DE60322845D1 - Peptide und peptidmimetika mit anti-proliferativer aktivität und deren verwendung - Google Patents
Peptide und peptidmimetika mit anti-proliferativer aktivität und deren verwendungInfo
- Publication number
- DE60322845D1 DE60322845D1 DE60322845T DE60322845T DE60322845D1 DE 60322845 D1 DE60322845 D1 DE 60322845D1 DE 60322845 T DE60322845 T DE 60322845T DE 60322845 T DE60322845 T DE 60322845T DE 60322845 D1 DE60322845 D1 DE 60322845D1
- Authority
- DE
- Germany
- Prior art keywords
- peptides
- peptide mimetics
- proliferative activity
- compounds
- cell growth
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 2
- 230000001028 anti-proliverative effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 230000010261 cell growth Effects 0.000 abstract 2
- 201000011510 cancer Diseases 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 230000012820 cell cycle checkpoint Effects 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 239000000816 peptidomimetic Substances 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
- 210000004881 tumor cell Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Hematology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35020802P | 2002-01-17 | 2002-01-17 | |
| PCT/IB2003/000425 WO2003059942A2 (en) | 2002-01-17 | 2003-01-17 | Peptides and peptidomimetics having anti-proliferative activity and their use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60322845D1 true DE60322845D1 (de) | 2008-09-25 |
Family
ID=23375680
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60322845T Expired - Lifetime DE60322845D1 (de) | 2002-01-17 | 2003-01-17 | Peptide und peptidmimetika mit anti-proliferativer aktivität und deren verwendung |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US6995135B2 (de) |
| EP (1) | EP1483290B1 (de) |
| JP (3) | JP4041066B2 (de) |
| KR (2) | KR101103412B1 (de) |
| CN (2) | CN100360564C (de) |
| AT (1) | ATE404584T1 (de) |
| AU (2) | AU2003235576C1 (de) |
| CA (1) | CA2471192C (de) |
| CY (1) | CY1108470T1 (de) |
| DE (1) | DE60322845D1 (de) |
| DK (1) | DK1483290T3 (de) |
| ES (1) | ES2311703T3 (de) |
| HK (1) | HK1069179A1 (de) |
| IL (2) | IL162836A0 (de) |
| NO (1) | NO332461B1 (de) |
| PT (1) | PT1483290E (de) |
| SI (1) | SI1483290T1 (de) |
| WO (1) | WO2003059942A2 (de) |
| ZA (1) | ZA200405455B (de) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2471192C (en) * | 2002-01-17 | 2014-05-20 | Canbas Co., Ltd. | Peptides and peptidomimetics having anti-proliferative activity and/or that augment nucleic acid damaging agents or treatments |
| CA2487388C (en) * | 2002-06-06 | 2011-05-10 | Canbas Co., Ltd. | Compounds that abrogate dna-damage-induced cell cycle g2 checkpoint and/or augment the anti-cancer activity of dna-damaging treatments |
| US20100233146A1 (en) * | 2002-09-09 | 2010-09-16 | Reactive Surfaces, Ltd. | Coatings and Surface Treatments Having Active Enzymes and Peptides |
| US20040109853A1 (en) | 2002-09-09 | 2004-06-10 | Reactive Surfaces, Ltd. | Biological active coating components, coatings, and coated surfaces |
| US20090238811A1 (en) * | 2002-09-09 | 2009-09-24 | Mcdaniel C Steven | Enzymatic Antimicrobial and Antifouling Coatings and Polymeric Materials |
| US20050058689A1 (en) * | 2003-07-03 | 2005-03-17 | Reactive Surfaces, Ltd. | Antifungal paints and coatings |
| US20110070376A1 (en) * | 2002-09-09 | 2011-03-24 | Reactive Surfaces, Ltd. | Anti-fouling Paints & Coatings |
| US20100210745A1 (en) * | 2002-09-09 | 2010-08-19 | Reactive Surfaces, Ltd. | Molecular Healing of Polymeric Materials, Coatings, Plastics, Elastomers, Composites, Laminates, Adhesives, and Sealants by Active Enzymes |
| US7125842B2 (en) * | 2003-04-07 | 2006-10-24 | Canbas Co. Ltd. | Anti-fungal compounds and methods of use |
| JP4705567B2 (ja) * | 2003-06-25 | 2011-06-22 | 株式会社 キャンバス | 免疫調整活性、抗炎症活性、および抗ウイルス活性を有するペプチドおよびペプチド模倣物 |
| US8618066B1 (en) | 2003-07-03 | 2013-12-31 | Reactive Surfaces, Ltd., Llp | Coating compositions having peptidic antimicrobial additives and antimicrobial additives of other configurations |
| WO2005014856A1 (en) * | 2003-08-08 | 2005-02-17 | Canbas Co., Ltd. | Sensitivity test to predict efficacy of anti-cancer therapies |
| US20060286006A1 (en) * | 2005-06-21 | 2006-12-21 | Mcdaniel C S | Method and apparatus for the treatment of fluid waste streams |
| WO2008043148A1 (en) * | 2006-10-11 | 2008-04-17 | Medvet Science Pty. Ltd. | The use of a dna damaging agent and a ligand for the treatment of cancer |
| US9130407B2 (en) * | 2008-05-13 | 2015-09-08 | Qualcomm Incorporated | Signaling charging in wireless power environment |
| WO2009139497A1 (en) * | 2008-05-14 | 2009-11-19 | Takeda Pharmaceutical Company Limited | Cbp501 -derived agents and methods based thereon for inhibiting g2 cell cycle arrest and sensitizing cells to dna damaging agents |
| US8388904B1 (en) | 2008-12-22 | 2013-03-05 | Reactive Surfaces, Ltd., Llp | Equipment decontamination system and method |
| FR2942798B1 (fr) * | 2009-03-05 | 2011-04-08 | Centre Nat Rech Scient | Peptides utilisables pour le traitement de la leucemie lymphoide chronique |
| CN103889437A (zh) * | 2011-08-31 | 2014-06-25 | 纽约大学 | 硫醚、醚和烷基胺连接的氢键替代物肽模拟物 |
| RS60180B1 (sr) * | 2013-06-24 | 2020-06-30 | Canbas Co Ltd | Kombinovana upotreba peptida i peptidomimetika i tretman subpopulacija pacijenata obolelih od kancera |
| ES2739613T3 (es) | 2014-05-21 | 2020-02-03 | Entrada Therapeutics Inc | Péptidos que penetran en las células y sus métodos de preparación y su uso |
| US10815276B2 (en) | 2014-05-21 | 2020-10-27 | Entrada Therapeutics, Inc. | Cell penetrating peptides and methods of making and using thereof |
| US10456443B2 (en) | 2014-08-27 | 2019-10-29 | Ohio State Innovation Foundation | Peptidyl calcineurin inhibitors |
| US10149887B2 (en) * | 2015-10-23 | 2018-12-11 | Canbas Co., Ltd. | Peptides and peptidomimetics in combination with t cell activating and/or checkpoint inhibiting agents for cancer treatment |
| TWI805542B (zh) * | 2015-10-23 | 2023-06-21 | 日商坎巴斯有限公司 | 用於癌症治療之肽及擬肽與ｔ細胞活化劑及／或查核點抑制劑之組合 |
| WO2019148194A2 (en) | 2018-01-29 | 2019-08-01 | Ohio State Innovation Foundation | Peptidyl inhibitors of calcineurin-nfat interaction |
| EP3755351A4 (de) | 2018-02-22 | 2021-11-24 | Entrada Therapeutics, Inc. | Zusammensetzungen und verfahren zur behandlung von mitochondrialer neurogastrointestinaler enzephalopathie |
| EP3790890A4 (de) | 2018-05-09 | 2022-03-02 | Ohio State Innovation Foundation | Zyklische, zellpenetrierende peptide mit einem oder mehreren hydrophoben resten |
| CN114989254B (zh) * | 2022-06-17 | 2023-11-03 | 中山大学 | 一种多肽及其设计方法和在制备抑制具核梭杆菌产品或预防结直肠癌药物中的应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2239037T3 (es) | 1999-09-22 | 2005-09-16 | Canbas Co., Ltd. | Metodos y composiciones para inhibir la deteccion del ciclo celular en g2 y sensibilizar celulas a agentes dañinos del dna. |
| WO2001094411A1 (en) | 2000-06-05 | 2001-12-13 | The Regents Of The University Of California | Peptides modulating protease activated receptors and methods of using same |
| CA2471192C (en) * | 2002-01-17 | 2014-05-20 | Canbas Co., Ltd. | Peptides and peptidomimetics having anti-proliferative activity and/or that augment nucleic acid damaging agents or treatments |
-
2003
- 2003-01-17 CA CA2471192A patent/CA2471192C/en not_active Expired - Lifetime
- 2003-01-17 JP JP2003560044A patent/JP4041066B2/ja not_active Expired - Lifetime
- 2003-01-17 CN CNB038062569A patent/CN100360564C/zh not_active Expired - Lifetime
- 2003-01-17 AU AU2003235576A patent/AU2003235576C1/en not_active Expired
- 2003-01-17 US US10/347,145 patent/US6995135B2/en not_active Expired - Lifetime
- 2003-01-17 PT PT03729533T patent/PT1483290E/pt unknown
- 2003-01-17 IL IL16283603A patent/IL162836A0/xx active IP Right Grant
- 2003-01-17 ES ES03729533T patent/ES2311703T3/es not_active Expired - Lifetime
- 2003-01-17 DK DK03729533T patent/DK1483290T3/da active
- 2003-01-17 CN CN2007101270243A patent/CN101092455B/zh not_active Expired - Lifetime
- 2003-01-17 KR KR1020077031027A patent/KR101103412B1/ko active IP Right Grant
- 2003-01-17 DE DE60322845T patent/DE60322845D1/de not_active Expired - Lifetime
- 2003-01-17 SI SI200331414T patent/SI1483290T1/sl unknown
- 2003-01-17 AT AT03729533T patent/ATE404584T1/de active
- 2003-01-17 WO PCT/IB2003/000425 patent/WO2003059942A2/en active IP Right Grant
- 2003-01-17 EP EP03729533A patent/EP1483290B1/de not_active Expired - Lifetime
- 2003-01-17 KR KR1020047011092A patent/KR100863090B1/ko active IP Right Grant
-
2004
- 2004-07-01 IL IL162836A patent/IL162836A/en unknown
- 2004-07-08 ZA ZA2004/05455A patent/ZA200405455B/en unknown
- 2004-11-17 NO NO20043381A patent/NO332461B1/no not_active IP Right Cessation
-
2005
- 2005-03-21 HK HK05102425.6A patent/HK1069179A1/xx not_active IP Right Cessation
- 2005-09-06 US US11/221,348 patent/US7476657B2/en not_active Expired - Lifetime
-
2007
- 2007-08-24 JP JP2007218979A patent/JP4873646B2/ja not_active Expired - Lifetime
-
2008
- 2008-10-31 CY CY20081101235T patent/CY1108470T1/el unknown
- 2008-12-04 US US12/328,632 patent/US20090253635A1/en not_active Abandoned
-
2009
- 2009-04-29 AU AU2009201711A patent/AU2009201711B2/en not_active Expired
-
2010
- 2010-11-09 JP JP2010251327A patent/JP2011037896A/ja not_active Withdrawn
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| R082 | Change of representative |
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