IL166306A0 - Novel synthesis of irbesartan - Google Patents
Novel synthesis of irbesartanInfo
- Publication number
- IL166306A0 IL166306A0 IL16630605A IL16630605A IL166306A0 IL 166306 A0 IL166306 A0 IL 166306A0 IL 16630605 A IL16630605 A IL 16630605A IL 16630605 A IL16630605 A IL 16630605A IL 166306 A0 IL166306 A0 IL 166306A0
- Authority
- IL
- Israel
- Prior art keywords
- irbesartan
- novel synthesis
- synthesis
- novel
- employing
- Prior art date
Links
- 239000002947 C09CA04 - Irbesartan Substances 0.000 title abstract 3
- YCPOHTHPUREGFM-UHFFFAOYSA-N irbesartan Chemical compound O=C1N(CC=2C=CC(=CC=2)C=2C(=CC=CC=2)C=2[N]N=NN=2)C(CCCC)=NC21CCCC2 YCPOHTHPUREGFM-UHFFFAOYSA-N 0.000 title abstract 3
- 229960002198 irbesartan Drugs 0.000 title abstract 3
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- 239000010419 fine particle Substances 0.000 abstract 1
- 239000003444 phase transfer catalyst Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Catalysts (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39642402P | 2002-07-16 | 2002-07-16 | |
| US40249002P | 2002-08-09 | 2002-08-09 | |
| PCT/US2003/022479 WO2004007482A2 (en) | 2002-07-16 | 2003-07-16 | Novel synthesis of irbesartan |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL166306A0 true IL166306A0 (en) | 2006-01-15 |
Family
ID=30118586
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL16630605A IL166306A0 (en) | 2002-07-16 | 2005-01-14 | Novel synthesis of irbesartan |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20050176794A1 (de) |
| EP (1) | EP1546135B1 (de) |
| CN (1) | CN1668612A (de) |
| AT (1) | ATE340793T1 (de) |
| AU (1) | AU2003256609A1 (de) |
| CA (1) | CA2492779A1 (de) |
| DE (1) | DE60308708T2 (de) |
| ES (1) | ES2273041T3 (de) |
| IL (1) | IL166306A0 (de) |
| PT (1) | PT1546135E (de) |
| WO (1) | WO2004007482A2 (de) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1759113A (zh) | 2003-01-16 | 2006-04-12 | 特瓦制药工业有限公司 | 伊贝沙坦的新合成方法 |
| US7038060B2 (en) * | 2003-02-05 | 2006-05-02 | Teva Pharmaceutical Industries Ltd. | Synthesis of 2-butyl-3-(2′-(1-trityl-1H-tetrazol-5-yl)biphenyl-4-yl)-1,3-diazaspiro[4.4]-non-ene-4-one |
| GB2419592A (en) * | 2004-10-26 | 2006-05-03 | Cipla Ltd | Process for the preparation of irbesartan hydrochloride |
| SI21965A (sl) * | 2005-01-05 | 2006-08-31 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Priprava tetrazolskega derivata |
| WO2006097121A1 (en) * | 2005-03-16 | 2006-09-21 | Ulkar Kimya Sanayii Ve Ticaret A.S. | Method for producing biphenyl-tetrazole compounds |
| WO2006136916A2 (en) * | 2005-06-20 | 2006-12-28 | Glenmark Pharmaceuticals Limited | Substantially pure micronized particles of telmisartan and pharmaceutical compositions containing same |
| US7964737B2 (en) | 2005-07-27 | 2011-06-21 | Jubilant Organosys Limited | Process for producing 2-(n-butyl)-3-[[2′-(tetrazol-5-yl)biphenyl-4-yl]methyl]-1,3-diazaspiro[4.4] non-1-en-4-one |
| EP1749828A1 (de) | 2005-08-04 | 2007-02-07 | Farmaprojects S.L. | Verfahren zur Herstellung eines Angiotensin-II-Antagonisten |
| DE602006013261D1 (de) | 2006-01-09 | 2010-05-12 | Krka D D | Irbesartan enthaltende feste Zubereitung |
| CA2654218C (en) | 2006-04-07 | 2014-07-22 | Lek Pharmaceuticals D.D. | Process for the preparation of pure irbesartan |
| JP2009515834A (ja) * | 2006-08-29 | 2009-04-16 | テバ ファーマシューティカル インダストリーズ リミティド | ５−フェニル−１−トリチル−１ｈ−テトラゾールの合成のための方法 |
| CN100413853C (zh) * | 2006-09-21 | 2008-08-27 | 浙江海正药业股份有限公司 | 厄贝沙坦的合成中间体及其制备方法和制备药物的用途 |
| RU2495040C1 (ru) * | 2012-05-03 | 2013-10-10 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Чувашский государственный университет имени И.Н. Ульянова" | Способ получения 3-амино-8-гидрокси-1,6-диоксо-2,7-диазаспиро[4.4]нон-3-ен-4-карбонитрилов |
| CN102875534B (zh) * | 2012-09-10 | 2015-05-27 | 珠海保税区丽珠合成制药有限公司 | 一种厄贝沙坦的合成方法 |
| CN105001209A (zh) * | 2015-06-29 | 2015-10-28 | 千辉药业（安徽）有限责任公司 | 一种厄贝沙坦的合成方法 |
| CN108218841A (zh) * | 2018-03-06 | 2018-06-29 | 大桐制药（中国）有限责任公司 | 一种高纯度抗高血压药物依贝沙坦的合成方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5138069A (en) * | 1986-07-11 | 1992-08-11 | E. I. Du Pont De Nemours And Company | Angiotensin II receptor blocking imidazoles |
| US5270317A (en) * | 1990-03-20 | 1993-12-14 | Elf Sanofi | N-substituted heterocyclic derivatives, their preparation and the pharmaceutical compositions in which they are present |
| FR2725987B1 (fr) * | 1994-10-19 | 1997-01-10 | Sanofi Sa | Procede pour la preparation d'un derive de tetrazole sous deux formes cristallines et nouvelle forme cristalline de ce derive |
| US6162922A (en) * | 1998-01-30 | 2000-12-19 | Bristol-Myers Squibb Co. | Method for preparing N-substituted heterocyclic derivatives using a phase-transfer catalyst |
-
2003
- 2003-07-16 AU AU2003256609A patent/AU2003256609A1/en not_active Abandoned
- 2003-07-16 EP EP03764805A patent/EP1546135B1/de not_active Expired - Lifetime
- 2003-07-16 WO PCT/US2003/022479 patent/WO2004007482A2/en not_active Ceased
- 2003-07-16 ES ES03764805T patent/ES2273041T3/es not_active Expired - Lifetime
- 2003-07-16 AT AT03764805T patent/ATE340793T1/de not_active IP Right Cessation
- 2003-07-16 PT PT03764805T patent/PT1546135E/pt unknown
- 2003-07-16 DE DE60308708T patent/DE60308708T2/de not_active Expired - Lifetime
- 2003-07-16 US US10/621,623 patent/US20050176794A1/en not_active Abandoned
- 2003-07-16 CA CA002492779A patent/CA2492779A1/en not_active Abandoned
- 2003-07-16 CN CNA038167336A patent/CN1668612A/zh active Pending
-
2005
- 2005-01-14 IL IL16630605A patent/IL166306A0/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PT1546135E (pt) | 2006-12-29 |
| DE60308708T2 (de) | 2007-08-23 |
| AU2003256609A1 (en) | 2004-02-02 |
| ES2273041T3 (es) | 2007-05-01 |
| WO2004007482A2 (en) | 2004-01-22 |
| DE60308708D1 (de) | 2006-11-09 |
| US20050176794A1 (en) | 2005-08-11 |
| AU2003256609A8 (en) | 2004-02-02 |
| CN1668612A (zh) | 2005-09-14 |
| EP1546135B1 (de) | 2006-09-27 |
| EP1546135A2 (de) | 2005-06-29 |
| WO2004007482A3 (en) | 2004-05-27 |
| CA2492779A1 (en) | 2004-01-22 |
| ATE340793T1 (de) | 2006-10-15 |
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