DE60332727D1 - Verwendung von fluor-nmr zum screening mit hohem durchsatz - Google Patents
Verwendung von fluor-nmr zum screening mit hohem durchsatzInfo
- Publication number
- DE60332727D1 DE60332727D1 DE60332727T DE60332727T DE60332727D1 DE 60332727 D1 DE60332727 D1 DE 60332727D1 DE 60332727 T DE60332727 T DE 60332727T DE 60332727 T DE60332727 T DE 60332727T DE 60332727 D1 DE60332727 D1 DE 60332727D1
- Authority
- DE
- Germany
- Prior art keywords
- fluor
- nmr
- performance screening
- screening
- performance
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000012216 screening Methods 0.000 title abstract 2
- 238000001514 detection method Methods 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N24/00—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
- G01N24/08—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using nuclear magnetic resonance
- G01N24/088—Assessment or manipulation of a chemical or biochemical reaction, e.g. verification whether a chemical reaction occurred or whether a ligand binds to a receptor in drug screening or assessing reaction kinetics
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N24/00—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N24/00—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
- G01N24/08—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using nuclear magnetic resonance
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/46—NMR spectroscopy
- G01R33/465—NMR spectroscopy applied to biological material, e.g. in vitro testing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/46—NMR spectroscopy
- G01R33/4625—Processing of acquired signals, e.g. elimination of phase errors, baseline fitting, chemometric analysis
Landscapes
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- High Energy & Nuclear Physics (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Silicates, Zeolites, And Molecular Sieves (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Developing Agents For Electrophotography (AREA)
- Vehicle Body Suspensions (AREA)
- Polyesters Or Polycarbonates (AREA)
- Photoreceptors In Electrophotography (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38689702P | 2002-06-05 | 2002-06-05 | |
| US38925202P | 2002-06-17 | 2002-06-17 | |
| US39887502P | 2002-07-26 | 2002-07-26 | |
| US45476503P | 2003-03-14 | 2003-03-14 | |
| US45476603P | 2003-03-14 | 2003-03-14 | |
| PCT/US2003/017729 WO2004051214A2 (en) | 2002-06-05 | 2003-06-05 | Use of fluorine nmr for high throughput screening |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60332727D1 true DE60332727D1 (de) | 2010-07-08 |
Family
ID=32475841
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60332727T Expired - Lifetime DE60332727D1 (de) | 2002-06-05 | 2003-06-05 | Verwendung von fluor-nmr zum screening mit hohem durchsatz |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20040091937A1 (enExample) |
| EP (1) | EP1511852B1 (enExample) |
| JP (1) | JP2005536763A (enExample) |
| KR (1) | KR20050008788A (enExample) |
| CN (1) | CN1668757A (enExample) |
| AT (1) | ATE469238T1 (enExample) |
| AU (1) | AU2003243406A1 (enExample) |
| CA (1) | CA2488473C (enExample) |
| DE (1) | DE60332727D1 (enExample) |
| IL (1) | IL165527A0 (enExample) |
| NO (1) | NO20045487L (enExample) |
| WO (1) | WO2004051214A2 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005529328A (ja) | 2002-06-05 | 2005-09-29 | ファーマシア アンド アップジョン カンパニー | 競合的結合１ｈｎｍｒ実験を用いたリガンドの同定方法 |
| US20040072211A1 (en) * | 2002-06-05 | 2004-04-15 | Pharmacia & Upjohn Company | Methods for identifying ligands using waterlogsy NMR |
| WO2006042120A2 (en) * | 2004-10-06 | 2006-04-20 | Regents Of The University Of Minnesota | Contrast from rotating frame relaxation by adiabatic pulses |
| EP1923397B1 (en) | 2006-11-14 | 2009-10-28 | NERVIANO MEDICAL SCIENCES S.r.l. | Fluorinated amino acids and peptides |
| CN102507627B (zh) * | 2011-11-14 | 2014-10-01 | 中国科学院武汉物理与数学研究所 | 一种高通量筛选药物的核磁共振方法 |
| CN103487455B (zh) * | 2013-09-24 | 2016-04-27 | 上海大学 | 一种快速定量检测橄榄油中含羟基化合物的方法 |
| CN103760184A (zh) * | 2014-01-16 | 2014-04-30 | 江南大学 | 一种测定铅离子的磁共振成像传感器的构建方法 |
| US10761157B2 (en) | 2016-09-20 | 2020-09-01 | Halliburton Energy Services, Inc. | Analyzing fluids in core samples contained in pressurized NMR core holders with 1H and 19F NMR |
| CN107831094B (zh) * | 2017-10-30 | 2020-04-07 | 中国人民解放军国防科技大学 | 基于碱金属原子弛豫率变化测量气体扩散常数的方法 |
| CN108303440A (zh) * | 2018-04-04 | 2018-07-20 | 山东大学 | 一种基于19f-nmr技术快速检测利奥西呱与蛋白相互作用的方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH05503691A (ja) * | 1989-12-29 | 1993-06-17 | ユニバーシティ・テクノロジーズ・インターナショナル・インコーポレイテッド | アゴニストおよびアンタゴニストを含む生物学的に活性なリガンドの３次構造モデルの設計方法およびアンギオテンシンに基づいた新規合成アンタゴニスト |
| US6110660A (en) * | 1995-08-20 | 2000-08-29 | The European Institute Of Science Ab | Procedure for quantitative and qualitative determination of chemical substances, based on molecular recognition and measurement of magnetic permeability |
| US6897028B1 (en) * | 1997-07-07 | 2005-05-24 | Florida State University | Identification of molecular targets |
| AU778998B2 (en) * | 1998-09-22 | 2004-12-23 | University Of Maryland At Baltimore | Cystine knot growth factor mutants |
| US6677160B1 (en) * | 1999-09-29 | 2004-01-13 | Pharmacia & Upjohn Company | Methods for creating a compound library and identifying lead chemical templates and ligands for target molecules |
| EP1221048A4 (en) * | 1999-09-29 | 2005-01-05 | Smithkline Beecham Corp | METHOD FOR USING ONE-DIMENSIONAL AND MULTIDIMENSIONAL NUCLEAR MAGNETIC RESONANCE FOR IDENTIFYING COMPOUNDS THAT INTERACT WITH TARGET BIOMOLECULARS |
| US6593341B2 (en) * | 2001-03-29 | 2003-07-15 | Molecular Design International, Inc. | β3-adrenoreceptor agonists, agonist compositions and methods of making and using the same |
| ES2871905T3 (es) * | 2002-03-01 | 2021-11-02 | Immunomedics Inc | Inmunoconjugado que comprende anticuerpos de RS7 humanizados |
| JP2005529328A (ja) * | 2002-06-05 | 2005-09-29 | ファーマシア アンド アップジョン カンパニー | 競合的結合１ｈｎｍｒ実験を用いたリガンドの同定方法 |
| US20040072211A1 (en) * | 2002-06-05 | 2004-04-15 | Pharmacia & Upjohn Company | Methods for identifying ligands using waterlogsy NMR |
-
2003
- 2003-06-05 KR KR10-2004-7019714A patent/KR20050008788A/ko not_active Withdrawn
- 2003-06-05 AT AT03812412T patent/ATE469238T1/de active
- 2003-06-05 JP JP2004557095A patent/JP2005536763A/ja active Pending
- 2003-06-05 DE DE60332727T patent/DE60332727D1/de not_active Expired - Lifetime
- 2003-06-05 CN CNA038172739A patent/CN1668757A/zh active Pending
- 2003-06-05 CA CA2488473A patent/CA2488473C/en not_active Expired - Fee Related
- 2003-06-05 AU AU2003243406A patent/AU2003243406A1/en not_active Abandoned
- 2003-06-05 EP EP03812412A patent/EP1511852B1/en not_active Expired - Lifetime
- 2003-06-05 WO PCT/US2003/017729 patent/WO2004051214A2/en not_active Ceased
- 2003-06-05 US US10/455,077 patent/US20040091937A1/en not_active Abandoned
-
2004
- 2004-12-02 IL IL16552704A patent/IL165527A0/xx unknown
- 2004-12-16 NO NO20045487A patent/NO20045487L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| US20040091937A1 (en) | 2004-05-13 |
| NO20045487L (no) | 2005-02-07 |
| CN1668757A (zh) | 2005-09-14 |
| EP1511852A2 (en) | 2005-03-09 |
| AU2003243406A1 (en) | 2004-06-23 |
| JP2005536763A (ja) | 2005-12-02 |
| CA2488473C (en) | 2013-02-05 |
| CA2488473A1 (en) | 2004-06-17 |
| WO2004051214A3 (en) | 2004-09-10 |
| KR20050008788A (ko) | 2005-01-21 |
| IL165527A0 (en) | 2006-01-15 |
| EP1511852B1 (en) | 2010-05-26 |
| ATE469238T1 (de) | 2010-06-15 |
| WO2004051214A2 (en) | 2004-06-17 |
| EP1511852A4 (en) | 2008-07-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |