DE60308708D1 - Neue synthese von irbesartan - Google Patents

Neue synthese von irbesartan

Info

Publication number
DE60308708D1
DE60308708D1 DE60308708T DE60308708T DE60308708D1 DE 60308708 D1 DE60308708 D1 DE 60308708D1 DE 60308708 T DE60308708 T DE 60308708T DE 60308708 T DE60308708 T DE 60308708T DE 60308708 D1 DE60308708 D1 DE 60308708D1
Authority
DE
Germany
Prior art keywords
irbesartan
new synthesis
synthesis
employing
particle size
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60308708T
Other languages
English (en)
Other versions
DE60308708T2 (de
Inventor
Gennady Nisnevich
Igor Rukhman
Boris Pertsikov
Julia Kaftanov
Ben-Zion Dolitzky
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teva Pharmaceutical Industries Ltd
Original Assignee
Teva Pharmaceutical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharmaceutical Industries Ltd filed Critical Teva Pharmaceutical Industries Ltd
Publication of DE60308708D1 publication Critical patent/DE60308708D1/de
Application granted granted Critical
Publication of DE60308708T2 publication Critical patent/DE60308708T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE60308708T 2002-07-16 2003-07-16 Neue synthese von irbesartan Expired - Lifetime DE60308708T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US39642402P 2002-07-16 2002-07-16
US396424P 2002-07-16
US40249002P 2002-08-09 2002-08-09
US402490P 2002-08-09
PCT/US2003/022479 WO2004007482A2 (en) 2002-07-16 2003-07-16 Novel synthesis of irbesartan

Publications (2)

Publication Number Publication Date
DE60308708D1 true DE60308708D1 (de) 2006-11-09
DE60308708T2 DE60308708T2 (de) 2007-08-23

Family

ID=30118586

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60308708T Expired - Lifetime DE60308708T2 (de) 2002-07-16 2003-07-16 Neue synthese von irbesartan

Country Status (11)

Country Link
US (1) US20050176794A1 (de)
EP (1) EP1546135B1 (de)
CN (1) CN1668612A (de)
AT (1) ATE340793T1 (de)
AU (1) AU2003256609A1 (de)
CA (1) CA2492779A1 (de)
DE (1) DE60308708T2 (de)
ES (1) ES2273041T3 (de)
IL (1) IL166306A0 (de)
PT (1) PT1546135E (de)
WO (1) WO2004007482A2 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1509517B1 (de) 2003-01-16 2008-06-11 Teva Pharmaceutical Industries Ltd. Neue synthese von irbesartan
US7038060B2 (en) 2003-02-05 2006-05-02 Teva Pharmaceutical Industries Ltd. Synthesis of 2-butyl-3-(2′-(1-trityl-1H-tetrazol-5-yl)biphenyl-4-yl)-1,3-diazaspiro[4.4]-non-ene-4-one
GB2419592A (en) * 2004-10-26 2006-05-03 Cipla Ltd Process for the preparation of irbesartan hydrochloride
SI21965A (sl) * 2005-01-05 2006-08-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Priprava tetrazolskega derivata
WO2006097121A1 (en) * 2005-03-16 2006-09-21 Ulkar Kimya Sanayii Ve Ticaret A.S. Method for producing biphenyl-tetrazole compounds
WO2006136916A2 (en) * 2005-06-20 2006-12-28 Glenmark Pharmaceuticals Limited Substantially pure micronized particles of telmisartan and pharmaceutical compositions containing same
EP1951714A1 (de) * 2005-07-27 2008-08-06 Jubilant Organosys Limited Verfahren zur herstellung von 2-(n-butyl)-3-[[2'-(tetrazol-5-yl)biphenyl-4-yl]methyl]-1,3-diazaspiro[4.4]non-1-en-4-on
EP1749828A1 (de) 2005-08-04 2007-02-07 Farmaprojects S.L. Verfahren zur Herstellung eines Angiotensin-II-Antagonisten
PL1806130T3 (pl) 2006-01-09 2010-08-31 Krka D D Novo Mesto Kompozycja farmaceutyczna w postaci stałej zawierająca irbesartan
ES2371910T3 (es) * 2006-04-07 2012-01-11 Lek Pharmaceuticals D.D. Procedimiento para la preparación de irbesartán puro.
WO2008027385A2 (en) * 2006-08-29 2008-03-06 Teva Pharmaceutical Industries Ltd. Processes for the synthesis of 5-phenyl -1 trityl-1h-tetrazole
CN100413853C (zh) * 2006-09-21 2008-08-27 浙江海正药业股份有限公司 厄贝沙坦的合成中间体及其制备方法和制备药物的用途
RU2495040C1 (ru) * 2012-05-03 2013-10-10 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Чувашский государственный университет имени И.Н. Ульянова" Способ получения 3-амино-8-гидрокси-1,6-диоксо-2,7-диазаспиро[4.4]нон-3-ен-4-карбонитрилов
CN102875534B (zh) * 2012-09-10 2015-05-27 珠海保税区丽珠合成制药有限公司 一种厄贝沙坦的合成方法
CN105001209A (zh) * 2015-06-29 2015-10-28 千辉药业（安徽）有限责任公司 一种厄贝沙坦的合成方法
CN108218841A (zh) * 2018-03-06 2018-06-29 大桐制药（中国）有限责任公司 一种高纯度抗高血压药物依贝沙坦的合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5138069A (en) * 1986-07-11 1992-08-11 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking imidazoles
US5270317A (en) * 1990-03-20 1993-12-14 Elf Sanofi N-substituted heterocyclic derivatives, their preparation and the pharmaceutical compositions in which they are present
FR2725987B1 (fr) * 1994-10-19 1997-01-10 Sanofi Sa Procede pour la preparation d'un derive de tetrazole sous deux formes cristallines et nouvelle forme cristalline de ce derive
US6162922A (en) * 1998-01-30 2000-12-19 Bristol-Myers Squibb Co. Method for preparing N-substituted heterocyclic derivatives using a phase-transfer catalyst

Also Published As

Publication number Publication date
PT1546135E (pt) 2006-12-29
CN1668612A (zh) 2005-09-14
WO2004007482A3 (en) 2004-05-27
ES2273041T3 (es) 2007-05-01
AU2003256609A1 (en) 2004-02-02
IL166306A0 (en) 2006-01-15
EP1546135B1 (de) 2006-09-27
CA2492779A1 (en) 2004-01-22
EP1546135A2 (de) 2005-06-29
AU2003256609A8 (en) 2004-02-02
US20050176794A1 (en) 2005-08-11
DE60308708T2 (de) 2007-08-23
ATE340793T1 (de) 2006-10-15
WO2004007482A2 (en) 2004-01-22

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8381 Inventor (new situation)

Inventor name: NISNEVICH, GENNADY, 34464 HAIFA, IL

Inventor name: RUKHMAN, IGOR, TECHNION CITY, HAIFA 32000, IL

Inventor name: KAFTANOV, JULIA, 35471 HAIFA, IL