DE60321774D1 - Aerosol-formulierungen von formoterol und mometason - Google Patents
Aerosol-formulierungen von formoterol und mometasonInfo
- Publication number
- DE60321774D1 DE60321774D1 DE60321774T DE60321774T DE60321774D1 DE 60321774 D1 DE60321774 D1 DE 60321774D1 DE 60321774 T DE60321774 T DE 60321774T DE 60321774 T DE60321774 T DE 60321774T DE 60321774 D1 DE60321774 D1 DE 60321774D1
- Authority
- DE
- Germany
- Prior art keywords
- formoterol
- mometason
- aerosol formulations
- solvate
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000203 mixture Substances 0.000 title abstract 3
- BPZSYCZIITTYBL-UHFFFAOYSA-N formoterol Chemical compound C1=CC(OC)=CC=C1CC(C)NCC(O)C1=CC=C(O)C(NC=O)=C1 BPZSYCZIITTYBL-UHFFFAOYSA-N 0.000 title abstract 2
- 229960002848 formoterol Drugs 0.000 title abstract 2
- 239000000443 aerosol Substances 0.000 title 1
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000012453 solvate Substances 0.000 abstract 2
- YFMFNYKEUDLDTL-UHFFFAOYSA-N 1,1,1,2,3,3,3-heptafluoropropane Chemical compound FC(F)(F)C(F)C(F)(F)F YFMFNYKEUDLDTL-UHFFFAOYSA-N 0.000 abstract 1
- LVGUZGTVOIAKKC-UHFFFAOYSA-N 1,1,1,2-tetrafluoroethane Chemical compound FCC(F)(F)F LVGUZGTVOIAKKC-UHFFFAOYSA-N 0.000 abstract 1
- 239000004067 bulking agent Substances 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- QLIIKPVHVRXHRI-CXSFZGCWSA-N mometasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CCl)(O)[C@@]1(C)C[C@@H]2O QLIIKPVHVRXHRI-CXSFZGCWSA-N 0.000 abstract 1
- 229960001664 mometasone Drugs 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 239000008249 pharmaceutical aerosol Substances 0.000 abstract 1
- 239000003380 propellant Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L9/00—Disinfection, sterilisation or deodorisation of air
- A61L9/14—Disinfection, sterilisation or deodorisation of air using sprayed or atomised substances including air-liquid contact processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
- A61K9/124—Aerosols; Foams characterised by the propellant
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Otolaryngology (AREA)
- Pain & Pain Management (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0207906.9A GB0207906D0 (en) | 2002-04-05 | 2002-04-05 | Formoterol and mometasone aerosol formulations |
| PCT/US2003/008710 WO2003086350A1 (en) | 2002-04-05 | 2003-03-21 | Formoterol and mometasone aerosol formulations |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60321774D1 true DE60321774D1 (de) | 2008-08-07 |
Family
ID=9934328
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60321774T Expired - Lifetime DE60321774D1 (de) | 2002-04-05 | 2003-03-21 | Aerosol-formulierungen von formoterol und mometason |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8252268B2 (de) |
| EP (1) | EP1492499B1 (de) |
| AT (1) | ATE398999T1 (de) |
| AU (1) | AU2003225915A1 (de) |
| DE (1) | DE60321774D1 (de) |
| GB (1) | GB0207906D0 (de) |
| WO (1) | WO2003086350A1 (de) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1878664B1 (de) * | 2002-08-27 | 2011-03-30 | Schering Corporation | Verfahren zur Herstellung von Formulierungen für Inhaliergeräte mit abgemessener Dosis |
| SE0301260D0 (sv) * | 2003-04-29 | 2003-04-29 | Astrazeneca Ab | Novel equipment |
| BRPI0414856A (pt) | 2003-10-03 | 2006-11-21 | 3M Innovative Properties Co | imidazoquinolinas alcóxi-substituìdas |
| MXPA06005910A (es) | 2003-11-25 | 2006-08-23 | 3M Innovative Properties Co | Sistemas de anillo imidazo sustituido y metodos. |
| US9248127B2 (en) | 2005-02-04 | 2016-02-02 | 3M Innovative Properties Company | Aqueous gel formulations containing immune response modifiers |
| SI1971369T1 (sl) * | 2005-12-21 | 2009-12-31 | Meda Pharma Gmbh & Co Kg | Kombinacija R,R-glikopirolata,roliprama in budezonida za zdravljenje vnetnih bolezni |
| EP1894568A1 (de) * | 2006-08-31 | 2008-03-05 | Novartis AG | Pharmazeutische Zusammensetzungen zur Behandlung von entzündlichen oder obstruktiven Atemwegserkrankungen |
| AU2007346134A1 (en) * | 2007-02-09 | 2008-08-14 | Merck Sharp & Dohme Corp. | Stable pharmaceutical drug aerosols |
| CA2754691C (en) | 2009-03-26 | 2019-07-30 | Pulmatrix, Inc. | Dry powder formulations and methods for treating pulmonary diseases |
| EP2410986A2 (de) * | 2009-03-26 | 2012-02-01 | Pulmatrix, Inc. | Calciumcitrat- und calciumlactat-formulierungen zur änderung der biophysikalischen eigenschaften der schleimhaut |
| US8815258B2 (en) | 2009-05-29 | 2014-08-26 | Pearl Therapeutics, Inc. | Compositions, methods and systems for respiratory delivery of two or more active agents |
| EP2435024B1 (de) * | 2009-05-29 | 2016-07-06 | Pearl Therapeutics, Inc. | Zusammensetzungen zur freisetzung von wirkstoffen über die atemwege sowie zugehörige verfahren und systeme |
| WO2011015226A1 (en) * | 2009-08-03 | 2011-02-10 | Pharmatex Italia Srl | Process for the preparation of sterile powdered pharmaceutical compounds in the form of micro and nanoparticles |
| WO2011093815A2 (en) * | 2010-01-29 | 2011-08-04 | Mahmut Bilgic | Pharmaceutical compositions comprising formoterol and mometasone |
| US20130164338A1 (en) | 2010-08-30 | 2013-06-27 | Pulmatrix, Inc. | Treatment of cystic fibrosis using calcium lactate, leucine and sodium chloride in a respiraple dry powder |
| CN105640925B (zh) | 2010-08-30 | 2019-08-16 | 普马特里克斯营业公司 | 干燥粉末配方及用于治疗肺部疾病的方法 |
| RU2640921C2 (ru) | 2010-09-29 | 2018-01-12 | Пулмэтрикс, Инк. | Катионы одновалентных металлов сухих порошков для ингаляций |
| CA2812417C (en) | 2010-09-29 | 2019-10-22 | Pulmatrix, Inc. | Cationic dry powders |
| CN104487075A (zh) | 2012-02-29 | 2015-04-01 | 普马特里克斯公司 | 可吸入干粉剂 |
| KR102391332B1 (ko) | 2013-03-15 | 2022-04-26 | 펄 테라퓨틱스 인코포레이티드 | 미립자 결정질 재료를 컨디셔닝하는 방법 및 시스템 |
| KR20150135328A (ko) | 2013-04-01 | 2015-12-02 | 풀매트릭스 인코퍼레이티드 | 티오트로피움 건조 분말 |
| WO2015199626A1 (en) * | 2014-06-27 | 2015-12-30 | World Medicine İlaç Sanayi̇ Ve Ti̇caret Anoni̇m Şi̇rketi̇ | STABLE AEROSOL FORMULATIONS OF β2- ADRENERGIC AGONISTS |
| EP3174522A1 (de) | 2014-07-29 | 2017-06-07 | 3M Innovative Properties Company | Verfahren zur herstellung einer pharmazeutischen zusammensetzung |
| GB2545025A (en) * | 2015-12-04 | 2017-06-07 | Mexichem Fluor Sa De Cv | Pharmaceutical composition |
| ES2866175T3 (es) | 2015-12-04 | 2021-10-19 | Mexichem Fluor Sa De Cv | Composición farmacéutica |
| WO2022217029A1 (en) * | 2021-04-09 | 2022-10-13 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Compositions and methods for delivering pharmaceutical agents |
| US11964121B2 (en) | 2021-10-13 | 2024-04-23 | Satio, Inc. | Mono dose dermal patch for pharmaceutical delivery |
| US11877848B2 (en) | 2021-11-08 | 2024-01-23 | Satio, Inc. | Dermal patch for collecting a physiological sample |
| US12048543B2 (en) | 2021-11-08 | 2024-07-30 | Satio, Inc. | Dermal patch for collecting a physiological sample with removable vial |
| US12023156B2 (en) | 2021-10-13 | 2024-07-02 | Satio, Inc. | Dermal patch for collecting a physiological sample |
| US12029562B2 (en) | 2021-04-14 | 2024-07-09 | Satio, Inc. | Dermal patch system |
| US12053284B2 (en) | 2021-11-08 | 2024-08-06 | Satio, Inc. | Dermal patch for collecting a physiological sample |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3260474D1 (en) * | 1981-02-02 | 1984-09-06 | Schering Corp | Aromatic heterocyclic esters of steroids, their preparation and pharmaceutical compositions containing them |
| DE19875032I2 (de) * | 1990-09-10 | 2007-04-19 | Schering Corp | Mometason-Furoate-Monohydrat, Verfahren zu seiner Herstellung und das enthaltende pharmazeutische Zusammensetzungen |
| US5795564A (en) * | 1991-04-05 | 1998-08-18 | Sepracor, Inc. | Methods and compositions for treating pulmonary disorders using optically pure (R,R)-formoterol |
| DE69413955T2 (de) | 1993-03-17 | 1999-04-01 | Minnesota Mining And Mfg. Co., Saint Paul, Minn. | Aerosolzusammensetzung enthaltend einen aus ester-, amid- oder merkaptoester- derivat dispergiermittel |
| AU679510B2 (en) | 1993-03-17 | 1997-07-03 | Minnesota Mining And Manufacturing Company | Aerosol formulation containing a diol-diacid derived dispersing aid |
| PE44995A1 (es) | 1994-01-27 | 1995-12-18 | Schering Corp | Furoato de mometasona para el tratamiento de las enfermedades pulmonares y de las vias respiratorias |
| ES2292526T3 (es) * | 1995-04-14 | 2008-03-16 | Smithkline Beecham Corporation | Procedimiento para la preparacion de un inhalador dosificador. |
| GB9612297D0 (en) | 1996-06-11 | 1996-08-14 | Minnesota Mining & Mfg | Medicinal aerosol formulations |
| ES2159148T3 (es) | 1996-08-29 | 2001-09-16 | Schering Corp | Formulaciones en aerosol de furoato de mometasona libres de clorofluorocarbonos. |
| AU722859B2 (en) | 1996-11-11 | 2000-08-10 | Sepracor, Inc. | Process for the preparation of optically pure isomers of formoterol |
| US6129905A (en) * | 1997-04-21 | 2000-10-10 | Aeropharm Technology, Inc. | Aerosol formulations containing a sugar as a dispersant |
| US6264923B1 (en) * | 1998-05-13 | 2001-07-24 | 3M Innovative Properties Company | Medicinal aerosol formulation of ciclesonide and related compounds |
| ATE234604T1 (de) | 1998-08-04 | 2003-04-15 | Jago Res Ag | Medizinische aerosolformulierungen |
| GB9904919D0 (en) | 1999-03-03 | 1999-04-28 | Novartis Ag | Organic compounds |
| SE9900833D0 (sv) * | 1999-03-09 | 1999-03-09 | Astra Ab | Novel combination |
| GB0009609D0 (en) * | 2000-04-18 | 2000-06-07 | Glaxo Group Ltd | Therapeutic compositions |
| GB0009612D0 (en) | 2000-04-18 | 2000-06-07 | Glaxo Group Ltd | Therapeutic formulations |
| AU2001278115A1 (en) | 2000-08-04 | 2002-02-18 | Longwood Pharmaceutical Research, Inc. | Formulations of mometasone and a bronchodilator for pulmonary administration |
| US20040081627A1 (en) * | 2000-10-09 | 2004-04-29 | Jinks Phillip A | Medicinal aerosol formulations |
| DE60118021T2 (de) * | 2000-10-09 | 2006-10-26 | 3M Innovative Properties Co., St. Paul | Medizinische aerosolzusammensetzung |
| AR036358A1 (es) | 2001-08-28 | 2004-09-01 | Schering Corp | Un inhalador de dosis medidas que contiene una formulacion de suspension en aerosol para inhalacion, un proceso para la produccion de la formulacion, el producto y el uso de una formulacion para la manufactura de un medicamento de asma |
| EP1878664B1 (de) | 2002-08-27 | 2011-03-30 | Schering Corporation | Verfahren zur Herstellung von Formulierungen für Inhaliergeräte mit abgemessener Dosis |
-
2002
- 2002-04-05 GB GBGB0207906.9A patent/GB0207906D0/en not_active Ceased
-
2003
- 2003-03-21 US US10/509,184 patent/US8252268B2/en active Active
- 2003-03-21 AT AT03746547T patent/ATE398999T1/de not_active IP Right Cessation
- 2003-03-21 DE DE60321774T patent/DE60321774D1/de not_active Expired - Lifetime
- 2003-03-21 EP EP03746547A patent/EP1492499B1/de not_active Expired - Lifetime
- 2003-03-21 AU AU2003225915A patent/AU2003225915A1/en not_active Abandoned
- 2003-03-21 WO PCT/US2003/008710 patent/WO2003086350A1/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| ATE398999T1 (de) | 2008-07-15 |
| US8252268B2 (en) | 2012-08-28 |
| EP1492499A1 (de) | 2005-01-05 |
| AU2003225915A1 (en) | 2003-10-27 |
| WO2003086350A1 (en) | 2003-10-23 |
| US20050255049A1 (en) | 2005-11-17 |
| GB0207906D0 (en) | 2002-05-15 |
| EP1492499B1 (de) | 2008-06-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |