490T DE60335490D1 DE 60335490 D1 DE60335490 D1 DE 60335490D1 DE 60335490 T DE60335490 T DE 60335490T DE 60335490 T DE60335490 T DE 60335490T DE 60335490 D1 DE60335490 D1 DE 60335490D1
- Authority
- DE
- Germany
- Prior art keywords
- precursor cells
- dopamin
- postmitotic
- specifically expressed
- neuronal precursor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2002307573 | 2002-10-22 | ||
PCT/JP2003/013420 WO2004038018A1 (ja) | 2002-10-22 | 2003-10-21 | 分裂停止後のドーパミン産生ニューロン前駆細胞に特異的に発現している遺伝子 |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60335490D1 true DE60335490D1 (de) | 2011-02-03 |
Family
ID=32170942
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60335490T Expired - Lifetime DE60335490D1 (de) | 2002-10-22 | 2003-10-21 | Spezifisch in postmitotischen dopamin-produzierenden neuronalen vorläuferzellen exprimiertes gen |
Country Status (9)
Country | Link |
---|---|
US (3) | US7622270B2 (de) |
EP (2) | EP1795595A1 (de) |
JP (1) | JP4118877B2 (de) |
CN (2) | CN1891826B (de) |
AT (1) | ATE492636T1 (de) |
AU (1) | AU2003301576A1 (de) |
DE (1) | DE60335490D1 (de) |
SG (1) | SG146441A1 (de) |
WO (1) | WO2004038018A1 (de) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7622270B2 (en) * | 2002-10-22 | 2009-11-24 | Eisai R&D Management Co., Ltd. | Methods of isolating dopaminergic neuron precursor cells |
WO2004065599A1 (ja) | 2003-01-24 | 2004-08-05 | Eisai Co., Ltd. | Lrp4/Corinドーパミン産生ニューロン増殖前駆細胞マーカー |
EP1712638B1 (de) | 2003-11-26 | 2009-06-10 | Eisai R&D Management Co., Ltd. | Spezifischer Marker Lmx1a für dopaminerge Neuronen |
JP4717797B2 (ja) * | 2004-07-22 | 2011-07-06 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | Lrp4/Corinドーパミン産生ニューロン前駆細胞マーカー |
EP1666590B1 (de) * | 2004-07-22 | 2015-11-04 | Eisai R&D Management Co., Ltd. | Lrp4/corin-marker von dopamin produzierenden neuronenvorläuferzellen |
JP4618736B2 (ja) * | 2004-07-22 | 2011-01-26 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | Lrp4/Corinドーパミン産生ニューロン前駆細胞マーカー |
WO2007021003A1 (ja) | 2005-08-18 | 2007-02-22 | Eisai R & D Management Co., Ltd. | ドーパミン産生ニューロン増殖前駆細胞マーカーNato3 |
CA2619736C (en) * | 2005-08-18 | 2012-05-22 | Eisai R & D Management Co., Ltd. | Dopaminergic neuron proliferative progenitor cell marker msx1/2 |
US8198081B2 (en) | 2006-04-11 | 2012-06-12 | Eisai R&D Management Co., Ltd. | Dopaminergic neuron progenitor cell marker 187A5 |
CA2677996C (en) | 2007-02-09 | 2018-06-12 | Eisai R&D Management Co., Ltd. | Gaba neuron progenitor cell marker 65b13 |
CA2726426A1 (en) * | 2008-06-04 | 2009-12-10 | The Arizona Board Of Regents, On Behalf Of The University Of Arizona | Diffuse large b-cell lymphoma markers and uses therefor |
WO2010016533A1 (ja) | 2008-08-08 | 2010-02-11 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | Neph3(65B13)とE-カドヘリンを用いたプルキンエ前駆細胞の取得方法 |
US8877449B2 (en) | 2008-12-22 | 2014-11-04 | Eisai R&D Management Co., Ltd. | Method for obtaining pancreatic progenitor cell using NEPH3 |
EP3578205A1 (de) | 2010-08-06 | 2019-12-11 | ModernaTX, Inc. | Pharmazeutische zusammensetzungen enthaltenbearbeitete nukleinsäuren und ihre medizinische verwendung |
CA3162352A1 (en) | 2010-10-01 | 2012-04-05 | Modernatx, Inc. | Modified nucleosides, nucleotides, and nucleic acids, and uses thereof |
DE12722942T1 (de) | 2011-03-31 | 2021-09-30 | Modernatx, Inc. | Freisetzung und formulierung von manipulierten nukleinsäuren |
JP6090937B2 (ja) * | 2011-07-27 | 2017-03-08 | 国立大学法人京都大学 | 新規ドーパミン産生神経前駆細胞マーカー |
US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
PT3682905T (pt) | 2011-10-03 | 2022-04-07 | Modernatx Inc | Nucleósidos, nucleótidos e ácidos nucleicos modificados e respetivas utilizações |
LT2791160T (lt) | 2011-12-16 | 2022-06-10 | Modernatx, Inc. | Modifikuotos mrnr sudėtys |
US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
CA2868996A1 (en) | 2012-04-02 | 2013-10-10 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of proteins |
US9303079B2 (en) | 2012-04-02 | 2016-04-05 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
PL2922554T3 (pl) | 2012-11-26 | 2022-06-20 | Modernatx, Inc. | Na zmodyfikowany na końcach |
US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
JP2016538829A (ja) | 2013-10-03 | 2016-12-15 | モデルナ セラピューティクス インコーポレイテッドModerna Therapeutics,Inc. | 低密度リポタンパク質受容体をコードするポリヌクレオチド |
CN112522425B (zh) * | 2020-12-25 | 2023-11-28 | 武汉睿健医药科技有限公司 | Dpc细胞鉴定分类用标记物基因、筛选方法及应用 |
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NZ207394A (en) | 1983-03-08 | 1987-03-06 | Commw Serum Lab Commission | Detecting or determining sequence of amino acids |
JP2928287B2 (ja) | 1988-09-29 | 1999-08-03 | 協和醗酵工業株式会社 | 新規ポリペプチド |
DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
EP0546026B1 (de) | 1990-08-30 | 2000-08-02 | Cargill Incorporated | Brassica-öle mit geänderten fettsäuregehalten |
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WO1993002227A1 (en) | 1991-07-15 | 1993-02-04 | Eco-Tec Limited | Process and apparatus for treating fluoride containing acid solutions |
IT1251435B (it) | 1991-09-04 | 1995-05-09 | Sclavo Spa | Vettore genetico per la integrazione multipla stabile di sequenze di dna nel genoma dei lieviti kluyveromyces lactis e saccharomyces cerevisiae e plasmidi che lo contengono. |
EP0617706B1 (de) | 1991-11-25 | 2001-10-17 | Enzon, Inc. | Multivalente antigen-bindende proteine |
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CA2159738A1 (en) | 1993-04-13 | 1994-10-27 | Eugene O. Major | Use of neuro-derived fetal cell lines for transplantation therapy |
US5753491A (en) | 1993-04-13 | 1998-05-19 | Us Health | Use of neuro-derived fetal cell lines for transplantation therapy |
JPH08509612A (ja) | 1993-04-26 | 1996-10-15 | ジェンファーム インターナショナル インコーポレイテッド | 異種抗体を産生することができるトランスジェニック非ヒト動物 |
US5554381A (en) | 1993-08-09 | 1996-09-10 | Cygnus, Inc. | Low flux matrix system for delivering potent drugs transdermally |
US6294383B1 (en) | 1994-11-08 | 2001-09-25 | The Mclean Hospital Corporation | Porcine neural cells and their use in treatment of neurological deficits due to neurodegenerative diseases |
US6204053B1 (en) | 1994-11-08 | 2001-03-20 | Diacrin, Inc. | Porcine cortical cells and their use in treatment of neurological deficits due to neurodegenerative diseases |
US6277372B1 (en) | 1994-11-08 | 2001-08-21 | Diacrin, Inc. | Porcine neural cells and their use in treatment of neurological deficits due to neurodegenerative diseases |
JP3699727B2 (ja) | 1995-03-13 | 2005-09-28 | ユニヴァーシティ オブ サウス フロリダ | 神経変性疾患用の神経回復誘発細胞としてのセルトーリ細胞 |
US5830460A (en) | 1995-03-13 | 1998-11-03 | University Of South Florida | Sertoli cells as transplantation facilitator for cell transplantation |
US6653134B2 (en) | 1995-03-28 | 2003-11-25 | Cp Hahnemann University | Isolated stromal cells for use in the treatment of diseases of the central nervous system |
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US20020127584A1 (en) * | 1997-09-18 | 2002-09-12 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
US20030032103A1 (en) * | 1997-09-18 | 2003-02-13 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
DE19756864C5 (de) | 1997-12-19 | 2014-07-10 | Oliver Brüstle | Neurale Vorläuferzellen, Verfahren zu ihrer Herstellung und ihre Verwendung zur Therapie von neuralen Defekten |
EP1096941B1 (de) | 1998-05-07 | 2005-08-10 | University Of South Florida | Knochenmarkszellen als quelle von neuronen zur wiederherstellung von gehirn und knochenmark |
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US6610540B1 (en) | 1998-11-18 | 2003-08-26 | California Institute Of Technology | Low oxygen culturing of central nervous system progenitor cells |
US7217565B2 (en) * | 1999-02-12 | 2007-05-15 | Stemcells California, Inc. | Enriched central nervous system stem cell and progenitor cell populations, and methods for identifying, isolating and enriching for such populations |
JP2001184757A (ja) | 1999-12-27 | 2001-07-06 | Aiwa Co Ltd | テープレコーダ |
IL151170A0 (en) * | 2000-03-14 | 2003-04-10 | Es Cell Int Pte Ltd | Embryonic stem cells and neural progenitor cells derived therefrom |
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JP2002051775A (ja) | 2000-06-01 | 2002-02-19 | Japan Science & Technology Corp | ドーパミン作動性ニューロンの濃縮・分離方法 |
AU2001270058B2 (en) * | 2000-06-22 | 2006-11-02 | Biogen Idec Ma Inc. | GP354 nucleic acids and polypeptides |
US20040241170A1 (en) * | 2001-08-24 | 2004-12-02 | Jensen Charlotte Harken | Isolation of cells from neural cell populations using antibodies to fa1/dlk1 |
US7622270B2 (en) | 2002-10-22 | 2009-11-24 | Eisai R&D Management Co., Ltd. | Methods of isolating dopaminergic neuron precursor cells |
WO2004065599A1 (ja) | 2003-01-24 | 2004-08-05 | Eisai Co., Ltd. | Lrp4/Corinドーパミン産生ニューロン増殖前駆細胞マーカー |
EP1712638B1 (de) * | 2003-11-26 | 2009-06-10 | Eisai R&D Management Co., Ltd. | Spezifischer Marker Lmx1a für dopaminerge Neuronen |
CA2677996C (en) | 2007-02-09 | 2018-06-12 | Eisai R&D Management Co., Ltd. | Gaba neuron progenitor cell marker 65b13 |
-
2003
- 2003-10-21 US US10/532,264 patent/US7622270B2/en not_active Expired - Fee Related
- 2003-10-21 CN CN200610091616XA patent/CN1891826B/zh not_active Expired - Fee Related
- 2003-10-21 DE DE60335490T patent/DE60335490D1/de not_active Expired - Lifetime
- 2003-10-21 EP EP07006167A patent/EP1795595A1/de not_active Withdrawn
- 2003-10-21 AT AT03756723T patent/ATE492636T1/de not_active IP Right Cessation
- 2003-10-21 WO PCT/JP2003/013420 patent/WO2004038018A1/ja active Application Filing
- 2003-10-21 SG SG200602669-4A patent/SG146441A1/en unknown
- 2003-10-21 AU AU2003301576A patent/AU2003301576A1/en not_active Abandoned
- 2003-10-21 JP JP2004546430A patent/JP4118877B2/ja not_active Expired - Fee Related
- 2003-10-21 CN CNB2003801072365A patent/CN100572535C/zh not_active Expired - Fee Related
- 2003-10-21 EP EP03756723A patent/EP1561814B1/de not_active Expired - Lifetime
-
2007
- 2007-01-11 US US11/622,312 patent/US20070122882A1/en not_active Abandoned
-
2009
- 2009-10-08 US US12/575,946 patent/US8039224B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US20060239978A1 (en) | 2006-10-26 |
SG146441A1 (en) | 2008-10-30 |
EP1795595A1 (de) | 2007-06-13 |
US7622270B2 (en) | 2009-11-24 |
JPWO2004038018A1 (ja) | 2006-02-23 |
CN1891826A (zh) | 2007-01-10 |
US20070122882A1 (en) | 2007-05-31 |
CN100572535C (zh) | 2009-12-23 |
US8039224B2 (en) | 2011-10-18 |
US20100203570A1 (en) | 2010-08-12 |
AU2003301576A1 (en) | 2004-05-13 |
CN1891826B (zh) | 2011-09-14 |
JP4118877B2 (ja) | 2008-07-16 |
EP1561814A1 (de) | 2005-08-10 |
EP1561814B1 (de) | 2010-12-22 |
ATE492636T1 (de) | 2011-01-15 |
EP1561814A4 (de) | 2005-12-07 |
WO2004038018A1 (ja) | 2004-05-06 |
CN1729290A (zh) | 2006-02-01 |
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